U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Triple-negative breast carcinoma

MedGen UID:
1649548
•Concept ID:
C4722518
•
Neoplastic Process
Synonyms: Triple Negative Breast Carcinoma; Triple-Negative Breast Cancer; triple-negative breast cancer; Triple-Negative Breast Carcinoma; triple-negative breast carcinoma; triple-receptor negative breast cancer
 
Monarch Initiative: MONDO:0005494

Definition

An invasive breast carcinoma which is negative for expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). [from NCI]

Professional guidelines

PubMed

Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article
Sensitization of rhTRAIL-resistant Triple-negative Breast Carcinoma Through Silibinin Co-Treatment.
Manouchehri JM, Kalafatis M
Anticancer Res 2017 Dec;37(12):6593-6599. doi: 10.21873/anticanres.12116. PMID: 29187434
Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment.
Bouchalova K, Cizkova M, Cwiertka K, Trojanec R, Hajduch M
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2009 Mar;153(1):13-7. doi: 10.5507/bp.2009.002. PMID: 19365520

Recent clinical studies

Etiology

The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer.
Yang Z, Zhang Q, Yu L, Zhu J, Cao Y, Gao X
J Ethnopharmacol 2021 Jan 10;264:113249. Epub 2020 Aug 15 doi: 10.1016/j.jep.2020.113249. PMID: 32810619
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature.
El Zein D, Hughes M, Kumar S, Peng X, Oyasiji T, Jabbour H, Khoury T
Clin Breast Cancer 2017 Aug;17(5):382-391. Epub 2017 Apr 26 doi: 10.1016/j.clbc.2017.04.009. PMID: 28529029Free PMC Article
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513
Triple-negative breast carcinoma: current and emerging concepts.
Schmadeka R, Harmon BE, Singh M
Am J Clin Pathol 2014 Apr;141(4):462-77. doi: 10.1309/AJCPQN8GZ8SILKGN. PMID: 24619745
Potential prognostic tumor biomarkers in triple-negative breast carcinoma.
Peng Y
Beijing Da Xue Xue Bao Yi Xue Ban 2012 Oct 18;44(5):666-72. PMID: 23073572

Diagnosis

TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.
Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Novel uses of immunohistochemistry in breast pathology: interpretation and pitfalls.
Cimino-Mathews A
Mod Pathol 2021 Jan;34(Suppl 1):62-77. Epub 2020 Oct 27 doi: 10.1038/s41379-020-00697-3. PMID: 33110239
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513

Therapy

miR-1205/DNAJB1 reverses docetaxel chemoresistance in human triple negative breast carcinoma cells via regulation of mutp53/TAp63 signaling.
Yin Y, Zhang J, Ma T, Chen D, Lu D
Acta Biochim Biophys Sin (Shanghai) 2022 Jan 25;54(1):37-46. doi: 10.3724/abbs.2021006. PMID: 35130632Free PMC Article
Programmed cell death ligand - 1 expression in triple negative breast carcinoma and its prognostic significance in Indian population.
Gajaria PK, Gupta MR, Patil A, Desai SB, Shet TM
Indian J Pathol Microbiol 2021 Oct-Dec;64(4):664-670. doi: 10.4103/IJPM.IJPM_1136_20. PMID: 34673583
Clinicopathological Features and Treatment Challenges in Triple Negative Breast Cancer Patients: A Retrospective Cohort Study.
Elwan A, Abdelrahman AE, Alnagar AA, Abdelhamid MI, Nawar N
Turk Patoloji Derg 2021;37(2):121-129. doi: 10.5146/tjpath.2020.01516. PMID: 33432555Free PMC Article
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer.
Yang Z, Zhang Q, Yu L, Zhu J, Cao Y, Gao X
J Ethnopharmacol 2021 Jan 10;264:113249. Epub 2020 Aug 15 doi: 10.1016/j.jep.2020.113249. PMID: 32810619
Anticancer activity of palladium-based complexes against triple-negative breast cancer.
Vojtek M, Marques MPM, Ferreira IMPLVO, Mota-Filipe H, Diniz C
Drug Discov Today 2019 Apr;24(4):1044-1058. Epub 2019 Mar 5 doi: 10.1016/j.drudis.2019.02.012. PMID: 30849441

Prognosis

Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses.
Cima L, Kaya H, Marchiò C, Nishimura R, Wen HY, Fabbri VP, Foschini MP
Virchows Arch 2022 Jan;480(1):109-126. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03174-7. PMID: 34458945Free PMC Article
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer.
Yang Z, Zhang Q, Yu L, Zhu J, Cao Y, Gao X
J Ethnopharmacol 2021 Jan 10;264:113249. Epub 2020 Aug 15 doi: 10.1016/j.jep.2020.113249. PMID: 32810619
MicroRNAs in regulation of triple-negative breast cancer progression.
Piasecka D, Braun M, Kordek R, Sadej R, Romanska H
J Cancer Res Clin Oncol 2018 Aug;144(8):1401-1411. Epub 2018 Jun 19 doi: 10.1007/s00432-018-2689-2. PMID: 29923083Free PMC Article
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513

Clinical prediction guides

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.
Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161
Composition and plasticity of triple-negative breast carcinoma-infiltrating regulatory T cells.
Cai B, Ma P, Ding P, Sun DW, Bu Q, Zhang J
APMIS 2020 Mar;128(3):260-269. Epub 2020 Jan 28 doi: 10.1111/apm.13022. PMID: 31811667
MicroRNAs in regulation of triple-negative breast cancer progression.
Piasecka D, Braun M, Kordek R, Sadej R, Romanska H
J Cancer Res Clin Oncol 2018 Aug;144(8):1401-1411. Epub 2018 Jun 19 doi: 10.1007/s00432-018-2689-2. PMID: 29923083Free PMC Article
Triple-negative Breast Carcinoma: Morphologic and Molecular Subtypes.
Bose S
Adv Anat Pathol 2015 Sep;22(5):306-13. doi: 10.1097/PAP.0000000000000084. PMID: 26262513

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...