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Refractory Leiomyosarcoma

MedGen UID:
1652428
Concept ID:
C4724965
Neoplastic Process

Definition

Leiomyosarcoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Leiomyosarcoma

Professional guidelines

PubMed

Elvin JA, Gay LM, Ort R, Shuluk J, Long J, Shelley L, Lee R, Chalmers ZR, Frampton GM, Ali SM, Schrock AB, Miller VA, Stephens PJ, Ross JS, Frank R
Oncologist 2017 Apr;22(4):416-421. Epub 2017 Mar 10 doi: 10.1634/theoncologist.2016-0310. PMID: 28283584Free PMC Article
Wagner MJ, Amodu LI, Duh MS, Korves C, Solleza F, Manson SC, Diaz J, Neary MP, Demetri GD
BMC Cancer 2015 Mar 25;15:175. doi: 10.1186/s12885-015-1182-4. PMID: 25885530Free PMC Article
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353

Recent clinical studies

Etiology

Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Reichardt P
Future Oncol 2014 Jun;10(8 Suppl):s19-27. doi: 10.2217/fon.14.116. PMID: 25048045
Mahmood ST, Agresta S, Vigil CE, Zhao X, Han G, D'Amato G, Calitri CE, Dean M, Garrett C, Schell MJ, Antonia S, Chiappori A
Int J Cancer 2011 Oct 15;129(8):1963-9. Epub 2011 Mar 25 doi: 10.1002/ijc.25843. PMID: 21154746Free PMC Article
McMeekin DS, Sill MW, Darcy KM, Stearns-Kurosawa DJ, Webster K, Waggoner S, Benbrook D
Gynecol Oncol 2007 Sep;106(3):596-603. Epub 2007 Jun 27 doi: 10.1016/j.ygyno.2007.05.013. PMID: 17597196
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225

Diagnosis

Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Reichardt P
Future Oncol 2014 Jun;10(8 Suppl):s19-27. doi: 10.2217/fon.14.116. PMID: 25048045
Perisano C, Maffulli N, Colelli P, Marzetti E, Panni AS, Maccauro G
BMC Musculoskelet Disord 2013 Feb 19;14:64. doi: 10.1186/1471-2474-14-64. PMID: 23421389Free PMC Article
Layfield LJ, Wallander ML
Diagn Cytopathol 2012 Jun;40(6):484-90. Epub 2012 Feb 20 doi: 10.1002/dc.22838. PMID: 22351482
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225

Therapy

Stacchiotti S, Baldi GG, Frezza AM, Morosi C, Greco FG, Collini P, Barisella M, Dagrada GP, Zaffaroni N, Pasquali S, Gronchi A, Huang P, Ingrosso M, Tinè G, Miceli R, Casali PG
Eur J Cancer 2023 Dec;195:113391. Epub 2023 Oct 18 doi: 10.1016/j.ejca.2023.113391. PMID: 37918286
Debien V, Vignot S, Massard C, Malouf G, Hollebecque A, Scoazec JY, Michiels S, Verlingue L
Crit Rev Oncol Hematol 2023 Jan;181:103888. Epub 2022 Nov 29 doi: 10.1016/j.critrevonc.2022.103888. PMID: 36460264
Kalinsky K, Hong F, McCourt CK, Sachdev JC, Mitchell EP, Zwiebel JA, Doyle LA, McShane LM, Li S, Gray RJ, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT
JAMA Oncol 2021 Feb 1;7(2):271-278. doi: 10.1001/jamaoncol.2020.6741. PMID: 33377972Free PMC Article
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225

Prognosis

Chi Y, Fang Z, Hong X, Yao Y, Sun P, Wang G, Du F, Sun Y, Wu Q, Qu G, Wang S, Song J, Yu J, Lu Y, Zhu X, Niu X, He Z, Wang J, Yu H, Cai J
Clin Cancer Res 2018 Nov 1;24(21):5233-5238. Epub 2018 Jun 12 doi: 10.1158/1078-0432.CCR-17-3766. PMID: 29895706
Layfield LJ, Wallander ML
Diagn Cytopathol 2012 Jun;40(6):484-90. Epub 2012 Feb 20 doi: 10.1002/dc.22838. PMID: 22351482
McMeekin DS, Sill MW, Darcy KM, Stearns-Kurosawa DJ, Webster K, Waggoner S, Benbrook D
Gynecol Oncol 2007 Sep;106(3):596-603. Epub 2007 Jun 27 doi: 10.1016/j.ygyno.2007.05.013. PMID: 17597196
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225

Clinical prediction guides

Stacchiotti S, Baldi GG, Frezza AM, Morosi C, Greco FG, Collini P, Barisella M, Dagrada GP, Zaffaroni N, Pasquali S, Gronchi A, Huang P, Ingrosso M, Tinè G, Miceli R, Casali PG
Eur J Cancer 2023 Dec;195:113391. Epub 2023 Oct 18 doi: 10.1016/j.ejca.2023.113391. PMID: 37918286
Schmoll HJ, Lindner LH, Reichardt P, Heißner K, Kopp HG, Kessler T, Mayer-Steinacker R, Rüssel J, Egerer G, Crysandt M, Kasper B, Niederwieser D, Kunitz A, Eigendorff E, Petersen I, Steighardt J, Cygon F, Meinert F, Stein A
JAMA Oncol 2021 Feb 1;7(2):255-262. doi: 10.1001/jamaoncol.2020.6564. PMID: 33355646Free PMC Article
Bauer S, Seeber S, Schütte J
Onkologie 2004 Apr;27(2):180-6. doi: 10.1159/000076910. PMID: 15138353
von Mehren M
Curr Treat Options Oncol 2003 Dec;4(6):441-51. doi: 10.1007/s11864-003-0045-4. PMID: 14585225
Senderowicz AM
Leukemia 2001 Jan;15(1):1-9. doi: 10.1038/sj.leu.2401994. PMID: 11243375

Supplemental Content

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