U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Moderate Hepatic Insufficiency

MedGen UID:
1653680
Concept ID:
C4725020
Disease or Syndrome
Synonym: Moderate Hepatic Impairment

Definition

Findings indicating moderate impairment of liver function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerate Hepatic Insufficiency

Professional guidelines

PubMed

Heidari S, Khalili H
Eur J Clin Pharmacol 2023 Feb;79(2):195-206. Epub 2022 Dec 24 doi: 10.1007/s00228-022-03446-4. PMID: 36565357
Cook AM, Morgan Jones G, Hawryluk GWJ, Mailloux P, McLaughlin D, Papangelou A, Samuel S, Tokumaru S, Venkatasubramanian C, Zacko C, Zimmermann LL, Hirsch K, Shutter L
Neurocrit Care 2020 Jun;32(3):647-666. doi: 10.1007/s12028-020-00959-7. PMID: 32227294Free PMC Article
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Recent clinical studies

Etiology

Cai L, Ke M, Wang H, Wu W, Lin R, Huang P, Lin C
Arch Toxicol 2023 Oct;97(10):2659-2673. Epub 2023 Aug 12 doi: 10.1007/s00204-023-03576-3. PMID: 37572130
Lauring B, Li XS, Liu Y, Corr C, Lazarus N, Cote J, Larson P, Levonas AO, Lasseter KC, Preston RA, Smith WB, Lai E, Wagner JA
J Clin Pharmacol 2014 Nov;54(11):1247-55. Epub 2014 Jun 6 doi: 10.1002/jcph.320. PMID: 24782116
Cawello W, Fichtner A, Boekens H, Braun M
Eur J Drug Metab Pharmacokinet 2014 Sep;39(3):155-63. Epub 2013 Sep 20 doi: 10.1007/s13318-013-0153-x. PMID: 24052490
Iwamoto M, Hanley WD, Petry AS, Friedman EJ, Kost JT, Breidinger SA, Lasseter KC, Robson R, Lunde NM, Wenning LA, Stone JA, Wagner JA
Antimicrob Agents Chemother 2009 May;53(5):1747-52. Epub 2009 Feb 17 doi: 10.1128/AAC.01194-08. PMID: 19223645Free PMC Article
Carr RA, André AK, Chen P, Grabowski BA, Chang MS, Locke CS, Williams LA, Chojkier M
Nephron Clin Pract 2006;103(3):c100-5. Epub 2006 Mar 13 doi: 10.1159/000092018. PMID: 16534233

Diagnosis

Cawello W, Fichtner A, Boekens H, Braun M
Eur J Drug Metab Pharmacokinet 2014 Sep;39(3):155-63. Epub 2013 Sep 20 doi: 10.1007/s13318-013-0153-x. PMID: 24052490
Kalbag J, Yeh CM, Milosavljev S, Lasseter K, Oberstein S, Rordorf C
Pharmacol Res 2004 Aug;50(2):181-6. doi: 10.1016/j.phrs.2004.03.002. PMID: 15177307

Therapy

Lauring B, Li XS, Liu Y, Corr C, Lazarus N, Cote J, Larson P, Levonas AO, Lasseter KC, Preston RA, Smith WB, Lai E, Wagner JA
J Clin Pharmacol 2014 Nov;54(11):1247-55. Epub 2014 Jun 6 doi: 10.1002/jcph.320. PMID: 24782116
Migoya EM, Stevens CH, Bergman AJ, Luo WL, Lasseter KC, Dilzer SC, Davies MJ, Wagner JA, Herman GA
Can J Clin Pharmacol 2009 Winter;16(1):e165-70. Epub 2009 Feb 16 PMID: 19221403
Carr RA, André AK, Chen P, Grabowski BA, Chang MS, Locke CS, Williams LA, Chojkier M
Nephron Clin Pract 2006;103(3):c100-5. Epub 2006 Mar 13 doi: 10.1159/000092018. PMID: 16534233
Stone EA, Fung HB, Kirschenbaum HL
Clin Ther 2002 Mar;24(3):351-77; discussion 329. doi: 10.1016/s0149-2918(02)85039-1. PMID: 11952021
Muijsers RB, Jarvis B
Drugs 2002;62(6):967-73; discussion 974-5. doi: 10.2165/00003495-200262060-00008. PMID: 11929342

Prognosis

Cai L, Ke M, Wang H, Wu W, Lin R, Huang P, Lin C
Arch Toxicol 2023 Oct;97(10):2659-2673. Epub 2023 Aug 12 doi: 10.1007/s00204-023-03576-3. PMID: 37572130

Clinical prediction guides

Cai L, Ke M, Wang H, Wu W, Lin R, Huang P, Lin C
Arch Toxicol 2023 Oct;97(10):2659-2673. Epub 2023 Aug 12 doi: 10.1007/s00204-023-03576-3. PMID: 37572130
Cawello W, Fichtner A, Boekens H, Braun M
Eur J Drug Metab Pharmacokinet 2014 Sep;39(3):155-63. Epub 2013 Sep 20 doi: 10.1007/s13318-013-0153-x. PMID: 24052490
Migoya EM, Stevens CH, Bergman AJ, Luo WL, Lasseter KC, Dilzer SC, Davies MJ, Wagner JA, Herman GA
Can J Clin Pharmacol 2009 Winter;16(1):e165-70. Epub 2009 Feb 16 PMID: 19221403
Brousil JA, Burke JM
Clin Ther 2003 Apr;25(4):1041-55. doi: 10.1016/s0149-2918(03)80066-8. PMID: 12809956
Stone EA, Fung HB, Kirschenbaum HL
Clin Ther 2002 Mar;24(3):351-77; discussion 329. doi: 10.1016/s0149-2918(02)85039-1. PMID: 11952021

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...