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Unresectable Carcinoma

MedGen UID:
1652812
•Concept ID:
C4724830
•
Neoplastic Process

Definition

Carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Carcinoma

Professional guidelines

PubMed

Treatment options for unresectable HCC with a focus on SIRT with Yttrium-90 resin microspheres.
Wang EA, Stein JP, Bellavia RJ, Broadwell SR
Int J Clin Pract 2017 Nov;71(11) Epub 2017 Jul 30 doi: 10.1111/ijcp.12972. PMID: 28758319
Management of biliary obstruction in patients with unresectable carcinoma of the pancreas.
McGrath PC, McNeill PM, Neifeld JP, Bear HD, Parker GA, Turner MA, Horsley JS 3rd, Lawrence W Jr
Ann Surg 1989 Mar;209(3):284-8. doi: 10.1097/00000658-198903000-00006. PMID: 2466448Free PMC Article
Primary carcinoma of the liver: diagnosis, prognosis, and management.
Lee YT
J Surg Oncol 1983 Jan;22(1):17-25. doi: 10.1002/jso.2930220107. PMID: 6185796

Recent clinical studies

Etiology

A Pilot Trial of S-1 and Paclitaxel in Unresectable or Postoperative Recurrent Esophageal Squamous Cell Carcinoma Pretreated by Fluorouracil, Cisplatin, and Docetaxel Chemotherapy.
Nakajima Y, Kawada K, Tokairin Y, Hoshino A, Okada T, Kawano T
Dig Surg 2018;35(2):131-137. Epub 2017 May 30 doi: 10.1159/000477265. PMID: 28554183
Opportunities of improvement in the management of pancreatic and periampullary tumors.
Nordby T, Ikdahl T, Lothe IM, Ånonsen K, Hauge T, Edwin B, Line PD, Labori KJ, Buanes T
Scand J Gastroenterol 2013 May;48(5):617-25. doi: 10.3109/00365521.2013.781218. PMID: 23597153Free PMC Article
Laparoscopic colon resection.
Schirmer BD
Surg Clin North Am 1996 Jun;76(3):571-83. doi: 10.1016/s0039-6109(05)70463-1. PMID: 8669016
Can the morbidity of esophagectomy be reduced by the thoracoscopic approach?
Gossot D, Cattan P, Fritsch S, Halimi B, Sarfati E, Celerier M
Surg Endosc 1995 Oct;9(10):1113-5. doi: 10.1007/BF00188998. PMID: 8553214
Surgery for carcinoma of the pancreas and periampullary structures: complications of resectional and palliative procedures.
Lee YT
J Surg Oncol 1984 Dec;27(4):280-5. doi: 10.1002/jso.2930270418. PMID: 6209511

Diagnosis

Chinese expert consensus on radioactive (125)I seeds interstitial implantation brachytherapy for pancreatic cancer.
Gai B, Zhang F
J Cancer Res Ther 2018;14(7):1455-1462. doi: 10.4103/jcrt.JCRT_96_18. PMID: 30589023
Palliation. Surgical and otherwise.
Lillemoe KD, Pitt HA
Cancer 1996 Aug 1;78(3 Suppl):605-14. doi: 10.1002/(SICI)1097-0142(19960801)78:3<605::AID-CNCR41>3.0.CO;2-#. PMID: 8681299
Surgery for carcinoma of the pancreas and periampullary structures: complications of resectional and palliative procedures.
Lee YT
J Surg Oncol 1984 Dec;27(4):280-5. doi: 10.1002/jso.2930270418. PMID: 6209511
Current trends in the diagnosis and treatment of carcinoma of the pancreas.
Warren KW, Christophi C, Armendariz R, Basu S
Am J Surg 1983 Jun;145(6):813-8. doi: 10.1016/0002-9610(83)90149-6. PMID: 6305226
Primary carcinoma of the liver: diagnosis, prognosis, and management.
Lee YT
J Surg Oncol 1983 Jan;22(1):17-25. doi: 10.1002/jso.2930220107. PMID: 6185796

Therapy

Chinese expert consensus on radioactive (125)I seeds interstitial implantation brachytherapy for pancreatic cancer.
Gai B, Zhang F
J Cancer Res Ther 2018;14(7):1455-1462. doi: 10.4103/jcrt.JCRT_96_18. PMID: 30589023
Unresectable carcinoma of the paranasal sinuses: outcomes and toxicities.
Hoppe BS, Nelson CJ, Gomez DR, Stegman LD, Wu AJ, Wolden SL, Pfister DG, Zelefsky MJ, Shah JP, Kraus DH, Lee NY
Int J Radiat Oncol Biol Phys 2008 Nov 1;72(3):763-9. Epub 2008 Apr 18 doi: 10.1016/j.ijrobp.2008.01.038. PMID: 18395361
Palliation. Surgical and otherwise.
Lillemoe KD, Pitt HA
Cancer 1996 Aug 1;78(3 Suppl):605-14. doi: 10.1002/(SICI)1097-0142(19960801)78:3<605::AID-CNCR41>3.0.CO;2-#. PMID: 8681299
Laparoscopic colon resection.
Schirmer BD
Surg Clin North Am 1996 Jun;76(3):571-83. doi: 10.1016/s0039-6109(05)70463-1. PMID: 8669016
Cisplatin and radiotherapy in the management of locally advanced head and neck cancer.
Forastiere AA
Int J Radiat Oncol Biol Phys 1993 Sep 30;27(2):465-70. doi: 10.1016/0360-3016(93)90260-3. PMID: 8407423

Prognosis

Chinese expert consensus on radioactive (125)I seeds interstitial implantation brachytherapy for pancreatic cancer.
Gai B, Zhang F
J Cancer Res Ther 2018;14(7):1455-1462. doi: 10.4103/jcrt.JCRT_96_18. PMID: 30589023
Palliation. Surgical and otherwise.
Lillemoe KD, Pitt HA
Cancer 1996 Aug 1;78(3 Suppl):605-14. doi: 10.1002/(SICI)1097-0142(19960801)78:3<605::AID-CNCR41>3.0.CO;2-#. PMID: 8681299
Can the morbidity of esophagectomy be reduced by the thoracoscopic approach?
Gossot D, Cattan P, Fritsch S, Halimi B, Sarfati E, Celerier M
Surg Endosc 1995 Oct;9(10):1113-5. doi: 10.1007/BF00188998. PMID: 8553214
Cisplatin and radiotherapy in the management of locally advanced head and neck cancer.
Forastiere AA
Int J Radiat Oncol Biol Phys 1993 Sep 30;27(2):465-70. doi: 10.1016/0360-3016(93)90260-3. PMID: 8407423
Primary carcinoma of the liver: diagnosis, prognosis, and management.
Lee YT
J Surg Oncol 1983 Jan;22(1):17-25. doi: 10.1002/jso.2930220107. PMID: 6185796

Clinical prediction guides

A Pilot Trial of S-1 and Paclitaxel in Unresectable or Postoperative Recurrent Esophageal Squamous Cell Carcinoma Pretreated by Fluorouracil, Cisplatin, and Docetaxel Chemotherapy.
Nakajima Y, Kawada K, Tokairin Y, Hoshino A, Okada T, Kawano T
Dig Surg 2018;35(2):131-137. Epub 2017 May 30 doi: 10.1159/000477265. PMID: 28554183
Opportunities of improvement in the management of pancreatic and periampullary tumors.
Nordby T, Ikdahl T, Lothe IM, Ånonsen K, Hauge T, Edwin B, Line PD, Labori KJ, Buanes T
Scand J Gastroenterol 2013 May;48(5):617-25. doi: 10.3109/00365521.2013.781218. PMID: 23597153Free PMC Article
Epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF) as neoadjuvant chemotherapy in gastro-oesophageal cancer.
Melcher AA, Mort D, Maughan TS
Br J Cancer 1996 Nov;74(10):1651-4. doi: 10.1038/bjc.1996.604. PMID: 8932350Free PMC Article
Paclitaxel in the treatment of carcinoma of the esophagus.
Ajani JA, Ilson DH, Daugherty K, Kelsen DP
Semin Oncol 1995 Jun;22(3 Suppl 6):35-40. PMID: 7541155
Improvement in regional ventilation and perfusion after radiotherapy for unresectable carcinoma of the bronchus.
Fazio F, Pratt TA, McKenzie CG, Steiner RE
AJR Am J Roentgenol 1979 Aug;133(2):191-200. doi: 10.2214/ajr.133.2.191. PMID: 222126

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