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NUTM1 Gene Rearrangement

MedGen UID:
1650471
•Concept ID:
C4727136
•
Cell or Molecular Dysfunction
Synonyms: C15orf55 Gene Rearrangement; FAM22H Gene Rearrangement; Nuclear Protein in Testis Gene Rearrangement; NUT Gene Rearrangement; NUT Midline Carcinoma, Family Member 1 Gene Rearrangement; NUT Rearrangement

Definition

A molecular abnormality indicating rearrangement of the NUTM1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNUTM1 Gene Rearrangement

Professional guidelines

PubMed

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.
Xie XH, Wang LQ, Qin YY, Lin XQ, Xie ZH, Liu M, Zhang JX, Ouyang M, Liu J, Gu YY, Li SY, Zhou CZ
Orphanet J Rare Dis 2020 Jul 10;15(1):183. doi: 10.1186/s13023-020-01449-x. PMID: 32650830Free PMC Article

Recent clinical studies

Etiology

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.
Xie XH, Wang LQ, Qin YY, Lin XQ, Xie ZH, Liu M, Zhang JX, Ouyang M, Liu J, Gu YY, Li SY, Zhou CZ
Orphanet J Rare Dis 2020 Jul 10;15(1):183. doi: 10.1186/s13023-020-01449-x. PMID: 32650830Free PMC Article

Diagnosis

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.
Xie XH, Wang LQ, Qin YY, Lin XQ, Xie ZH, Liu M, Zhang JX, Ouyang M, Liu J, Gu YY, Li SY, Zhou CZ
Orphanet J Rare Dis 2020 Jul 10;15(1):183. doi: 10.1186/s13023-020-01449-x. PMID: 32650830Free PMC Article
Primary malignant epithelioid and rhabdoid tumor of bone harboring ZNF532-NUTM1 fusion: the expanding NUT cancer family.
Chien YW, Hsieh TH, Chu PY, Hsieh SM, Liu ML, Lee JC, Liu YR, Ku JW, Kao YC
Genes Chromosomes Cancer 2019 Nov;58(11):809-814. Epub 2019 Jul 30 doi: 10.1002/gcc.22785. PMID: 31334571

Therapy

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.
Xie XH, Wang LQ, Qin YY, Lin XQ, Xie ZH, Liu M, Zhang JX, Ouyang M, Liu J, Gu YY, Li SY, Zhou CZ
Orphanet J Rare Dis 2020 Jul 10;15(1):183. doi: 10.1186/s13023-020-01449-x. PMID: 32650830Free PMC Article

Prognosis

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.
Xie XH, Wang LQ, Qin YY, Lin XQ, Xie ZH, Liu M, Zhang JX, Ouyang M, Liu J, Gu YY, Li SY, Zhou CZ
Orphanet J Rare Dis 2020 Jul 10;15(1):183. doi: 10.1186/s13023-020-01449-x. PMID: 32650830Free PMC Article

Clinical prediction guides

NUT carcinoma of the parotid gland: report of two cases, one with a rare ZNF532-NUTM1 fusion.
Chen M, Zhao S, Liang Z, Wang W, Zhou P, Jiang L
Virchows Arch 2022 Apr;480(4):887-897. Epub 2022 Jan 22 doi: 10.1007/s00428-021-03253-9. PMID: 35064291
Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.
Xie XH, Wang LQ, Qin YY, Lin XQ, Xie ZH, Liu M, Zhang JX, Ouyang M, Liu J, Gu YY, Li SY, Zhou CZ
Orphanet J Rare Dis 2020 Jul 10;15(1):183. doi: 10.1186/s13023-020-01449-x. PMID: 32650830Free PMC Article
Tumor Mutation Burden and Checkpoint Immunotherapy Markers in NUT Midline Carcinoma.
He M, Chernock R, Zhou S, Gondim M, Dehner LP, Pfeifer JD
Appl Immunohistochem Mol Morphol 2020 Aug;28(7):495-500. doi: 10.1097/PAI.0000000000000781. PMID: 31180909
Primary malignant epithelioid and rhabdoid tumor of bone harboring ZNF532-NUTM1 fusion: the expanding NUT cancer family.
Chien YW, Hsieh TH, Chu PY, Hsieh SM, Liu ML, Lee JC, Liu YR, Ku JW, Kao YC
Genes Chromosomes Cancer 2019 Nov;58(11):809-814. Epub 2019 Jul 30 doi: 10.1002/gcc.22785. PMID: 31334571

Supplemental Content

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