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Metastatic Bladder Urothelial Carcinoma

MedGen UID:
1653371
•Concept ID:
C4725793
•
Neoplastic Process

Definition

Bladder urothelial carcinoma that has spread to another anatomical site. [from NCI]

Professional guidelines

PubMed

Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience.
Guercio BJ, Sarfaty M, Teo MY, Ratna N, Duzgol C, Funt SA, Lee CH, Aggen DH, Regazzi AM, Chen Z, Lattanzi M, Al-Ahmadie HA, Brannon AR, Shah R, Chu C, Lenis AT, Pietzak E, Bochner BH, Berger MF, Solit DB, Rosenberg JE, Bajorin DF, Iyer G
Clin Cancer Res 2023 Nov 14;29(22):4586-4595. doi: 10.1158/1078-0432.CCR-23-1283. PMID: 37682528
Efficacy and toxicity of antibody-drug conjugates in the treatment of metastatic urothelial cancer: A scoping review.
Padua TC, Moschini M, Martini A, Pederzoli F, Nocera L, Marandino L, Raggi D, Briganti A, Montorsi F, Necchi A
Urol Oncol 2022 Oct;40(10):413-423. Epub 2022 Aug 13 doi: 10.1016/j.urolonc.2022.07.006. PMID: 35973928
Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.
Flaig TW, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Chang S, Downs TM, Efstathiou JA, Friedlander T, Greenberg RE, Guru KA, Guzzo T, Herr HW, Hoffman-Censits J, Hoimes C, Inman BA, Jimbo M, Kader AK, Lele SM, Michalski J, Montgomery JS, Nandagopal L, Pagliaro LC, Pal SK, Patterson A, Plimack ER, Pohar KS, Preston MA, Sexton WJ, Siefker-Radtke AO, Tward J, Wright JL, Gurski LA, Johnson-Chilla A
J Natl Compr Canc Netw 2020 Mar;18(3):329-354. doi: 10.6004/jnccn.2020.0011. PMID: 32135513

Recent clinical studies

Etiology

Anti-PD-L1 monoclonal antibody for the management of chronic disseminated intravascular coagulation secondary to a urothelial carcinoma: a case report.
Maiorano S, Gulden-Sala W, Gerber B, Ghilardi G
J Med Case Rep 2022 Mar 21;16(1):113. doi: 10.1186/s13256-022-03338-2. PMID: 35307010Free PMC Article
Female, Black, and Unmarried Patients Are More Likely to Present With Metastatic Bladder Urothelial Carcinoma.
Klaassen Z, DiBianco JM, Jen RP, Evans AJ, Reinstatler L, Terris MK, Madi R
Clin Genitourin Cancer 2016 Oct;14(5):e489-e492. Epub 2016 Apr 29 doi: 10.1016/j.clgc.2016.04.006. PMID: 27212042
Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer.
Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD
Clin Genitourin Cancer 2012 Mar;10(1):15-20. Epub 2011 Nov 29 doi: 10.1016/j.clgc.2011.10.004. PMID: 22130294

Diagnosis

Anti-PD-L1 monoclonal antibody for the management of chronic disseminated intravascular coagulation secondary to a urothelial carcinoma: a case report.
Maiorano S, Gulden-Sala W, Gerber B, Ghilardi G
J Med Case Rep 2022 Mar 21;16(1):113. doi: 10.1186/s13256-022-03338-2. PMID: 35307010Free PMC Article
Female, Black, and Unmarried Patients Are More Likely to Present With Metastatic Bladder Urothelial Carcinoma.
Klaassen Z, DiBianco JM, Jen RP, Evans AJ, Reinstatler L, Terris MK, Madi R
Clin Genitourin Cancer 2016 Oct;14(5):e489-e492. Epub 2016 Apr 29 doi: 10.1016/j.clgc.2016.04.006. PMID: 27212042
Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer.
Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD
Clin Genitourin Cancer 2012 Mar;10(1):15-20. Epub 2011 Nov 29 doi: 10.1016/j.clgc.2011.10.004. PMID: 22130294

Therapy

Anti-PD-L1 monoclonal antibody for the management of chronic disseminated intravascular coagulation secondary to a urothelial carcinoma: a case report.
Maiorano S, Gulden-Sala W, Gerber B, Ghilardi G
J Med Case Rep 2022 Mar 21;16(1):113. doi: 10.1186/s13256-022-03338-2. PMID: 35307010Free PMC Article
The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study.
Kuo KL, Liu SH, Lin WC, Chow PM, Chang YW, Yang SP, Shi CS, Hsu CH, Liao SM, Chang HC, Huang KH
Cells 2019 Oct 17;8(10) doi: 10.3390/cells8101268. PMID: 31627336Free PMC Article
Trifluoperazine, an Antipsychotic Drug, Effectively Reduces Drug Resistance in Cisplatin-Resistant Urothelial Carcinoma Cells via Suppressing Bcl-xL: An In Vitro and In Vivo Study.
Kuo KL, Liu SH, Lin WC, Hsu FS, Chow PM, Chang YW, Yang SP, Shi CS, Hsu CH, Liao SM, Chang HC, Huang KH
Int J Mol Sci 2019 Jun 30;20(13) doi: 10.3390/ijms20133218. PMID: 31262032Free PMC Article
Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer.
Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD
Clin Genitourin Cancer 2012 Mar;10(1):15-20. Epub 2011 Nov 29 doi: 10.1016/j.clgc.2011.10.004. PMID: 22130294

Prognosis

Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer.
Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD
Clin Genitourin Cancer 2012 Mar;10(1):15-20. Epub 2011 Nov 29 doi: 10.1016/j.clgc.2011.10.004. PMID: 22130294
Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors.
Jimenez RE, Hussain M, Bianco FJ Jr, Vaishampayan U, Tabazcka P, Sakr WA, Pontes JE, Wood DP Jr, Grignon DJ
Clin Cancer Res 2001 Aug;7(8):2440-7. PMID: 11489824

Clinical prediction guides

MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma.
Ho IL, Kuo KL, Liu SH, Chang HC, Hsieh JT, Wu JT, Chiang CK, Lin WC, Tsai YC, Chou CT, Hsu CH, Pu YS, Shi CS, Huang KH
Sci Rep 2015 Nov 23;5:16948. doi: 10.1038/srep16948. PMID: 26592553Free PMC Article
Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer.
Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD
Clin Genitourin Cancer 2012 Mar;10(1):15-20. Epub 2011 Nov 29 doi: 10.1016/j.clgc.2011.10.004. PMID: 22130294
Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors.
Jimenez RE, Hussain M, Bianco FJ Jr, Vaishampayan U, Tabazcka P, Sakr WA, Pontes JE, Wood DP Jr, Grignon DJ
Clin Cancer Res 2001 Aug;7(8):2440-7. PMID: 11489824

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