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Locally Advanced Soft Tissue Sarcoma

MedGen UID:
1648947
•Concept ID:
C4727772
•
Neoplastic Process

Definition

Soft tissue sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: a systematic review.
Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681
Neoadjuvant treatment of locally advanced soft tissue sarcoma of the limbs: which treatment to choose?
Hohenberger P, Wysocki WM
Oncologist 2008 Feb;13(2):175-86. doi: 10.1634/theoncologist.2007-0165. PMID: 18305063

Recent clinical studies

Etiology

Final Safety and Health-Related Quality of LIfe Results of the Phase 2/3 Act.In.Sarc Study With Preoperative NBTXR3 Plus Radiation Therapy Versus Radiation Therapy in Locally Advanced Soft-Tissue Sarcoma.
Bonvalot S, Rutkowski PL, Thariat J, Carrère S, Ducassou A, Sunyach MP, Agoston P, Hong AM, Mervoyer A, Rastrelli M, Moreno V, Li RK, Tiangco BJ, Herráez AC, Gronchi A, Sy-Ortin T, Hohenberger P, de Baère T, Cesne AL, Helfre S, Saada-Bouzid E, Anghel RM, Kantor G, Montero A, Loong HH, Vergés R, Kacso G, Austen L, Servois VF, Wardelmann E, Dimitriu M, Said P, Lazar AJ, Bovée JVMG, Péchoux CL, Pápai Z
Int J Radiat Oncol Biol Phys 2022 Nov 1;114(3):422-432. Epub 2022 Jul 16 doi: 10.1016/j.ijrobp.2022.07.001. PMID: 35850363
Practice changing data and emerging concepts from recent radiation therapy randomised clinical trials.
Espenel S, Chargari C, Blanchard P, Bockel S, Morel D, Rivera S, Levy A, Deutsch E
Eur J Cancer 2022 Aug;171:242-258. Epub 2022 Jun 29 doi: 10.1016/j.ejca.2022.04.038. PMID: 35779346
Patterns of Care and Survival in Elderly Patients With Locally Advanced Soft Tissue Sarcoma.
Greto D, Saieva C, Loi M, Desideri I, Delli Paoli C, Lo Russo M, Pezzulla D, Teriaca MA, Lucidi S, Visani L, Terziani F, Olmetto E, Becherini C, Bonomo P, Francolini G, Campanacci DA, Scoccianti G, Livi L
Am J Clin Oncol 2019 Oct;42(10):749-754. doi: 10.1097/COC.0000000000000594. PMID: 31503061
Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma.
Greto D, Loi M, Saieva C, Muntoni C, Delli Paoli C, Becherini C, Ciabatti C, Perna M, Campanacci D, Terziani F, Beltrami G, Scoccianti G, Bonomo P, Meattini I, Desideri I, Simontacchi G, Mangoni M, Livi L
Tumori 2018 Oct;104(5):322-329. Epub 2018 Apr 11 doi: 10.1177/0300891618765565. PMID: 29714662
Neoadjuvant treatment of locally advanced soft tissue sarcoma of the limbs: which treatment to choose?
Hohenberger P, Wysocki WM
Oncologist 2008 Feb;13(2):175-86. doi: 10.1634/theoncologist.2007-0165. PMID: 18305063

Diagnosis

Complete pathological response to neoadjuvant treatment is associated with better survival outcomes in patients with soft tissue sarcoma: Results of a retrospective multicenter study.
Bonvalot S, Wunder J, Gronchi A, Broto JM, Turcotte R, Rastrelli M, Papai Z, Radaelli S, Lindner LH, Shumelinsky F, Cubillo A, Rutkowski P, Demaire C, Strens D, Nalbantov G
Eur J Surg Oncol 2021 Aug;47(8):2166-2172. Epub 2021 Feb 26 doi: 10.1016/j.ejso.2021.02.024. PMID: 33676792
Pharmacokinetics of doxorubicin following concomitant intravenous administration of olaratumab (IMC-3G3) to patients with advanced soft tissue sarcoma.
Villalobos VM, Mo G, Agulnik M, Pollack SM, Rushing DA, Singh A, Van Tine BA, McNaughton R, Decker RL, Zhang W, Shahir A, Cronier DM
Cancer Med 2020 Feb;9(3):882-893. Epub 2019 Dec 10 doi: 10.1002/cam4.2728. PMID: 31821732Free PMC Article
Patterns of Care and Survival in Elderly Patients With Locally Advanced Soft Tissue Sarcoma.
Greto D, Saieva C, Loi M, Desideri I, Delli Paoli C, Lo Russo M, Pezzulla D, Teriaca MA, Lucidi S, Visani L, Terziani F, Olmetto E, Becherini C, Bonomo P, Francolini G, Campanacci DA, Scoccianti G, Livi L
Am J Clin Oncol 2019 Oct;42(10):749-754. doi: 10.1097/COC.0000000000000594. PMID: 31503061
L-[1-11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer.
van Ginkel RJ, Kole AC, Nieweg OE, Molenaar WM, Pruim J, Koops HS, Vaalburg W, Hoekstra HJ
J Nucl Med 1999 Feb;40(2):262-7. PMID: 10025833
Angiographic response of locally advanced soft-tissue sarcoma following hyperthermic isolated limb perfusion with tumor necrosis factor.
Olieman AF, van Ginkel RJ, Hoekstra HJ, Mooyaart EL, Molenaar WM, Koops HS
Ann Surg Oncol 1997 Jan;4(1):64-9. doi: 10.1007/BF02316812. PMID: 8985519

Therapy

Final Safety and Health-Related Quality of LIfe Results of the Phase 2/3 Act.In.Sarc Study With Preoperative NBTXR3 Plus Radiation Therapy Versus Radiation Therapy in Locally Advanced Soft-Tissue Sarcoma.
Bonvalot S, Rutkowski PL, Thariat J, Carrère S, Ducassou A, Sunyach MP, Agoston P, Hong AM, Mervoyer A, Rastrelli M, Moreno V, Li RK, Tiangco BJ, Herráez AC, Gronchi A, Sy-Ortin T, Hohenberger P, de Baère T, Cesne AL, Helfre S, Saada-Bouzid E, Anghel RM, Kantor G, Montero A, Loong HH, Vergés R, Kacso G, Austen L, Servois VF, Wardelmann E, Dimitriu M, Said P, Lazar AJ, Bovée JVMG, Péchoux CL, Pápai Z
Int J Radiat Oncol Biol Phys 2022 Nov 1;114(3):422-432. Epub 2022 Jul 16 doi: 10.1016/j.ijrobp.2022.07.001. PMID: 35850363
Practice changing data and emerging concepts from recent radiation therapy randomised clinical trials.
Espenel S, Chargari C, Blanchard P, Bockel S, Morel D, Rivera S, Levy A, Deutsch E
Eur J Cancer 2022 Aug;171:242-258. Epub 2022 Jun 29 doi: 10.1016/j.ejca.2022.04.038. PMID: 35779346
Pharmacokinetics of doxorubicin following concomitant intravenous administration of olaratumab (IMC-3G3) to patients with advanced soft tissue sarcoma.
Villalobos VM, Mo G, Agulnik M, Pollack SM, Rushing DA, Singh A, Van Tine BA, McNaughton R, Decker RL, Zhang W, Shahir A, Cronier DM
Cancer Med 2020 Feb;9(3):882-893. Epub 2019 Dec 10 doi: 10.1002/cam4.2728. PMID: 31821732Free PMC Article
Neoadjuvant treatment of locally advanced soft tissue sarcoma of the limbs: which treatment to choose?
Hohenberger P, Wysocki WM
Oncologist 2008 Feb;13(2):175-86. doi: 10.1634/theoncologist.2007-0165. PMID: 18305063
Pharmacokinetics of intraperitoneal cisplatin and doxorubicin.
Rossi CR, Mocellin S, Pilati P, Foletto M, Quintieri L, Palatini P, Lise M
Surg Oncol Clin N Am 2003 Jul;12(3):781-94. doi: 10.1016/s1055-3207(03)00030-9. PMID: 14567031

Prognosis

The role of Ifosfamide-doxorubicin chemotherapy in histology-specific, high grade, locally advanced soft tissue sarcoma, a 14-year experience.
Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Patterns of Care and Survival in Elderly Patients With Locally Advanced Soft Tissue Sarcoma.
Greto D, Saieva C, Loi M, Desideri I, Delli Paoli C, Lo Russo M, Pezzulla D, Teriaca MA, Lucidi S, Visani L, Terziani F, Olmetto E, Becherini C, Bonomo P, Francolini G, Campanacci DA, Scoccianti G, Livi L
Am J Clin Oncol 2019 Oct;42(10):749-754. doi: 10.1097/COC.0000000000000594. PMID: 31503061
Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma.
Greto D, Loi M, Saieva C, Muntoni C, Delli Paoli C, Becherini C, Ciabatti C, Perna M, Campanacci D, Terziani F, Beltrami G, Scoccianti G, Bonomo P, Meattini I, Desideri I, Simontacchi G, Mangoni M, Livi L
Tumori 2018 Oct;104(5):322-329. Epub 2018 Apr 11 doi: 10.1177/0300891618765565. PMID: 29714662
Pharmacokinetics of intraperitoneal cisplatin and doxorubicin.
Rossi CR, Mocellin S, Pilati P, Foletto M, Quintieri L, Palatini P, Lise M
Surg Oncol Clin N Am 2003 Jul;12(3):781-94. doi: 10.1016/s1055-3207(03)00030-9. PMID: 14567031
Isolated limb perfusion with cisplatin and doxorubicin for locally advanced soft tissue sarcoma of an extremity.
Eroglu A, Kocaoglu H, Demirci S, Akgül H
Eur J Surg Oncol 2000 Apr;26(3):213-21. doi: 10.1053/ejso.1999.0779. PMID: 10753532

Clinical prediction guides

Final Safety and Health-Related Quality of LIfe Results of the Phase 2/3 Act.In.Sarc Study With Preoperative NBTXR3 Plus Radiation Therapy Versus Radiation Therapy in Locally Advanced Soft-Tissue Sarcoma.
Bonvalot S, Rutkowski PL, Thariat J, Carrère S, Ducassou A, Sunyach MP, Agoston P, Hong AM, Mervoyer A, Rastrelli M, Moreno V, Li RK, Tiangco BJ, Herráez AC, Gronchi A, Sy-Ortin T, Hohenberger P, de Baère T, Cesne AL, Helfre S, Saada-Bouzid E, Anghel RM, Kantor G, Montero A, Loong HH, Vergés R, Kacso G, Austen L, Servois VF, Wardelmann E, Dimitriu M, Said P, Lazar AJ, Bovée JVMG, Péchoux CL, Pápai Z
Int J Radiat Oncol Biol Phys 2022 Nov 1;114(3):422-432. Epub 2022 Jul 16 doi: 10.1016/j.ijrobp.2022.07.001. PMID: 35850363
The role of Ifosfamide-doxorubicin chemotherapy in histology-specific, high grade, locally advanced soft tissue sarcoma, a 14-year experience.
Goy BW, Syed S, Padmanabhan A, Burchette RJ, Helmstedter CS
Radiother Oncol 2021 Dec;165:174-178. Epub 2021 Nov 7 doi: 10.1016/j.radonc.2021.10.019. PMID: 34758339
Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial.
Monga V, Miller BJ, Tanas M, Boukhar S, Allen B, Anderson C, Stephens L, Hartwig S, Varga S, Houtman J, Wang L, Zhang W, Jaber O, Thomason J, Kuehn D, Rajput M, Metz C, Zamba KD, Mott S, Abanonu C, Bhatia S, Milhem M
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2021-003119. PMID: 34330766Free PMC Article
Safety of concurrent adjuvant radiotherapy and chemotherapy for locally advanced soft tissue sarcoma.
Greto D, Loi M, Saieva C, Muntoni C, Delli Paoli C, Becherini C, Ciabatti C, Perna M, Campanacci D, Terziani F, Beltrami G, Scoccianti G, Bonomo P, Meattini I, Desideri I, Simontacchi G, Mangoni M, Livi L
Tumori 2018 Oct;104(5):322-329. Epub 2018 Apr 11 doi: 10.1177/0300891618765565. PMID: 29714662
Pharmacokinetics of intraperitoneal cisplatin and doxorubicin.
Rossi CR, Mocellin S, Pilati P, Foletto M, Quintieri L, Palatini P, Lise M
Surg Oncol Clin N Am 2003 Jul;12(3):781-94. doi: 10.1016/s1055-3207(03)00030-9. PMID: 14567031

Recent systematic reviews

Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: a systematic review.
Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A
Eur J Surg Oncol 2013 Apr;39(4):311-9. Epub 2013 Jan 23 doi: 10.1016/j.ejso.2012.12.018. PMID: 23351681

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