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STK11 Gene Rearrangement

MedGen UID:
1651551
•Concept ID:
C4727313
•
Cell or Molecular Dysfunction
Synonyms: Liver Kinase B1 Gene Rearrangement; LKB1 Gene Rearrangement; Serine/Threonine Kinase 11 Gene Rearrangement; STK11 Rearrangement

Definition

A molecular abnormality indicating rearrangement of the STK11 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSTK11 Gene Rearrangement

Recent clinical studies

Therapy

Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R
Anticancer Res 2015 May;35(5):3007-12. PMID: 25964588
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.
Okamoto I, Sakai K, Morita S, Yoshioka H, Kaneda H, Takeda K, Hirashima T, Kogure Y, Kimura T, Takahashi T, Atagi S, Seto T, Sawa T, Yamamoto M, Satouchi M, Okuno M, Nagase S, Takayama K, Tomii K, Maeda T, Oizumi S, Fujii S, Akashi Y, Nishino K, Ebi N, Nakagawa K, Nakanishi Y, Nishio K
Oncotarget 2014 Apr 30;5(8):2293-304. doi: 10.18632/oncotarget.1906. PMID: 24810493Free PMC Article

Prognosis

Molecular, clinicopathological characteristics and surgical results of resectable SMARCA4-deficient thoracic tumors.
Luo J, Ding B, Campisi A, Chen T, Teng H, Ji C
J Cancer Res Clin Oncol 2023 Jul;149(8):4455-4463. Epub 2022 Sep 19 doi: 10.1007/s00432-022-04359-6. PMID: 36121510
The long tail of molecular alterations in non-small cell lung cancer: a single-institution experience of next-generation sequencing in clinical molecular diagnostics.
Fumagalli C, Vacirca D, Rappa A, Passaro A, Guarize J, Rafaniello Raviele P, de Marinis F, Spaggiari L, Casadio C, Viale G, Barberis M, Guerini-Rocco E
J Clin Pathol 2018 Sep;71(9):767-773. Epub 2018 Mar 13 doi: 10.1136/jclinpath-2018-205032. PMID: 29535211
Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R
Anticancer Res 2015 May;35(5):3007-12. PMID: 25964588

Clinical prediction guides

Molecular, clinicopathological characteristics and surgical results of resectable SMARCA4-deficient thoracic tumors.
Luo J, Ding B, Campisi A, Chen T, Teng H, Ji C
J Cancer Res Clin Oncol 2023 Jul;149(8):4455-4463. Epub 2022 Sep 19 doi: 10.1007/s00432-022-04359-6. PMID: 36121510
The long tail of molecular alterations in non-small cell lung cancer: a single-institution experience of next-generation sequencing in clinical molecular diagnostics.
Fumagalli C, Vacirca D, Rappa A, Passaro A, Guarize J, Rafaniello Raviele P, de Marinis F, Spaggiari L, Casadio C, Viale G, Barberis M, Guerini-Rocco E
J Clin Pathol 2018 Sep;71(9):767-773. Epub 2018 Mar 13 doi: 10.1136/jclinpath-2018-205032. PMID: 29535211
Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R
Anticancer Res 2015 May;35(5):3007-12. PMID: 25964588
Aberrant firing of replication origins potentially explains intragenic nonrecurrent rearrangements within genes, including the human DMD gene.
Ankala A, Kohn JN, Hegde A, Meka A, Ephrem CL, Askree SH, Bhide S, Hegde MR
Genome Res 2012 Jan;22(1):25-34. Epub 2011 Nov 16 doi: 10.1101/gr.123463.111. PMID: 22090376Free PMC Article
Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer.
Komiya T, Coxon A, Park Y, Chen WD, Zajac-Kaye M, Meltzer P, Karpova T, Kaye FJ
Oncogene 2010 Mar 18;29(11):1672-80. Epub 2009 Dec 14 doi: 10.1038/onc.2009.453. PMID: 20010869Free PMC Article

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