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N1 diffuse large B-cell lymphoma

MedGen UID:
1650336
Concept ID:
C4725004
Neoplastic Process
Synonym: N1 Diffuse Large B-Cell Lymphoma
 
Monarch Initiative: MONDO:0850471

Definition

A diffuse large B-cell lymphoma molecular subtype characterized by the presence of NOTCH1 gene mutations. Patients who belong in this subtype have an inferior outcome. (NEJM 2018; 378: 1396-407) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Witte HM, Riedl J, Künstner A, Fähnrich A, Ketzer J, Fliedner SMJ, Reimer N, Bernard V, von Bubnoff N, Merz H, Busch H, Feller A, Gebauer N
Target Oncol 2023 Sep;18(5):749-765. Epub 2023 Jul 24 doi: 10.1007/s11523-023-00983-5. PMID: 37488307Free PMC Article
Nie G, Sun L, Zhang C, Yuan Y, Mao H, Wang Z, Li J, Duan S, Xing C, Zhang B
Front Immunol 2022;13:903315. Epub 2022 Sep 12 doi: 10.3389/fimmu.2022.903315. PMID: 36172352Free PMC Article
Wei XJ, Yuan H, Khong PL, Zhang F, Liao PJ, Jiang XM, Huang L, Guo HG, Chen FL, Liu SC, Huang YY, Wang SX, Li WY
Acta Oncol 2021 Sep;60(9):1122-1129. Epub 2021 Aug 17 doi: 10.1080/0284186X.2021.1950923. PMID: 34402368

Recent clinical studies

Etiology

Nie G, Sun L, Zhang C, Yuan Y, Mao H, Wang Z, Li J, Duan S, Xing C, Zhang B
Front Immunol 2022;13:903315. Epub 2022 Sep 12 doi: 10.3389/fimmu.2022.903315. PMID: 36172352Free PMC Article
Wang SS, Vajdic CM, Linet MS, Slager SL, Voutsinas J, Nieters A, Casabonne D, Cerhan JR, Cozen W, Alarcón G, Martínez-Maza O, Brown EE, Bracci PM, Turner J, Hjalgrim H, Bhatti P, Zhang Y, Birmann BM, Flowers CR, Paltiel O, Holly EA, Kane E, Weisenburger DD, Maynadié M, Cocco P, Foretova L, Breen EC, Lan Q, Brooks-Wilson A, De Roos AJ, Smith MT, Roman E, Boffetta P, Kricker A, Zheng T, Skibola CF, Clavel J, Monnereau A, Chanock SJ, Rothman N, Benavente Y, Hartge P, Smedby KE
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1103-1110. doi: 10.1158/1055-9965.EPI-21-0875. PMID: 35244686Free PMC Article
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Locke FL, Neelapu SS, Bartlett NL, Siddiqi T, Chavez JC, Hosing CM, Ghobadi A, Budde LE, Bot A, Rossi JM, Jiang Y, Xue AX, Elias M, Aycock J, Wiezorek J, Go WY
Mol Ther 2017 Jan 4;25(1):285-295. doi: 10.1016/j.ymthe.2016.10.020. PMID: 28129122Free PMC Article
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Diagnosis

Zhou T, Wang HW, Ng SB, Summers T, Xi L, Raffeld M, Pittaluga S, Jaffe ES
Am J Surg Pathol 2024 Apr 1;48(4):426-436. Epub 2023 Nov 21 doi: 10.1097/PAS.0000000000002160. PMID: 37988030Free PMC Article
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Nie G, Sun L, Zhang C, Yuan Y, Mao H, Wang Z, Li J, Duan S, Xing C, Zhang B
Front Immunol 2022;13:903315. Epub 2022 Sep 12 doi: 10.3389/fimmu.2022.903315. PMID: 36172352Free PMC Article
Foo TL, Yak R, Puhaindran ME
J Hand Surg Asian Pac Vol 2017 Mar;22(1):104-107. doi: 10.1142/S0218810417720042. PMID: 28205463
Locke FL, Neelapu SS, Bartlett NL, Siddiqi T, Chavez JC, Hosing CM, Ghobadi A, Budde LE, Bot A, Rossi JM, Jiang Y, Xue AX, Elias M, Aycock J, Wiezorek J, Go WY
Mol Ther 2017 Jan 4;25(1):285-295. doi: 10.1016/j.ymthe.2016.10.020. PMID: 28129122Free PMC Article

Therapy

Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Wilson WH, Wright GW, Huang DW, Hodkinson B, Balasubramanian S, Fan Y, Vermeulen J, Shreeve M, Staudt LM
Cancer Cell 2021 Dec 13;39(12):1643-1653.e3. Epub 2021 Nov 4 doi: 10.1016/j.ccell.2021.10.006. PMID: 34739844Free PMC Article
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article
Locke FL, Neelapu SS, Bartlett NL, Siddiqi T, Chavez JC, Hosing CM, Ghobadi A, Budde LE, Bot A, Rossi JM, Jiang Y, Xue AX, Elias M, Aycock J, Wiezorek J, Go WY
Mol Ther 2017 Jan 4;25(1):285-295. doi: 10.1016/j.ymthe.2016.10.020. PMID: 28129122Free PMC Article

Prognosis

Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article
Locke FL, Neelapu SS, Bartlett NL, Siddiqi T, Chavez JC, Hosing CM, Ghobadi A, Budde LE, Bot A, Rossi JM, Jiang Y, Xue AX, Elias M, Aycock J, Wiezorek J, Go WY
Mol Ther 2017 Jan 4;25(1):285-295. doi: 10.1016/j.ymthe.2016.10.020. PMID: 28129122Free PMC Article
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Clinical prediction guides

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Hubbeling H, Silverman EA, Michaud L, Tomas AA, Shouval R, Flynn J, Devlin S, Wijetunga NA, Tringale KR, Batlevi C, Dahi P, Giralt S, Lin R, Park J, Scordo M, Sauter C, Shah G, Hajj C, Salles G, Schoder H, Palomba ML, Perales MA, Yahalom J, Imber BS
Transplant Cell Ther 2023 Apr;29(4):259.e1-259.e10. Epub 2022 Dec 30 doi: 10.1016/j.jtct.2022.12.021. PMID: 36587744Free PMC Article
Hu M, Gu W, Chen S, Mei J, Wang W
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221075529. doi: 10.1177/15330338221075529. PMID: 35253550Free PMC Article
Wang SS, Vajdic CM, Linet MS, Slager SL, Voutsinas J, Nieters A, Casabonne D, Cerhan JR, Cozen W, Alarcón G, Martínez-Maza O, Brown EE, Bracci PM, Turner J, Hjalgrim H, Bhatti P, Zhang Y, Birmann BM, Flowers CR, Paltiel O, Holly EA, Kane E, Weisenburger DD, Maynadié M, Cocco P, Foretova L, Breen EC, Lan Q, Brooks-Wilson A, De Roos AJ, Smith MT, Roman E, Boffetta P, Kricker A, Zheng T, Skibola CF, Clavel J, Monnereau A, Chanock SJ, Rothman N, Benavente Y, Hartge P, Smedby KE
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1103-1110. doi: 10.1158/1055-9965.EPI-21-0875. PMID: 35244686Free PMC Article
Locke FL, Neelapu SS, Bartlett NL, Siddiqi T, Chavez JC, Hosing CM, Ghobadi A, Budde LE, Bot A, Rossi JM, Jiang Y, Xue AX, Elias M, Aycock J, Wiezorek J, Go WY
Mol Ther 2017 Jan 4;25(1):285-295. doi: 10.1016/j.ymthe.2016.10.020. PMID: 28129122Free PMC Article

Recent systematic reviews

Portuguese AJ, Gauthier J, Tykodi SS, Hall ET, Hirayama AV, Yeung CCS, Blosser CD
Bone Marrow Transplant 2023 Apr;58(4):353-359. Epub 2022 Dec 27 doi: 10.1038/s41409-022-01907-z. PMID: 36575360
Suero Molina E, Revuelta Barbero JM, Ewelt C, Stummer W, Carrau RL, Prevedello DM
Neurosurg Rev 2021 Feb;44(1):249-259. Epub 2020 Feb 10 doi: 10.1007/s10143-020-01247-w. PMID: 32040778Free PMC Article
Takyar J, Raut M, Borse R, Balakumaran A, Sehgal M
Expert Rev Hematol 2020 Mar;13(3):275-287. Epub 2020 Jan 28 doi: 10.1080/17474086.2020.1716725. PMID: 31951774
Kang DH, Huh J, Lee JH, Jeong YK, Cha HJ
World J Gastroenterol 2017 Sep 21;23(35):6491-6499. doi: 10.3748/wjg.v23.i35.6491. PMID: 29085199Free PMC Article
Adams HJ, Nievelstein RA, Kwee TC
Br J Haematol 2015 Jul;170(2):185-91. Epub 2015 Apr 1 doi: 10.1111/bjh.13420. PMID: 25833790

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