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Metastatic Unresectable Carcinoma

MedGen UID:
1651753
Concept ID:
C4727166
Neoplastic Process

Definition

A carcinoma that has spread from its original site of growth to another anatomic site and is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Fanta P, Farjah F, Gerdes H, Gibson MK, Hochwald S, Hofstetter WL, Ilson DH, Keswani RN, Kim S, Kleinberg LR, Klempner SJ, Lacy J, Ly QP, Matkowskyj KA, McNamara M, Mulcahy MF, Outlaw D, Park H, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian N, Pluchino LA
J Natl Compr Canc Netw 2022 Feb;20(2):167-192. doi: 10.6004/jnccn.2022.0008. PMID: 35130500
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131

Recent clinical studies

Etiology

Colombo N, Dubot C, Lorusso D, Caceres MV, Hasegawa K, Shapira-Frommer R, Tewari KS, Salman P, Hoyos Usta E, Yañez E, Gümüş M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Toker S, Li K, Keefe SM, Monk BJ; KEYNOTE-826 Investigators
N Engl J Med 2021 Nov 11;385(20):1856-1867. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112435. PMID: 34534429
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Chidambaranathan-Reghupaty S, Fisher PB, Sarkar D
Adv Cancer Res 2021;149:1-61. Epub 2020 Nov 28 doi: 10.1016/bs.acr.2020.10.001. PMID: 33579421Free PMC Article
Maubec E
Acta Derm Venereol 2020 Jun 3;100(11):adv00143. doi: 10.2340/00015555-3498. PMID: 32346744Free PMC Article
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983

Diagnosis

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131
Chidambaranathan-Reghupaty S, Fisher PB, Sarkar D
Adv Cancer Res 2021;149:1-61. Epub 2020 Nov 28 doi: 10.1016/bs.acr.2020.10.001. PMID: 33579421Free PMC Article
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article

Therapy

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Colombo N, Dubot C, Lorusso D, Caceres MV, Hasegawa K, Shapira-Frommer R, Tewari KS, Salman P, Hoyos Usta E, Yañez E, Gümüş M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Toker S, Li K, Keefe SM, Monk BJ; KEYNOTE-826 Investigators
N Engl J Med 2021 Nov 11;385(20):1856-1867. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112435. PMID: 34534429
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article
Weaver A, Bossaer JB
J Oncol Pharm Pract 2021 Apr;27(3):702-710. Epub 2020 Dec 29 doi: 10.1177/1078155220983425. PMID: 33375902
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article

Prognosis

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, Arranz JÁ, Pal S, Ohyama C, Saci A, Qu X, Lambert A, Krishnan S, Azrilevich A, Galsky MD
Lancet Oncol 2017 Mar;18(3):312-322. Epub 2017 Jan 26 doi: 10.1016/S1470-2045(17)30065-7. PMID: 28131785
Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H
Lancet Oncol 2015 Feb;16(2):187-99. Epub 2015 Jan 16 doi: 10.1016/S1470-2045(14)71207-0. PMID: 25601342Free PMC Article
Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, Au HJ, Murawa P, Walde D, Wolff RA, Campos D, Lim R, Ding K, Clark G, Voskoglou-Nomikos T, Ptasynski M, Parulekar W; National Cancer Institute of Canada Clinical Trials Group
J Clin Oncol 2007 May 20;25(15):1960-6. Epub 2007 Apr 23 doi: 10.1200/JCO.2006.07.9525. PMID: 17452677

Clinical prediction guides

Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Colombo N, Dubot C, Lorusso D, Caceres MV, Hasegawa K, Shapira-Frommer R, Tewari KS, Salman P, Hoyos Usta E, Yañez E, Gümüş M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Toker S, Li K, Keefe SM, Monk BJ; KEYNOTE-826 Investigators
N Engl J Med 2021 Nov 11;385(20):1856-1867. Epub 2021 Sep 18 doi: 10.1056/NEJMoa2112435. PMID: 34534429
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
El-Diwany R, Pawlik TM, Ejaz A
Surg Oncol Clin N Am 2019 Oct;28(4):587-599. doi: 10.1016/j.soc.2019.06.002. PMID: 31472907
Balar AV, Castellano D, O'Donnell PH, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, Pang L, Savage MJ, Perini RF, Keefe SM, Bajorin D, Bellmunt J
Lancet Oncol 2017 Nov;18(11):1483-1492. Epub 2017 Sep 26 doi: 10.1016/S1470-2045(17)30616-2. PMID: 28967485

Recent systematic reviews

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Lobo L, Yakoub D, Picado O, Ripat C, Pendola F, Sharma R, ElTawil R, Kwon D, Venkat S, Portelance L, Yechieli R
Cardiovasc Intervent Radiol 2016 Nov;39(11):1580-1588. Epub 2016 Sep 1 doi: 10.1007/s00270-016-1426-y. PMID: 27586657
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

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