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Advanced Lymphoma

MedGen UID:
1655589
•Concept ID:
C4727071
•
Neoplastic Process

Definition

Lymphoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Have treatment protocols for primary CNS lymphoma advanced in the past 10 years.
Seidel S, Schlegel U
Expert Rev Anticancer Ther 2019 Oct;19(10):909-915. Epub 2019 Oct 14 doi: 10.1080/14737140.2019.1677157. PMID: 31594423
Who does not receive treatment for cancer?
Ward MM, Ullrich F, Matthews K, Rushton G, Goldstein MA, Bajorin DF, Hanley A, Lynch CF
J Oncol Pract 2013 Jan;9(1):20-6. doi: 10.1200/JOP.2012.000829. PMID: 23633967Free PMC Article
Gallium nitrate in the treatment of lymphoma.
Straus DJ
Semin Oncol 2003 Apr;30(2 Suppl 5):25-33. doi: 10.1016/s0093-7754(03)00173-8. PMID: 12776257

Recent clinical studies

Etiology

CAR γδ T cells for cancer immunotherapy. Is the field more yellow than green?
Ganapathy T, Radhakrishnan R, Sakshi S, Martin S
Cancer Immunol Immunother 2023 Feb;72(2):277-286. Epub 2022 Aug 12 doi: 10.1007/s00262-022-03260-y. PMID: 35960333
90Y-ibritumomab tiuxetan, fludarabine, busulfan and antithymocyte globulin reduced-intensity allogeneic transplant conditioning for patients with advanced and high-risk B-cell lymphomas.
Bouabdallah K, Furst S, Asselineau J, Chevalier P, Tournilhac O, Ceballos P, Vigouroux S, Tabrizi R, Doussau A, Bouabdallah R, Mohty M, Le Gouill S, Blaise D, Milpied N
Ann Oncol 2015 Jan;26(1):193-198. Epub 2014 Oct 30 doi: 10.1093/annonc/mdu503. PMID: 25361987
Nonmyeloablative conditioning, unmanipulated haploidentical SCT and post-infusion CY for advanced lymphomas.
Castagna L, Bramanti S, Furst S, Giordano L, Crocchiolo R, Sarina B, Mauro E, Morabito L, Bouabdallah R, Coso D, Balzarotti M, Broussais F, El-Cheikh J, Stella CC, Brusamolino E, Blaise D, Santoro A
Bone Marrow Transplant 2014 Dec;49(12):1475-80. Epub 2014 Sep 15 doi: 10.1038/bmt.2014.197. PMID: 25222502
Histology and time to progression predict survival for lymphoma recurring after reduced-intensity conditioning and allogeneic hematopoietic cell transplantation.
Ram R, Gooley TA, Maloney DG, Press OW, Pagel JM, Petersdorf SH, Shustov AR, Flowers ME, O'Donnell P, Sandmaier BM, Storb RF, Gopal AK
Biol Blood Marrow Transplant 2011 Oct;17(10):1537-45. Epub 2011 Apr 12 doi: 10.1016/j.bbmt.2011.03.010. PMID: 21536145Free PMC Article
Autotransplantation for advanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy.
Rapoport AP, Meisenberg B, Sarkodee-Adoo C, Fassas A, Frankel SR, Mookerjee B, Takebe N, Fenton R, Heyman M, Badros A, Kennedy A, Jacobs M, Hudes R, Ruehle K, Smith R, Kight L, Chambers S, MacFadden M, Cottler-Fox M, Chen T, Phillips G, Tricot G
Bone Marrow Transplant 2002 Feb;29(4):303-12. doi: 10.1038/sj.bmt.1703363. PMID: 11896427Free PMC Article

Diagnosis

CAR γδ T cells for cancer immunotherapy. Is the field more yellow than green?
Ganapathy T, Radhakrishnan R, Sakshi S, Martin S
Cancer Immunol Immunother 2023 Feb;72(2):277-286. Epub 2022 Aug 12 doi: 10.1007/s00262-022-03260-y. PMID: 35960333
Jejunocolic fistula presenting as chronic diarrhoea from advanced lymphoma.
Velasco RN Jr, Ando MM, Babaran HM, Manuntag MCC, Sacdalan DL
BMJ Case Rep 2022 Mar 3;15(3) doi: 10.1136/bcr-2021-245495. PMID: 35241445Free PMC Article
Outcomes of Haploidentical Stem Cell Transplantation for Lymphoma with Melphalan-Based Conditioning.
Brammer JE, Khouri I, Gaballa S, Anderlini P, Tomuleasa C, Ahmed S, Ledesma C, Hosing C, Champlin RE, Ciurea SO
Biol Blood Marrow Transplant 2016 Mar;22(3):493-8. Epub 2015 Oct 20 doi: 10.1016/j.bbmt.2015.10.015. PMID: 26497906
Histology and time to progression predict survival for lymphoma recurring after reduced-intensity conditioning and allogeneic hematopoietic cell transplantation.
Ram R, Gooley TA, Maloney DG, Press OW, Pagel JM, Petersdorf SH, Shustov AR, Flowers ME, O'Donnell P, Sandmaier BM, Storb RF, Gopal AK
Biol Blood Marrow Transplant 2011 Oct;17(10):1537-45. Epub 2011 Apr 12 doi: 10.1016/j.bbmt.2011.03.010. PMID: 21536145Free PMC Article
Lymphoma metastasizing to the pituitary: an unusual presentation of a treatable disease.
Megan Ogilvie C, Payne S, Evanson J, Lister TA, Grossman AB
Pituitary 2005;8(2):139-46. doi: 10.1007/s11102-005-4535-1. PMID: 16379034

Therapy

Antibody-Drug Conjugates: A Clinical Pharmacy Perspective on an Emerging Cancer Therapy.
Jerjian TV, Glode AE, Thompson LA, O'Bryant CL
Pharmacotherapy 2016 Jan;36(1):99-116. doi: 10.1002/phar.1687. PMID: 26799352
Gallium nitrate in the treatment of lymphoma.
Straus DJ
Semin Oncol 2003 Apr;30(2 Suppl 5):25-33. doi: 10.1016/s0093-7754(03)00173-8. PMID: 12776257
Gallium nitrate revisited.
Chitambar CR
Semin Oncol 2003 Apr;30(2 Suppl 5):1-4. doi: 10.1016/s0093-7754(03)00169-6. PMID: 12776253
Autotransplantation for advanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy.
Rapoport AP, Meisenberg B, Sarkodee-Adoo C, Fassas A, Frankel SR, Mookerjee B, Takebe N, Fenton R, Heyman M, Badros A, Kennedy A, Jacobs M, Hudes R, Ruehle K, Smith R, Kight L, Chambers S, MacFadden M, Cottler-Fox M, Chen T, Phillips G, Tricot G
Bone Marrow Transplant 2002 Feb;29(4):303-12. doi: 10.1038/sj.bmt.1703363. PMID: 11896427Free PMC Article
Bexarotene and DAB(389)IL-2 (denileukin diftitox, ONTAK) in treatment of cutaneous T-cell lymphomas: algorithms.
Duvic M
Clin Lymphoma 2000 Nov;1 Suppl 1:S51-5. doi: 10.3816/clm.2000.s.010. PMID: 11707865

Prognosis

Illness Understanding and Advance Care Planning in Patients with Advanced Lymphoma.
Trevino KM, Rutherford SC, Marte C, Ouyang DJ, Martin P, Prigerson HG, Leonard JP
J Palliat Med 2020 Jun;23(6):832-837. Epub 2019 Oct 18 doi: 10.1089/jpm.2019.0311. PMID: 31633432Free PMC Article
Nonmyeloablative conditioning, unmanipulated haploidentical SCT and post-infusion CY for advanced lymphomas.
Castagna L, Bramanti S, Furst S, Giordano L, Crocchiolo R, Sarina B, Mauro E, Morabito L, Bouabdallah R, Coso D, Balzarotti M, Broussais F, El-Cheikh J, Stella CC, Brusamolino E, Blaise D, Santoro A
Bone Marrow Transplant 2014 Dec;49(12):1475-80. Epub 2014 Sep 15 doi: 10.1038/bmt.2014.197. PMID: 25222502
Histology and time to progression predict survival for lymphoma recurring after reduced-intensity conditioning and allogeneic hematopoietic cell transplantation.
Ram R, Gooley TA, Maloney DG, Press OW, Pagel JM, Petersdorf SH, Shustov AR, Flowers ME, O'Donnell P, Sandmaier BM, Storb RF, Gopal AK
Biol Blood Marrow Transplant 2011 Oct;17(10):1537-45. Epub 2011 Apr 12 doi: 10.1016/j.bbmt.2011.03.010. PMID: 21536145Free PMC Article
Autotransplantation for advanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy.
Rapoport AP, Meisenberg B, Sarkodee-Adoo C, Fassas A, Frankel SR, Mookerjee B, Takebe N, Fenton R, Heyman M, Badros A, Kennedy A, Jacobs M, Hudes R, Ruehle K, Smith R, Kight L, Chambers S, MacFadden M, Cottler-Fox M, Chen T, Phillips G, Tricot G
Bone Marrow Transplant 2002 Feb;29(4):303-12. doi: 10.1038/sj.bmt.1703363. PMID: 11896427Free PMC Article
Bexarotene and DAB(389)IL-2 (denileukin diftitox, ONTAK) in treatment of cutaneous T-cell lymphomas: algorithms.
Duvic M
Clin Lymphoma 2000 Nov;1 Suppl 1:S51-5. doi: 10.3816/clm.2000.s.010. PMID: 11707865

Clinical prediction guides

Illness Understanding and Advance Care Planning in Patients with Advanced Lymphoma.
Trevino KM, Rutherford SC, Marte C, Ouyang DJ, Martin P, Prigerson HG, Leonard JP
J Palliat Med 2020 Jun;23(6):832-837. Epub 2019 Oct 18 doi: 10.1089/jpm.2019.0311. PMID: 31633432Free PMC Article
Phase IA/II, multicentre, open-label study of the CD40 antagonistic monoclonal antibody lucatumumab in adult patients with advanced non-Hodgkin or Hodgkin lymphoma.
Fanale M, Assouline S, Kuruvilla J, Solal-Céligny P, Heo DS, Verhoef G, Corradini P, Abramson JS, Offner F, Engert A, Dyer MJ, Carreon D, Ewald B, Baeck J, Younes A, Freedman AS
Br J Haematol 2014 Jan;164(2):258-65. Epub 2013 Nov 13 doi: 10.1111/bjh.12630. PMID: 24219359Free PMC Article
Histology and time to progression predict survival for lymphoma recurring after reduced-intensity conditioning and allogeneic hematopoietic cell transplantation.
Ram R, Gooley TA, Maloney DG, Press OW, Pagel JM, Petersdorf SH, Shustov AR, Flowers ME, O'Donnell P, Sandmaier BM, Storb RF, Gopal AK
Biol Blood Marrow Transplant 2011 Oct;17(10):1537-45. Epub 2011 Apr 12 doi: 10.1016/j.bbmt.2011.03.010. PMID: 21536145Free PMC Article
Efficacy of palliative low-dose involved-field radiation therapy in advanced lymphoma: a phase II study.
Murthy V, Thomas K, Foo K, Cunningham D, Johnson B, Norman A, Horwich A
Clin Lymphoma Myeloma 2008 Aug;8(4):241-5. doi: 10.3816/CLM.2008.n.032. PMID: 18765312
Gallium nitrate in the treatment of lymphoma.
Straus DJ
Semin Oncol 2003 Apr;30(2 Suppl 5):25-33. doi: 10.1016/s0093-7754(03)00173-8. PMID: 12776257

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