U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thyroid Gland Follicular Carcinoma, Widely Invasive

MedGen UID:
1655103
•Concept ID:
C4744587
•
Neoplastic Process
Synonym: FTC, Widely Invasive

Definition

A follicular carcinoma of the thyroid gland with extension into surrounding thyroid or extrathyroid tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Carcinoma, Widely Invasive

Professional guidelines

PubMed

Management of follicular thyroid carcinoma should be individualised based on degree of capsular and vascular invasion.
O'Neill CJ, Vaughan L, Learoyd DL, Sidhu SB, Delbridge LW, Sywak MS
Eur J Surg Oncol 2011 Feb;37(2):181-5. Epub 2010 Dec 8 doi: 10.1016/j.ejso.2010.11.005. PMID: 21144693
Therapeutic strategy for differentiated thyroid carcinoma in Japan based on a newly established guideline managed by Japanese Society of Thyroid Surgeons and Japanese Association of Endocrine Surgeons.
Takami H, Ito Y, Okamoto T, Yoshida A
World J Surg 2011 Jan;35(1):111-21. doi: 10.1007/s00268-010-0832-6. PMID: 21042913
Classification and treatment of follicular thyroid neoplasms are discordant between and within medical specialties.
Perrier ND, Ituarte PH, Treseler P, D'Avanzo A, Siperstein A, Duh QY, Clark OH
Surgery 1999 Dec;126(6):1063-8; discussion 1069. doi: 10.1067/msy.2099.101424. PMID: 10598189

Recent clinical studies

Etiology

Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article
Follicular and Hurthle Cell Carcinoma: Comparison of Clinicopathological Features and Clinical Outcomes.
Matsuura D, Yuan A, Wang L, Ranganath R, Adilbay D, Harries V, Patel S, Tuttle M, Xu B, Ghossein R, Ganly I
Thyroid 2022 Mar;32(3):245-254. doi: 10.1089/thy.2021.0424. PMID: 35078345Free PMC Article
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas.
Huang CC, Hsueh C, Liu FH, Chao TC, Lin JD
Surg Oncol 2011 Mar;20(1):1-6. Epub 2009 Jul 10 doi: 10.1016/j.suronc.2009.06.006. PMID: 19596568
Follicular carcinoma.
Franssila KO, Ackerman LV, Brown CL, Hedinger CE
Semin Diagn Pathol 1985 May;2(2):101-22. PMID: 3843689

Diagnosis

Prognostic factors for follicular thyroid carcinoma: the importance of vascular invasion.
Ito Y, Hirokawa M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Sep 28;69(9):1149-1156. Epub 2022 Apr 29 doi: 10.1507/endocrj.EJ22-0077. PMID: 35491160
Ultrasonographic features for differentiating follicular thyroid carcinoma and follicular adenoma.
Kuo TC, Wu MH, Chen KY, Hsieh MS, Chen A, Chen CN
Asian J Surg 2020 Jan;43(1):339-346. Epub 2019 Jun 8 doi: 10.1016/j.asjsur.2019.04.016. PMID: 31182260
Expression and clinicopathological role of miR146a in thyroid follicular carcinoma.
Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G
Endocrine 2019 Jun;64(3):575-583. Epub 2019 Jan 30 doi: 10.1007/s12020-019-01845-9. PMID: 30701447
Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas.
Huang CC, Hsueh C, Liu FH, Chao TC, Lin JD
Surg Oncol 2011 Mar;20(1):1-6. Epub 2009 Jul 10 doi: 10.1016/j.suronc.2009.06.006. PMID: 19596568
Follicular carcinoma.
Franssila KO, Ackerman LV, Brown CL, Hedinger CE
Semin Diagn Pathol 1985 May;2(2):101-22. PMID: 3843689

Therapy

Thick tumor capsule is a valuable risk factor for distant metastasis in follicular thyroid carcinoma.
Shimbashi W, Sugitani I, Kawabata K, Mitani H, Toda K, Yamada K, Sato Y
Auris Nasus Larynx 2018 Feb;45(1):147-155. Epub 2017 May 12 doi: 10.1016/j.anl.2017.05.002. PMID: 28506522
Prognostic factors of minimally invasive follicular thyroid carcinoma: extensive vascular invasion significantly affects patient prognosis.
Ito Y, Hirokawa M, Masuoka H, Yabuta T, Kihara M, Higashiyama T, Takamura Y, Kobayashi K, Miya A, Miyauchi A
Endocr J 2013;60(5):637-42. Epub 2013 Jan 18 doi: 10.1507/endocrj.ej12-0419. PMID: 23327839
Outcomes and prognostic factors of 251 patients with minimally invasive follicular thyroid carcinoma.
Sugino K, Kameyama K, Ito K, Nagahama M, Kitagawa W, Shibuya H, Ohkuwa K, Yano Y, Uruno T, Akaishi J, Suzuki A, Masaki C, Ito K
Thyroid 2012 Aug;22(8):798-804. doi: 10.1089/thy.2012.0051. PMID: 22853727
Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas.
Huang CC, Hsueh C, Liu FH, Chao TC, Lin JD
Surg Oncol 2011 Mar;20(1):1-6. Epub 2009 Jul 10 doi: 10.1016/j.suronc.2009.06.006. PMID: 19596568
Classification and treatment of follicular thyroid neoplasms are discordant between and within medical specialties.
Perrier ND, Ituarte PH, Treseler P, D'Avanzo A, Siperstein A, Duh QY, Clark OH
Surgery 1999 Dec;126(6):1063-8; discussion 1069. doi: 10.1067/msy.2099.101424. PMID: 10598189

Prognosis

Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article
DICER1 Mutations Do Not Always Indicate Dismal Prognosis in Pediatric Poorly Differentiated Thyroid Carcinomas.
Yegen G, Altay AY, Yılmaz İ, İşcan Y, Sormaz İC, Aksakal N, Önder S, Mete Ö
Endocr Pathol 2023 Sep;34(3):279-286. Epub 2023 Aug 14 doi: 10.1007/s12022-023-09780-2. PMID: 37574466
Follicular and Hurthle Cell Carcinoma: Comparison of Clinicopathological Features and Clinical Outcomes.
Matsuura D, Yuan A, Wang L, Ranganath R, Adilbay D, Harries V, Patel S, Tuttle M, Xu B, Ghossein R, Ganly I
Thyroid 2022 Mar;32(3):245-254. doi: 10.1089/thy.2021.0424. PMID: 35078345Free PMC Article
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Follicular carcinoma.
Franssila KO, Ackerman LV, Brown CL, Hedinger CE
Semin Diagn Pathol 1985 May;2(2):101-22. PMID: 3843689

Clinical prediction guides

Prognostic factors for follicular thyroid carcinoma: the importance of vascular invasion.
Ito Y, Hirokawa M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Sep 28;69(9):1149-1156. Epub 2022 Apr 29 doi: 10.1507/endocrj.EJ22-0077. PMID: 35491160
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Prediction of follicular thyroid carcinoma associated with distant metastasis in the preoperative and postoperative model.
Kim H, Shin JH, Hahn SY, Oh YL, Kim SW, Park KW, Lim Y
Head Neck 2019 Aug;41(8):2507-2513. Epub 2019 Mar 19 doi: 10.1002/hed.25721. PMID: 30891875
Expression and clinicopathological role of miR146a in thyroid follicular carcinoma.
Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G
Endocrine 2019 Jun;64(3):575-583. Epub 2019 Jan 30 doi: 10.1007/s12020-019-01845-9. PMID: 30701447
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology.
Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T
J Clin Endocrinol Metab 2018 Jul 1;103(7):2640-2650. doi: 10.1210/jc.2018-00277. PMID: 29726952

Recent systematic reviews

Prevalence of Differentiated High-Grade Thyroid Carcinoma Among Well-Differentiated Tumors: A Systematic Review and Meta-Analysis.
Poma AM, Macerola E, Ghossein RA, Tallini G, Basolo F
Thyroid 2024 Mar;34(3):314-323. doi: 10.1089/thy.2023.0350. PMID: 38115626Free PMC Article
Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...