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Coma Greater than 24 Hours

MedGen UID:
1646242
•Concept ID:
C4683647
•
Finding

Definition

An indication that coma has lasted more than 24 hours. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComa Greater than 24 Hours

Professional guidelines

PubMed

Late Awakening Is Common in Settings Without Withdrawal of Life-Sustaining Therapy in Out-of-Hospital Cardiac Arrest Survivors Who Undergo Targeted Temperature Management.
Lee DH, Cho YS, Lee BK, Lee HY, Jeung KW, Jung YH, Park KN, Kim YJ, Chae MK, Seo DW; Korean Hypothermia Network (KORHN) Investigators
Crit Care Med 2022 Feb 1;50(2):235-244. doi: 10.1097/CCM.0000000000005274. PMID: 34524155
Delineation of Criteria for Admission to Step Down in the Mild Traumatic Brain Injury Patient.
Bardes JM, Turner J, Bonasso P, Hobbs G, Wilson A
Am Surg 2016 Jan;82(1):36-40. PMID: 26802855Free PMC Article
Clinical policy: neuroimaging and decisionmaking in adult mild traumatic brain injury in the acute setting.
Jagoda AS, Bazarian JJ, Bruns JJ Jr, Cantrill SV, Gean AD, Howard PK, Ghajar J, Riggio S, Wright DW, Wears RL, Bakshy A, Burgess P, Wald MM, Whitson RR; American College of Emergency Physicians; Centers for Disease Control and Prevention
Ann Emerg Med 2008 Dec;52(6):714-48. doi: 10.1016/j.annemergmed.2008.08.021. PMID: 19027497

Recent clinical studies

Etiology

Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest.
Ashton NJ, Moseby-Knappe M, Benedet AL, Grötschel L, Lantero-Rodriguez J, Karikari TK, Hassager C, Wise MP, Stammet P, Kjaergaard J, Friberg H, Nielsen N, Cronberg T, Zetterberg H, Blennow K
JAMA Neurol 2023 Apr 1;80(4):388-396. doi: 10.1001/jamaneurol.2023.0050. PMID: 36877496Free PMC Article
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest.
Kjaergaard J, Møller JE, Schmidt H, Grand J, Mølstrøm S, Borregaard B, Venø S, Sarkisian L, Mamaev D, Jensen LO, Nyholm B, Høfsten DE, Josiassen J, Thomsen JH, Thune JJ, Obling LER, Lindholm MG, Frydland M, Meyer MAS, Winther-Jensen M, Beske RP, Frikke-Schmidt R, Wiberg S, Boesgaard S, Madsen SA, Jørgensen VL, Hassager C
N Engl J Med 2022 Oct 20;387(16):1456-1466. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2208687. PMID: 36027564
Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial.
Le May M, Osborne C, Russo J, So D, Chong AY, Dick A, Froeschl M, Glover C, Hibbert B, Marquis JF, De Roock S, Labinaz M, Bernick J, Marshall S, Maze R, Wells G
JAMA 2021 Oct 19;326(15):1494-1503. doi: 10.1001/jama.2021.15703. PMID: 34665203Free PMC Article
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm.
Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J; CRICS-TRIGGERSEP Group
N Engl J Med 2019 Dec 12;381(24):2327-2337. Epub 2019 Oct 2 doi: 10.1056/NEJMoa1906661. PMID: 31577396
Anticoagulant rodenticides.
Watt BE, Proudfoot AT, Bradberry SM, Vale JA
Toxicol Rev 2005;24(4):259-69. doi: 10.2165/00139709-200524040-00005. PMID: 16499407

Diagnosis

Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest.
Ashton NJ, Moseby-Knappe M, Benedet AL, Grötschel L, Lantero-Rodriguez J, Karikari TK, Hassager C, Wise MP, Stammet P, Kjaergaard J, Friberg H, Nielsen N, Cronberg T, Zetterberg H, Blennow K
JAMA Neurol 2023 Apr 1;80(4):388-396. doi: 10.1001/jamaneurol.2023.0050. PMID: 36877496Free PMC Article
Improving ICU Risk Predictive Models Through Automation Designed for Resiliency Against Documentation Bias.
Liu X, Armaignac DL, Becker C, Hiddleson C, Dubouchet EM, Rincon T, Amelung PJ, French R, Scurlock C, Atallah L, Badawi O
Crit Care Med 2023 Mar 1;51(3):376-387. Epub 2022 Dec 27 doi: 10.1097/CCM.0000000000005750. PMID: 36576215
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest.
Kjaergaard J, Møller JE, Schmidt H, Grand J, Mølstrøm S, Borregaard B, Venø S, Sarkisian L, Mamaev D, Jensen LO, Nyholm B, Høfsten DE, Josiassen J, Thomsen JH, Thune JJ, Obling LER, Lindholm MG, Frydland M, Meyer MAS, Winther-Jensen M, Beske RP, Frikke-Schmidt R, Wiberg S, Boesgaard S, Madsen SA, Jørgensen VL, Hassager C
N Engl J Med 2022 Oct 20;387(16):1456-1466. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2208687. PMID: 36027564
Evaluation of Nonfatal Strangulation in Alert Adults.
Matusz EC, Schaffer JT, Bachmeier BA, Kirschner JM, Musey PI Jr, Roumpf SK, Strachan CC, Hunter BR
Ann Emerg Med 2020 Mar;75(3):329-338. Epub 2019 Oct 4 doi: 10.1016/j.annemergmed.2019.07.018. PMID: 31591013
After-Hours EEG: Relative Value of Emergent Routine Versus Prolonged EEG Recordings.
Singh J, Britton J, Alwaki A, Singh P
J Clin Neurophysiol 2019 Jan;36(1):32-35. doi: 10.1097/WNP.0000000000000529. PMID: 30608366

Therapy

Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest.
Ashton NJ, Moseby-Knappe M, Benedet AL, Grötschel L, Lantero-Rodriguez J, Karikari TK, Hassager C, Wise MP, Stammet P, Kjaergaard J, Friberg H, Nielsen N, Cronberg T, Zetterberg H, Blennow K
JAMA Neurol 2023 Apr 1;80(4):388-396. doi: 10.1001/jamaneurol.2023.0050. PMID: 36877496Free PMC Article
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest.
Kjaergaard J, Møller JE, Schmidt H, Grand J, Mølstrøm S, Borregaard B, Venø S, Sarkisian L, Mamaev D, Jensen LO, Nyholm B, Høfsten DE, Josiassen J, Thomsen JH, Thune JJ, Obling LER, Lindholm MG, Frydland M, Meyer MAS, Winther-Jensen M, Beske RP, Frikke-Schmidt R, Wiberg S, Boesgaard S, Madsen SA, Jørgensen VL, Hassager C
N Engl J Med 2022 Oct 20;387(16):1456-1466. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2208687. PMID: 36027564
Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial.
Le May M, Osborne C, Russo J, So D, Chong AY, Dick A, Froeschl M, Glover C, Hibbert B, Marquis JF, De Roock S, Labinaz M, Bernick J, Marshall S, Maze R, Wells G
JAMA 2021 Oct 19;326(15):1494-1503. doi: 10.1001/jama.2021.15703. PMID: 34665203Free PMC Article
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm.
Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J; CRICS-TRIGGERSEP Group
N Engl J Med 2019 Dec 12;381(24):2327-2337. Epub 2019 Oct 2 doi: 10.1056/NEJMoa1906661. PMID: 31577396
Anticoagulant rodenticides.
Watt BE, Proudfoot AT, Bradberry SM, Vale JA
Toxicol Rev 2005;24(4):259-69. doi: 10.2165/00139709-200524040-00005. PMID: 16499407

Prognosis

Risk Factors Associated With Development of Multiple-Organ Dysfunction Syndrome After Pediatric Drowning.
Southard-Goebel C, Pike F, Rowan CM, Cater DT
Pediatr Emerg Care 2023 Dec 1;39(12):902-906. Epub 2023 Nov 15 doi: 10.1097/PEC.0000000000003071. PMID: 37968113
Swallowing Dysfunction after Acute Stroke: The Incidence, Predictors and Outcome.
Londhe C, Agrawal A, Pednekar S, Pandey D, Khan MF
J Assoc Physicians India 2023 Aug;71(8):11-12. doi: 10.59556/japi.71.0301. PMID: 37651239
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest.
Ashton NJ, Moseby-Knappe M, Benedet AL, Grötschel L, Lantero-Rodriguez J, Karikari TK, Hassager C, Wise MP, Stammet P, Kjaergaard J, Friberg H, Nielsen N, Cronberg T, Zetterberg H, Blennow K
JAMA Neurol 2023 Apr 1;80(4):388-396. doi: 10.1001/jamaneurol.2023.0050. PMID: 36877496Free PMC Article
Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial.
Le May M, Osborne C, Russo J, So D, Chong AY, Dick A, Froeschl M, Glover C, Hibbert B, Marquis JF, De Roock S, Labinaz M, Bernick J, Marshall S, Maze R, Wells G
JAMA 2021 Oct 19;326(15):1494-1503. doi: 10.1001/jama.2021.15703. PMID: 34665203Free PMC Article
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm.
Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J; CRICS-TRIGGERSEP Group
N Engl J Med 2019 Dec 12;381(24):2327-2337. Epub 2019 Oct 2 doi: 10.1056/NEJMoa1906661. PMID: 31577396

Clinical prediction guides

Swallowing Dysfunction after Acute Stroke: The Incidence, Predictors and Outcome.
Londhe C, Agrawal A, Pednekar S, Pandey D, Khan MF
J Assoc Physicians India 2023 Aug;71(8):11-12. doi: 10.59556/japi.71.0301. PMID: 37651239
Alzheimer Disease Blood Biomarkers in Patients With Out-of-Hospital Cardiac Arrest.
Ashton NJ, Moseby-Knappe M, Benedet AL, Grötschel L, Lantero-Rodriguez J, Karikari TK, Hassager C, Wise MP, Stammet P, Kjaergaard J, Friberg H, Nielsen N, Cronberg T, Zetterberg H, Blennow K
JAMA Neurol 2023 Apr 1;80(4):388-396. doi: 10.1001/jamaneurol.2023.0050. PMID: 36877496Free PMC Article
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest.
Kjaergaard J, Møller JE, Schmidt H, Grand J, Mølstrøm S, Borregaard B, Venø S, Sarkisian L, Mamaev D, Jensen LO, Nyholm B, Høfsten DE, Josiassen J, Thomsen JH, Thune JJ, Obling LER, Lindholm MG, Frydland M, Meyer MAS, Winther-Jensen M, Beske RP, Frikke-Schmidt R, Wiberg S, Boesgaard S, Madsen SA, Jørgensen VL, Hassager C
N Engl J Med 2022 Oct 20;387(16):1456-1466. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2208687. PMID: 36027564
Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial.
Le May M, Osborne C, Russo J, So D, Chong AY, Dick A, Froeschl M, Glover C, Hibbert B, Marquis JF, De Roock S, Labinaz M, Bernick J, Marshall S, Maze R, Wells G
JAMA 2021 Oct 19;326(15):1494-1503. doi: 10.1001/jama.2021.15703. PMID: 34665203Free PMC Article
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm.
Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J; CRICS-TRIGGERSEP Group
N Engl J Med 2019 Dec 12;381(24):2327-2337. Epub 2019 Oct 2 doi: 10.1056/NEJMoa1906661. PMID: 31577396

Recent systematic reviews

Clinical and cost-effectiveness of continuous subcutaneous insulin infusion for diabetes.
Colquitt JL, Green C, Sidhu MK, Hartwell D, Waugh N
Health Technol Assess 2004 Oct;8(43):iii, 1-171. doi: 10.3310/hta8430. PMID: 15488165

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