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Resectable Soft Tissue Sarcoma

MedGen UID:
1654952
•Concept ID:
C4727013
•
Neoplastic Process

Definition

Soft tissue sarcoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Soft Tissue Sarcoma

Professional guidelines

PubMed

Management of Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma.
Crago AM, Cardona K, Koseła-Paterczyk H, Rutkowski P
Surg Oncol Clin N Am 2022 Jul;31(3):419-430. doi: 10.1016/j.soc.2022.03.006. PMID: 35715142
Osteosarcoma: A comprehensive review of management and treatment strategies.
Jafari F, Javdansirat S, Sanaie S, Naseri A, Shamekh A, Rostamzadeh D, Dolati S
Ann Diagn Pathol 2020 Dec;49:151654. Epub 2020 Oct 25 doi: 10.1016/j.anndiagpath.2020.151654. PMID: 33130384
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Recent clinical studies

Etiology

External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis.
Albertsmeier M, Rauch A, Roeder F, Hasenhütl S, Pratschke S, Kirschneck M, Gronchi A, Jebsen NL, Cassier PA, Sargos P, Belka C, Lindner LH, Werner J, Angele MK
Ann Surg Oncol 2018 Mar;25(3):754-767. Epub 2017 Sep 11 doi: 10.1245/s10434-017-6081-2. PMID: 28895107
Lower limb function and quality of life after ILP for soft-tissue sarcoma.
Podleska LE, Kaya N, Farzaliyev F, Pöttgen C, Bauer S, Taeger G
World J Surg Oncol 2017 Apr 13;15(1):84. doi: 10.1186/s12957-017-1150-3. PMID: 28403880Free PMC Article
Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy.
Schenone AD, Luo J, Montgomery L, Morgensztern D, Adkins DR, Van Tine BA
Cancer Med 2014 Jun;3(3):603-12. Epub 2014 Feb 27 doi: 10.1002/cam4.209. PMID: 24574357Free PMC Article
Adjuvant therapy for resectable high-risk soft tissue sarcoma: feasibility and efficacy of a sandwich chemoradiotherapy strategy.
Brandts CH, Schulz C, Willich N, Steffen B, Hardes J, Gosheger G, Winkelmann W, Serve H, Heinecke A, Berdel WE, Thomas M
Cancer Chemother Pharmacol 2012 Mar;69(3):613-20. Epub 2011 Sep 24 doi: 10.1007/s00280-011-1731-8. PMID: 21947168
A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma.
Al-Absi E, Farrokhyar F, Sharma R, Whelan K, Corbett T, Patel M, Ghert M
Ann Surg Oncol 2010 May;17(5):1367-74. Epub 2010 Mar 9 doi: 10.1245/s10434-009-0885-7. PMID: 20217260

Diagnosis

Surgery in soft tissue sarcoma: the thin line between a surgical or more conservative approach.
Gronchi A
Future Oncol 2021 Jul;17(21s):3-6. Epub 2021 Jun 10 doi: 10.2217/fon-2021-0449. PMID: 34107729
Treating soft tissue sarcomas with adjuvant chemotherapy.
Patrikidou A, Domont J, Cioffi A, Le Cesne A
Curr Treat Options Oncol 2011 Mar;12(1):21-31. doi: 10.1007/s11864-011-0145-5. PMID: 21384115
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899

Therapy

Lower limb function and quality of life after ILP for soft-tissue sarcoma.
Podleska LE, Kaya N, Farzaliyev F, Pöttgen C, Bauer S, Taeger G
World J Surg Oncol 2017 Apr 13;15(1):84. doi: 10.1186/s12957-017-1150-3. PMID: 28403880Free PMC Article
A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma.
Al-Absi E, Farrokhyar F, Sharma R, Whelan K, Corbett T, Patel M, Ghert M
Ann Surg Oncol 2010 May;17(5):1367-74. Epub 2010 Mar 9 doi: 10.1245/s10434-009-0885-7. PMID: 20217260
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899
Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults.
Sarcoma Meta-analysis Collaboration (SMAC)
Cochrane Database Syst Rev 2000;(4):CD001419. doi: 10.1002/14651858.CD001419. PMID: 11034717
Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults. Sarcoma Meta-analysis Collaboration (SMAC).
Cochrane Database Syst Rev 2000;(2):CD001419. doi: 10.1002/14651858.CD001419. PMID: 10796873

Prognosis

External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis.
Albertsmeier M, Rauch A, Roeder F, Hasenhütl S, Pratschke S, Kirschneck M, Gronchi A, Jebsen NL, Cassier PA, Sargos P, Belka C, Lindner LH, Werner J, Angele MK
Ann Surg Oncol 2018 Mar;25(3):754-767. Epub 2017 Sep 11 doi: 10.1245/s10434-017-6081-2. PMID: 28895107
Lower limb function and quality of life after ILP for soft-tissue sarcoma.
Podleska LE, Kaya N, Farzaliyev F, Pöttgen C, Bauer S, Taeger G
World J Surg Oncol 2017 Apr 13;15(1):84. doi: 10.1186/s12957-017-1150-3. PMID: 28403880Free PMC Article
Implications of Lymph Node Evaluation in the Management of Resectable Soft Tissue Sarcoma.
Ecker BL, Peters MG, McMillan MT, Sinnamon AJ, Zhang PJ, Kelz RR, Roses RE, Drebin JA, Fraker DL, Karakousis GC
Ann Surg Oncol 2017 Feb;24(2):425-433. Epub 2016 Oct 26 doi: 10.1245/s10434-016-5641-1. PMID: 27785659
Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy.
Schenone AD, Luo J, Montgomery L, Morgensztern D, Adkins DR, Van Tine BA
Cancer Med 2014 Jun;3(3):603-12. Epub 2014 Feb 27 doi: 10.1002/cam4.209. PMID: 24574357Free PMC Article
Adjuvant therapy for resectable high-risk soft tissue sarcoma: feasibility and efficacy of a sandwich chemoradiotherapy strategy.
Brandts CH, Schulz C, Willich N, Steffen B, Hardes J, Gosheger G, Winkelmann W, Serve H, Heinecke A, Berdel WE, Thomas M
Cancer Chemother Pharmacol 2012 Mar;69(3):613-20. Epub 2011 Sep 24 doi: 10.1007/s00280-011-1731-8. PMID: 21947168

Clinical prediction guides

Oncologic outcomes of pre- versus post-operative radiation in Resectable soft tissue sarcoma: a systematic review and meta-analysis.
Yang X, Zhang L, Yang X, Yu W, Fu J
Radiat Oncol 2020 Jun 23;15(1):158. doi: 10.1186/s13014-020-01600-9. PMID: 32576267Free PMC Article
Implications of Lymph Node Evaluation in the Management of Resectable Soft Tissue Sarcoma.
Ecker BL, Peters MG, McMillan MT, Sinnamon AJ, Zhang PJ, Kelz RR, Roses RE, Drebin JA, Fraker DL, Karakousis GC
Ann Surg Oncol 2017 Feb;24(2):425-433. Epub 2016 Oct 26 doi: 10.1245/s10434-016-5641-1. PMID: 27785659
Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy.
Schenone AD, Luo J, Montgomery L, Morgensztern D, Adkins DR, Van Tine BA
Cancer Med 2014 Jun;3(3):603-12. Epub 2014 Feb 27 doi: 10.1002/cam4.209. PMID: 24574357Free PMC Article
Adjuvant therapy for resectable high-risk soft tissue sarcoma: feasibility and efficacy of a sandwich chemoradiotherapy strategy.
Brandts CH, Schulz C, Willich N, Steffen B, Hardes J, Gosheger G, Winkelmann W, Serve H, Heinecke A, Berdel WE, Thomas M
Cancer Chemother Pharmacol 2012 Mar;69(3):613-20. Epub 2011 Sep 24 doi: 10.1007/s00280-011-1731-8. PMID: 21947168
Treating soft tissue sarcomas with adjuvant chemotherapy.
Patrikidou A, Domont J, Cioffi A, Le Cesne A
Curr Treat Options Oncol 2011 Mar;12(1):21-31. doi: 10.1007/s11864-011-0145-5. PMID: 21384115

Recent systematic reviews

External Beam Radiation Therapy for Resectable Soft Tissue Sarcoma: A Systematic Review and Meta-Analysis.
Albertsmeier M, Rauch A, Roeder F, Hasenhütl S, Pratschke S, Kirschneck M, Gronchi A, Jebsen NL, Cassier PA, Sargos P, Belka C, Lindner LH, Werner J, Angele MK
Ann Surg Oncol 2018 Mar;25(3):754-767. Epub 2017 Sep 11 doi: 10.1245/s10434-017-6081-2. PMID: 28895107
A systematic review and meta-analysis of oncologic outcomes of pre- versus postoperative radiation in localized resectable soft-tissue sarcoma.
Al-Absi E, Farrokhyar F, Sharma R, Whelan K, Corbett T, Patel M, Ghert M
Ann Surg Oncol 2010 May;17(5):1367-74. Epub 2010 Mar 9 doi: 10.1245/s10434-009-0885-7. PMID: 20217260
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M
Cancer 2008 Aug 1;113(3):573-81. doi: 10.1002/cncr.23592. PMID: 18521899
Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults.
Sarcoma Meta-analysis Collaboration (SMAC)
Cochrane Database Syst Rev 2000;(4):CD001419. doi: 10.1002/14651858.CD001419. PMID: 11034717
Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults. Sarcoma Meta-analysis Collaboration (SMAC).
Cochrane Database Syst Rev 2000;(2):CD001419. doi: 10.1002/14651858.CD001419. PMID: 10796873

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