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EZB diffuse large B-cell lymphoma

MedGen UID:
1653316
Concept ID:
C4725006
Neoplastic Process
Synonym: EZB Diffuse Large B-Cell Lymphoma
 
Monarch Initiative: MONDO:0850469

Definition

A diffuse large B-cell lymphoma molecular subtype characterized by the presence of EZH2 gene mutations and BCL2 gene translocations. Patients who belong in this subtype have a favorable outcome. (NEJM 2018; 378: 1396-407) [from NCI]

Term Hierarchy

Recent clinical studies

Etiology

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Liu J, Wei J, Jiang X, Yu W, Tong H, Jin J, Yan S, Xu W
Leuk Lymphoma 2022 Dec;63(14):3362-3369. Epub 2022 Sep 23 doi: 10.1080/10428194.2022.2126279. PMID: 36148555
Frauenfeld L, Castrejon-de-Anta N, Ramis-Zaldivar JE, Streich S, Salmerón-Villalobos J, Otto F, Mayer AK, Steinhilber J, Pinyol M, Mankel B, Ramsower C, Bonzheim I, Fend F, Rimsza LM, Salaverria I, Campo E, Balagué O, Quintanilla-Martinez L
Blood Adv 2022 Apr 12;6(7):2361-2372. doi: 10.1182/bloodadvances.2021006034. PMID: 34654055Free PMC Article
Pedrosa L, Fernández-Miranda I, Pérez-Callejo D, Quero C, Rodríguez M, Martín-Acosta P, Gómez S, González-Rincón J, Santos A, Tarin C, García JF, García-Arroyo FR, Rueda A, Camacho FI, García-Cosío M, Heredero A, Llanos M, Mollejo M, Piris-Villaespesa M, Gómez-Codina J, Yanguas-Casás N, Sánchez A, Piris MA, Provencio M, Sánchez-Beato M
Sci Rep 2021 Jan 21;11(1):1886. doi: 10.1038/s41598-020-80376-0. PMID: 33479306Free PMC Article
Zhang W, Yang L, Guan YQ, Shen KF, Zhang ML, Cai HD, Wang JC, Wang Y, Huang L, Cao Y, Wang N, Tan XH, Young KH, Xiao M, Zhou JF
BMC Cancer 2020 Jul 31;20(1):714. doi: 10.1186/s12885-020-07198-1. PMID: 32736575Free PMC Article

Diagnosis

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Frauenfeld L, Castrejon-de-Anta N, Ramis-Zaldivar JE, Streich S, Salmerón-Villalobos J, Otto F, Mayer AK, Steinhilber J, Pinyol M, Mankel B, Ramsower C, Bonzheim I, Fend F, Rimsza LM, Salaverria I, Campo E, Balagué O, Quintanilla-Martinez L
Blood Adv 2022 Apr 12;6(7):2361-2372. doi: 10.1182/bloodadvances.2021006034. PMID: 34654055Free PMC Article
Pedrosa L, Fernández-Miranda I, Pérez-Callejo D, Quero C, Rodríguez M, Martín-Acosta P, Gómez S, González-Rincón J, Santos A, Tarin C, García JF, García-Arroyo FR, Rueda A, Camacho FI, García-Cosío M, Heredero A, Llanos M, Mollejo M, Piris-Villaespesa M, Gómez-Codina J, Yanguas-Casás N, Sánchez A, Piris MA, Provencio M, Sánchez-Beato M
Sci Rep 2021 Jan 21;11(1):1886. doi: 10.1038/s41598-020-80376-0. PMID: 33479306Free PMC Article

Therapy

Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Xu-Monette ZY, Wei L, Fang X, Au Q, Nunns H, Nagy M, Tzankov A, Zhu F, Visco C, Bhagat G, Dybkaer K, Chiu A, Tam W, Zu Y, Hsi ED, Hagemeister FB, Sun X, Han X, Go H, Ponzoni M, Ferreri AJM, Møller MB, Parsons BM, van Krieken JH, Piris MA, Winter JN, Li Y, Xu B, Albitar M, You H, Young KH
Clin Cancer Res 2022 Mar 1;28(5):972-983. doi: 10.1158/1078-0432.CCR-21-2949. PMID: 34980601Free PMC Article
Pedrosa L, Fernández-Miranda I, Pérez-Callejo D, Quero C, Rodríguez M, Martín-Acosta P, Gómez S, González-Rincón J, Santos A, Tarin C, García JF, García-Arroyo FR, Rueda A, Camacho FI, García-Cosío M, Heredero A, Llanos M, Mollejo M, Piris-Villaespesa M, Gómez-Codina J, Yanguas-Casás N, Sánchez A, Piris MA, Provencio M, Sánchez-Beato M
Sci Rep 2021 Jan 21;11(1):1886. doi: 10.1038/s41598-020-80376-0. PMID: 33479306Free PMC Article
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article

Prognosis

Ivanova VS, Davies J, Menter T, Wild D, Müller A, Krasniqi F, Stenner F, Papachristofilou A, Dirnhofer S, Tzankov A
Histopathology 2024 Feb;84(3):525-538. Epub 2023 Nov 15 doi: 10.1111/his.15096. PMID: 37965677
Shen R, Fu D, Dong L, Zhang MC, Shi Q, Shi ZY, Cheng S, Wang L, Xu PP, Zhao WL
Signal Transduct Target Ther 2023 Apr 10;8(1):145. doi: 10.1038/s41392-023-01358-y. PMID: 37032379Free PMC Article
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Künstner A, Witte HM, Riedl J, Bernard V, Stölting S, Merz H, Olschewski V, Peter W, Ketzer J, Busch Y, Trojok P, Bubnoff NV, Busch H, Feller AC, Gebauer N
Haematologica 2022 Aug 1;107(8):1850-1863. doi: 10.3324/haematol.2021.279631. PMID: 34788985Free PMC Article
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM
N Engl J Med 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966Free PMC Article

Clinical prediction guides

Cao B, Sun C, Bi R, Liu Z, Jia Y, Cui W, Sun M, Yu B, Li X, Zhou X
BMC Med Genomics 2024 Apr 13;17(1):84. doi: 10.1186/s12920-024-01866-y. PMID: 38609996Free PMC Article
Wang Y, Shi Q, Shi ZY, Tian S, Zhang MC, Shen R, Fu D, Dong L, Yi HM, Ouyang BS, Mu RJ, Cheng S, Wang L, Xu PP, Zhao WL
Blood Adv 2024 Apr 9;8(7):1587-1599. doi: 10.1182/bloodadvances.2023011425. PMID: 38170757Free PMC Article
Gasljevic G, Boltezar L, Novakovic S, Setrajcic-Dragos V, Jezersek-Novakovic B, Kloboves-Prevodnik V
Radiol Oncol 2023 Jun 1;57(2):249-256. Epub 2023 Mar 21 doi: 10.2478/raon-2023-0016. PMID: 36942468Free PMC Article
Künstner A, Witte HM, Riedl J, Bernard V, Stölting S, Merz H, Olschewski V, Peter W, Ketzer J, Busch Y, Trojok P, Bubnoff NV, Busch H, Feller AC, Gebauer N
Haematologica 2022 Aug 1;107(8):1850-1863. doi: 10.3324/haematol.2021.279631. PMID: 34788985Free PMC Article
Song JY, Perry AM, Herrera AF, Chen L, Skrabek P, Nasr MR, Ottesen RA, Nikowitz J, Bedell V, Murata-Collins J, Li Y, McCarthy C, Pillai R, Wang J, Wu X, Zain J, Popplewell L, Kwak LW, Nademanee AP, Niland JC, Scott DW, Gong Q, Chan WC, Weisenburger DD
Clin Cancer Res 2021 Mar 15;27(6):1671-1680. Epub 2021 Jan 7 doi: 10.1158/1078-0432.CCR-20-2378. PMID: 33414134Free PMC Article

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