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Stage II Malignant Mediastinal Germ Cell Tumor

MedGen UID:
1646676
Concept ID:
C4687507
Neoplastic Process
Synonym: Stage II Malignant Thymic Germ Cell Tumor

Definition

Locoregional tumor, non-metastatic, macroscopic complete resection but microscopic residual tumor. (WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart, 2015) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage II Malignant Mediastinal Germ Cell Tumor

Professional guidelines

PubMed

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Pizzocaro G, Salvioni R, Nicolai N
Eur Urol 1995;28(4):267-72. doi: 10.1159/000475066. PMID: 8575492
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Recent clinical studies

Etiology

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Teshima M, Otsuki N, Morita N, Furukawa T, Shinomiya H, Shinomiya H, Nibu KI
Auris Nasus Larynx 2018 Dec;45(6):1233-1238. Epub 2018 May 7 doi: 10.1016/j.anl.2018.04.008. PMID: 29747960
Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W
Int J Radiat Oncol Biol Phys 1997 Sep 1;39(2):321-6. doi: 10.1016/s0360-3016(97)00155-7. PMID: 9308934
Speer TW, Sombeck MD, Parsons JT, Million RR
Int J Radiat Oncol Biol Phys 1995 Aug 30;33(1):89-97. doi: 10.1016/0360-3016(95)00069-B. PMID: 7642436
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Diagnosis

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Teshima M, Otsuki N, Morita N, Furukawa T, Shinomiya H, Shinomiya H, Nibu KI
Auris Nasus Larynx 2018 Dec;45(6):1233-1238. Epub 2018 May 7 doi: 10.1016/j.anl.2018.04.008. PMID: 29747960
Asakura K, Izumi Y, Ikeda T, Kimura Y, Horinouchi H, Hayashi Y, Nomori H
Ann Thorac Surg 2010 Sep;90(3):1014-6. doi: 10.1016/j.athoracsur.2009.12.081. PMID: 20732540
Mayordomo JI, Paz-Ares L, Rivera F, López-Brea M, López Martín E, Mendiola C, Díaz-Puente MT, Lianes P, García-Prats MD, Cortés-Funes H
Ann Oncol 1994 Mar;5(3):225-31. doi: 10.1093/oxfordjournals.annonc.a058797. PMID: 7514435
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Therapy

Adra N, Einhorn LH, Althouse SK, Ammakkanavar NR, Musapatika D, Albany C, Vaughn D, Hanna NH
Ann Oncol 2018 Jan 1;29(1):209-214. doi: 10.1093/annonc/mdx680. PMID: 29045540
Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W
Int J Radiat Oncol Biol Phys 1997 Sep 1;39(2):321-6. doi: 10.1016/s0360-3016(97)00155-7. PMID: 9308934
Speer TW, Sombeck MD, Parsons JT, Million RR
Int J Radiat Oncol Biol Phys 1995 Aug 30;33(1):89-97. doi: 10.1016/0360-3016(95)00069-B. PMID: 7642436
Marks LB, Anscher MS, Shipley WU
Hematol Oncol Clin North Am 1991 Dec;5(6):1143-72. PMID: 1663938
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Prognosis

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Chiappetta M, Sperduti I, Ciavarella LP, Leuzzi G, Bria E, Mucilli F, Lococo F, Filosso P, Ratto G, Spaggiari L, Facciolo F, Margaritora S
Interact Cardiovasc Thorac Surg 2020 Sep 1;31(3):315-323. doi: 10.1093/icvts/ivaa114. PMID: 32747930
Depani S, Stoneham S, Krailo M, Xia C, Nicholson J
Eur J Cancer 2019 Sep;118:49-57. Epub 2019 Jul 12 doi: 10.1016/j.ejca.2019.05.001. PMID: 31306943
Chung PW, Gospodarowicz MK, Panzarella T, Jewett MA, Sturgeon JF, Tew-George B, Bayley AJ, Catton CN, Milosevic MF, Moore M, Warde PR
Eur Urol 2004 Jun;45(6):754-59; discussion 759-60. doi: 10.1016/j.eururo.2004.01.020. PMID: 15149748
Mayordomo JI, Paz-Ares L, Rivera F, López-Brea M, López Martín E, Mendiola C, Díaz-Puente MT, Lianes P, García-Prats MD, Cortés-Funes H
Ann Oncol 1994 Mar;5(3):225-31. doi: 10.1093/oxfordjournals.annonc.a058797. PMID: 7514435

Clinical prediction guides

Depani S, Stoneham S, Krailo M, Xia C, Nicholson J
Eur J Cancer 2019 Sep;118:49-57. Epub 2019 Jul 12 doi: 10.1016/j.ejca.2019.05.001. PMID: 31306943
Teshima M, Otsuki N, Morita N, Furukawa T, Shinomiya H, Shinomiya H, Nibu KI
Auris Nasus Larynx 2018 Dec;45(6):1233-1238. Epub 2018 May 7 doi: 10.1016/j.anl.2018.04.008. PMID: 29747960
Adra N, Einhorn LH, Althouse SK, Ammakkanavar NR, Musapatika D, Albany C, Vaughn D, Hanna NH
Ann Oncol 2018 Jan 1;29(1):209-214. doi: 10.1093/annonc/mdx680. PMID: 29045540
Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W
Int J Radiat Oncol Biol Phys 1997 Sep 1;39(2):321-6. doi: 10.1016/s0360-3016(97)00155-7. PMID: 9308934
Moran CA, Suster S, Przygodzki RM, Koss MN
Cancer 1997 Aug 15;80(4):691-8. doi: 10.1002/(sici)1097-0142(19970815)80:4<691::aid-cncr7>3.0.co;2-q. PMID: 9264352

Recent systematic reviews

Rubio-Rivas M, Moreira C, Marcoval J
Autoimmun Rev 2020 Aug;19(8):102587. Epub 2020 Jun 14 doi: 10.1016/j.autrev.2020.102587. PMID: 32553612

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