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Metastatic Triple-Negative Breast Carcinoma

MedGen UID:
1654154
•Concept ID:
C4727787
•
Neoplastic Process

Definition

A triple-negative breast carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Triple-Negative Breast Carcinoma

Professional guidelines

PubMed

Triple-negative breast cancer molecular subtyping and treatment progress.
Yin L, Duan JJ, Bian XW, Yu SC
Breast Cancer Res 2020 Jun 9;22(1):61. doi: 10.1186/s13058-020-01296-5. PMID: 32517735Free PMC Article
Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment.
Garrido-Castro AC, Lin NU, Polyak K
Cancer Discov 2019 Feb;9(2):176-198. Epub 2019 Jan 24 doi: 10.1158/2159-8290.CD-18-1177. PMID: 30679171Free PMC Article
Breast Cancer Treatment: A Review.
Waks AG, Winer EP
JAMA 2019 Jan 22;321(3):288-300. doi: 10.1001/jama.2018.19323. PMID: 30667505

Recent clinical studies

Etiology

Synthesis, Structure and Cytotoxicity of N,N and N,O-Coordinated Ru(II) Complexes of 3-Aminobenzoate Schiff Bases against Triple-negative Breast Cancer.
Mukherjee A, Koley TS, Chakraborty A, Purkait K, Mukherjee A
Chem Asian J 2021 Nov 15;16(22):3729-3742. Epub 2021 Oct 11 doi: 10.1002/asia.202100917. PMID: 34549886

Diagnosis

Metastatic triple-negative breast carcinoma mimicking melanoma: A potential diagnostic pitfall.
Fliorent R, Benedetto C, Theroux Z
J Cutan Pathol 2024 Sep;51(9):654-657. Epub 2024 May 20 doi: 10.1111/cup.14658. PMID: 38767140
A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma.
Tavares MC, Sampaio CD, Lima GE, Andrade VP, Gonçalves DG, Macedo MP, Cordeiro de Lima VC
BMC Cancer 2021 Aug 6;21(1):901. doi: 10.1186/s12885-021-08636-4. PMID: 34362334Free PMC Article
Clinical and pathologic features associated with PD-L1 (SP142) expression in stromal tumor-infiltrating immune cells of triple-negative breast carcinoma.
Hoda RS, Brogi E, Dos Anjos CH, Grabenstetter A, Ventura K, Patil S, Selenica P, Weigelt B, Reis-Filho JS, Traina T, Robson M, Norton L, Wen HY
Mod Pathol 2020 Nov;33(11):2221-2232. Epub 2020 Jul 1 doi: 10.1038/s41379-020-0606-0. PMID: 32612248Free PMC Article
Can we cure stage IV triple-negative breast carcinoma?: Another case report of long-term survival (7 years).
Chue BM, La Course BD
Medicine (Baltimore) 2019 Sep;98(38):e17251. doi: 10.1097/MD.0000000000017251. PMID: 31567994Free PMC Article
Case report of long-term survival with metastatic triple-negative breast carcinoma: Treatment possibilities for metastatic disease.
Chue BM, La Course BD
Medicine (Baltimore) 2019 Apr;98(16):e15302. doi: 10.1097/MD.0000000000015302. PMID: 31008982Free PMC Article

Therapy

Case report of long-term survival with metastatic triple-negative breast carcinoma: Treatment possibilities for metastatic disease.
Chue BM, La Course BD
Medicine (Baltimore) 2019 Apr;98(16):e15302. doi: 10.1097/MD.0000000000015302. PMID: 31008982Free PMC Article

Prognosis

Extrauterine epithelioid trophoblastic tumour and its somatic carcinoma mimics: short tandem repeat genotyping meets the diagnostic challenges.
Niu N, Ordulu Z, Burak Z, Buza N, Hui P
Histopathology 2024 Jan;84(2):325-335. Epub 2023 Sep 24 doi: 10.1111/his.15054. PMID: 37743102
Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases.
Voutilainen S, Heikkilä P, Bartkova J, Nevanlinna H, Blomqvist C, Bartek J, Mattson J
BMC Cancer 2022 Dec 12;22(1):1298. doi: 10.1186/s12885-022-10408-7. PMID: 36503417Free PMC Article
A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma.
Tavares MC, Sampaio CD, Lima GE, Andrade VP, Gonçalves DG, Macedo MP, Cordeiro de Lima VC
BMC Cancer 2021 Aug 6;21(1):901. doi: 10.1186/s12885-021-08636-4. PMID: 34362334Free PMC Article
Can we cure stage IV triple-negative breast carcinoma?: Another case report of long-term survival (7 years).
Chue BM, La Course BD
Medicine (Baltimore) 2019 Sep;98(38):e17251. doi: 10.1097/MD.0000000000017251. PMID: 31567994Free PMC Article
Case report of long-term survival with metastatic triple-negative breast carcinoma: Treatment possibilities for metastatic disease.
Chue BM, La Course BD
Medicine (Baltimore) 2019 Apr;98(16):e15302. doi: 10.1097/MD.0000000000015302. PMID: 31008982Free PMC Article

Clinical prediction guides

A high CD8 to FOXP3 ratio in the tumor stroma and expression of PTEN in tumor cells are associated with improved survival in non-metastatic triple-negative breast carcinoma.
Tavares MC, Sampaio CD, Lima GE, Andrade VP, Gonçalves DG, Macedo MP, Cordeiro de Lima VC
BMC Cancer 2021 Aug 6;21(1):901. doi: 10.1186/s12885-021-08636-4. PMID: 34362334Free PMC Article
Significantly increased PELP1 protein expression in primary and metastatic triple-negative breast carcinoma: comparison with GATA3 expression and PELP1's potential role in triple-negative breast carcinoma.
Dang DN, Raj G, Sarode V, Molberg KH, Vadlamudi RK, Peng Y
Hum Pathol 2015 Dec;46(12):1829-35. Epub 2015 Aug 12 doi: 10.1016/j.humpath.2015.07.023. PMID: 26428280

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