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Castration-Sensitive

MedGen UID:
1651549
Concept ID:
C4727178
Finding

Definition

A finding indicating that a metastatic prostate carcinoma is sensitive to androgen-deprivation therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCastration-Sensitive

Professional guidelines

PubMed

Schaeffer EM, Srinivas S, Adra N, An Y, Barocas D, Bitting R, Bryce A, Chapin B, Cheng HH, D'Amico AV, Desai N, Dorff T, Eastham JA, Farrington TA, Gao X, Gupta S, Guzzo T, Ippolito JE, Kuettel MR, Lang JM, Lotan T, McKay RR, Morgan T, Netto G, Pow-Sang JM, Reiter R, Roach M, Robin T, Rosenfeld S, Shabsigh A, Spratt D, Teply BA, Tward J, Valicenti R, Wong JK, Shead DA, Snedeker J, Freedman-Cass DA
J Natl Compr Canc Netw 2023 Oct;21(10):1067-1096. doi: 10.6004/jnccn.2023.0050. PMID: 37856213
Riaz IB, Naqvi SAA, He H, Asghar N, Siddiqi R, Liu H, Singh P, Childs DS, Ravi P, Hussain SA, Murad MH, Boorjian SA, Sweeney C, Van Allen EM, Bryce AH
JAMA Oncol 2023 May 1;9(5):635-645. doi: 10.1001/jamaoncol.2022.7762. PMID: 36862387Free PMC Article
Cao B, Kim M, Reizine NM, Moreira DM
Eur Urol Oncol 2023 Jun;6(3):237-250. Epub 2023 Jan 20 doi: 10.1016/j.euo.2023.01.001. PMID: 36682938

Recent clinical studies

Etiology

Schaeffer EM, Srinivas S, Adra N, An Y, Barocas D, Bitting R, Bryce A, Chapin B, Cheng HH, D'Amico AV, Desai N, Dorff T, Eastham JA, Farrington TA, Gao X, Gupta S, Guzzo T, Ippolito JE, Kuettel MR, Lang JM, Lotan T, McKay RR, Morgan T, Netto G, Pow-Sang JM, Reiter R, Roach M, Robin T, Rosenfeld S, Shabsigh A, Spratt D, Teply BA, Tward J, Valicenti R, Wong JK, Shead DA, Snedeker J, Freedman-Cass DA
J Natl Compr Canc Netw 2023 Oct;21(10):1067-1096. doi: 10.6004/jnccn.2023.0050. PMID: 37856213
Agarwal N, Azad AA, Carles J, Fay AP, Matsubara N, Heinrich D, Szczylik C, De Giorgi U, Young Joung J, Fong PCC, Voog E, Jones RJ, Shore ND, Dunshee C, Zschäbitz S, Oldenburg J, Lin X, Healy CG, Di Santo N, Zohren F, Fizazi K
Lancet 2023 Jul 22;402(10398):291-303. Epub 2023 Jun 4 doi: 10.1016/S0140-6736(23)01055-3. PMID: 37285865
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Chi KN, Agarwal N, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez Soto Á, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Deprince K, Naini V, Li J, Cheng S, Yu MK, Zhang K, Larsen JS, McCarthy S, Chowdhury S; TITAN Investigators
N Engl J Med 2019 Jul 4;381(1):13-24. Epub 2019 May 31 doi: 10.1056/NEJMoa1903307. PMID: 31150574

Diagnosis

Schaeffer EM, Srinivas S, Adra N, An Y, Barocas D, Bitting R, Bryce A, Chapin B, Cheng HH, D'Amico AV, Desai N, Dorff T, Eastham JA, Farrington TA, Gao X, Gupta S, Guzzo T, Ippolito JE, Kuettel MR, Lang JM, Lotan T, McKay RR, Morgan T, Netto G, Pow-Sang JM, Reiter R, Roach M, Robin T, Rosenfeld S, Shabsigh A, Spratt D, Teply BA, Tward J, Valicenti R, Wong JK, Shead DA, Snedeker J, Freedman-Cass DA
J Natl Compr Canc Netw 2023 Oct;21(10):1067-1096. doi: 10.6004/jnccn.2023.0050. PMID: 37856213
Agarwal N, Azad AA, Carles J, Fay AP, Matsubara N, Heinrich D, Szczylik C, De Giorgi U, Young Joung J, Fong PCC, Voog E, Jones RJ, Shore ND, Dunshee C, Zschäbitz S, Oldenburg J, Lin X, Healy CG, Di Santo N, Zohren F, Fizazi K
Lancet 2023 Jul 22;402(10398):291-303. Epub 2023 Jun 4 doi: 10.1016/S0140-6736(23)01055-3. PMID: 37285865
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Chi KN, Agarwal N, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez Soto Á, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Deprince K, Naini V, Li J, Cheng S, Yu MK, Zhang K, Larsen JS, McCarthy S, Chowdhury S; TITAN Investigators
N Engl J Med 2019 Jul 4;381(1):13-24. Epub 2019 May 31 doi: 10.1056/NEJMoa1903307. PMID: 31150574

Therapy

Schaeffer EM, Srinivas S, Adra N, An Y, Barocas D, Bitting R, Bryce A, Chapin B, Cheng HH, D'Amico AV, Desai N, Dorff T, Eastham JA, Farrington TA, Gao X, Gupta S, Guzzo T, Ippolito JE, Kuettel MR, Lang JM, Lotan T, McKay RR, Morgan T, Netto G, Pow-Sang JM, Reiter R, Roach M, Robin T, Rosenfeld S, Shabsigh A, Spratt D, Teply BA, Tward J, Valicenti R, Wong JK, Shead DA, Snedeker J, Freedman-Cass DA
J Natl Compr Canc Netw 2023 Oct;21(10):1067-1096. doi: 10.6004/jnccn.2023.0050. PMID: 37856213
Agarwal N, Azad AA, Carles J, Fay AP, Matsubara N, Heinrich D, Szczylik C, De Giorgi U, Young Joung J, Fong PCC, Voog E, Jones RJ, Shore ND, Dunshee C, Zschäbitz S, Oldenburg J, Lin X, Healy CG, Di Santo N, Zohren F, Fizazi K
Lancet 2023 Jul 22;402(10398):291-303. Epub 2023 Jun 4 doi: 10.1016/S0140-6736(23)01055-3. PMID: 37285865
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Chi KN, Agarwal N, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez Soto Á, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Deprince K, Naini V, Li J, Cheng S, Yu MK, Zhang K, Larsen JS, McCarthy S, Chowdhury S; TITAN Investigators
N Engl J Med 2019 Jul 4;381(1):13-24. Epub 2019 May 31 doi: 10.1056/NEJMoa1903307. PMID: 31150574

Prognosis

Deek MP, Van der Eecken K, Sutera P, Deek RA, Fonteyne V, Mendes AA, Decaestecker K, Kiess AP, Lumen N, Phillips R, De Bruycker A, Mishra M, Rana Z, Molitoris J, Lambert B, Delrue L, Wang H, Lowe K, Verbeke S, Van Dorpe J, Bultijnck R, Villeirs G, De Man K, Ameye F, Song DY, DeWeese T, Paller CJ, Feng FY, Wyatt A, Pienta KJ, Diehn M, Bentzen SM, Joniau S, Vanhaverbeke F, De Meerleer G, Antonarakis ES, Lotan TL, Berlin A, Siva S, Ost P, Tran PT
J Clin Oncol 2022 Oct 10;40(29):3377-3382. Epub 2022 Aug 24 doi: 10.1200/JCO.22.00644. PMID: 36001857Free PMC Article
Freedland SJ, De Giorgi U, Gleave M, Rosbrook B, Shen Q, Sugg J, Haas GP, Shore ND
BMJ Open 2021 Aug 12;11(8):e046588. doi: 10.1136/bmjopen-2020-046588. PMID: 34385241Free PMC Article
Fizazi K, Tran N, Fein L, Matsubara N, Rodriguez-Antolin A, Alekseev BY, Özgüroğlu M, Ye D, Feyerabend S, Protheroe A, Sulur G, Luna Y, Li S, Mundle S, Chi KN
Lancet Oncol 2019 May;20(5):686-700. Epub 2019 Apr 12 doi: 10.1016/S1470-2045(19)30082-8. PMID: 30987939
Barata PC, Sartor AO
Cancer 2019 Jun 1;125(11):1777-1788. Epub 2019 Apr 1 doi: 10.1002/cncr.32039. PMID: 30933324
Clegg NJ, Wongvipat J, Joseph JD, Tran C, Ouk S, Dilhas A, Chen Y, Grillot K, Bischoff ED, Cai L, Aparicio A, Dorow S, Arora V, Shao G, Qian J, Zhao H, Yang G, Cao C, Sensintaffar J, Wasielewska T, Herbert MR, Bonnefous C, Darimont B, Scher HI, Smith-Jones P, Klang M, Smith ND, De Stanchina E, Wu N, Ouerfelli O, Rix PJ, Heyman RA, Jung ME, Sawyers CL, Hager JH
Cancer Res 2012 Mar 15;72(6):1494-503. Epub 2012 Jan 20 doi: 10.1158/0008-5472.CAN-11-3948. PMID: 22266222Free PMC Article

Clinical prediction guides

Riaz IB, Naqvi SAA, He H, Asghar N, Siddiqi R, Liu H, Singh P, Childs DS, Ravi P, Hussain SA, Murad MH, Boorjian SA, Sweeney C, Van Allen EM, Bryce AH
JAMA Oncol 2023 May 1;9(5):635-645. doi: 10.1001/jamaoncol.2022.7762. PMID: 36862387Free PMC Article
Chowdhury S, Bjartell A, Agarwal N, Chung BH, Given RW, Pereira de Santana Gomes AJ, Merseburger AS, Özgüroğlu M, Juárez Soto Á, Uemura H, Ye D, Brookman-May SD, Londhe A, Bhaumik A, Mundle SD, Larsen JS, McCarthy SA, Chi KN
Ann Oncol 2023 May;34(5):477-485. Epub 2023 Feb 27 doi: 10.1016/j.annonc.2023.02.009. PMID: 36858151
Deek MP, Van der Eecken K, Sutera P, Deek RA, Fonteyne V, Mendes AA, Decaestecker K, Kiess AP, Lumen N, Phillips R, De Bruycker A, Mishra M, Rana Z, Molitoris J, Lambert B, Delrue L, Wang H, Lowe K, Verbeke S, Van Dorpe J, Bultijnck R, Villeirs G, De Man K, Ameye F, Song DY, DeWeese T, Paller CJ, Feng FY, Wyatt A, Pienta KJ, Diehn M, Bentzen SM, Joniau S, Vanhaverbeke F, De Meerleer G, Antonarakis ES, Lotan TL, Berlin A, Siva S, Ost P, Tran PT
J Clin Oncol 2022 Oct 10;40(29):3377-3382. Epub 2022 Aug 24 doi: 10.1200/JCO.22.00644. PMID: 36001857Free PMC Article
Chi KN, Chowdhury S, Bjartell A, Chung BH, Pereira de Santana Gomes AJ, Given R, Juárez A, Merseburger AS, Özgüroğlu M, Uemura H, Ye D, Brookman-May S, Mundle SD, McCarthy SA, Larsen JS, Sun W, Bevans KB, Zhang K, Bandyopadhyay N, Agarwal N
J Clin Oncol 2021 Jul 10;39(20):2294-2303. Epub 2021 Apr 29 doi: 10.1200/JCO.20.03488. PMID: 33914595
Fizazi K, Tran N, Fein L, Matsubara N, Rodriguez-Antolin A, Alekseev BY, Özgüroğlu M, Ye D, Feyerabend S, Protheroe A, De Porre P, Kheoh T, Park YC, Todd MB, Chi KN; LATITUDE Investigators
N Engl J Med 2017 Jul 27;377(4):352-360. Epub 2017 Jun 4 doi: 10.1056/NEJMoa1704174. PMID: 28578607

Recent systematic reviews

Riaz IB, Naqvi SAA, He H, Asghar N, Siddiqi R, Liu H, Singh P, Childs DS, Ravi P, Hussain SA, Murad MH, Boorjian SA, Sweeney C, Van Allen EM, Bryce AH
JAMA Oncol 2023 May 1;9(5):635-645. doi: 10.1001/jamaoncol.2022.7762. PMID: 36862387Free PMC Article
Cao B, Kim M, Reizine NM, Moreira DM
Eur Urol Oncol 2023 Jun;6(3):237-250. Epub 2023 Jan 20 doi: 10.1016/j.euo.2023.01.001. PMID: 36682938
Sathianathen NJ, Pan HYC, Lawrentschuk N, Siva S, Azad AA, Tran B, Bolton D, Murphy DG
Urol Oncol 2023 May;41(5):233-239. Epub 2022 Nov 18 doi: 10.1016/j.urolonc.2022.10.016. PMID: 36411180
Verma V, Yegya-Raman N, Sprave T, Han G, Kantarjian HM, Welsh JW, Chang JY, Lin SH
Int J Radiat Oncol Biol Phys 2022 Dec 1;114(5):977-988. Epub 2022 Jun 5 doi: 10.1016/j.ijrobp.2022.05.042. PMID: 35675852
Wang L, Paller CJ, Hong H, De Felice A, Alexander GC, Brawley O
JAMA Oncol 2021 Mar 1;7(3):412-420. doi: 10.1001/jamaoncol.2020.6973. PMID: 33443584Free PMC Article

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