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Locally Advanced Pancreatic Ductal Adenocarcinoma

MedGen UID:
1652785
Concept ID:
C4745272
Neoplastic Process

Definition

A pancreatic ductal adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Pancreatic Ductal Adenocarcinoma

Professional guidelines

PubMed

Harrison JM, Wo JY, Ferrone CR, Horick NK, Keane FK, Qadan M, Lillemoe KD, Hong TS, Clark JW, Blaszkowsky LS, Allen JN, Castillo CF
Ann Surg Oncol 2020 May;27(5):1400-1406. Epub 2019 Nov 22 doi: 10.1245/s10434-019-08084-2. PMID: 31758284
Loehrer AP, Kinnier CV, Ferrone CR
Adv Surg 2016 Sep;50(1):115-28. Epub 2016 Jul 7 doi: 10.1016/j.yasu.2016.03.010. PMID: 27520867
Loehrer AP, Ferrone CR
Dig Surg 2016;33(4):343-50. Epub 2016 May 25 doi: 10.1159/000445020. PMID: 27216011

Recent clinical studies

Etiology

Kim H, Olsen JR, Green OL, Chin RI, Hawkins WG, Fields RC, Hammill C, Doyle MB, Chapman W, Suresh R, Tan B, Pedersen K, Jansen B, DeWees TA, Lu E, Henke LE, Badiyan S, Parikh PJ, Roach MC, Wang-Gillam A, Lim KH
Int J Radiat Oncol Biol Phys 2023 Jan 1;115(1):214-223. Epub 2022 Jul 22 doi: 10.1016/j.ijrobp.2022.07.015. PMID: 35878713
Lv W, Wang Q, Hu Q, Wang X, Cao D
BMJ Open 2022 Jul 13;12(7):e050558. doi: 10.1136/bmjopen-2021-050558. PMID: 35831044Free PMC Article
Schneider M, Hackert T, Strobel O, Büchler MW
Br J Surg 2021 Jul 23;108(7):777-785. doi: 10.1093/bjs/znab133. PMID: 34046668
Zhang L, Tan S, Huang S, Zhong C, Lü M, Peng Y, Tang X
Scand J Gastroenterol 2020 Sep;55(9):1121-1131. Epub 2020 Jul 30 doi: 10.1080/00365521.2020.1797870. PMID: 32730715
Harrison JM, Wo JY, Ferrone CR, Horick NK, Keane FK, Qadan M, Lillemoe KD, Hong TS, Clark JW, Blaszkowsky LS, Allen JN, Castillo CF
Ann Surg Oncol 2020 May;27(5):1400-1406. Epub 2019 Nov 22 doi: 10.1245/s10434-019-08084-2. PMID: 31758284

Diagnosis

Wu L, Lu Y, Chen L, Yue X, Cen C, Zheng C, Han P
Curr Oncol 2022 Oct 18;29(10):7912-7924. doi: 10.3390/curroncol29100625. PMID: 36290902Free PMC Article
Lv W, Wang Q, Hu Q, Wang X, Cao D
BMJ Open 2022 Jul 13;12(7):e050558. doi: 10.1136/bmjopen-2021-050558. PMID: 35831044Free PMC Article
Wolfe AR, Robb R, Hegazi A, Abushahin L, Yang L, Shyu DL, Trevino JG, Cruz-Monserrate Z, Jacob JR, Palanichamy K, Chakravarti A, Williams TM
Clin Cancer Res 2021 Jan 15;27(2):554-565. Epub 2020 Oct 21 doi: 10.1158/1078-0432.CCR-20-1422. PMID: 33087331Free PMC Article
Maggino L, Malleo G, Marchegiani G, Viviani E, Nessi C, Ciprani D, Esposito A, Landoni L, Casetti L, Tuveri M, Paiella S, Casciani F, Sereni E, Binco A, Bonamini D, Secchettin E, Auriemma A, Merz V, Simionato F, Zecchetto C, D'Onofrio M, Melisi D, Bassi C, Salvia R
JAMA Surg 2019 Oct 1;154(10):932-942. doi: 10.1001/jamasurg.2019.2277. PMID: 31339530Free PMC Article
Alemi F, Alseidi A, Scott Helton W, Rocha FG
Curr Probl Surg 2015 Sep;52(9):362-98. Epub 2015 Jul 17 doi: 10.1067/j.cpsurg.2015.07.003. PMID: 26363649

Therapy

Ogawa A, Yoshimura M, Nakamura M, Adachi T, Iwai T, Ashida R, Mizowaki T
Radiat Oncol 2023 Jun 19;18(1):103. doi: 10.1186/s13014-023-02288-3. PMID: 37337247Free PMC Article
Lv W, Wang Q, Hu Q, Wang X, Cao D
BMJ Open 2022 Jul 13;12(7):e050558. doi: 10.1136/bmjopen-2021-050558. PMID: 35831044Free PMC Article
Michelakos T, Cai L, Villani V, Sabbatino F, Kontos F, Fernández-Del Castillo C, Yamada T, Neyaz A, Taylor MS, Deshpande V, Kurokawa T, Ting DT, Qadan M, Weekes CD, Allen JN, Clark JW, Hong TS, Ryan DP, Wo JY, Warshaw AL, Lillemoe KD, Ferrone S, Ferrone CR
J Natl Cancer Inst 2021 Feb 1;113(2):182-191. doi: 10.1093/jnci/djaa073. PMID: 32497200Free PMC Article
Harrison JM, Wo JY, Ferrone CR, Horick NK, Keane FK, Qadan M, Lillemoe KD, Hong TS, Clark JW, Blaszkowsky LS, Allen JN, Castillo CF
Ann Surg Oncol 2020 May;27(5):1400-1406. Epub 2019 Nov 22 doi: 10.1245/s10434-019-08084-2. PMID: 31758284
Loehrer AP, Ferrone CR
Dig Surg 2016;33(4):343-50. Epub 2016 May 25 doi: 10.1159/000445020. PMID: 27216011

Prognosis

Mahmood U, Carrier E, Khan K
Cancer Treat Rev 2024 Jun;127:102750. Epub 2024 May 3 doi: 10.1016/j.ctrv.2024.102750. PMID: 38703592
Buss EJ, Kachnic LA, Horowitz DP
Semin Oncol 2021 Feb;48(1):106-110. Epub 2021 Feb 23 doi: 10.1053/j.seminoncol.2021.02.005. PMID: 33771355
Loehrer AP, Kinnier CV, Ferrone CR
Adv Surg 2016 Sep;50(1):115-28. Epub 2016 Jul 7 doi: 10.1016/j.yasu.2016.03.010. PMID: 27520867
Alemi F, Alseidi A, Scott Helton W, Rocha FG
Curr Probl Surg 2015 Sep;52(9):362-98. Epub 2015 Jul 17 doi: 10.1067/j.cpsurg.2015.07.003. PMID: 26363649
D'Onofrio M, Barbi E, Girelli R, Martone E, Gallotti A, Salvia R, Martini PT, Bassi C, Pederzoli P, Pozzi Mucelli R
World J Gastroenterol 2010 Jul 28;16(28):3478-83. doi: 10.3748/wjg.v16.i28.3478. PMID: 20653055Free PMC Article

Clinical prediction guides

Mahmood U, Carrier E, Khan K
Cancer Treat Rev 2024 Jun;127:102750. Epub 2024 May 3 doi: 10.1016/j.ctrv.2024.102750. PMID: 38703592
Kim H, Olsen JR, Green OL, Chin RI, Hawkins WG, Fields RC, Hammill C, Doyle MB, Chapman W, Suresh R, Tan B, Pedersen K, Jansen B, DeWees TA, Lu E, Henke LE, Badiyan S, Parikh PJ, Roach MC, Wang-Gillam A, Lim KH
Int J Radiat Oncol Biol Phys 2023 Jan 1;115(1):214-223. Epub 2022 Jul 22 doi: 10.1016/j.ijrobp.2022.07.015. PMID: 35878713
Wu L, Lu Y, Chen L, Yue X, Cen C, Zheng C, Han P
Curr Oncol 2022 Oct 18;29(10):7912-7924. doi: 10.3390/curroncol29100625. PMID: 36290902Free PMC Article
Lv W, Wang Q, Hu Q, Wang X, Cao D
BMJ Open 2022 Jul 13;12(7):e050558. doi: 10.1136/bmjopen-2021-050558. PMID: 35831044Free PMC Article
Maggino L, Malleo G, Marchegiani G, Viviani E, Nessi C, Ciprani D, Esposito A, Landoni L, Casetti L, Tuveri M, Paiella S, Casciani F, Sereni E, Binco A, Bonamini D, Secchettin E, Auriemma A, Merz V, Simionato F, Zecchetto C, D'Onofrio M, Melisi D, Bassi C, Salvia R
JAMA Surg 2019 Oct 1;154(10):932-942. doi: 10.1001/jamasurg.2019.2277. PMID: 31339530Free PMC Article

Recent systematic reviews

Saha A, Wadsley J, Sirohi B, Goody R, Anthony A, Perumal K, Ulahanan D, Collinson F
Pancreas 2023 Jan 1;52(1):e7-e20. doi: 10.1097/MPA.0000000000002215. PMID: 37378896
Buwenge M, Arcelli A, Cellini F, Deodato F, Macchia G, Cilla S, Galietta E, Strigari L, Malizia C, Cammelli S, Morganti AG
Curr Oncol 2022 Apr 11;29(4):2616-2629. doi: 10.3390/curroncol29040214. PMID: 35448188Free PMC Article
Lindemann J, du Toit L, Kotze U, Bernon M, Krige J, Jonas E
HPB (Oxford) 2021 Feb;23(2):173-186. Epub 2020 Oct 22 doi: 10.1016/j.hpb.2020.09.022. PMID: 33268268
Zhang L, Tan S, Huang S, Zhong C, Lü M, Peng Y, Tang X
Scand J Gastroenterol 2020 Sep;55(9):1121-1131. Epub 2020 Jul 30 doi: 10.1080/00365521.2020.1797870. PMID: 32730715
Schorn S, Demir IE, Reyes CM, Saricaoglu C, Samm N, Schirren R, Tieftrunk E, Hartmann D, Friess H, Ceyhan GO
Cancer Treat Rev 2017 Apr;55:96-106. Epub 2017 Mar 14 doi: 10.1016/j.ctrv.2017.03.003. PMID: 28342938

Supplemental Content

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