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Metastatic Cervical Carcinoma

MedGen UID:
1649025
•Concept ID:
C4727217
•
Neoplastic Process

Definition

A carcinoma of the cervix that has spread to another anatomic site. [from NCI]

Professional guidelines

PubMed

Neck dissection and ipsilateral radiotherapy in the management of cervical metastatic carcinoma from an unknown primary.
McMahon J, Hruby G, O'Brien CJ, McNeil EB, Bagia JS, Clifford AR, Jackson MA
Aust N Z J Surg 2000 Apr;70(4):263-8. doi: 10.1046/j.1440-1622.2000.01804.x. PMID: 10779057
Combined chemotherapy using cisplatin, ifosfamide and bleomycin (PIB) in the treatment of advanced and recurrent cervical carcinoma.
Tay SK, Lai FM, Soh LT, Ho TH, Ang PT, Au E
Aust N Z J Obstet Gynaecol 1992 Aug;32(3):263-6. doi: 10.1111/j.1479-828x.1992.tb01962.x. PMID: 1280100
The treatment of recurrent and metastatic cervical carcinoma. Evaluation of an antiblastic combination of methotrexate-adriamycin-bleomycin (MAB).
Adamo V, Altavilla G, Buemi B, Caristi N, Scalisi R, Tropea F
Chemioterapia 1985 Apr;4(2):143-6. PMID: 2408771

Recent clinical studies

Etiology

Camrelizumab (SHR-1210) with carboplatin and albumin-binding paclitaxel in patients with metastatic or recurrent cervical cancer: An open-label, phase 2 trial.
Zhang X, Chen J, Liu N, Wang Q, Wu Q, Gao F, Sang Y, Wang P
J Cancer Res Ther 2022 Apr;18(2):482-487. doi: 10.4103/jcrt.jcrt_1851_21. PMID: 35645118
Epidemiology and Outcomes with Platinum-Based Chemotherapy in Recurrent or Metastatic Carcinoma Cervix in a Developing Country: Experience from a Tertiary Oncology Centre in Southern India.
Lakshmaiah KC, Thanky AH, Lokanatha D, Govind Babu K, Jacob L, Babu S, Rudresha AH, Lokesh KN, Rajeev LK, Sridharmurthy A
Gulf J Oncolog 2017 Sep;1(25):20-26. PMID: 29019326
Circulating tumour cells and lung microvascular tumour cell retention in patients with metastatic breast and cervical cancer.
Peeters DJ, Brouwer A, Van den Eynden GG, Rutten A, Onstenk W, Sieuwerts AM, Van Laere SJ, Huget P, Pauwels P, Peeters M, Vermeulen PB, Dirix LY
Cancer Lett 2015 Jan 28;356(2 Pt B):872-9. Epub 2014 Nov 4 doi: 10.1016/j.canlet.2014.10.039. PMID: 25449778
Metastatic cervical carcinoma from an unknown primary: literature review.
Arrangoiz R, Galloway TJ, Papavasiliou P, Ridge JA, Lango MN
Ear Nose Throat J 2014 Apr-May;93(4-5):E1-10. PMID: 24817234
Docetaxel, carboplatin and 5-fluorouracil (TCF) chemotherapy in patients with unresectable metastatic carcinoma of cervix.
Lin JT, Shih SC, Chang TH, Chang CS
Gynecol Oncol 2010 Apr;117(1):65-9. Epub 2010 Jan 27 doi: 10.1016/j.ygyno.2010.01.001. PMID: 20106511

Diagnosis

CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure.
Coquan E, Brachet PE, Licaj I, Leconte A, Castera M, Lequesne J, Meriaux E, Bonnet I, Lelaidier A, Clarisse B, Joly F
BMC Cancer 2021 Sep 25;21(1):1054. doi: 10.1186/s12885-021-08758-9. PMID: 34563169Free PMC Article
Neck lymph node metastases from unknown primary.
Arosio AD, Pignataro L, Gaini RM, Garavello W
Cancer Treat Rev 2017 Feb;53:1-9. Epub 2016 Dec 10 doi: 10.1016/j.ctrv.2016.11.014. PMID: 28027480
Metastatic cervical carcinoma of the jaw presenting as periapical disease.
Torregrossa VR, Faria KM, Bicudo MM, Vargas PA, Almeida OP, Lopes MA, Santos-Silva AR
Int Endod J 2016 Feb;49(2):203-11. Epub 2015 Mar 16 doi: 10.1111/iej.12442. PMID: 25702771
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article
Metastatic cervical carcinoma from an unknown primary: literature review.
Arrangoiz R, Galloway TJ, Papavasiliou P, Ridge JA, Lango MN
Ear Nose Throat J 2014 Apr-May;93(4-5):E1-10. PMID: 24817234

Therapy

Pembrolizumab Improves Survival After Resection of Intracardiac Metastatic Cervical Carcinoma.
Steely AM, Watkins AA, Vidal B, White D, Chu LM
Ann Thorac Surg 2022 Nov;114(5):e323-e325. Epub 2022 Jan 26 doi: 10.1016/j.athoracsur.2021.12.066. PMID: 35090858
CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure.
Coquan E, Brachet PE, Licaj I, Leconte A, Castera M, Lequesne J, Meriaux E, Bonnet I, Lelaidier A, Clarisse B, Joly F
BMC Cancer 2021 Sep 25;21(1):1054. doi: 10.1186/s12885-021-08758-9. PMID: 34563169Free PMC Article
Cervical cancer - State of the science: From angiogenesis blockade to checkpoint inhibition.
Minion LE, Tewari KS
Gynecol Oncol 2018 Mar;148(3):609-621. Epub 2018 Feb 3 doi: 10.1016/j.ygyno.2018.01.009. PMID: 29666026Free PMC Article
Neck lymph node metastases from unknown primary.
Arosio AD, Pignataro L, Gaini RM, Garavello W
Cancer Treat Rev 2017 Feb;53:1-9. Epub 2016 Dec 10 doi: 10.1016/j.ctrv.2016.11.014. PMID: 28027480
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article

Prognosis

CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure.
Coquan E, Brachet PE, Licaj I, Leconte A, Castera M, Lequesne J, Meriaux E, Bonnet I, Lelaidier A, Clarisse B, Joly F
BMC Cancer 2021 Sep 25;21(1):1054. doi: 10.1186/s12885-021-08758-9. PMID: 34563169Free PMC Article
Neck lymph node metastases from unknown primary.
Arosio AD, Pignataro L, Gaini RM, Garavello W
Cancer Treat Rev 2017 Feb;53:1-9. Epub 2016 Dec 10 doi: 10.1016/j.ctrv.2016.11.014. PMID: 28027480
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article
The role of human papilloma virus and p16 in occult primary of the head and neck: a comprehensive review of the literature.
Fotopoulos G, Pavlidis N
Oral Oncol 2015 Feb;51(2):119-23. Epub 2014 Nov 18 doi: 10.1016/j.oraloncology.2014.10.018. PMID: 25467774
Metastatic cervical carcinoma from an unknown primary: literature review.
Arrangoiz R, Galloway TJ, Papavasiliou P, Ridge JA, Lango MN
Ear Nose Throat J 2014 Apr-May;93(4-5):E1-10. PMID: 24817234

Clinical prediction guides

A phase 2 study of nanoparticle albumin-bound paclitaxel plus nedaplatin for patients with advanced, recurrent, or metastatic cervical carcinoma.
Li Y, Zeng J, Huang M, An J, Bai P, Wu L, Zhang R
Cancer 2017 Feb 1;123(3):420-425. Epub 2016 Oct 3 doi: 10.1002/cncr.30328. PMID: 27696395
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article
Brain metastases from cervical cancer--a short review.
Branch BC, Henry J, Vecil GG
Tumori 2014 Sep-Oct;100(5):e171-9. doi: 10.1700/1660.18186. PMID: 25343555
Altered HLA expression by metastatic cervical carcinoma cells as a factor in impaired immune surveillance.
Hilders CG, Munoz IM, Nooyen Y, Fleuren GJ
Gynecol Oncol 1995 Jun;57(3):366-75. doi: 10.1006/gyno.1995.1156. PMID: 7774840
Lymphoscintigraphy of the neck.
Blakeslee DB, Becker GD, Simpson GT, Patten DH, Sprengelmeyer J
Otolaryngol Head Neck Surg 1985 Jun;93(3):361-5. doi: 10.1177/019459988509300314. PMID: 3927231

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