U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Type VI atherosclerotic lesion

MedGen UID:
1645949
Concept ID:
C4703478
Disease or Syndrome
HPO: HP:0031683

Definition

Type VI atherosclerotic lesions generally have the underlying morphology of type IV or V lesions, surface disruptions, hematoma, and thrombosis may be (although less often) superimposed on any other type of lesion and even on intima without an apparent lesion. Complicating features may arise because of individual differences in risk factors and tissue reactions. These may include differences in composition of the blood, the relative quantities and distributions in the components of the underlying lesion or intima, as well as modifications of shear and tensile forces to which the lesion or intima is exposed. Clinical imaging of lesions may be expected to contribute greatly to the understanding of type VI lesions and the associated clinical syndromes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVType VI atherosclerotic lesion

Recent clinical studies

Etiology

Eilenberg W, Stojkovic S, Kaider A, Kozakowski N, Domenig CM, Burghuber C, Nanobachvili J, Huber K, Klinger M, Neumayer C, Huk I, Wojta J, Demyanets S
Clin Chem Lab Med 2017 Nov 27;56(1):147-156. doi: 10.1515/cclm-2017-0156. PMID: 28672747
Pini R, Faggioli G, Fittipaldi S, Vasuri F, Longhi M, Gallitto E, Pasquinelli G, Gargiulo M, Stella A
Ann Vasc Surg 2017 Oct;44:336-342. Epub 2017 May 4 doi: 10.1016/j.avsg.2017.04.017. PMID: 28479433
Grimm JM, Schindler A, Freilinger T, Cyran CC, Bamberg F, Yuan C, Reiser MF, Dichgans M, Freilinger C, Nikolaou K, Saam T
J Cardiovasc Magn Reson 2013 May 24;15(1):44. doi: 10.1186/1532-429X-15-44. PMID: 23705576Free PMC Article
Leinonen M, Saikku P
Scand Cardiovasc J 2000;34(1):12-20. doi: 10.1080/14017430050142341. PMID: 10816055
Fuster V, Badimon J, Chesebro JH, Fallon JT
Haemostasis 1996 Oct;26 Suppl 4:269-84. doi: 10.1159/000217308. PMID: 8979133

Diagnosis

Ge X, Zhou Z, Zhao H, Li X, Sun B, Suo S, Hackett ML, Wan J, Xu J, Liu X
J Magn Reson Imaging 2017 Sep;46(3):870-876. Epub 2017 Jan 24 doi: 10.1002/jmri.25637. PMID: 28120364
Grimm JM, Schindler A, Freilinger T, Cyran CC, Bamberg F, Yuan C, Reiser MF, Dichgans M, Freilinger C, Nikolaou K, Saam T
J Cardiovasc Magn Reson 2013 May 24;15(1):44. doi: 10.1186/1532-429X-15-44. PMID: 23705576Free PMC Article
Gao T, Zhang Z, Yu W, Zhang Z, Wang Y
Cerebrovasc Dis 2009;27(4):345-52. Epub 2009 Feb 14 doi: 10.1159/000202011. PMID: 19218800Free PMC Article
Jabs WJ, Theissing E, Nitschke M, Bechtel JF, Duchrow M, Mohamed S, Jahrbeck B, Sievers HH, Steinhoff J, Bartels C
Circulation 2003 Sep 23;108(12):1428-31. Epub 2003 Sep 15 doi: 10.1161/01.CIR.0000092184.43176.91. PMID: 12975260
Wang J, Geng YJ, Guo B, Klima T, Lal BN, Willerson JT, Casscells W
J Am Coll Cardiol 2002 Apr 17;39(8):1305-13. doi: 10.1016/s0735-1097(02)01767-9. PMID: 11955848

Therapy

Jabs WJ, Theissing E, Nitschke M, Bechtel JF, Duchrow M, Mohamed S, Jahrbeck B, Sievers HH, Steinhoff J, Bartels C
Circulation 2003 Sep 23;108(12):1428-31. Epub 2003 Sep 15 doi: 10.1161/01.CIR.0000092184.43176.91. PMID: 12975260
Tangirala RK, Praticó D, FitzGerald GA, Chun S, Tsukamoto K, Maugeais C, Usher DC, Puré E, Rader DJ
J Biol Chem 2001 Jan 5;276(1):261-6. doi: 10.1074/jbc.M003324200. PMID: 11024044
Leinonen M, Saikku P
Scand Cardiovasc J 2000;34(1):12-20. doi: 10.1080/14017430050142341. PMID: 10816055
Pickering JG, Takeshita S, Feldman L, Losordo DW, Isner JM
Semin Interv Cardiol 1996 Mar;1(1):84-8. PMID: 9552498
Fuster V, Badimon J, Chesebro JH, Fallon JT
Haemostasis 1996 Oct;26 Suppl 4:269-84. doi: 10.1159/000217308. PMID: 8979133

Prognosis

Marlevi D, Mulvagh SL, Huang R, DeMarco JK, Ota H, Huston J 3rd, Winter R, Macedo TA, Abdelmoneim SS, Larsson M, Pellikka PA, Urban MW
Sci Rep 2020 Jan 15;10(1):403. doi: 10.1038/s41598-019-57317-7. PMID: 31942025Free PMC Article
Grimm JM, Schindler A, Schwarz F, Cyran CC, Bayer-Karpinska A, Freilinger T, Yuan C, Linn J, Trelles M, Reiser MF, Nikolaou K, Saam T
J Cardiovasc Magn Reson 2014 Oct 7;16(1):84. doi: 10.1186/s12968-014-0084-y. PMID: 25315518Free PMC Article
Grimm JM, Schindler A, Freilinger T, Cyran CC, Bamberg F, Yuan C, Reiser MF, Dichgans M, Freilinger C, Nikolaou K, Saam T
J Cardiovasc Magn Reson 2013 May 24;15(1):44. doi: 10.1186/1532-429X-15-44. PMID: 23705576Free PMC Article
Jabs WJ, Theissing E, Nitschke M, Bechtel JF, Duchrow M, Mohamed S, Jahrbeck B, Sievers HH, Steinhoff J, Bartels C
Circulation 2003 Sep 23;108(12):1428-31. Epub 2003 Sep 15 doi: 10.1161/01.CIR.0000092184.43176.91. PMID: 12975260
Wang J, Geng YJ, Guo B, Klima T, Lal BN, Willerson JT, Casscells W
J Am Coll Cardiol 2002 Apr 17;39(8):1305-13. doi: 10.1016/s0735-1097(02)01767-9. PMID: 11955848

Clinical prediction guides

Zernecke A, Erhard F, Weinberger T, Schulz C, Ley K, Saliba AE, Cochain C
Cardiovasc Res 2023 Jul 6;119(8):1676-1689. doi: 10.1093/cvr/cvac161. PMID: 36190844Free PMC Article
Wehrum T, Dragonu I, Strecker C, Hennig J, Harloff A
Eur J Radiol 2017 Jun;91:148-154. Epub 2017 Apr 17 doi: 10.1016/j.ejrad.2017.04.011. PMID: 28629561
Panutsopulos D, Papalambros E, Sigala F, Zafiropoulos A, Arvanitis DL, Spandidos DA
Int J Mol Med 2005 Apr;15(4):603-10. PMID: 15754021
Wang J, Geng YJ, Guo B, Klima T, Lal BN, Willerson JT, Casscells W
J Am Coll Cardiol 2002 Apr 17;39(8):1305-13. doi: 10.1016/s0735-1097(02)01767-9. PMID: 11955848
Häkkinen T, Karkola K, Ylä-Herttuala S
Virchows Arch 2000 Oct;437(4):396-405. doi: 10.1007/s004280000239. PMID: 11097365

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...