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Refractory Nasopharyngeal Carcinoma

MedGen UID:
1653446
•Concept ID:
C4725030
•
Neoplastic Process

Definition

Nasopharyngeal carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Nasopharyngeal Carcinoma

Professional guidelines

PubMed

The Role of Reed-Sternberg CD30 Receptor and Lymphocytes in Pathogenesis of Disease and Its Implication for Treatment.
Rinaldi I
Acta Med Indones 2018 Apr;50(2):93-95. PMID: 29950526
Long-term treatment outcomes of juvenile nasopharyngeal angiofibroma treated with radiotherapy.
Mallick S, Benson R, Bhasker S, Mohanti BK
Acta Otorhinolaryngol Ital 2015 Apr;35(2):75-9. PMID: 26019389Free PMC Article
Photodynamic therapy in management of head and neck cancers and precancerous lesions.
Kulapaditharom B, Boonkitticharoen V
J Med Assoc Thai 2000 Mar;83(3):249-58. PMID: 10808679

Recent clinical studies

Etiology

Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma.
Chi KH, Myers JN, Chow KC, Chan WK, Tsang YW, Chao Y, Yen SH, Lotze MT
Oncology 2001;60(2):110-5. doi: 10.1159/000055306. PMID: 11244324

Diagnosis

Recombined humanized endostatin (Endostar) intravenous infusion in the treatment of refractory nasopharyngeal carcinoma: Three case reports.
Chen C, Liu SR, Zhou S, Li XH, Wang XH, Tao YL, Chang H, Zhang WW, Li WF, Zhou SL, Xia YF
Medicine (Baltimore) 2019 Aug;98(32):e16592. doi: 10.1097/MD.0000000000016592. PMID: 31393358Free PMC Article

Therapy

Apatinib, a novel VEGFR-2 tyrosine kinase inhibitor, for relapsed and refractory nasopharyngeal carcinoma: data from an open-label, single-arm, exploratory study.
Li L, Kong F, Zhang L, Li X, Fu X, Wang X, Wu J, Zhang F, Ren L, Zhang M
Invest New Drugs 2020 Dec;38(6):1847-1853. Epub 2020 May 3 doi: 10.1007/s10637-020-00925-2. PMID: 32363427Free PMC Article
Recombined humanized endostatin (Endostar) intravenous infusion in the treatment of refractory nasopharyngeal carcinoma: Three case reports.
Chen C, Liu SR, Zhou S, Li XH, Wang XH, Tao YL, Chang H, Zhang WW, Li WF, Zhou SL, Xia YF
Medicine (Baltimore) 2019 Aug;98(32):e16592. doi: 10.1097/MD.0000000000016592. PMID: 31393358Free PMC Article
Refractory nasopharyngeal carcinoma: positron emission tomography combined with computed tomography-guided 125I seed implantation therapy after repeated traditional radiochemotherapy.
Zhang F, Wu K, Gao F, Zhang W, Shi F, Li C
Otolaryngol Head Neck Surg 2013 Sep;149(3):417-23. Epub 2013 May 28 doi: 10.1177/0194599813491221. PMID: 23715683
A pharmacokinetic and safety study of single dose intravenous combretastatin A4 phosphate in Chinese patients with refractory solid tumours.
He X, Li S, Huang H, Li Z, Chen L, Ye S, Huang J, Zhan J, Lin T
Br J Clin Pharmacol 2011 Jun;71(6):860-70. doi: 10.1111/j.1365-2125.2011.03928.x. PMID: 21276042Free PMC Article
Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma.
Chi KH, Myers JN, Chow KC, Chan WK, Tsang YW, Chao Y, Yen SH, Lotze MT
Oncology 2001;60(2):110-5. doi: 10.1159/000055306. PMID: 11244324

Prognosis

Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma.
Chi KH, Myers JN, Chow KC, Chan WK, Tsang YW, Chao Y, Yen SH, Lotze MT
Oncology 2001;60(2):110-5. doi: 10.1159/000055306. PMID: 11244324

Clinical prediction guides

Refractory nasopharyngeal carcinoma: positron emission tomography combined with computed tomography-guided 125I seed implantation therapy after repeated traditional radiochemotherapy.
Zhang F, Wu K, Gao F, Zhang W, Shi F, Li C
Otolaryngol Head Neck Surg 2013 Sep;149(3):417-23. Epub 2013 May 28 doi: 10.1177/0194599813491221. PMID: 23715683
A pharmacokinetic and safety study of single dose intravenous combretastatin A4 phosphate in Chinese patients with refractory solid tumours.
He X, Li S, Huang H, Li Z, Chen L, Ye S, Huang J, Zhan J, Lin T
Br J Clin Pharmacol 2011 Jun;71(6):860-70. doi: 10.1111/j.1365-2125.2011.03928.x. PMID: 21276042Free PMC Article
Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma.
Chi KH, Myers JN, Chow KC, Chan WK, Tsang YW, Chao Y, Yen SH, Lotze MT
Oncology 2001;60(2):110-5. doi: 10.1159/000055306. PMID: 11244324

Supplemental Content

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