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Metastatic Cervical Carcinoma

MedGen UID:
1649025
•Concept ID:
C4727217
•
Neoplastic Process

Definition

A carcinoma of the cervix that has spread to another anatomic site. [from NCI]

Professional guidelines

PubMed

Neck dissection and ipsilateral radiotherapy in the management of cervical metastatic carcinoma from an unknown primary.
McMahon J, Hruby G, O'Brien CJ, McNeil EB, Bagia JS, Clifford AR, Jackson MA
Aust N Z J Surg 2000 Apr;70(4):263-8. doi: 10.1046/j.1440-1622.2000.01804.x. PMID: 10779057
Combined chemotherapy using cisplatin, ifosfamide and bleomycin (PIB) in the treatment of advanced and recurrent cervical carcinoma.
Tay SK, Lai FM, Soh LT, Ho TH, Ang PT, Au E
Aust N Z J Obstet Gynaecol 1992 Aug;32(3):263-6. doi: 10.1111/j.1479-828x.1992.tb01962.x. PMID: 1280100
Cytostatic treatment of metastatic cervical carcinoma.
Roth A, Kolarić K, Zupanc D
Acta Med Iugosl 1989;43(1):65-75. PMID: 2711862

Recent clinical studies

Etiology

Final survival analysis of topotecan and paclitaxel for first-line treatment of advanced cervical cancer: An NRG oncology randomized study.
Tewari KS, Sill MW, Birrer MJ, Penson RT, Huang H, Moore DH, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, Michael HE, Monk BJ
Gynecol Oncol 2023 Apr;171:141-150. Epub 2023 Mar 8 doi: 10.1016/j.ygyno.2023.01.010. PMID: 36898292Free PMC Article
Camrelizumab (SHR-1210) with carboplatin and albumin-binding paclitaxel in patients with metastatic or recurrent cervical cancer: An open-label, phase 2 trial.
Zhang X, Chen J, Liu N, Wang Q, Wu Q, Gao F, Sang Y, Wang P
J Cancer Res Ther 2022 Apr;18(2):482-487. doi: 10.4103/jcrt.jcrt_1851_21. PMID: 35645118
Epidemiology and Outcomes with Platinum-Based Chemotherapy in Recurrent or Metastatic Carcinoma Cervix in a Developing Country: Experience from a Tertiary Oncology Centre in Southern India.
Lakshmaiah KC, Thanky AH, Lokanatha D, Govind Babu K, Jacob L, Babu S, Rudresha AH, Lokesh KN, Rajeev LK, Sridharmurthy A
Gulf J Oncolog 2017 Sep;1(25):20-26. PMID: 29019326
Metastatic cervical carcinoma from an unknown primary: literature review.
Arrangoiz R, Galloway TJ, Papavasiliou P, Ridge JA, Lango MN
Ear Nose Throat J 2014 Apr-May;93(4-5):E1-10. PMID: 24817234
Docetaxel, carboplatin and 5-fluorouracil (TCF) chemotherapy in patients with unresectable metastatic carcinoma of cervix.
Lin JT, Shih SC, Chang TH, Chang CS
Gynecol Oncol 2010 Apr;117(1):65-9. Epub 2010 Jan 27 doi: 10.1016/j.ygyno.2010.01.001. PMID: 20106511

Diagnosis

Pembrolizumab Improves Survival After Resection of Intracardiac Metastatic Cervical Carcinoma.
Steely AM, Watkins AA, Vidal B, White D, Chu LM
Ann Thorac Surg 2022 Nov;114(5):e323-e325. Epub 2022 Jan 26 doi: 10.1016/j.athoracsur.2021.12.066. PMID: 35090858
CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure.
Coquan E, Brachet PE, Licaj I, Leconte A, Castera M, Lequesne J, Meriaux E, Bonnet I, Lelaidier A, Clarisse B, Joly F
BMC Cancer 2021 Sep 25;21(1):1054. doi: 10.1186/s12885-021-08758-9. PMID: 34563169Free PMC Article
Neck lymph node metastases from unknown primary.
Arosio AD, Pignataro L, Gaini RM, Garavello W
Cancer Treat Rev 2017 Feb;53:1-9. Epub 2016 Dec 10 doi: 10.1016/j.ctrv.2016.11.014. PMID: 28027480
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article
Metastatic cervical carcinoma from an unknown primary: literature review.
Arrangoiz R, Galloway TJ, Papavasiliou P, Ridge JA, Lango MN
Ear Nose Throat J 2014 Apr-May;93(4-5):E1-10. PMID: 24817234

Therapy

Final survival analysis of topotecan and paclitaxel for first-line treatment of advanced cervical cancer: An NRG oncology randomized study.
Tewari KS, Sill MW, Birrer MJ, Penson RT, Huang H, Moore DH, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, Michael HE, Monk BJ
Gynecol Oncol 2023 Apr;171:141-150. Epub 2023 Mar 8 doi: 10.1016/j.ygyno.2023.01.010. PMID: 36898292Free PMC Article
CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure.
Coquan E, Brachet PE, Licaj I, Leconte A, Castera M, Lequesne J, Meriaux E, Bonnet I, Lelaidier A, Clarisse B, Joly F
BMC Cancer 2021 Sep 25;21(1):1054. doi: 10.1186/s12885-021-08758-9. PMID: 34563169Free PMC Article
Cervical cancer - State of the science: From angiogenesis blockade to checkpoint inhibition.
Minion LE, Tewari KS
Gynecol Oncol 2018 Mar;148(3):609-621. Epub 2018 Feb 3 doi: 10.1016/j.ygyno.2018.01.009. PMID: 29666026Free PMC Article
Neck lymph node metastases from unknown primary.
Arosio AD, Pignataro L, Gaini RM, Garavello W
Cancer Treat Rev 2017 Feb;53:1-9. Epub 2016 Dec 10 doi: 10.1016/j.ctrv.2016.11.014. PMID: 28027480
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article

Prognosis

CABOCOL-01 trial: a single-arm phase II study assessing safety and efficacy of Cabozantinib for advanced or metastatic cervical carcinoma after platinum treatment failure.
Coquan E, Brachet PE, Licaj I, Leconte A, Castera M, Lequesne J, Meriaux E, Bonnet I, Lelaidier A, Clarisse B, Joly F
BMC Cancer 2021 Sep 25;21(1):1054. doi: 10.1186/s12885-021-08758-9. PMID: 34563169Free PMC Article
Neck lymph node metastases from unknown primary.
Arosio AD, Pignataro L, Gaini RM, Garavello W
Cancer Treat Rev 2017 Feb;53:1-9. Epub 2016 Dec 10 doi: 10.1016/j.ctrv.2016.11.014. PMID: 28027480
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article
The role of human papilloma virus and p16 in occult primary of the head and neck: a comprehensive review of the literature.
Fotopoulos G, Pavlidis N
Oral Oncol 2015 Feb;51(2):119-23. Epub 2014 Nov 18 doi: 10.1016/j.oraloncology.2014.10.018. PMID: 25467774
Metastatic cervical carcinoma from an unknown primary: literature review.
Arrangoiz R, Galloway TJ, Papavasiliou P, Ridge JA, Lango MN
Ear Nose Throat J 2014 Apr-May;93(4-5):E1-10. PMID: 24817234

Clinical prediction guides

A phase 2 study of nanoparticle albumin-bound paclitaxel plus nedaplatin for patients with advanced, recurrent, or metastatic cervical carcinoma.
Li Y, Zeng J, Huang M, An J, Bai P, Wu L, Zhang R
Cancer 2017 Feb 1;123(3):420-425. Epub 2016 Oct 3 doi: 10.1002/cncr.30328. PMID: 27696395
Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma.
Burotto M, Edgerly M, Poruchynsky M, Velarde M, Wilkerson J, Kotz H, Bates S, Balasubramaniam S, Fojo T
Oncologist 2015 Jul;20(7):725-6. Epub 2015 Jun 3 doi: 10.1634/theoncologist.2015-0104. PMID: 26040622Free PMC Article
Brain metastases from cervical cancer--a short review.
Branch BC, Henry J, Vecil GG
Tumori 2014 Sep-Oct;100(5):e171-9. doi: 10.1700/1660.18186. PMID: 25343555
Use of squamous cell carcinoma antigen as a biomarker of chemotherapy response in patients with metastatic cervical carcinoma.
Hashimoto K, Yonemori K, Katsumata N, Hirakawa A, Hirata T, Yamamoto H, Shimizu C, Tamura K, Ando M, Fujiwara Y
Eur J Obstet Gynecol Reprod Biol 2011 Dec;159(2):394-8. Epub 2011 Aug 10 doi: 10.1016/j.ejogrb.2011.07.001. PMID: 21831511
Lymphoscintigraphy of the neck.
Blakeslee DB, Becker GD, Simpson GT, Patten DH, Sprengelmeyer J
Otolaryngol Head Neck Surg 1985 Jun;93(3):361-5. doi: 10.1177/019459988509300314. PMID: 3927231

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