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RARA Gene Translocation

MedGen UID:
1650639
Concept ID:
C4744762
Cell or Molecular Dysfunction
Synonyms: NR1B1 Gene Translocation; RARA Translocation; RARalpha Gene Translocation; Retinoic Acid Receptor Alpha Gene Translocation

Definition

A cytogenetic abnormality that refers to any translocation involving the RARA gene. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Suguna E, Farhana R, Kanimozhi E, Kumar PS, Kumaramanickavel G, Kumar CS
Cardiovasc Hematol Disord Drug Targets 2018;18(3):199-207. doi: 10.2174/1871529X18666180515130136. PMID: 29766829
Lengfelder E, Hofmann WK, Nowak D
Expert Rev Anticancer Ther 2013 Sep;13(9):1035-43. doi: 10.1586/14737140.2013.833681. PMID: 24053202

Recent clinical studies

Etiology

Korsos V, Miller WH Jr
J Mol Endocrinol 2022 Nov 1;69(4):T69-T83. Epub 2022 Oct 11 doi: 10.1530/JME-22-0141. PMID: 36112505
Cicconi L, Fenaux P, Kantarjian H, Tallman M, Sanz MA, Lo-Coco F
Leukemia 2018 Aug;32(8):1671-1678. Epub 2018 Jul 19 doi: 10.1038/s41375-018-0219-5. PMID: 30026570
Suguna E, Farhana R, Kanimozhi E, Kumar PS, Kumaramanickavel G, Kumar CS
Cardiovasc Hematol Disord Drug Targets 2018;18(3):199-207. doi: 10.2174/1871529X18666180515130136. PMID: 29766829
Uribesalgo I, Di Croce L
Brief Funct Genomics 2011 Jan;10(1):18-29. Epub 2011 Jan 21 doi: 10.1093/bfgp/elr002. PMID: 21258047Free PMC Article
Borrow J, Solomon E
Baillieres Clin Haematol 1992 Oct;5(4):833-56. doi: 10.1016/s0950-3536(11)80048-x. PMID: 1339190

Diagnosis

Korsos V, Miller WH Jr
J Mol Endocrinol 2022 Nov 1;69(4):T69-T83. Epub 2022 Oct 11 doi: 10.1530/JME-22-0141. PMID: 36112505
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Suguna E, Farhana R, Kanimozhi E, Kumar PS, Kumaramanickavel G, Kumar CS
Cardiovasc Hematol Disord Drug Targets 2018;18(3):199-207. doi: 10.2174/1871529X18666180515130136. PMID: 29766829
Saleem M, Yusoff NM
Hematology 2016 Oct;21(9):501-12. Epub 2016 Feb 24 doi: 10.1080/10245332.2015.1106816. PMID: 26871368

Therapy

Korsos V, Miller WH Jr
J Mol Endocrinol 2022 Nov 1;69(4):T69-T83. Epub 2022 Oct 11 doi: 10.1530/JME-22-0141. PMID: 36112505
Hunsu VO, Facey COB, Fields JZ, Boman BM
Int J Mol Sci 2021 Jul 20;22(14) doi: 10.3390/ijms22147731. PMID: 34299349Free PMC Article
Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Cicconi L, Fenaux P, Kantarjian H, Tallman M, Sanz MA, Lo-Coco F
Leukemia 2018 Aug;32(8):1671-1678. Epub 2018 Jul 19 doi: 10.1038/s41375-018-0219-5. PMID: 30026570

Prognosis

Yilmaz M, Kantarjian H, Ravandi F
Blood Cancer J 2021 Jun 30;11(6):123. doi: 10.1038/s41408-021-00514-3. PMID: 34193815Free PMC Article
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Cicconi L, Fenaux P, Kantarjian H, Tallman M, Sanz MA, Lo-Coco F
Leukemia 2018 Aug;32(8):1671-1678. Epub 2018 Jul 19 doi: 10.1038/s41375-018-0219-5. PMID: 30026570
Suguna E, Farhana R, Kanimozhi E, Kumar PS, Kumaramanickavel G, Kumar CS
Cardiovasc Hematol Disord Drug Targets 2018;18(3):199-207. doi: 10.2174/1871529X18666180515130136. PMID: 29766829
Saleem M, Yusoff NM
Hematology 2016 Oct;21(9):501-12. Epub 2016 Feb 24 doi: 10.1080/10245332.2015.1106816. PMID: 26871368

Clinical prediction guides

Gagnon MF, Berg HE, Meyer RG, Sukov WR, Van Dyke DL, Jenkins RB, Greipp PT, Thorland EC, Hoppman NL, Xu X, Baughn LB, Reichard KK, Ketterling RP, Peterson JF
Genes Chromosomes Cancer 2022 Oct;61(10):629-634. Epub 2022 Jun 10 doi: 10.1002/gcc.23070. PMID: 35639830
Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Cancer Med 2021 Jun;10(12):3839-3847. Epub 2021 May 27 doi: 10.1002/cam4.3904. PMID: 34042280Free PMC Article
Kosik P, Skorvaga M, Belyaev I
Neoplasma 2016;63(5):659-72. doi: 10.4149/neo_2016_502. PMID: 27468869
Chaudhuri JP, Karamanov S, Paulraj P, McGill JR, Walther J
Anticancer Res 2008 Nov-Dec;28(6A):3573-8. PMID: 19189637
Reiter A, Lengfelder E, Grimwade D
Acta Haematol 2004;112(1-2):55-67. doi: 10.1159/000077560. PMID: 15179005

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