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Recurrent Mediastinal Lymphoma

MedGen UID:
1651350
•Concept ID:
C4727073
•
Neoplastic Process
Synonym: Recurrent Primary Mediastinal Lymphoma

Definition

The reemergence of a mediastinal lymphoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Mediastinal Lymphoma

Professional guidelines

PubMed

Noninvasive Prenatal Test Results Indicative of Maternal Malignancies: A Nationwide Genetic and Clinical Follow-Up Study.
Heesterbeek CJ, Aukema SM, Galjaard RH, Boon EMJ, Srebniak MI, Bouman K, Faas BHW, Govaerts LCP, Hoffer MJV, den Hollander NS, Lichtenbelt KD, van Maarle MC, van Prooyen Schuurman L, van Rij MC, Schuring-Blom GH, Stevens SJC, Tan-Sindhunata G, Zamani Esteki M, de Die-Smulders CEM, Tjan-Heijnen VCG, Henneman L, Sistermans EA, Macville MVE; Dutch NIPT Consortium
J Clin Oncol 2022 Aug 1;40(22):2426-2435. Epub 2022 Apr 8 doi: 10.1200/JCO.21.02260. PMID: 35394817
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Recent clinical studies

Etiology

Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma.
Castellino SM, Pei Q, Parsons SK, Hodgson D, McCarten K, Horton T, Cho S, Wu Y, Punnett A, Dave H, Henderson TO, Hoppe BS, Charpentier AM, Keller FG, Kelly KM
N Engl J Med 2022 Nov 3;387(18):1649-1660. doi: 10.1056/NEJMoa2206660. PMID: 36322844Free PMC Article
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma.
Armand P, Rodig S, Melnichenko V, Thieblemont C, Bouabdallah K, Tumyan G, Özcan M, Portino S, Fogliatto L, Caballero MD, Walewski J, Gulbas Z, Ribrag V, Christian B, Perini GF, Salles G, Svoboda J, Zain J, Patel S, Chen PH, Ligon AH, Ouyang J, Neuberg D, Redd R, Chatterjee A, Balakumaran A, Orlowski R, Shipp M, Zinzani PL
J Clin Oncol 2019 Dec 1;37(34):3291-3299. Epub 2019 Oct 14 doi: 10.1200/JCO.19.01389. PMID: 31609651Free PMC Article
Nivolumab Combined With Brentuximab Vedotin for Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Efficacy and Safety From the Phase II CheckMate 436 Study.
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ
J Clin Oncol 2019 Nov 20;37(33):3081-3089. Epub 2019 Aug 9 doi: 10.1200/JCO.19.01492. PMID: 31398081Free PMC Article

Diagnosis

Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma.
Castellino SM, Pei Q, Parsons SK, Hodgson D, McCarten K, Horton T, Cho S, Wu Y, Punnett A, Dave H, Henderson TO, Hoppe BS, Charpentier AM, Keller FG, Kelly KM
N Engl J Med 2022 Nov 3;387(18):1649-1660. doi: 10.1056/NEJMoa2206660. PMID: 36322844Free PMC Article
Noninvasive Prenatal Test Results Indicative of Maternal Malignancies: A Nationwide Genetic and Clinical Follow-Up Study.
Heesterbeek CJ, Aukema SM, Galjaard RH, Boon EMJ, Srebniak MI, Bouman K, Faas BHW, Govaerts LCP, Hoffer MJV, den Hollander NS, Lichtenbelt KD, van Maarle MC, van Prooyen Schuurman L, van Rij MC, Schuring-Blom GH, Stevens SJC, Tan-Sindhunata G, Zamani Esteki M, de Die-Smulders CEM, Tjan-Heijnen VCG, Henneman L, Sistermans EA, Macville MVE; Dutch NIPT Consortium
J Clin Oncol 2022 Aug 1;40(22):2426-2435. Epub 2022 Apr 8 doi: 10.1200/JCO.21.02260. PMID: 35394817
T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292Free PMC Article
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797

Therapy

Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma.
Castellino SM, Pei Q, Parsons SK, Hodgson D, McCarten K, Horton T, Cho S, Wu Y, Punnett A, Dave H, Henderson TO, Hoppe BS, Charpentier AM, Keller FG, Kelly KM
N Engl J Med 2022 Nov 3;387(18):1649-1660. doi: 10.1056/NEJMoa2206660. PMID: 36322844Free PMC Article
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study.
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma.
Armand P, Rodig S, Melnichenko V, Thieblemont C, Bouabdallah K, Tumyan G, Özcan M, Portino S, Fogliatto L, Caballero MD, Walewski J, Gulbas Z, Ribrag V, Christian B, Perini GF, Salles G, Svoboda J, Zain J, Patel S, Chen PH, Ligon AH, Ouyang J, Neuberg D, Redd R, Chatterjee A, Balakumaran A, Orlowski R, Shipp M, Zinzani PL
J Clin Oncol 2019 Dec 1;37(34):3291-3299. Epub 2019 Oct 14 doi: 10.1200/JCO.19.01389. PMID: 31609651Free PMC Article
Nivolumab Combined With Brentuximab Vedotin for Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Efficacy and Safety From the Phase II CheckMate 436 Study.
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ
J Clin Oncol 2019 Nov 20;37(33):3081-3089. Epub 2019 Aug 9 doi: 10.1200/JCO.19.01492. PMID: 31398081Free PMC Article

Prognosis

Noninvasive Prenatal Test Results Indicative of Maternal Malignancies: A Nationwide Genetic and Clinical Follow-Up Study.
Heesterbeek CJ, Aukema SM, Galjaard RH, Boon EMJ, Srebniak MI, Bouman K, Faas BHW, Govaerts LCP, Hoffer MJV, den Hollander NS, Lichtenbelt KD, van Maarle MC, van Prooyen Schuurman L, van Rij MC, Schuring-Blom GH, Stevens SJC, Tan-Sindhunata G, Zamani Esteki M, de Die-Smulders CEM, Tjan-Heijnen VCG, Henneman L, Sistermans EA, Macville MVE; Dutch NIPT Consortium
J Clin Oncol 2022 Aug 1;40(22):2426-2435. Epub 2022 Apr 8 doi: 10.1200/JCO.21.02260. PMID: 35394817
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma.
Armand P, Rodig S, Melnichenko V, Thieblemont C, Bouabdallah K, Tumyan G, Özcan M, Portino S, Fogliatto L, Caballero MD, Walewski J, Gulbas Z, Ribrag V, Christian B, Perini GF, Salles G, Svoboda J, Zain J, Patel S, Chen PH, Ligon AH, Ouyang J, Neuberg D, Redd R, Chatterjee A, Balakumaran A, Orlowski R, Shipp M, Zinzani PL
J Clin Oncol 2019 Dec 1;37(34):3291-3299. Epub 2019 Oct 14 doi: 10.1200/JCO.19.01389. PMID: 31609651Free PMC Article
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Remediastinoscopy.
Van Schil P, De Waele M, Hendriks J, Lauwers P
J Thorac Oncol 2007 Apr;2(4):365-6. doi: 10.1097/01.JTO.0000263724.07439.ff. PMID: 17409813

Clinical prediction guides

Nivolumab combined with brentuximab vedotin for R/R primary mediastinal large B-cell lymphoma: a 3-year follow-up.
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Lisano J, Wen R, Akyol A, Moskowitz AJ
Blood Adv 2023 Sep 26;7(18):5272-5280. doi: 10.1182/bloodadvances.2023010254. PMID: 37352266Free PMC Article
Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma.
Castellino SM, Pei Q, Parsons SK, Hodgson D, McCarten K, Horton T, Cho S, Wu Y, Punnett A, Dave H, Henderson TO, Hoppe BS, Charpentier AM, Keller FG, Kelly KM
N Engl J Med 2022 Nov 3;387(18):1649-1660. doi: 10.1056/NEJMoa2206660. PMID: 36322844Free PMC Article
Clinical Features and Treatment Outcomes of Children with Anaplastic Large Cell Lymphoma.
Mehreen A, Wali R, Riaz S
J Coll Physicians Surg Pak 2020 Jul;30(7):749-753. doi: 10.29271/jcpsp.2020.07.749. PMID: 32811608
Structural genomic alterations in primary mediastinal large B-cell lymphoma.
Twa DD, Steidl C
Leuk Lymphoma 2015;56(8):2239-50. Epub 2015 Jan 21 doi: 10.3109/10428194.2014.985673. PMID: 25393674
Primary pulmonary lymphoma.
Graham BB, Mathisen DJ, Mark EJ, Takvorian RW
Ann Thorac Surg 2005 Oct;80(4):1248-53. doi: 10.1016/j.athoracsur.2005.04.014. PMID: 16181848

Recent systematic reviews

Relapsed/refractory primary mediastinal large B-cell lymphoma: a structured review of epidemiology, treatment guidelines and real-world treatment practices.
Takyar J, Raut M, Borse R, Balakumaran A, Sehgal M
Expert Rev Hematol 2020 Mar;13(3):275-287. Epub 2020 Jan 28 doi: 10.1080/17474086.2020.1716725. PMID: 31951774
Diagnostic Accuracy of Endobronchial Ultrasound Transbronchial Needle Aspiration in Lymphoma. A Systematic Review and Meta-Analysis.
Labarca G, Sierra-Ruiz M, Kheir F, Folch E, Majid A, Mehta HJ, Jantz MA, Fernandez-Bussy S
Ann Am Thorac Soc 2019 Nov;16(11):1432-1439. doi: 10.1513/AnnalsATS.201902-175OC. PMID: 31291126
Brentuximab vedotin for treatment of non-Hodgkin lymphomas: A systematic review.
Berger GK, McBride A, Lawson S, Royball K, Yun S, Gee K, Bin Riaz I, Saleh AA, Puvvada S, Anwer F
Crit Rev Oncol Hematol 2017 Jan;109:42-50. Epub 2016 Nov 21 doi: 10.1016/j.critrevonc.2016.11.009. PMID: 28010897Free PMC Article
A systematic overview of chemotherapy effects in Hodgkin's disease.
Brandt L, Kimby E, Nygren P, Glimelius B; SBU-group. Swedish Council of Technology Assessment in Health Care
Acta Oncol 2001;40(2-3):185-97. doi: 10.1080/02841860151116240. PMID: 11441931

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