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PIK3CB Gene Amplification

MedGen UID:
1646576
•Concept ID:
C4683734
•
Cell or Molecular Dysfunction
Synonyms: p110-Beta Gene Amplification; P110BETA Gene Amplification; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Gene Amplification; PI3KBETA Gene Amplification; PIK3C1 Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the PIK3CB gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPIK3CB Gene Amplification

Recent clinical studies

Diagnosis

Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer.
Xing M
Thyroid 2010 Jul;20(7):697-706. doi: 10.1089/thy.2010.1646. PMID: 20578891Free PMC Article

Therapy

PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer.
Crowder RJ, Phommaly C, Tao Y, Hoog J, Luo J, Perou CM, Parker JS, Miller MA, Huntsman DG, Lin L, Snider J, Davies SR, Olson JA Jr, Watson MA, Saporita A, Weber JD, Ellis MJ
Cancer Res 2009 May 1;69(9):3955-62. Epub 2009 Apr 14 doi: 10.1158/0008-5472.CAN-08-4450. PMID: 19366795Free PMC Article

Prognosis

A seven-gene signature to predict the prognosis of oral squamous cell carcinoma.
Ribeiro IP, Esteves L, Santos A, Barroso L, Marques F, Caramelo F, Melo JB, Carreira IM
Oncogene 2021 Jun;40(22):3859-3869. Epub 2021 May 10 doi: 10.1038/s41388-021-01806-5. PMID: 33972685
Genetic alterations in the phosphatidylinositol-3 kinase/Akt pathway in thyroid cancer.
Xing M
Thyroid 2010 Jul;20(7):697-706. doi: 10.1089/thy.2010.1646. PMID: 20578891Free PMC Article

Clinical prediction guides

A seven-gene signature to predict the prognosis of oral squamous cell carcinoma.
Ribeiro IP, Esteves L, Santos A, Barroso L, Marques F, Caramelo F, Melo JB, Carreira IM
Oncogene 2021 Jun;40(22):3859-3869. Epub 2021 May 10 doi: 10.1038/s41388-021-01806-5. PMID: 33972685

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