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BN2 diffuse large B-cell lymphoma

MedGen UID:
1650982
Concept ID:
C4725003
Neoplastic Process
Synonym: BN2 Diffuse Large B-Cell Lymphoma
 
Monarch Initiative: MONDO:0850468

Definition

A diffuse large B-cell lymphoma molecular subtype characterized by the presence of BCL6 gene fusions and NOTCH2 gene mutations. Patients who belong in this subtype have a favorable outcome. (NEJM 2018; 378: 1396-407) [from NCI]

Term Hierarchy

Recent clinical studies

Etiology

Sciarra R, Merli M, Cristinelli C, Lucioni M, Zibellini S, Riboni R, Furlan D, Uccella S, Zerbi C, Bianchi B, Gotti M, Ferretti VV, Varraso C, Fraticelli S, Lazic T, Defrancesco I, Mora B, Libera L, Mazzacane A, Carpi F, Berliner M, Neri G, Rizzo E, De Paoli F, Sessa F, Passamonti F, Paulli M, Arcaini L
Br J Haematol 2024 Jun;204(6):2242-2253. Epub 2024 Mar 5 doi: 10.1111/bjh.19378. PMID: 38442902
Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Ivanova VS, Vela V, Dirnhofer S, Dobbie M, Stenner F, Knoblich J, Tzankov A, Menter T
Pathobiology 2024;91(4):245-253. Epub 2023 Dec 21 doi: 10.1159/000535938. PMID: 38128501Free PMC Article
Pedrosa L, Fernández-Miranda I, Pérez-Callejo D, Quero C, Rodríguez M, Martín-Acosta P, Gómez S, González-Rincón J, Santos A, Tarin C, García JF, García-Arroyo FR, Rueda A, Camacho FI, García-Cosío M, Heredero A, Llanos M, Mollejo M, Piris-Villaespesa M, Gómez-Codina J, Yanguas-Casás N, Sánchez A, Piris MA, Provencio M, Sánchez-Beato M
Sci Rep 2021 Jan 21;11(1):1886. doi: 10.1038/s41598-020-80376-0. PMID: 33479306Free PMC Article
Meriranta L, Pasanen A, Alkodsi A, Haukka J, Karjalainen-Lindsberg ML, Leppä S
Blood Adv 2020 Aug 11;4(15):3742-3753. doi: 10.1182/bloodadvances.2020001727. PMID: 32780847Free PMC Article

Diagnosis

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Pedrosa L, Fernández-Miranda I, Pérez-Callejo D, Quero C, Rodríguez M, Martín-Acosta P, Gómez S, González-Rincón J, Santos A, Tarin C, García JF, García-Arroyo FR, Rueda A, Camacho FI, García-Cosío M, Heredero A, Llanos M, Mollejo M, Piris-Villaespesa M, Gómez-Codina J, Yanguas-Casás N, Sánchez A, Piris MA, Provencio M, Sánchez-Beato M
Sci Rep 2021 Jan 21;11(1):1886. doi: 10.1038/s41598-020-80376-0. PMID: 33479306Free PMC Article
Zhou H, Yang L, Dang Q, Huang J, Cheng Y, Zhang Y, Shi W
Cancer Biol Ther 2020 Apr 2;21(4):303-308. Epub 2020 Jan 13 doi: 10.1080/15384047.2019.1700743. PMID: 31931656Free PMC Article

Therapy

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Xu-Monette ZY, Wei L, Fang X, Au Q, Nunns H, Nagy M, Tzankov A, Zhu F, Visco C, Bhagat G, Dybkaer K, Chiu A, Tam W, Zu Y, Hsi ED, Hagemeister FB, Sun X, Han X, Go H, Ponzoni M, Ferreri AJM, Møller MB, Parsons BM, van Krieken JH, Piris MA, Winter JN, Li Y, Xu B, Albitar M, You H, Young KH
Clin Cancer Res 2022 Mar 1;28(5):972-983. doi: 10.1158/1078-0432.CCR-21-2949. PMID: 34980601Free PMC Article
Wilson WH, Wright GW, Huang DW, Hodkinson B, Balasubramanian S, Fan Y, Vermeulen J, Shreeve M, Staudt LM
Cancer Cell 2021 Dec 13;39(12):1643-1653.e3. Epub 2021 Nov 4 doi: 10.1016/j.ccell.2021.10.006. PMID: 34739844Free PMC Article
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article

Prognosis

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Ivanova VS, Vela V, Dirnhofer S, Dobbie M, Stenner F, Knoblich J, Tzankov A, Menter T
Pathobiology 2024;91(4):245-253. Epub 2023 Dec 21 doi: 10.1159/000535938. PMID: 38128501Free PMC Article
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article

Clinical prediction guides

Cao B, Sun C, Bi R, Liu Z, Jia Y, Cui W, Sun M, Yu B, Li X, Zhou X
BMC Med Genomics 2024 Apr 13;17(1):84. doi: 10.1186/s12920-024-01866-y. PMID: 38609996Free PMC Article
Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Meriranta L, Pasanen A, Alkodsi A, Haukka J, Karjalainen-Lindsberg ML, Leppä S
Blood Adv 2020 Aug 11;4(15):3742-3753. doi: 10.1182/bloodadvances.2020001727. PMID: 32780847Free PMC Article

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