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Metastatic Fibrolamellar Carcinoma

MedGen UID:
1652119
•Concept ID:
C4727458
•
Neoplastic Process
Synonyms: Metastatic Fibrolamellar Hepatocellular Carcinoma; Metastatic FLC

Definition

A fibrolamellar carcinoma that has spread from the liver to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Fibrolamellar Carcinoma

Professional guidelines

PubMed

Fibrolamellar Hepatocellular Carcinoma: Comprehensive Review of Diagnosis, Imaging, and Management.
Aziz H, Brown ZJ, Panid Madani S, Kamel IR, Pawlik TM
J Am Coll Surg 2023 Feb 1;236(2):399-410. Epub 2022 Nov 4 doi: 10.1097/XCS.0000000000000476. PMID: 36648268
Liver transplantation for malignancy: current treatment strategies and future perspectives.
Hackl C, Schlitt HJ, Kirchner GI, Knoppke B, Loss M
World J Gastroenterol 2014 May 14;20(18):5331-44. doi: 10.3748/wjg.v20.i18.5331. PMID: 24833863Free PMC Article
Radiologic spectrum of cholangiocarcinoma: emphasis on unusual manifestations and differential diagnoses.
Lee WJ, Lim HK, Jang KM, Kim SH, Lee SJ, Lim JH, Choo IW
Radiographics 2001 Oct;21 Spec No:S97-S116. doi: 10.1148/radiographics.21.suppl_1.g01oc12s97. PMID: 11598251

Recent clinical studies

Etiology

CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients.
Do RK, McErlean A, Ang CS, DeMatteo RP, Abou-Alfa GK
Br J Radiol 2014 Aug;87(1040):20140024. Epub 2014 Jun 4 doi: 10.1259/bjr.20140024. PMID: 24896196Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Liver transplantation for malignant disease.
Heneghan MA, O'Grady JG
Baillieres Best Pract Res Clin Gastroenterol 1999 Dec;13(4):575-91. doi: 10.1053/bega.1999.0049. PMID: 10654921
Surgery of liver tumours.
Guest J, Blumgart LH
Baillieres Clin Gastroenterol 1987 Jan;1(1):131-50. doi: 10.1016/0950-3528(87)90037-6. PMID: 3034356
Hepatic neoplasia: selected clinical aspects.
Schiff L
Semin Roentgenol 1983 Apr;18(2):71-4. doi: 10.1016/0037-198x(83)90004-4. PMID: 6191395

Diagnosis

Fibrolamellar carcinoma: An entity all its own.
O'Neill AF, Church AJ, Perez-Atayde AR, Shaikh R, Marcus KJ, Vakili K
Curr Probl Cancer 2021 Aug;45(4):100770. Epub 2021 Jul 1 doi: 10.1016/j.currproblcancer.2021.100770. PMID: 34272087
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Primary biliary tract malignancies: MRI spectrum and mimics with histopathological correlation.
Mittal PK, Moreno CC, Kalb B, Mittal A, Camacho JC, Maddu K, Kitajima HD, Quigley BC, Kokabi N, Small WC
Abdom Imaging 2015 Aug;40(6):1520-57. doi: 10.1007/s00261-014-0300-0. PMID: 25416002
Hypervascular liver lesions.
Kamaya A, Maturen KE, Tye GA, Liu YI, Parti NN, Desser TS
Semin Ultrasound CT MR 2009 Oct;30(5):387-407. doi: 10.1053/j.sult.2009.06.001. PMID: 19842564
Surgery of liver tumours.
Guest J, Blumgart LH
Baillieres Clin Gastroenterol 1987 Jan;1(1):131-50. doi: 10.1016/0950-3528(87)90037-6. PMID: 3034356

Therapy

Fibrolamellar hepatocellular carcinoma treated with atezolizumab and bevacizumab: two case reports.
Al Zahrani A, Alfakeeh A
J Med Case Rep 2021 Mar 16;15(1):132. doi: 10.1186/s13256-021-02695-8. PMID: 33722275Free PMC Article
Liver transplantation for malignancy: current treatment strategies and future perspectives.
Hackl C, Schlitt HJ, Kirchner GI, Knoppke B, Loss M
World J Gastroenterol 2014 May 14;20(18):5331-44. doi: 10.3748/wjg.v20.i18.5331. PMID: 24833863Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Hepatocellular carcinoma: an update.
Dominguez-Malagón H, Gaytan-Graham S
Ultrastruct Pathol 2001 Nov-Dec;25(6):497-516. doi: 10.1080/019131201753343539. PMID: 11783914
Hepatic neoplasia: selected clinical aspects.
Schiff L
Semin Roentgenol 1983 Apr;18(2):71-4. doi: 10.1016/0037-198x(83)90004-4. PMID: 6191395

Prognosis

Fibrolamellar Hepatocellular Carcinoma: Comprehensive Review of Diagnosis, Imaging, and Management.
Aziz H, Brown ZJ, Panid Madani S, Kamel IR, Pawlik TM
J Am Coll Surg 2023 Feb 1;236(2):399-410. Epub 2022 Nov 4 doi: 10.1097/XCS.0000000000000476. PMID: 36648268
Natural history of hepatocellular carcinoma including fibrolamellar and hepato-cholangiocarcinoma variants.
Okuda K
J Gastroenterol Hepatol 2002 Apr;17(4):401-5. doi: 10.1046/j.1440-1746.2002.02734.x. PMID: 11982719
Hepatocellular carcinoma: an update.
Dominguez-Malagón H, Gaytan-Graham S
Ultrastruct Pathol 2001 Nov-Dec;25(6):497-516. doi: 10.1080/019131201753343539. PMID: 11783914
Liver transplantation for malignant disease.
Heneghan MA, O'Grady JG
Baillieres Best Pract Res Clin Gastroenterol 1999 Dec;13(4):575-91. doi: 10.1053/bega.1999.0049. PMID: 10654921
Surgery of liver tumours.
Guest J, Blumgart LH
Baillieres Clin Gastroenterol 1987 Jan;1(1):131-50. doi: 10.1016/0950-3528(87)90037-6. PMID: 3034356

Clinical prediction guides

Intracranial metastasis in fibrolamellar hepatocellular carcinoma.
Hammond WJ, Lalazar G, Saltsman JA, Farber BA, Danzer E, Sherpa TC, Banda CD, Andolina JR, Karimi S, Brennan CW, Torbenson MS, La Quaglia MP, Simon SM
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26919. PMID: 29286561Free PMC Article
Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study.
El Sayed SM, Mohamed WG, Seddik MA, Ahmed AS, Mahmoud AG, Amer WH, Helmy Nabo MM, Hamed AR, Ahmed NS, Abd-Allah AA
Chin J Cancer 2014 Jul;33(7):356-64. Epub 2014 Mar 14 doi: 10.5732/cjc.013.10111. PMID: 24636230Free PMC Article
Liver transplantation for malignant disease.
Heneghan MA, O'Grady JG
Baillieres Best Pract Res Clin Gastroenterol 1999 Dec;13(4):575-91. doi: 10.1053/bega.1999.0049. PMID: 10654921
Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation.
Schlitt HJ, Neipp M, Weimann A, Oldhafer KJ, Schmoll E, Boeker K, Nashan B, Kubicka S, Maschek H, Tusch G, Raab R, Ringe B, Manns MP, Pichlmayr R
J Clin Oncol 1999 Jan;17(1):324-31. doi: 10.1200/JCO.1999.17.1.324. PMID: 10458250
Metastatic nonresectable fibrolamellar hepatoma: prognostic features and natural history.
Epstein BE, Pajak TF, Haulk TL, Herpst JM, Order SE, Abrams RA
Am J Clin Oncol 1999 Feb;22(1):22-8. doi: 10.1097/00000421-199902000-00006. PMID: 10025374

Recent systematic reviews

Fibrolamellar Hepatocellular Carcinoma: Comprehensive Review of Diagnosis, Imaging, and Management.
Aziz H, Brown ZJ, Panid Madani S, Kamel IR, Pawlik TM
J Am Coll Surg 2023 Feb 1;236(2):399-410. Epub 2022 Nov 4 doi: 10.1097/XCS.0000000000000476. PMID: 36648268

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