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Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

MedGen UID:
1649451
•Concept ID:
C4744569
•
Neoplastic Process

Definition

The reemergence of a blastic plasmacytoid dendritic cell neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

Professional guidelines

PubMed

Blastic Plasmacytoid Dendritic Cell Neoplasm: A Comprehensive Review of the Disease, Central Nervous System Presentations, and Treatment Strategies.
Mehra S, Taylor J
Cells 2024 Jan 28;13(3) doi: 10.3390/cells13030243. PMID: 38334635Free PMC Article
Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches.
Cheng W, Yu TT, Tang AP, He Young K, Yu L
Curr Med Sci 2021 Jun;41(3):405-419. Epub 2021 Jul 3 doi: 10.1007/s11596-021-2393-3. PMID: 34218354
Blastic plasmacytoid dendritic cell neoplasia (BPDC) in elderly patients: results of a treatment algorithm employing allogeneic stem cell transplantation with moderately reduced conditioning intensity.
Dietrich S, Andrulis M, Hegenbart U, Schmitt T, Bellos F, Martens UM, Meissner J, Krämer A, Ho AD, Dreger P
Biol Blood Marrow Transplant 2011 Aug;17(8):1250-4. Epub 2011 Jan 6 doi: 10.1016/j.bbmt.2010.12.706. PMID: 21215813

Recent clinical studies

Etiology

Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis.
Murthy HS, Zhang MJ, Chen K, Ahmed S, Deotare U, Ganguly S, Kansagra A, Michelis FV, Nishihori T, Patnaik M, Abid MB, Aljurf M, Arai Y, Bacher U, Badar T, Badawy SM, Ballen K, Battiwalla M, Beitinjaneh A, Bejanyan N, Bhatt VR, Brown VI, Martino R, Cahn JY, Castillo P, Cerny J, Chhabra S, Copelan E, Daly A, Dholaria B, Diaz Perez MA, Freytes CO, Grunwald MR, Hashmi S, Hildebrandt GC, Jamy O, Joseph J, Kanakry CG, Khera N, Krem MM, Kuwatsuka Y, Lazarus HM, Lekakis LJ, Liu H, Modi D, Munshi PN, Mussetti A, Palmisiano N, Patel SS, Rizzieri DA, Seo S, Shah MV, Sharma A, Sohl M, Solomon SR, Ulrickson M, Ustun C, van der Poel M, Verdonck LF, Wagner JL, Wang T, Wirk B, Zeidan A, Litzow M, Kebriaei P, Hourigan CS, Weisdorf DJ, Saber W, Kharfan-Dabaja MA
Blood Adv 2023 Nov 28;7(22):7007-7016. doi: 10.1182/bloodadvances.2023011308. PMID: 37792849Free PMC Article
Retrospective analysis of hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: conditioning intensity matters.
Bruch PM, Dietrich S, Finel H, Boumendil A, Greinix H, Heinicke T, Bethge W, Beelen D, Schmid C, Martin H, Castagna L, Scheid C, Schäfer-Eckart K, Bittenbring J, Finke J, Sengeloev H, Heiblig M, Cornelissen J, Chevallier P, Mohty M, Robinson S, Montoto S, Dreger P
Leukemia 2023 Feb;37(2):465-472. Epub 2022 Dec 22 doi: 10.1038/s41375-022-01782-z. PMID: 36550212
North American Blastic Plasmacytoid Dendritic Cell Neoplasm Consortium: position on standards of care and areas of need.
Pemmaraju N, Kantarjian H, Sweet K, Wang E, Senapati J, Wilson NR, Konopleva M, Frankel AE, Gupta V, Mesa R, Ulrickson M, Gorak E, Bhatia S, Budak-Alpdogan T, Mason J, Garcia-Romero MT, Lopez-Santiago N, Cesarman-Maus G, Vachhani P, Lee S, Bhatt VR, Blum W, Walter RB, Bixby D, Gojo I, Duvic M, Rampal RK, de Lima M, Foran J, Fathi AT, Hall AC, Jacoby MA, Lancet J, Mannis G, Stein AS, Mims A, Rizzieri D, Olin R, Perl A, Schiller G, Shami P, Stone RM, Strickland S, Wieduwilt MJ, Daver N, Ravandi F, Vasu S, Guzman M, Roboz GJ, Khoury J, Qazilbash M, Aung PP, Cuglievan B, Madanat Y, Kharfan-Dabaja MA, Pawlowska A, Taylor J, Tallman M, Dhakal P, Lane AA
Blood 2023 Feb 9;141(6):567-578. doi: 10.1182/blood.2022017865. PMID: 36399715
Blastic plasmacytoid dendritic cell neoplasm: First retrospective study in the Czech Republic.
Cernan M, Szotkowski T, Hisemova M, Cetkovsky P, Sramkova L, Stary J, Racil Z, Mayer J, Sramek J, Jindra P, Visek B, Zak P, Novak J, Kozak T, Furst T, Papajik T
Neoplasma 2020 May;67(3):650-659. Epub 2020 Feb 17 doi: 10.4149/neo_2020_190507N407. PMID: 32064883
Clinical experience with the BCL2-inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies.
DiNardo CD, Rausch CR, Benton C, Kadia T, Jain N, Pemmaraju N, Daver N, Covert W, Marx KR, Mace M, Jabbour E, Cortes J, Garcia-Manero G, Ravandi F, Bhalla KN, Kantarjian H, Konopleva M
Am J Hematol 2018 Mar;93(3):401-407. Epub 2017 Dec 23 doi: 10.1002/ajh.25000. PMID: 29218851

Diagnosis

Systemic mastocytosis mimicking blastic plasmacytoid dendritic cell neoplasm: a case report.
Zhang X, Han J, Zhu N, Ji Y, Hou Y
Diagn Pathol 2023 Feb 10;18(1):17. doi: 10.1186/s13000-023-01301-3. PMID: 36759849Free PMC Article
Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches.
Cheng W, Yu TT, Tang AP, He Young K, Yu L
Curr Med Sci 2021 Jun;41(3):405-419. Epub 2021 Jul 3 doi: 10.1007/s11596-021-2393-3. PMID: 34218354
Cytogenetics of Blastic Plasmacytoid Dendritic Cell Neoplasm: Chromosomal Rearrangements and DNA Copy-Number Alterations.
Sakamoto K, Takeuchi K
Hematol Oncol Clin North Am 2020 Jun;34(3):523-538. Epub 2020 Mar 18 doi: 10.1016/j.hoc.2020.01.003. PMID: 32336417
Blastic plasmacytoid dendritic cell neoplasm: First retrospective study in the Czech Republic.
Cernan M, Szotkowski T, Hisemova M, Cetkovsky P, Sramkova L, Stary J, Racil Z, Mayer J, Sramek J, Jindra P, Visek B, Zak P, Novak J, Kozak T, Furst T, Papajik T
Neoplasma 2020 May;67(3):650-659. Epub 2020 Feb 17 doi: 10.4149/neo_2020_190507N407. PMID: 32064883
Neoplasms derived from plasmacytoid dendritic cells.
Facchetti F, Cigognetti M, Fisogni S, Rossi G, Lonardi S, Vermi W
Mod Pathol 2016 Feb;29(2):98-111. Epub 2016 Jan 8 doi: 10.1038/modpathol.2015.145. PMID: 26743477

Therapy

Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis.
Murthy HS, Zhang MJ, Chen K, Ahmed S, Deotare U, Ganguly S, Kansagra A, Michelis FV, Nishihori T, Patnaik M, Abid MB, Aljurf M, Arai Y, Bacher U, Badar T, Badawy SM, Ballen K, Battiwalla M, Beitinjaneh A, Bejanyan N, Bhatt VR, Brown VI, Martino R, Cahn JY, Castillo P, Cerny J, Chhabra S, Copelan E, Daly A, Dholaria B, Diaz Perez MA, Freytes CO, Grunwald MR, Hashmi S, Hildebrandt GC, Jamy O, Joseph J, Kanakry CG, Khera N, Krem MM, Kuwatsuka Y, Lazarus HM, Lekakis LJ, Liu H, Modi D, Munshi PN, Mussetti A, Palmisiano N, Patel SS, Rizzieri DA, Seo S, Shah MV, Sharma A, Sohl M, Solomon SR, Ulrickson M, Ustun C, van der Poel M, Verdonck LF, Wagner JL, Wang T, Wirk B, Zeidan A, Litzow M, Kebriaei P, Hourigan CS, Weisdorf DJ, Saber W, Kharfan-Dabaja MA
Blood Adv 2023 Nov 28;7(22):7007-7016. doi: 10.1182/bloodadvances.2023011308. PMID: 37792849Free PMC Article
Characteristics and outcomes of patients with blastic plasmacytoid dendritic cell neoplasm treated with frontline HCVAD.
Pemmaraju N, Wilson NR, Garcia-Manero G, Sasaki K, Khoury JD, Jain N, Borthakur G, Ravandi F, Daver N, Kadia T, DiNardo C, Jabbour E, Pierce S, Qazilbash M, Konopleva M, Kantarjian H
Blood Adv 2022 May 24;6(10):3027-3035. doi: 10.1182/bloodadvances.2021006645. PMID: 35061885Free PMC Article
Clinical experience with the BCL2-inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies.
DiNardo CD, Rausch CR, Benton C, Kadia T, Jain N, Pemmaraju N, Daver N, Covert W, Marx KR, Mace M, Jabbour E, Cortes J, Garcia-Manero G, Ravandi F, Bhalla KN, Kantarjian H, Konopleva M
Am J Hematol 2018 Mar;93(3):401-407. Epub 2017 Dec 23 doi: 10.1002/ajh.25000. PMID: 29218851
Haematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a North American multicentre collaborative study.
Kharfan-Dabaja MA, Al Malki MM, Deotare U, Raj RV, El-Jurdi N, Majhail N, Cherry MA, Bashir Q, Darrah J, Nishihori T, Sibai H, Hamadani M, de Lima M, Gerds AT, Selby G, Qazilbash MH, Forman SJ, Ayala E, Lipton JH, Hari PN, Muzzafar T, Zhang L, Olteanu H, Perkins J, Sokol L, Kumar A, Ahmed S
Br J Haematol 2017 Dec;179(5):781-789. Epub 2017 Oct 4 doi: 10.1111/bjh.14954. PMID: 28980314
Diagnostic and therapeutic advances in blastic plasmacytoid dendritic cell neoplasm: a focus on hematopoietic cell transplantation.
Kharfan-Dabaja MA, Lazarus HM, Nishihori T, Mahfouz RA, Hamadani M
Biol Blood Marrow Transplant 2013 Jul;19(7):1006-12. Epub 2013 Feb 5 doi: 10.1016/j.bbmt.2013.01.027. PMID: 23396213

Prognosis

Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis.
Murthy HS, Zhang MJ, Chen K, Ahmed S, Deotare U, Ganguly S, Kansagra A, Michelis FV, Nishihori T, Patnaik M, Abid MB, Aljurf M, Arai Y, Bacher U, Badar T, Badawy SM, Ballen K, Battiwalla M, Beitinjaneh A, Bejanyan N, Bhatt VR, Brown VI, Martino R, Cahn JY, Castillo P, Cerny J, Chhabra S, Copelan E, Daly A, Dholaria B, Diaz Perez MA, Freytes CO, Grunwald MR, Hashmi S, Hildebrandt GC, Jamy O, Joseph J, Kanakry CG, Khera N, Krem MM, Kuwatsuka Y, Lazarus HM, Lekakis LJ, Liu H, Modi D, Munshi PN, Mussetti A, Palmisiano N, Patel SS, Rizzieri DA, Seo S, Shah MV, Sharma A, Sohl M, Solomon SR, Ulrickson M, Ustun C, van der Poel M, Verdonck LF, Wagner JL, Wang T, Wirk B, Zeidan A, Litzow M, Kebriaei P, Hourigan CS, Weisdorf DJ, Saber W, Kharfan-Dabaja MA
Blood Adv 2023 Nov 28;7(22):7007-7016. doi: 10.1182/bloodadvances.2023011308. PMID: 37792849Free PMC Article
Retrospective analysis of hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: conditioning intensity matters.
Bruch PM, Dietrich S, Finel H, Boumendil A, Greinix H, Heinicke T, Bethge W, Beelen D, Schmid C, Martin H, Castagna L, Scheid C, Schäfer-Eckart K, Bittenbring J, Finke J, Sengeloev H, Heiblig M, Cornelissen J, Chevallier P, Mohty M, Robinson S, Montoto S, Dreger P
Leukemia 2023 Feb;37(2):465-472. Epub 2022 Dec 22 doi: 10.1038/s41375-022-01782-z. PMID: 36550212
Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches.
Cheng W, Yu TT, Tang AP, He Young K, Yu L
Curr Med Sci 2021 Jun;41(3):405-419. Epub 2021 Jul 3 doi: 10.1007/s11596-021-2393-3. PMID: 34218354
Blastic plasmacytoid dendritic cell neoplasm: First retrospective study in the Czech Republic.
Cernan M, Szotkowski T, Hisemova M, Cetkovsky P, Sramkova L, Stary J, Racil Z, Mayer J, Sramek J, Jindra P, Visek B, Zak P, Novak J, Kozak T, Furst T, Papajik T
Neoplasma 2020 May;67(3):650-659. Epub 2020 Feb 17 doi: 10.4149/neo_2020_190507N407. PMID: 32064883
Neoplasms derived from plasmacytoid dendritic cells.
Facchetti F, Cigognetti M, Fisogni S, Rossi G, Lonardi S, Vermi W
Mod Pathol 2016 Feb;29(2):98-111. Epub 2016 Jan 8 doi: 10.1038/modpathol.2015.145. PMID: 26743477

Clinical prediction guides

Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis.
Murthy HS, Zhang MJ, Chen K, Ahmed S, Deotare U, Ganguly S, Kansagra A, Michelis FV, Nishihori T, Patnaik M, Abid MB, Aljurf M, Arai Y, Bacher U, Badar T, Badawy SM, Ballen K, Battiwalla M, Beitinjaneh A, Bejanyan N, Bhatt VR, Brown VI, Martino R, Cahn JY, Castillo P, Cerny J, Chhabra S, Copelan E, Daly A, Dholaria B, Diaz Perez MA, Freytes CO, Grunwald MR, Hashmi S, Hildebrandt GC, Jamy O, Joseph J, Kanakry CG, Khera N, Krem MM, Kuwatsuka Y, Lazarus HM, Lekakis LJ, Liu H, Modi D, Munshi PN, Mussetti A, Palmisiano N, Patel SS, Rizzieri DA, Seo S, Shah MV, Sharma A, Sohl M, Solomon SR, Ulrickson M, Ustun C, van der Poel M, Verdonck LF, Wagner JL, Wang T, Wirk B, Zeidan A, Litzow M, Kebriaei P, Hourigan CS, Weisdorf DJ, Saber W, Kharfan-Dabaja MA
Blood Adv 2023 Nov 28;7(22):7007-7016. doi: 10.1182/bloodadvances.2023011308. PMID: 37792849Free PMC Article
Systemic mastocytosis mimicking blastic plasmacytoid dendritic cell neoplasm: a case report.
Zhang X, Han J, Zhu N, Ji Y, Hou Y
Diagn Pathol 2023 Feb 10;18(1):17. doi: 10.1186/s13000-023-01301-3. PMID: 36759849Free PMC Article
Blastic plasmacytoid dendritic cell neoplasm: First retrospective study in the Czech Republic.
Cernan M, Szotkowski T, Hisemova M, Cetkovsky P, Sramkova L, Stary J, Racil Z, Mayer J, Sramek J, Jindra P, Visek B, Zak P, Novak J, Kozak T, Furst T, Papajik T
Neoplasma 2020 May;67(3):650-659. Epub 2020 Feb 17 doi: 10.4149/neo_2020_190507N407. PMID: 32064883
Clinical experience with the BCL2-inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies.
DiNardo CD, Rausch CR, Benton C, Kadia T, Jain N, Pemmaraju N, Daver N, Covert W, Marx KR, Mace M, Jabbour E, Cortes J, Garcia-Manero G, Ravandi F, Bhalla KN, Kantarjian H, Konopleva M
Am J Hematol 2018 Mar;93(3):401-407. Epub 2017 Dec 23 doi: 10.1002/ajh.25000. PMID: 29218851
Neoplasms derived from plasmacytoid dendritic cells.
Facchetti F, Cigognetti M, Fisogni S, Rossi G, Lonardi S, Vermi W
Mod Pathol 2016 Feb;29(2):98-111. Epub 2016 Jan 8 doi: 10.1038/modpathol.2015.145. PMID: 26743477

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