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Testicular Follicular Lymphoma

MedGen UID:
1654691
Concept ID:
C4725856
Neoplastic Process

Definition

A distinctive variant of follicular lymphoma arising from the testis. It has been reported with higher frequency in children, but is also seen rarely in adults. It differs biologically from nodal follicular lymphoma because it lacks evidence of the BCL2 translocation. It is usually of high cytological grade, usually grade 3A, but has a good prognosis, even without additional therapy beyond surgical excision. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Follicular Lymphoma

Professional guidelines

PubMed

Lasota J, Nordling S, Miettinen M
Virchows Arch 2000 Mar;436(3):276-83. doi: 10.1007/s004280050041. PMID: 10782887

Recent clinical studies

Etiology

Jaffe ES
Am J Pathol 2023 Dec;193(12):1880-1886. Epub 2023 Sep 19 doi: 10.1016/j.ajpath.2023.08.012. PMID: 37734589Free PMC Article
Cegla P, Scibisz-Dziedzic K, Witkowska K, Kubiak A, Wierzchoslawska E, Kycler W, Chrapko B, Czepczyński R
Nucl Med Rev Cent East Eur 2022;25(1):25-30. doi: 10.5603/NMR.a2022.0006. PMID: 35137934
Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM
Br J Haematol 2005 Oct;131(2):193-200. doi: 10.1111/j.1365-2141.2005.05756.x. PMID: 16197449

Diagnosis

Jaffe ES
Am J Pathol 2023 Dec;193(12):1880-1886. Epub 2023 Sep 19 doi: 10.1016/j.ajpath.2023.08.012. PMID: 37734589Free PMC Article
Laurent C, Cook JR, Yoshino T, Quintanilla-Martinez L, Jaffe ES
Virchows Arch 2023 Jan;482(1):149-162. Epub 2022 Nov 17 doi: 10.1007/s00428-022-03432-2. PMID: 36394631Free PMC Article
Wright DH
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):319-28. Epub 2012 Apr 3 doi: 10.1016/j.clon.2012.02.004. PMID: 22480571
Swerdlow SH
Am J Clin Pathol 2004 Dec;122 Suppl:S98-109. doi: 10.1309/4BKNAKE4D7CT3C1B. PMID: 15690646
Lasota J, Nordling S, Miettinen M
Virchows Arch 2000 Mar;436(3):276-83. doi: 10.1007/s004280050041. PMID: 10782887

Therapy

Nomani AZ, Wazir M, Kashmir SB, Qureshi MS
J Coll Physicians Surg Pak 2014 Mar;24 Suppl 1:S11-3. PMID: 24717988
Wright DH
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):319-28. Epub 2012 Apr 3 doi: 10.1016/j.clon.2012.02.004. PMID: 22480571
Dölken MT, Schüler F, Hirt C, Lorenz G, Hosten N, Dölken G
Leuk Lymphoma 2006 Feb;47(2):369-71. doi: 10.1080/10428190500287687. PMID: 16321874
Jacobsen E, Lomo L, Briccetti F, Longtine J, Freedman A
Leuk Lymphoma 2005 Nov;46(11):1663-6. doi: 10.1080/10428190500178548. PMID: 16236619
Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM
Br J Haematol 2005 Oct;131(2):193-200. doi: 10.1111/j.1365-2141.2005.05756.x. PMID: 16197449

Prognosis

Mansoor A, Akhter A, Hamidi M, Roshan TM, Shabani-Rad MT, Stewart D
Anticancer Res 2023 Nov;43(11):4801-4807. doi: 10.21873/anticanres.16677. PMID: 37909960
Lones MA, Raphael M, McCarthy K, Wotherspoon A, Terrier-Lacombe MJ, Ramsay AD, Maclennan K, Cairo MS, Gerrard M, Michon J, Patte C, Pinkerton R, Sender L, Auperin A, Sposto R, Weston C, Heerema NA, Sanger WG, von Allmen D, Perkins SL
J Pediatr Hematol Oncol 2012 Jan;34(1):68-71. doi: 10.1097/MPH.0b013e31820e4636. PMID: 22215099Free PMC Article
Bacon CM, Ye H, Diss TC, McNamara C, Kueck B, Hasserjian RP, Rohatiner AZ, Ferry J, Du MQ, Dogan A
Am J Surg Pathol 2007 Jul;31(7):1050-8. doi: 10.1097/PAS.0b013e31802ee4ab. PMID: 17592272
Yamane GK
Aviat Space Environ Med 2006 Aug;77(8):789-94. PMID: 16909871
Pileri SA, Sabattini E, Rosito P, Zinzani PL, Ascani S, Fraternali-Orcioni G, Gamberi B, Piccioli M, Vivenza D, Falini B, Gaidano G
J Clin Pathol 2002 Sep;55(9):684-8. doi: 10.1136/jcp.55.9.684. PMID: 12194999Free PMC Article

Clinical prediction guides

Mansoor A, Akhter A, Hamidi M, Roshan TM, Shabani-Rad MT, Stewart D
Anticancer Res 2023 Nov;43(11):4801-4807. doi: 10.21873/anticanres.16677. PMID: 37909960
Oda R, Okuda K, Murase T, Watanabe T, Sakane T, Tatematsu T, Yokota K, Haneda H, Nakanishi R
Thorac Cancer 2019 Jan;10(1):116-119. Epub 2018 Nov 23 doi: 10.1111/1759-7714.12914. PMID: 30467988Free PMC Article
Cheung CW, Burton C, Smith P, Linch DC, Hoskin PJ, Ardeshna KM
Br J Haematol 2005 Oct;131(2):193-200. doi: 10.1111/j.1365-2141.2005.05756.x. PMID: 16197449
Hyland J, Lasota J, Jasinski M, Petersen RO, Nordling S, Miettinen M
Hum Pathol 1998 Nov;29(11):1231-9. doi: 10.1016/s0046-8177(98)90250-7. PMID: 9824100

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