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Refractory Hormone Receptor-Positive Breast Carcinoma

MedGen UID:
1650178
•Concept ID:
C4745241
•
Neoplastic Process
Synonyms: Refractory Hormone Receptor Positive Breast Adenocarcinoma; Refractory Hormone Receptor Positive Breast Carcinoma

Definition

Hormone receptor-positive breast adenocarcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Hormone Receptor-Positive Breast Carcinoma

Professional guidelines

PubMed

An evaluation of fulvestrant for the treatment of metastatic breast cancer.
Soleja M, Raj GV, Unni N
Expert Opin Pharmacother 2019 Oct;20(15):1819-1829. Epub 2019 Sep 5 doi: 10.1080/14656566.2019.1651293. PMID: 31486688
Review of Cyclin-Dependent Kinase 4/6 Inhibitors for the Treatment of Hormone Receptor-Positive Advanced Breast Cancer.
Hecht KA, Selby C
Ann Pharmacother 2019 Feb;53(2):195-203. Epub 2018 Aug 6 doi: 10.1177/1060028018793656. PMID: 30079740
mTOR inhibitors in the treatment of breast cancer.
Vinayak S, Carlson RW
Oncology (Williston Park) 2013 Jan;27(1):38-44, 46, 48 passim. PMID: 23461041

Recent clinical studies

Etiology

Phase I/II Trial of Exemestane, Ribociclib, and Everolimus in Women with HR(+)/HER2(-) Advanced Breast Cancer after Progression on CDK4/6 Inhibitors (TRINITI-1).
Bardia A, Hurvitz SA, DeMichele A, Clark AS, Zelnak A, Yardley DA, Karuturi M, Sanft T, Blau S, Hart L, Ma C, Rugo HS, Purkayastha D, Moulder S
Clin Cancer Res 2021 Aug 1;27(15):4177-4185. Epub 2021 Mar 15 doi: 10.1158/1078-0432.CCR-20-2114. PMID: 33722897Free PMC Article
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Lapatinib.
Voigtlaender M, Schneider-Merck T, Trepel M
Recent Results Cancer Res 2018;211:19-44. doi: 10.1007/978-3-319-91442-8_2. PMID: 30069757
Long-term management of patients with hormone receptor-positive metastatic breast cancer: Concepts for sequential and combination endocrine-based therapies.
Brufsky AM
Cancer Treat Rev 2017 Sep;59:22-32. Epub 2017 Jul 6 doi: 10.1016/j.ctrv.2017.06.004. PMID: 28719836
Breast cancer in men.
Giordano SH, Buzdar AU, Hortobagyi GN
Ann Intern Med 2002 Oct 15;137(8):678-87. doi: 10.7326/0003-4819-137-8-200210150-00013. PMID: 12379069

Diagnosis

Sequencing systemic therapy in hormone-receptor positive metastatic breast cancer: a modern paradigm.
Haddad SA, Dizon DS, Graff SL
Chin Clin Oncol 2023 Aug;12(4):42. Epub 2023 Aug 10 doi: 10.21037/cco-23-22. PMID: 37574571
Increased androgen receptor expression in estrogen receptor-positive/progesterone receptor-negative breast cancer.
García X, Elía A, Galizzi L, May M, Spengler E, Martínez Vázquez P, Burruchaga J, Gass H, Lanari C, Lamb CA
Breast Cancer Res Treat 2020 Feb;180(1):257-263. Epub 2020 Jan 16 doi: 10.1007/s10549-020-05527-3. PMID: 31950383
The Growing Role of CDK4/6 Inhibitors in Treating Hormone Receptor-Positive Advanced Breast Cancer.
Shah AN, Cristofanilli M
Curr Treat Options Oncol 2017 Jan;18(1):6. doi: 10.1007/s11864-017-0443-7. PMID: 28197838
New approaches in the management of male breast cancer.
Patten DK, Sharifi LK, Fazel M
Clin Breast Cancer 2013 Oct;13(5):309-14. Epub 2013 Jul 9 doi: 10.1016/j.clbc.2013.04.003. PMID: 23845572
Breast cancer in men.
Giordano SH, Buzdar AU, Hortobagyi GN
Ann Intern Med 2002 Oct 15;137(8):678-87. doi: 10.7326/0003-4819-137-8-200210150-00013. PMID: 12379069

Therapy

CCNE1 and PLK1 Mediate Resistance to Palbociclib in HR+/HER2- Metastatic Breast Cancer.
Guerrero-Zotano Á, Belli S, Zielinski C, Gil-Gil M, Fernandez-Serra A, Ruiz-Borrego M, Ciruelos Gil EM, Pascual J, Muñoz-Mateu M, Bermejo B, Margeli Vila M, Antón A, Murillo L, Nissenbaum B, Liu Y, Herranz J, Fernández-García D, Caballero R, López-Guerrero JA, Bianco R, Formisano L, Turner N, Martín M
Clin Cancer Res 2023 Apr 14;29(8):1557-1568. doi: 10.1158/1078-0432.CCR-22-2206. PMID: 36749874Free PMC Article
Phase I/II Trial of Exemestane, Ribociclib, and Everolimus in Women with HR(+)/HER2(-) Advanced Breast Cancer after Progression on CDK4/6 Inhibitors (TRINITI-1).
Bardia A, Hurvitz SA, DeMichele A, Clark AS, Zelnak A, Yardley DA, Karuturi M, Sanft T, Blau S, Hart L, Ma C, Rugo HS, Purkayastha D, Moulder S
Clin Cancer Res 2021 Aug 1;27(15):4177-4185. Epub 2021 Mar 15 doi: 10.1158/1078-0432.CCR-20-2114. PMID: 33722897Free PMC Article
Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study.
Banerji U, van Herpen CML, Saura C, Thistlethwaite F, Lord S, Moreno V, Macpherson IR, Boni V, Rolfo C, de Vries EGE, Rottey S, Geenen J, Eskens F, Gil-Martin M, Mommers EC, Koper NP, Aftimos P
Lancet Oncol 2019 Aug;20(8):1124-1135. Epub 2019 Jun 27 doi: 10.1016/S1470-2045(19)30328-6. PMID: 31257177
MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR(+)/HER2(-) Metastatic Breast Cancer.
Dickler MN, Tolaney SM, Rugo HS, Cortés J, Diéras V, Patt D, Wildiers H, Hudis CA, O'Shaughnessy J, Zamora E, Yardley DA, Frenzel M, Koustenis A, Baselga J
Clin Cancer Res 2017 Sep 1;23(17):5218-5224. Epub 2017 May 22 doi: 10.1158/1078-0432.CCR-17-0754. PMID: 28533223Free PMC Article
Breast Cancer: Current Molecular Therapeutic Targets and New Players.
Nagini S
Anticancer Agents Med Chem 2017;17(2):152-163. doi: 10.2174/1871520616666160502122724. PMID: 27137076

Prognosis

Lapatinib.
Voigtlaender M, Schneider-Merck T, Trepel M
Recent Results Cancer Res 2018;211:19-44. doi: 10.1007/978-3-319-91442-8_2. PMID: 30069757
Long-term management of patients with hormone receptor-positive metastatic breast cancer: Concepts for sequential and combination endocrine-based therapies.
Brufsky AM
Cancer Treat Rev 2017 Sep;59:22-32. Epub 2017 Jul 6 doi: 10.1016/j.ctrv.2017.06.004. PMID: 28719836
MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR(+)/HER2(-) Metastatic Breast Cancer.
Dickler MN, Tolaney SM, Rugo HS, Cortés J, Diéras V, Patt D, Wildiers H, Hudis CA, O'Shaughnessy J, Zamora E, Yardley DA, Frenzel M, Koustenis A, Baselga J
Clin Cancer Res 2017 Sep 1;23(17):5218-5224. Epub 2017 May 22 doi: 10.1158/1078-0432.CCR-17-0754. PMID: 28533223Free PMC Article
The Growing Role of CDK4/6 Inhibitors in Treating Hormone Receptor-Positive Advanced Breast Cancer.
Shah AN, Cristofanilli M
Curr Treat Options Oncol 2017 Jan;18(1):6. doi: 10.1007/s11864-017-0443-7. PMID: 28197838
Breast Cancer: Current Molecular Therapeutic Targets and New Players.
Nagini S
Anticancer Agents Med Chem 2017;17(2):152-163. doi: 10.2174/1871520616666160502122724. PMID: 27137076

Clinical prediction guides

nextMONARCH Phase 2 randomized clinical trial: overall survival analysis of abemaciclib monotherapy or in combination with tamoxifen in patients with endocrine-refractory HR + , HER2- metastatic breast cancer.
Hamilton E, Cortes J, Ozyilkan O, Chen SC, Petrakova K, Manikhas A, Jerusalem G, Hegg R, Huober J, Zhang W, Chen Y, Martin M
Breast Cancer Res Treat 2022 Aug;195(1):55-64. Epub 2022 Jul 12 doi: 10.1007/s10549-022-06662-9. PMID: 35829935Free PMC Article
Phase I/II Trial of Exemestane, Ribociclib, and Everolimus in Women with HR(+)/HER2(-) Advanced Breast Cancer after Progression on CDK4/6 Inhibitors (TRINITI-1).
Bardia A, Hurvitz SA, DeMichele A, Clark AS, Zelnak A, Yardley DA, Karuturi M, Sanft T, Blau S, Hart L, Ma C, Rugo HS, Purkayastha D, Moulder S
Clin Cancer Res 2021 Aug 1;27(15):4177-4185. Epub 2021 Mar 15 doi: 10.1158/1078-0432.CCR-20-2114. PMID: 33722897Free PMC Article
Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study.
Banerji U, van Herpen CML, Saura C, Thistlethwaite F, Lord S, Moreno V, Macpherson IR, Boni V, Rolfo C, de Vries EGE, Rottey S, Geenen J, Eskens F, Gil-Martin M, Mommers EC, Koper NP, Aftimos P
Lancet Oncol 2019 Aug;20(8):1124-1135. Epub 2019 Jun 27 doi: 10.1016/S1470-2045(19)30328-6. PMID: 31257177
The Growing Role of CDK4/6 Inhibitors in Treating Hormone Receptor-Positive Advanced Breast Cancer.
Shah AN, Cristofanilli M
Curr Treat Options Oncol 2017 Jan;18(1):6. doi: 10.1007/s11864-017-0443-7. PMID: 28197838
Overview of resistance to systemic therapy in patients with breast cancer.
Gonzalez-Angulo AM, Morales-Vasquez F, Hortobagyi GN
Adv Exp Med Biol 2007;608:1-22. doi: 10.1007/978-0-387-74039-3_1. PMID: 17993229

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