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Locally Advanced Sinonasal Squamous Cell Carcinoma

MedGen UID:
1652282
•Concept ID:
C4727579
•
Neoplastic Process
Synonyms: Locally Advanced Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; Locally Advanced Squamous Cell Carcinoma of the Nasal Cavity and Paranasal Sinus; Locally Advanced Squamous Cell Carcinoma of the Nasal Cavity and/or Paranasal Sinuses

Definition

A squamous cell carcinoma that arises from the nasal cavity and/or paranasal sinuses and has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Sinonasal Squamous Cell Carcinoma

Professional guidelines

PubMed

What is the Role of Induction Chemotherapy in the Treatment of Locally Advanced Sinonasal Squamous Cell Carcinoma?
Abiri A, St John MA, Kuan EC
Laryngoscope 2023 Feb;133(2):214-215. Epub 2022 Nov 2 doi: 10.1002/lary.30474. PMID: 36321818
Clinical study of cetuximab combined with radical radiotherapy in the treatment of locally advanced sinonasal squamous cell carcinoma.
Qiu X, Yang J
J BUON 2018 Jul-Aug;23(4):1111-1117. PMID: 30358219
Treatment outcomes of concurrent chemoradiotherapy for locally advanced sinonasal squamous cell carcinoma: A single-institution study.
Kim JH, Lee YS, Chung YS, Jang YJ, Kim SB, Lee SW, Lee BJ
Acta Otolaryngol 2015;135(11):1189-95. Epub 2015 Jun 25 doi: 10.3109/00016489.2015.1061697. PMID: 26112831

Recent clinical studies

Etiology

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
The SINTART 1 study. A phase II non-randomised controlled trial of induction chemotherapy, surgery, photon-, proton- and carbon ion-based radiotherapy integration in patients with locally advanced resectable sinonasal tumours.
Resteghini C, Castelnuovo P, Nicolai P, Orlandi E, Bossi P, Vischioni B, Schreiber A, Gambazza S, Iacovelli NA, Battaglia P, Guzzo M, Turri-Zanoni M, Mattavelli D, Facchinetti N, Calareso G, Ravanelli M, Facco C, Tartaro T, Licitra L
Eur J Cancer 2023 Jul;187:185-194. Epub 2023 Apr 5 doi: 10.1016/j.ejca.2023.03.033. PMID: 37164774
The Role of Induction Therapy for Sinonasal Cancers.
Kong KA, Thorp BD, Sheth SH
Curr Treat Options Oncol 2023 Mar;24(3):162-169. Epub 2023 Jan 25 doi: 10.1007/s11864-022-01046-z. PMID: 36696082
Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy.
Murr AT, Lenze NR, Weiss JM, Grilley-Olson JE, Patel SA, Shen C, Chera BS, Zanation AM, Thorp BD, Sheth SH
Otolaryngol Head Neck Surg 2022 Nov;167(5):846-851. Epub 2022 Mar 8 doi: 10.1177/01945998221083097. PMID: 35259033Free PMC Article
Personalizing Postoperative Treatment of Head and Neck Cancers.
Maghami E, Koyfman SA, Weiss J
Am Soc Clin Oncol Educ Book 2018 May 23;38:515-522. doi: 10.1200/EDBK_201087. PMID: 30231315

Diagnosis

The SINTART 1 study. A phase II non-randomised controlled trial of induction chemotherapy, surgery, photon-, proton- and carbon ion-based radiotherapy integration in patients with locally advanced resectable sinonasal tumours.
Resteghini C, Castelnuovo P, Nicolai P, Orlandi E, Bossi P, Vischioni B, Schreiber A, Gambazza S, Iacovelli NA, Battaglia P, Guzzo M, Turri-Zanoni M, Mattavelli D, Facchinetti N, Calareso G, Ravanelli M, Facco C, Tartaro T, Licitra L
Eur J Cancer 2023 Jul;187:185-194. Epub 2023 Apr 5 doi: 10.1016/j.ejca.2023.03.033. PMID: 37164774
Including Surgical Resection in the Multimodal Management of Very Locally Advanced Sinonasal Cancer.
Karp JM, Hu KS, Persky M, Persky M, Jacobson A, Tran T, Li Z, Givi B, Tam MM
Otolaryngol Head Neck Surg 2022 Sep;167(3):494-500. Epub 2021 Dec 28 doi: 10.1177/01945998211067503. PMID: 34962843
Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour.
Bishop JA, Westra WH
Oral Oncol 2018 Dec;87:17-20. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.10.011. PMID: 30527234
Personalizing Postoperative Treatment of Head and Neck Cancers.
Maghami E, Koyfman SA, Weiss J
Am Soc Clin Oncol Educ Book 2018 May 23;38:515-522. doi: 10.1200/EDBK_201087. PMID: 30231315
Outcomes of multimodal management for sinonasal squamous cell carcinoma.
Paré A, Blanchard P, Rosellini S, Aupérin A, Gorphe P, Casiraghi O, Temam S, Bidault F, Page P, Kolb F, Janot F, Moya Plana A
J Craniomaxillofac Surg 2017 Aug;45(8):1124-1132. Epub 2017 May 12 doi: 10.1016/j.jcms.2017.05.006. PMID: 28601297

Therapy

Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma.
Contrera KJ, Ferrarotto R, Gunn B, Su SY, Kies MS, Glisson BS, Garden AS, Roberts D, Habna C, Hoff CO, El-Naggar A, Williams MD, Raza SM, DeMonte F, Chen MM, Chambers MS, Hanna EY
Clin Cancer Res 2025 Jan 17;31(2):258-265. doi: 10.1158/1078-0432.CCR-24-1416. PMID: 39531535
Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
What is the Role of Induction Chemotherapy in the Treatment of Locally Advanced Sinonasal Squamous Cell Carcinoma?
Abiri A, St John MA, Kuan EC
Laryngoscope 2023 Feb;133(2):214-215. Epub 2022 Nov 2 doi: 10.1002/lary.30474. PMID: 36321818
Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy.
Murr AT, Lenze NR, Weiss JM, Grilley-Olson JE, Patel SA, Shen C, Chera BS, Zanation AM, Thorp BD, Sheth SH
Otolaryngol Head Neck Surg 2022 Nov;167(5):846-851. Epub 2022 Mar 8 doi: 10.1177/01945998221083097. PMID: 35259033Free PMC Article
Sinonasal cancers treatments: state of the art.
Ferrari M, Orlandi E, Bossi P
Curr Opin Oncol 2021 May 1;33(3):196-205. doi: 10.1097/CCO.0000000000000726. PMID: 33756515Free PMC Article

Prognosis

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
The SINTART 1 study. A phase II non-randomised controlled trial of induction chemotherapy, surgery, photon-, proton- and carbon ion-based radiotherapy integration in patients with locally advanced resectable sinonasal tumours.
Resteghini C, Castelnuovo P, Nicolai P, Orlandi E, Bossi P, Vischioni B, Schreiber A, Gambazza S, Iacovelli NA, Battaglia P, Guzzo M, Turri-Zanoni M, Mattavelli D, Facchinetti N, Calareso G, Ravanelli M, Facco C, Tartaro T, Licitra L
Eur J Cancer 2023 Jul;187:185-194. Epub 2023 Apr 5 doi: 10.1016/j.ejca.2023.03.033. PMID: 37164774
Sinonasal cancers treatments: state of the art.
Ferrari M, Orlandi E, Bossi P
Curr Opin Oncol 2021 May 1;33(3):196-205. doi: 10.1097/CCO.0000000000000726. PMID: 33756515Free PMC Article
Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma.
Li Y, Wang C, Wang R, Zhang J, Liu H, Shi Q, Chen X, Hou L, Ma H, Zhong Q, Li P, Feng L, He S, Zhang L, Fang J
Am J Rhinol Allergy 2021 Jan;35(1):114-121. Epub 2020 Jul 12 doi: 10.1177/1945892420939422. PMID: 32659112
Outcomes of multimodal management for sinonasal squamous cell carcinoma.
Paré A, Blanchard P, Rosellini S, Aupérin A, Gorphe P, Casiraghi O, Temam S, Bidault F, Page P, Kolb F, Janot F, Moya Plana A
J Craniomaxillofac Surg 2017 Aug;45(8):1124-1132. Epub 2017 May 12 doi: 10.1016/j.jcms.2017.05.006. PMID: 28601297

Clinical prediction guides

Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma.
Contrera KJ, Ferrarotto R, Gunn B, Su SY, Kies MS, Glisson BS, Garden AS, Roberts D, Habna C, Hoff CO, El-Naggar A, Williams MD, Raza SM, DeMonte F, Chen MM, Chambers MS, Hanna EY
Clin Cancer Res 2025 Jan 17;31(2):258-265. doi: 10.1158/1078-0432.CCR-24-1416. PMID: 39531535
Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy.
Murr AT, Lenze NR, Weiss JM, Grilley-Olson JE, Patel SA, Shen C, Chera BS, Zanation AM, Thorp BD, Sheth SH
Otolaryngol Head Neck Surg 2022 Nov;167(5):846-851. Epub 2022 Mar 8 doi: 10.1177/01945998221083097. PMID: 35259033Free PMC Article
Neoadjuvant chemotherapy for locoregionally advanced squamous cell carcinoma of the paranasal sinuses.
Abdelmeguid AS, Teeramatwanich W, Roberts DB, Amit M, Ferraroto R, Glisson BS, Kupferman ME, Su SY, Phan J, Garden AS, Raza SM, DeMonte F, Hanna EY
Cancer 2021 Jun 1;127(11):1788-1795. Epub 2021 Feb 10 doi: 10.1002/cncr.33452. PMID: 33567468
Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma.
Li Y, Wang C, Wang R, Zhang J, Liu H, Shi Q, Chen X, Hou L, Ma H, Zhong Q, Li P, Feng L, He S, Zhang L, Fang J
Am J Rhinol Allergy 2021 Jan;35(1):114-121. Epub 2020 Jul 12 doi: 10.1177/1945892420939422. PMID: 32659112
Outcomes of multimodal management for sinonasal squamous cell carcinoma.
Paré A, Blanchard P, Rosellini S, Aupérin A, Gorphe P, Casiraghi O, Temam S, Bidault F, Page P, Kolb F, Janot F, Moya Plana A
J Craniomaxillofac Surg 2017 Aug;45(8):1124-1132. Epub 2017 May 12 doi: 10.1016/j.jcms.2017.05.006. PMID: 28601297

Recent systematic reviews

Recurrence rates of de-novo versus inverted papilloma-transformed sinonasal squamous cell carcinoma: a meta-analysis.
Birkenbeuel JL, Goshtasbi K, Adappa ND, Palmer JN, Tong CCL, Kuan EC
Rhinology 2022 Dec 1;60(6):402-410. doi: 10.4193/Rhin22.187. PMID: 36150160
Role of induction chemotherapy in sinonasal malignancies: a systematic review.
Khoury T, Jang D, Carrau R, Ready N, Barak I, Hachem RA
Int Forum Allergy Rhinol 2019 Feb;9(2):212-219. Epub 2018 Nov 9 doi: 10.1002/alr.22229. PMID: 30411867

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