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Thinking seizures

MedGen UID:
1647683
Concept ID:
C4706523
Disease or Syndrome
Synonyms: Thinking epilepsy; thinking seizures
SNOMED CT: Thinking seizures (763622006); Thinking epilepsy (763622006)
 
Monarch Initiative: MONDO:0015647
Orphanet: ORPHA166424

Definition

A rare neurologic disease characterized by seizures induced by specific cognitive tasks, such as calculation or solving arithmetic problems, playing thinking games (e.g. chess, cards), thinking, making decisions and abstract reasoning. Idiopathic generalized seizures are mainly involved, but partial epilepsies may, in rare cases, be observed. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThinking seizures

Professional guidelines

PubMed

Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J
Epilepsia 2022 Jul;63(7):1761-1777. Epub 2022 May 12 doi: 10.1111/epi.17274. PMID: 35490361Free PMC Article
Hyman SL, Levy SE, Myers SM; COUNCIL ON CHILDREN WITH DISABILITIES, SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
Pediatrics 2020 Jan;145(1) Epub 2019 Dec 16 doi: 10.1542/peds.2019-3447. PMID: 31843864
Leitinger M, Beniczky S, Rohracher A, Gardella E, Kalss G, Qerama E, Höfler J, Hess Lindberg-Larsen A, Kuchukhidze G, Dobesberger J, Langthaler PB, Trinka E
Epilepsy Behav 2015 Aug;49:158-63. Epub 2015 Jun 17 doi: 10.1016/j.yebeh.2015.05.007. PMID: 26092326

Recent clinical studies

Etiology

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Najm I, Lal D, Alonso Vanegas M, Cendes F, Lopes-Cendes I, Palmini A, Paglioli E, Sarnat HB, Walsh CA, Wiebe S, Aronica E, Baulac S, Coras R, Kobow K, Cross JH, Garbelli R, Holthausen H, Rössler K, Thom M, El-Osta A, Lee JH, Miyata H, Guerrini R, Piao YS, Zhou D, Blümcke I
Epilepsia 2022 Aug;63(8):1899-1919. Epub 2022 Jun 15 doi: 10.1111/epi.17301. PMID: 35706131Free PMC Article
Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J
Epilepsia 2022 Jul;63(7):1761-1777. Epub 2022 May 12 doi: 10.1111/epi.17274. PMID: 35490361Free PMC Article
Severino M, Geraldo AF, Utz N, Tortora D, Pogledic I, Klonowski W, Triulzi F, Arrigoni F, Mankad K, Leventer RJ, Mancini GMS, Barkovich JA, Lequin MH, Rossi A
Brain 2020 Oct 1;143(10):2874-2894. doi: 10.1093/brain/awaa174. PMID: 32779696Free PMC Article
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM
Epilepsia 2017 Apr;58(4):512-521. Epub 2017 Mar 8 doi: 10.1111/epi.13709. PMID: 28276062Free PMC Article

Diagnosis

Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J
Epilepsia 2022 Jul;63(7):1761-1777. Epub 2022 May 12 doi: 10.1111/epi.17274. PMID: 35490361Free PMC Article
Severino M, Geraldo AF, Utz N, Tortora D, Pogledic I, Klonowski W, Triulzi F, Arrigoni F, Mankad K, Leventer RJ, Mancini GMS, Barkovich JA, Lequin MH, Rossi A
Brain 2020 Oct 1;143(10):2874-2894. doi: 10.1093/brain/awaa174. PMID: 32779696Free PMC Article
Hyman SL, Levy SE, Myers SM; COUNCIL ON CHILDREN WITH DISABILITIES, SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
Pediatrics 2020 Jan;145(1) Epub 2019 Dec 16 doi: 10.1542/peds.2019-3447. PMID: 31843864
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM
Epilepsia 2017 Apr;58(4):512-521. Epub 2017 Mar 8 doi: 10.1111/epi.13709. PMID: 28276062Free PMC Article
Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr
Epilepsia 2005 Apr;46(4):470-2. doi: 10.1111/j.0013-9580.2005.66104.x. PMID: 15816939

Therapy

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Coughlin CR 2nd, Tseng LA, Abdenur JE, Ashmore C, Boemer F, Bok LA, Boyer M, Buhas D, Clayton PT, Das A, Dekker H, Evangeliou A, Feillet F, Footitt EJ, Gospe SM Jr, Hartmann H, Kara M, Kristensen E, Lee J, Lilje R, Longo N, Lunsing RJ, Mills P, Papadopoulou MT, Pearl PL, Piazzon F, Plecko B, Saini AG, Santra S, Sjarif DR, Stockler-Ipsiroglu S, Striano P, Van Hove JLK, Verhoeven-Duif NM, Wijburg FA, Zuberi SM, van Karnebeek CDM
J Inherit Metab Dis 2021 Jan;44(1):178-192. Epub 2020 Dec 1 doi: 10.1002/jimd.12332. PMID: 33200442
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Decker BS, Goldfarb DS, Dargan PI, Friesen M, Gosselin S, Hoffman RS, Lavergne V, Nolin TD, Ghannoum M; EXTRIP Workgroup
Clin J Am Soc Nephrol 2015 May 7;10(5):875-87. Epub 2015 Jan 12 doi: 10.2215/CJN.10021014. PMID: 25583292Free PMC Article
Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Moshé SL, Perucca E, Wiebe S, French J
Epilepsia 2010 Jun;51(6):1069-77. Epub 2009 Nov 3 doi: 10.1111/j.1528-1167.2009.02397.x. PMID: 19889013

Prognosis

Schaper FLWVJ, Nordberg J, Cohen AL, Lin C, Hsu J, Horn A, Ferguson MA, Siddiqi SH, Drew W, Soussand L, Winkler AM, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon AJ, Ackermans L, Bubrick EJ, Peters JM, Wu O, Rost NS, Grafman J, Blumenfeld H, Temel Y, Rouhl RPW, Joutsa J, Fox MD
JAMA Neurol 2023 Sep 1;80(9):891-902. doi: 10.1001/jamaneurol.2023.1988. PMID: 37399040Free PMC Article
Riva A, Coppola A, Bonaventura CD, Elia M, Ferlazzo E, Gobbi G, Marini C, Meletti S, Romeo A, Santoro K, Verrotti A, Capovilla G, Striano P; Italian LGS Delphi Group
Seizure 2022 Oct;101:134-140. Epub 2022 Jul 15 doi: 10.1016/j.seizure.2022.07.004. PMID: 35981474
Shum J, Fogarty A, Dugan P, Holmes MG, Leeman-Markowski BA, Liu AA, Fisher RS, Friedman D
Seizure 2020 May;78:86-90. Epub 2020 Mar 18 doi: 10.1016/j.seizure.2020.03.008. PMID: 32276233Free PMC Article
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Freestone DR, Karoly PJ, Cook MJ
Curr Opin Neurol 2017 Apr;30(2):167-173. doi: 10.1097/WCO.0000000000000429. PMID: 28118302

Clinical prediction guides

McGonigal A, Bartolomei F, Chauvel P
Epilepsia 2021 Sep;62(9):2019-2035. Epub 2021 Jul 11 doi: 10.1111/epi.16994. PMID: 34247399
Shum J, Fogarty A, Dugan P, Holmes MG, Leeman-Markowski BA, Liu AA, Fisher RS, Friedman D
Seizure 2020 May;78:86-90. Epub 2020 Mar 18 doi: 10.1016/j.seizure.2020.03.008. PMID: 32276233Free PMC Article
Freestone DR, Karoly PJ, Cook MJ
Curr Opin Neurol 2017 Apr;30(2):167-173. doi: 10.1097/WCO.0000000000000429. PMID: 28118302
Leitinger M, Beniczky S, Rohracher A, Gardella E, Kalss G, Qerama E, Höfler J, Hess Lindberg-Larsen A, Kuchukhidze G, Dobesberger J, Langthaler PB, Trinka E
Epilepsy Behav 2015 Aug;49:158-63. Epub 2015 Jun 17 doi: 10.1016/j.yebeh.2015.05.007. PMID: 26092326
Litt B, Echauz J
Lancet Neurol 2002 May;1(1):22-30. doi: 10.1016/s1474-4422(02)00003-0. PMID: 12849542

Recent systematic reviews

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Coughlin CR 2nd, Tseng LA, Abdenur JE, Ashmore C, Boemer F, Bok LA, Boyer M, Buhas D, Clayton PT, Das A, Dekker H, Evangeliou A, Feillet F, Footitt EJ, Gospe SM Jr, Hartmann H, Kara M, Kristensen E, Lee J, Lilje R, Longo N, Lunsing RJ, Mills P, Papadopoulou MT, Pearl PL, Piazzon F, Plecko B, Saini AG, Santra S, Sjarif DR, Stockler-Ipsiroglu S, Striano P, Van Hove JLK, Verhoeven-Duif NM, Wijburg FA, Zuberi SM, van Karnebeek CDM
J Inherit Metab Dis 2021 Jan;44(1):178-192. Epub 2020 Dec 1 doi: 10.1002/jimd.12332. PMID: 33200442
Panebianco M, Sridharan K, Ramaratnam S
Cochrane Database Syst Rev 2017 Oct 5;10(10):CD001524. doi: 10.1002/14651858.CD001524.pub3. PMID: 28982217Free PMC Article
Panebianco M, Sridharan K, Ramaratnam S
Cochrane Database Syst Rev 2015 May 2;(5):CD001524. doi: 10.1002/14651858.CD001524.pub2. PMID: 25934967
Decker BS, Goldfarb DS, Dargan PI, Friesen M, Gosselin S, Hoffman RS, Lavergne V, Nolin TD, Ghannoum M; EXTRIP Workgroup
Clin J Am Soc Nephrol 2015 May 7;10(5):875-87. Epub 2015 Jan 12 doi: 10.2215/CJN.10021014. PMID: 25583292Free PMC Article

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