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Advanced Kaposi Sarcoma

MedGen UID:
1650954
•Concept ID:
C4744850
•
Neoplastic Process

Definition

Kaposi sarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Kaposi Sarcoma

Professional guidelines

PubMed

Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi sarcoma in Kenya: a cost-effectiveness analysis.
Freeman EE, McCann NC, Semeere A, Reddy KP, Laker-Oketta M, Byakwaga H, Pei PP, Hajny Fernandez ME, Kiprono S, Busakhala N, Martin JN, Maurer T, Bassett IV, Freedberg KA, Hyle EP
Lancet Glob Health 2022 Aug;10(8):e1179-e1188. doi: 10.1016/S2214-109X(22)00242-X. PMID: 35839816Free PMC Article
Isolated limb perfusion is an effective treatment modality for locally advanced Kaposi sarcoma of the extremities.
Boere T, Huis In 't Veld EA, Deroose JP, van Ginhoven TM, Wouters MWJM, Grünhagen DJ, Verhoef C, van Houdt WJ
Eur J Surg Oncol 2020 Jul;46(7):1315-1319. Epub 2020 Apr 14 doi: 10.1016/j.ejso.2020.04.012. PMID: 32359920

Recent clinical studies

Etiology

Isolated limb perfusion is an effective treatment modality for locally advanced Kaposi sarcoma of the extremities.
Boere T, Huis In 't Veld EA, Deroose JP, van Ginhoven TM, Wouters MWJM, Grünhagen DJ, Verhoef C, van Houdt WJ
Eur J Surg Oncol 2020 Jul;46(7):1315-1319. Epub 2020 Apr 14 doi: 10.1016/j.ejso.2020.04.012. PMID: 32359920
A Pilot Study of Liposomal Doxorubicin Combined with Bevacizumab followed by Bevacizumab Monotherapy in Patients with Advanced Kaposi Sarcoma.
Ramaswami R, Uldrick TS, Polizzotto MN, Wyvill KM, Goncalves P, Widell A, Lurain K, Steinberg SM, Figg WD, Tosato G, Whitby D, Yarchoan R
Clin Cancer Res 2019 Jul 15;25(14):4238-4247. Epub 2019 Apr 12 doi: 10.1158/1078-0432.CCR-18-3528. PMID: 30979736Free PMC Article
Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: higher incidence and mortality in Africa than in the UK.
Letang E, Lewis JJ, Bower M, Mosam A, Borok M, Campbell TB, Naniche D, Newsom-Davis T, Shaik F, Fiorillo S, Miro JM, Schellenberg D, Easterbrook PJ
AIDS 2013 Jun 19;27(10):1603-13. doi: 10.1097/QAD.0b013e328360a5a1. PMID: 23462220
Wolf in sheep's clothing: advanced Kaposi sarcoma mimicking vulvar abscess.
Laartz BW, Cooper C, Degryse A, Sinnott JT
South Med J 2005 Apr;98(4):475-7. doi: 10.1097/01.SMJ.0000157557.92795.18. PMID: 15898528
Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma.
Joerger M, Huitema AD, Meenhorst PL, Schellens JH, Beijnen JH
Cancer Chemother Pharmacol 2005 May;55(5):488-96. Epub 2005 Feb 23 doi: 10.1007/s00280-004-0900-4. PMID: 15726371

Diagnosis

Changing therapeutic landscape in advanced Kaposi sarcoma: Current state and future directions.
Goff CB, Dasanu CA
J Oncol Pharm Pract 2023 Jun;29(4):917-926. Epub 2023 Jan 30 doi: 10.1177/10781552221148417. PMID: 36718515
Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi sarcoma in Kenya: a cost-effectiveness analysis.
Freeman EE, McCann NC, Semeere A, Reddy KP, Laker-Oketta M, Byakwaga H, Pei PP, Hajny Fernandez ME, Kiprono S, Busakhala N, Martin JN, Maurer T, Bassett IV, Freedberg KA, Hyle EP
Lancet Glob Health 2022 Aug;10(8):e1179-e1188. doi: 10.1016/S2214-109X(22)00242-X. PMID: 35839816Free PMC Article
Plasma biomarkers of clinical response during chemotherapy plus combination antiretroviral therapy (cART) in HIV+ patients with advanced Kaposi sarcoma.
Tedeschi R, Bidoli E, Bortolin MT, Schioppa O, Vaccher E, De Paoli P
Oncotarget 2015 Oct 6;6(30):30334-42. doi: 10.18632/oncotarget.4571. PMID: 26296972Free PMC Article
Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: higher incidence and mortality in Africa than in the UK.
Letang E, Lewis JJ, Bower M, Mosam A, Borok M, Campbell TB, Naniche D, Newsom-Davis T, Shaik F, Fiorillo S, Miro JM, Schellenberg D, Easterbrook PJ
AIDS 2013 Jun 19;27(10):1603-13. doi: 10.1097/QAD.0b013e328360a5a1. PMID: 23462220
Wolf in sheep's clothing: advanced Kaposi sarcoma mimicking vulvar abscess.
Laartz BW, Cooper C, Degryse A, Sinnott JT
South Med J 2005 Apr;98(4):475-7. doi: 10.1097/01.SMJ.0000157557.92795.18. PMID: 15898528

Therapy

Changing therapeutic landscape in advanced Kaposi sarcoma: Current state and future directions.
Goff CB, Dasanu CA
J Oncol Pharm Pract 2023 Jun;29(4):917-926. Epub 2023 Jan 30 doi: 10.1177/10781552221148417. PMID: 36718515
Evaluation of four chemotherapy regimens for treatment of advanced AIDS-associated Kaposi sarcoma in Kenya: a cost-effectiveness analysis.
Freeman EE, McCann NC, Semeere A, Reddy KP, Laker-Oketta M, Byakwaga H, Pei PP, Hajny Fernandez ME, Kiprono S, Busakhala N, Martin JN, Maurer T, Bassett IV, Freedberg KA, Hyle EP
Lancet Glob Health 2022 Aug;10(8):e1179-e1188. doi: 10.1016/S2214-109X(22)00242-X. PMID: 35839816Free PMC Article
A Pilot Study of Liposomal Doxorubicin Combined with Bevacizumab followed by Bevacizumab Monotherapy in Patients with Advanced Kaposi Sarcoma.
Ramaswami R, Uldrick TS, Polizzotto MN, Wyvill KM, Goncalves P, Widell A, Lurain K, Steinberg SM, Figg WD, Tosato G, Whitby D, Yarchoan R
Clin Cancer Res 2019 Jul 15;25(14):4238-4247. Epub 2019 Apr 12 doi: 10.1158/1078-0432.CCR-18-3528. PMID: 30979736Free PMC Article
Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda.
Coghill AE, Schenk JM, Mahkoul Z, Orem J, Phipps W, Casper C
AIDS 2018 Feb 20;32(4):505-512. doi: 10.1097/QAD.0000000000001722. PMID: 29381560Free PMC Article
Plasma biomarkers of clinical response during chemotherapy plus combination antiretroviral therapy (cART) in HIV+ patients with advanced Kaposi sarcoma.
Tedeschi R, Bidoli E, Bortolin MT, Schioppa O, Vaccher E, De Paoli P
Oncotarget 2015 Oct 6;6(30):30334-42. doi: 10.18632/oncotarget.4571. PMID: 26296972Free PMC Article

Prognosis

Isolated limb perfusion is an effective treatment modality for locally advanced Kaposi sarcoma of the extremities.
Boere T, Huis In 't Veld EA, Deroose JP, van Ginhoven TM, Wouters MWJM, Grünhagen DJ, Verhoef C, van Houdt WJ
Eur J Surg Oncol 2020 Jul;46(7):1315-1319. Epub 2020 Apr 14 doi: 10.1016/j.ejso.2020.04.012. PMID: 32359920
Plasma biomarkers of clinical response during chemotherapy plus combination antiretroviral therapy (cART) in HIV+ patients with advanced Kaposi sarcoma.
Tedeschi R, Bidoli E, Bortolin MT, Schioppa O, Vaccher E, De Paoli P
Oncotarget 2015 Oct 6;6(30):30334-42. doi: 10.18632/oncotarget.4571. PMID: 26296972Free PMC Article
Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: higher incidence and mortality in Africa than in the UK.
Letang E, Lewis JJ, Bower M, Mosam A, Borok M, Campbell TB, Naniche D, Newsom-Davis T, Shaik F, Fiorillo S, Miro JM, Schellenberg D, Easterbrook PJ
AIDS 2013 Jun 19;27(10):1603-13. doi: 10.1097/QAD.0b013e328360a5a1. PMID: 23462220
Chemotherapy for advanced Kaposi sarcoma.
Lanzotti VJ, Campos LT, Sinkovics JG, Samuels ML
Arch Dermatol 1975 Oct;111(10):1331-3. PMID: 53034

Clinical prediction guides

Isolated limb perfusion is an effective treatment modality for locally advanced Kaposi sarcoma of the extremities.
Boere T, Huis In 't Veld EA, Deroose JP, van Ginhoven TM, Wouters MWJM, Grünhagen DJ, Verhoef C, van Houdt WJ
Eur J Surg Oncol 2020 Jul;46(7):1315-1319. Epub 2020 Apr 14 doi: 10.1016/j.ejso.2020.04.012. PMID: 32359920
Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda.
Coghill AE, Schenk JM, Mahkoul Z, Orem J, Phipps W, Casper C
AIDS 2018 Feb 20;32(4):505-512. doi: 10.1097/QAD.0000000000001722. PMID: 29381560Free PMC Article
Plasma biomarkers of clinical response during chemotherapy plus combination antiretroviral therapy (cART) in HIV+ patients with advanced Kaposi sarcoma.
Tedeschi R, Bidoli E, Bortolin MT, Schioppa O, Vaccher E, De Paoli P
Oncotarget 2015 Oct 6;6(30):30334-42. doi: 10.18632/oncotarget.4571. PMID: 26296972Free PMC Article
Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma: higher incidence and mortality in Africa than in the UK.
Letang E, Lewis JJ, Bower M, Mosam A, Borok M, Campbell TB, Naniche D, Newsom-Davis T, Shaik F, Fiorillo S, Miro JM, Schellenberg D, Easterbrook PJ
AIDS 2013 Jun 19;27(10):1603-13. doi: 10.1097/QAD.0b013e328360a5a1. PMID: 23462220
Liposomal doxorubicin in the treatment of advanced AIDS-related Kaposi sarcoma.
Bogner JR, Kronawitter U, Rolinski B, Truebenbach K, Goebel FD
J Acquir Immune Defic Syndr (1988) 1994 May;7(5):463-8. PMID: 8158540

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