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Refractory Ovarian Carcinoma

MedGen UID:
1651209
•Concept ID:
C4725612
•
Neoplastic Process

Definition

Ovarian carcinoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Phase II trial of intraperitoneal mitoxantrone in the management of refractory ovarian cancer.
Markman M, George M, Hakes T, Reichman B, Hoskins W, Rubin S, Jones W, Almadrones L, Lewis JL Jr
J Clin Oncol 1990 Jan;8(1):146-50. doi: 10.1200/JCO.1990.8.1.146. PMID: 2295905
Intraperitoneal therapy in the management of ovarian carcinoma.
Markman M, Hakes T, Reichman B, Hoskins W, Rubin S, Jones W, Almadones L, Lewis JL Jr
Yale J Biol Med 1989 Jul-Aug;62(4):393-403. PMID: 2688324Free PMC Article
Intraperitoneal cisplatin chemotherapy in the management of ovarian carcinoma.
Markman M
Semin Oncol 1989 Aug;16(4 Suppl 6):79-82. PMID: 2669140

Recent clinical studies

Etiology

Efficacy and safety of low-dose apatinib in ovarian cancer patients with platinum-resistance or platinum-refractoriness: A single-center retrospective study.
Chen W, Li Z, Zheng Z, Wu X
Cancer Med 2020 Aug;9(16):5899-5907. Epub 2020 Jul 6 doi: 10.1002/cam4.3282. PMID: 32627959Free PMC Article
Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study.
Fracasso PM, Brady MF, Moore DH, Walker JL, Rose PG, Letvak L, Grogan TM, McGuire WP
J Clin Oncol 2001 Jun 15;19(12):2975-82. doi: 10.1200/JCO.2001.19.12.2975. PMID: 11408492
Treatment of refractory ovarian carcinoma with paclitaxel and cisplatin after treatment failure with single-agent paclitaxel.
Johnston CM, Pearl ML, Reynolds RK, Roberts JA, Morley GW
Eur J Gynaecol Oncol 1995;16(6):439-47. PMID: 8536758
A phase II trial of high-dose mitoxantrone, carboplatin, and cyclophosphamide with autologous bone marrow rescue for recurrent epithelial ovarian carcinoma: analysis of risk factors for clinical outcome.
Stiff P, Bayer R, Camarda M, Tan S, Dolan J, Potkul R, Loutfi S, Kinch L, Sosman J, Peace D
Gynecol Oncol 1995 Jun;57(3):278-85. doi: 10.1006/gyno.1995.1143. PMID: 7774830
Dose intensity analysis of high-dose carboplatin in refractory ovarian carcinoma relative to age.
Cornelison TL, Reed E
Cancer 1993 Jan 15;71(2 Suppl):650-5. doi: 10.1002/cncr.2820710225. PMID: 8420690

Diagnosis

Inflammatory skin metastases from ovarian carcinoma--a case report and review of the literature.
Schonmann R, Altaras M, Biron T, Bernheim J, Fishman A
Gynecol Oncol 2003 Sep;90(3):670-2. doi: 10.1016/s0090-8258(03)00366-4. PMID: 13678744
Modulation of cisplatin sensitivity by taxol in cisplatin-sensitive and -resistant human ovarian carcinoma cell lines.
Yamamoto K, Kikuchi Y, Kudoh K, Nagata I
J Cancer Res Clin Oncol 2000 Mar;126(3):168-72. doi: 10.1007/s004320050027. PMID: 10741911
In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems.
Romanelli S, Perego P, Pratesi G, Carenini N, Tortoreto M, Zunino F
Cancer Chemother Pharmacol 1998;41(5):385-90. doi: 10.1007/s002800050755. PMID: 9523734
A phase II trial of high-dose mitoxantrone, carboplatin, and cyclophosphamide with autologous bone marrow rescue for recurrent epithelial ovarian carcinoma: analysis of risk factors for clinical outcome.
Stiff P, Bayer R, Camarda M, Tan S, Dolan J, Potkul R, Loutfi S, Kinch L, Sosman J, Peace D
Gynecol Oncol 1995 Jun;57(3):278-85. doi: 10.1006/gyno.1995.1143. PMID: 7774830
Paclitaxel (Taxol): a novel anticancer chemotherapeutic drug.
Long HJ
Mayo Clin Proc 1994 Apr;69(4):341-5. doi: 10.1016/s0025-6196(12)62219-8. PMID: 7909575

Therapy

Efficacy and safety of low-dose apatinib in ovarian cancer patients with platinum-resistance or platinum-refractoriness: A single-center retrospective study.
Chen W, Li Z, Zheng Z, Wu X
Cancer Med 2020 Aug;9(16):5899-5907. Epub 2020 Jul 6 doi: 10.1002/cam4.3282. PMID: 32627959Free PMC Article
Paclitaxel efficacy and tolerability in second-line treatment of refractory and relapsed ovarian cancer patients.
Oliverio G, Canuti D, Tononi A, Scarpellini M, Panzini I, Galli I, Ravaioli A
J Chemother 1999 Aug;11(4):301-5. doi: 10.1179/joc.1999.11.4.301. PMID: 10465133
In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems.
Romanelli S, Perego P, Pratesi G, Carenini N, Tortoreto M, Zunino F
Cancer Chemother Pharmacol 1998;41(5):385-90. doi: 10.1007/s002800050755. PMID: 9523734
Paclitaxel (Taxol): a novel anticancer chemotherapeutic drug.
Long HJ
Mayo Clin Proc 1994 Apr;69(4):341-5. doi: 10.1016/s0025-6196(12)62219-8. PMID: 7909575
Intraperitoneal therapy in the management of ovarian carcinoma.
Markman M, Hakes T, Reichman B, Hoskins W, Rubin S, Jones W, Almadones L, Lewis JL Jr
Yale J Biol Med 1989 Jul-Aug;62(4):393-403. PMID: 2688324Free PMC Article

Prognosis

Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study.
Fracasso PM, Brady MF, Moore DH, Walker JL, Rose PG, Letvak L, Grogan TM, McGuire WP
J Clin Oncol 2001 Jun 15;19(12):2975-82. doi: 10.1200/JCO.2001.19.12.2975. PMID: 11408492
Treatment of refractory ovarian carcinoma with paclitaxel and cisplatin after treatment failure with single-agent paclitaxel.
Johnston CM, Pearl ML, Reynolds RK, Roberts JA, Morley GW
Eur J Gynaecol Oncol 1995;16(6):439-47. PMID: 8536758
A phase II trial of high-dose mitoxantrone, carboplatin, and cyclophosphamide with autologous bone marrow rescue for recurrent epithelial ovarian carcinoma: analysis of risk factors for clinical outcome.
Stiff P, Bayer R, Camarda M, Tan S, Dolan J, Potkul R, Loutfi S, Kinch L, Sosman J, Peace D
Gynecol Oncol 1995 Jun;57(3):278-85. doi: 10.1006/gyno.1995.1143. PMID: 7774830
Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.
Rowinsky EK, Grochow LB, Hendricks CB, Ettinger DS, Forastiere AA, Hurowitz LA, McGuire WP, Sartorius SE, Lubejko BG, Kaufmann SH
J Clin Oncol 1992 Apr;10(4):647-56. doi: 10.1200/JCO.1992.10.4.647. PMID: 1312588
Combination intraperitoneal chemotherapy with cisplatin, cytarabine, and doxorubicin for refractory ovarian carcinoma and other malignancies principally confined to the peritoneal cavity.
Markman M, Howell SB, Lucas WE, Pfeifle CE, Green MR
J Clin Oncol 1984 Dec;2(12):1321-6. doi: 10.1200/JCO.1984.2.12.1321. PMID: 6542584

Clinical prediction guides

Gemcitabine and anthracyclines in platinum-resistant ovarian cancer.
Galligioni E, Arcuri C, Sorio R, Griso C
Ann Oncol 2006 May;17 Suppl 5:v195-8. doi: 10.1093/annonc/mdj980. PMID: 16807455
Paclitaxel efficacy and tolerability in second-line treatment of refractory and relapsed ovarian cancer patients.
Oliverio G, Canuti D, Tononi A, Scarpellini M, Panzini I, Galli I, Ravaioli A
J Chemother 1999 Aug;11(4):301-5. doi: 10.1179/joc.1999.11.4.301. PMID: 10465133
In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems.
Romanelli S, Perego P, Pratesi G, Carenini N, Tortoreto M, Zunino F
Cancer Chemother Pharmacol 1998;41(5):385-90. doi: 10.1007/s002800050755. PMID: 9523734
Increased thymidine kinase and thymidylate synthase activities in human epithelial ovarian carcinoma.
Look KY, Moore DH, Sutton GP, Prajda N, Abonyi M, Weber G
Anticancer Res 1997 Jul-Aug;17(4A):2353-6. PMID: 9252646
Intraperitoneal therapy in the management of ovarian carcinoma.
Markman M, Hakes T, Reichman B, Hoskins W, Rubin S, Jones W, Almadones L, Lewis JL Jr
Yale J Biol Med 1989 Jul-Aug;62(4):393-403. PMID: 2688324Free PMC Article

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