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Stage III Malignant Mediastinal Germ Cell Tumor

MedGen UID:
1647726
Concept ID:
C4687508
Neoplastic Process
Synonym: Stage III Malignant Thymic Germ Cell Tumor

Definition

Locoregional tumor, regional lymph nodes negative or positive; no distant metastasis; biopsy only or gross residual tumor after primary resection. (WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart, 2015) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStage III Malignant Mediastinal Germ Cell Tumor

Professional guidelines

PubMed

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Kaiser LR
Hematol Oncol Clin North Am 2008 Jun;22(3):475-88. doi: 10.1016/j.hoc.2008.03.009. PMID: 18514128
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Recent clinical studies

Etiology

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Teshima M, Otsuki N, Morita N, Furukawa T, Shinomiya H, Shinomiya H, Nibu KI
Auris Nasus Larynx 2018 Dec;45(6):1233-1238. Epub 2018 May 7 doi: 10.1016/j.anl.2018.04.008. PMID: 29747960
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Speer TW, Sombeck MD, Parsons JT, Million RR
Int J Radiat Oncol Biol Phys 1995 Aug 30;33(1):89-97. doi: 10.1016/0360-3016(95)00069-B. PMID: 7642436
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Diagnosis

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Teshima M, Otsuki N, Morita N, Furukawa T, Shinomiya H, Shinomiya H, Nibu KI
Auris Nasus Larynx 2018 Dec;45(6):1233-1238. Epub 2018 May 7 doi: 10.1016/j.anl.2018.04.008. PMID: 29747960
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Asakura K, Izumi Y, Ikeda T, Kimura Y, Horinouchi H, Hayashi Y, Nomori H
Ann Thorac Surg 2010 Sep;90(3):1014-6. doi: 10.1016/j.athoracsur.2009.12.081. PMID: 20732540
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Therapy

Huang J, Tan Y, Zhen Z, Lu S, Sun F, Zhu J, Wang J, Liao R, Sun X
PLoS One 2017;12(8):e0183219. Epub 2017 Aug 16 doi: 10.1371/journal.pone.0183219. PMID: 28813488Free PMC Article
Kuwano H, Tsuchiya T, Murayama T, Sano A, Nagayama K, Yoshida Y, Murakawa T, Nakajima J
Surg Today 2014 Mar;44(3):499-504. Epub 2013 Apr 4 doi: 10.1007/s00595-013-0562-0. PMID: 23553421
Speer TW, Sombeck MD, Parsons JT, Million RR
Int J Radiat Oncol Biol Phys 1995 Aug 30;33(1):89-97. doi: 10.1016/0360-3016(95)00069-B. PMID: 7642436
Marks LB, Anscher MS, Shipley WU
Hematol Oncol Clin North Am 1991 Dec;5(6):1143-72. PMID: 1663938
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Prognosis

Dabkara D, Ganguly S, Ghosh J, Mukherjee S, Gupta S, Mallick I, Mukherjee S, Midha D, Chatterjee M, Basu A, Hasan A, Biswas B
Natl Med J India 2021 Mar-Apr;34(2):68-72. doi: 10.4103/0970-258X.326752. PMID: 34599114
Chiappetta M, Sperduti I, Ciavarella LP, Leuzzi G, Bria E, Mucilli F, Lococo F, Filosso P, Ratto G, Spaggiari L, Facciolo F, Margaritora S
Interact Cardiovasc Thorac Surg 2020 Sep 1;31(3):315-323. doi: 10.1093/icvts/ivaa114. PMID: 32747930
Huang J, Tan Y, Zhen Z, Lu S, Sun F, Zhu J, Wang J, Liao R, Sun X
PLoS One 2017;12(8):e0183219. Epub 2017 Aug 16 doi: 10.1371/journal.pone.0183219. PMID: 28813488Free PMC Article
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Mayordomo JI, Paz-Ares L, Rivera F, López-Brea M, López Martín E, Mendiola C, Díaz-Puente MT, Lianes P, García-Prats MD, Cortés-Funes H
Ann Oncol 1994 Mar;5(3):225-31. doi: 10.1093/oxfordjournals.annonc.a058797. PMID: 7514435

Clinical prediction guides

Teshima M, Otsuki N, Morita N, Furukawa T, Shinomiya H, Shinomiya H, Nibu KI
Auris Nasus Larynx 2018 Dec;45(6):1233-1238. Epub 2018 May 7 doi: 10.1016/j.anl.2018.04.008. PMID: 29747960
Marciello F, Mercier O, Ferolla P, Scoazec JY, Filosso PL, Chapelier A, Guggino G, Monaco R, Grimaldi F, Pizzolitto S, Guigay J, de Latour BR, Giuffrida D, Longchampt E, de Montpreville VT, Fadel E, Colao A, Planchard D, Papotti M, Faggiano A, Baudin E
Neuroendocrinology 2018;106(3):264-273. Epub 2017 Aug 17 doi: 10.1159/000480015. PMID: 28813709
Sarkaria IS, Bains MS, Sood S, Sima CS, Reuter VE, Flores RM, Motzer RJ, Bosl GJ, Rusch VW
J Thorac Oncol 2011 Jul;6(7):1236-41. doi: 10.1097/JTO.0b013e31821d513e. PMID: 21610519
Moran CA, Suster S, Przygodzki RM, Koss MN
Cancer 1997 Aug 15;80(4):691-8. doi: 10.1002/(sici)1097-0142(19970815)80:4<691::aid-cncr7>3.0.co;2-q. PMID: 9264352
Kawakita M, Terachi T, Hida S, Takeuchi H, Yoshida O
Int J Urol 1994 Jun;1(2):172-6. doi: 10.1111/j.1442-2042.1994.tb00029.x. PMID: 7627853

Recent systematic reviews

Rubio-Rivas M, Moreira C, Marcoval J
Autoimmun Rev 2020 Aug;19(8):102587. Epub 2020 Jun 14 doi: 10.1016/j.autrev.2020.102587. PMID: 32553612

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