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STK11 Gene Rearrangement

MedGen UID:
1651551
•Concept ID:
C4727313
•
Cell or Molecular Dysfunction
Synonyms: Liver Kinase B1 Gene Rearrangement; LKB1 Gene Rearrangement; Serine/Threonine Kinase 11 Gene Rearrangement; STK11 Rearrangement

Definition

A molecular abnormality indicating rearrangement of the STK11 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSTK11 Gene Rearrangement

Recent clinical studies

Etiology

Hybrid Capture-based Genomic Profiling of Circulating Tumor DNA From Patients With Advanced Ovarian Cancer.
Shen W, Shan B, Liang S, Zhang J, Yu Y, Zhang Y, Wang G, Bai Y, Qian B, Lu J, Jiang Z
Pathol Oncol Res 2021;27:581534. Epub 2021 Apr 9 doi: 10.3389/pore.2021.581534. PMID: 34257528Free PMC Article
Novel germline STK11 variants and breast cancer phenotype identified in an Indian cohort of Peutz-Jeghers syndrome.
Lipsa A, Kowtal P, Sarin R
Hum Mol Genet 2019 Jun 1;28(11):1885-1893. doi: 10.1093/hmg/ddz027. PMID: 30689838
Coexistent genetic alterations involving ALK, RET, ROS1 or MET in 15 cases of lung adenocarcinoma.
Tang Z, Zhang J, Lu X, Wang W, Chen H, Robinson MK, Cheng J, Tang G, Medeiros LJ
Mod Pathol 2018 Feb;31(2):307-312. Epub 2017 Sep 15 doi: 10.1038/modpathol.2017.109. PMID: 28914263
Breast cancer risk and germline genomic profiling of women with neurofibromatosis type 1 who developed breast cancer.
Wang X, Teer JK, Tousignant RN, Levin AM, Boulware D, Chitale DA, Shaw BM, Chen Z, Zhang Y, Blakeley JO, Acosta MT, Messiaen LM, Korf BR, Tainsky MA
Genes Chromosomes Cancer 2018 Jan;57(1):19-27. Epub 2017 Sep 30 doi: 10.1002/gcc.22503. PMID: 28891274Free PMC Article
Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.
Mehenni H, Resta N, Guanti G, Mota-Vieira L, Lerner A, Peyman M, Chong KA, Aissa L, Ince A, Cosme A, Costanza MC, Rossier C, Radhakrishna U, Burt RW, Picard D
Dig Dis Sci 2007 Aug;52(8):1924-33. Epub 2007 Apr 3 doi: 10.1007/s10620-006-9435-3. PMID: 17404884

Diagnosis

Molecular, clinicopathological characteristics and surgical results of resectable SMARCA4-deficient thoracic tumors.
Luo J, Ding B, Campisi A, Chen T, Teng H, Ji C
J Cancer Res Clin Oncol 2023 Jul;149(8):4455-4463. Epub 2022 Sep 19 doi: 10.1007/s00432-022-04359-6. PMID: 36121510
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Morphologic and Molecular Study of 26 Cases Confirms Recurrent NCOA1-3 Rearrangement.
Goebel EA, Hernandez Bonilla S, Dong F, Dickson BC, Hoang LN, Hardisson D, Lacambra MD, Lu FI, Fletcher CDM, Crum CP, Antonescu CR, Nucci MR, Kolin DL
Am J Surg Pathol 2020 Jan;44(1):30-42. doi: 10.1097/PAS.0000000000001348. PMID: 31464709Free PMC Article
The long tail of molecular alterations in non-small cell lung cancer: a single-institution experience of next-generation sequencing in clinical molecular diagnostics.
Fumagalli C, Vacirca D, Rappa A, Passaro A, Guarize J, Rafaniello Raviele P, de Marinis F, Spaggiari L, Casadio C, Viale G, Barberis M, Guerini-Rocco E
J Clin Pathol 2018 Sep;71(9):767-773. Epub 2018 Mar 13 doi: 10.1136/jclinpath-2018-205032. PMID: 29535211
Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R
Anticancer Res 2015 May;35(5):3007-12. PMID: 25964588
Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.
Mehenni H, Resta N, Guanti G, Mota-Vieira L, Lerner A, Peyman M, Chong KA, Aissa L, Ince A, Cosme A, Costanza MC, Rossier C, Radhakrishna U, Burt RW, Picard D
Dig Dis Sci 2007 Aug;52(8):1924-33. Epub 2007 Apr 3 doi: 10.1007/s10620-006-9435-3. PMID: 17404884

Therapy

Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R
Anticancer Res 2015 May;35(5):3007-12. PMID: 25964588
Multiplex genomic profiling of non-small cell lung cancers from the LETS phase III trial of first-line S-1/carboplatin versus paclitaxel/carboplatin: results of a West Japan Oncology Group study.
Okamoto I, Sakai K, Morita S, Yoshioka H, Kaneda H, Takeda K, Hirashima T, Kogure Y, Kimura T, Takahashi T, Atagi S, Seto T, Sawa T, Yamamoto M, Satouchi M, Okuno M, Nagase S, Takayama K, Tomii K, Maeda T, Oizumi S, Fujii S, Akashi Y, Nishino K, Ebi N, Nakagawa K, Nakanishi Y, Nishio K
Oncotarget 2014 Apr 30;5(8):2293-304. doi: 10.18632/oncotarget.1906. PMID: 24810493Free PMC Article

Prognosis

Molecular, clinicopathological characteristics and surgical results of resectable SMARCA4-deficient thoracic tumors.
Luo J, Ding B, Campisi A, Chen T, Teng H, Ji C
J Cancer Res Clin Oncol 2023 Jul;149(8):4455-4463. Epub 2022 Sep 19 doi: 10.1007/s00432-022-04359-6. PMID: 36121510
The long tail of molecular alterations in non-small cell lung cancer: a single-institution experience of next-generation sequencing in clinical molecular diagnostics.
Fumagalli C, Vacirca D, Rappa A, Passaro A, Guarize J, Rafaniello Raviele P, de Marinis F, Spaggiari L, Casadio C, Viale G, Barberis M, Guerini-Rocco E
J Clin Pathol 2018 Sep;71(9):767-773. Epub 2018 Mar 13 doi: 10.1136/jclinpath-2018-205032. PMID: 29535211
Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R
Anticancer Res 2015 May;35(5):3007-12. PMID: 25964588

Clinical prediction guides

Molecular, clinicopathological characteristics and surgical results of resectable SMARCA4-deficient thoracic tumors.
Luo J, Ding B, Campisi A, Chen T, Teng H, Ji C
J Cancer Res Clin Oncol 2023 Jul;149(8):4455-4463. Epub 2022 Sep 19 doi: 10.1007/s00432-022-04359-6. PMID: 36121510
The long tail of molecular alterations in non-small cell lung cancer: a single-institution experience of next-generation sequencing in clinical molecular diagnostics.
Fumagalli C, Vacirca D, Rappa A, Passaro A, Guarize J, Rafaniello Raviele P, de Marinis F, Spaggiari L, Casadio C, Viale G, Barberis M, Guerini-Rocco E
J Clin Pathol 2018 Sep;71(9):767-773. Epub 2018 Mar 13 doi: 10.1136/jclinpath-2018-205032. PMID: 29535211
Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer.
Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R
Anticancer Res 2015 May;35(5):3007-12. PMID: 25964588
Aberrant firing of replication origins potentially explains intragenic nonrecurrent rearrangements within genes, including the human DMD gene.
Ankala A, Kohn JN, Hegde A, Meka A, Ephrem CL, Askree SH, Bhide S, Hegde MR
Genome Res 2012 Jan;22(1):25-34. Epub 2011 Nov 16 doi: 10.1101/gr.123463.111. PMID: 22090376Free PMC Article
Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer.
Komiya T, Coxon A, Park Y, Chen WD, Zajac-Kaye M, Meltzer P, Karpova T, Kaye FJ
Oncogene 2010 Mar 18;29(11):1672-80. Epub 2009 Dec 14 doi: 10.1038/onc.2009.453. PMID: 20010869Free PMC Article

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