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Thyroid Gland Follicular Tumor of Uncertain Malignant Potential

MedGen UID:
1650267
•Concept ID:
C4744484
•
Neoplastic Process
Synonym: Thyroid Gland Follicular Neoplasm of Uncertain Malignant Potential

Definition

An encapsulated or well-circumscribed thyroid gland tumor composed of well-differentiated follicular cells with no nuclear features of papillary thyroid carcinoma and with questionable capsular or vascular invasion. This is a tumor indeterminate between follicular adenoma and follicular carcinoma. (WHO) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin.
Ceyran AB, Şenol S, Şimşek BÇ, Sağıroğlu J, Aydın A
Int J Clin Exp Pathol 2015;8(4):3670-80. Epub 2015 Apr 1 PMID: 26097548Free PMC Article
Diagnostic criteria of well differentiated thyroid tumor of uncertain malignant potential; a histomorphological and immunohistochemical appraisal.
Yassin Fel-Z
J Egypt Natl Canc Inst 2015 Jun;27(2):59-67. Epub 2015 Mar 21 doi: 10.1016/j.jnci.2015.02.003. PMID: 25800580

Recent clinical studies

Etiology

Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article
Immunohistochemical and morphometrical evaluation of well-differentiated thyroid tumor of uncertain malignant potential.
Mohamed DA, Shamlola MM
Indian J Pathol Microbiol 2019 Jan-Mar;62(1):17-23. doi: 10.4103/IJPM.IJPM_199_18. PMID: 30706854

Diagnosis

Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach.
Jung CK, Bychkov A, Kakudo K
Endocrinol Metab (Seoul) 2022 Oct;37(5):703-718. Epub 2022 Oct 4 doi: 10.3803/EnM.2022.1553. PMID: 36193717Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347

Therapy

Thyroid fine-needle aspiration with atypia of undetermined significance: a necessary or optional category?
Shi Y, Ding X, Klein M, Sugrue C, Matano S, Edelman M, Wasserman P
Cancer 2009 Oct 25;117(5):298-304. doi: 10.1002/cncy.20039. PMID: 19711470

Prognosis

Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article
Thyroid tumors of uncertain malignant potential: morphologic and imunohistochemical analysis of 29 cases.
Nechifor-Boila A, Borda A, Sassolas G, Hafdi-Nejjari Z, Cătană R, Borson-Chazot F, Berger N, Decaussin-Petrucci M
Pathol Res Pract 2015 Apr;211(4):320-5. Epub 2014 Dec 22 doi: 10.1016/j.prp.2014.12.005. PMID: 25595997
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347

Clinical prediction guides

Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis.
Apellaniz-Ruiz M, Sabbaghian N, Chong AL, de Kock L, Cetinkaya S, Bayramoğlu E, Dinjens WNM, McCluggage WG, Wagner A, Yilmaz AA, Foulkes WD
Fam Cancer 2023 Oct;22(4):487-493. Epub 2023 May 30 doi: 10.1007/s10689-023-00336-1. PMID: 37248399Free PMC Article
Mutation profiles of follicular thyroid tumors by targeted sequencing.
Duan H, Liu X, Ren X, Zhang H, Wu H, Liang Z
Diagn Pathol 2019 May 10;14(1):39. doi: 10.1186/s13000-019-0817-1. PMID: 31077238Free PMC Article
Clear Cell Variant of a Follicular Thyroid Tumor With Uncertain Malignant Potential: A Case Report.
Juhlin CC, Bränström R, Shabo I, Höög A
Int J Surg Pathol 2019 May;27(3):290-293. Epub 2018 Oct 29 doi: 10.1177/1066896918809490. PMID: 30370813
Follicular patterned lesions of the thyroid gland: a practical algorithmic approach.
Chetty R
J Clin Pathol 2011 Sep;64(9):737-41. Epub 2011 May 18 doi: 10.1136/jclinpath-2011-200121. PMID: 21593347
Do benign thyroid nodules have malignant potential? An evidence-based review.
Arora N, Scognamiglio T, Zhu B, Fahey TJ 3rd
World J Surg 2008 Jul;32(7):1237-46. doi: 10.1007/s00268-008-9484-1. PMID: 18327528

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