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MAP2K2 Gene Rearrangement

MedGen UID:
1655646
•Concept ID:
C4727127
•
Cell or Molecular Dysfunction
Synonyms: MAPKK2 Gene Rearrangement; MEK2 Gene Rearrangement; Mitogen-Activated Protein Kinase Kinase 2 Gene Rearrangement; MKK2 Gene Rearrangement; PRKMK2 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the MAP2K2 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMAP2K2 Gene Rearrangement

Recent clinical studies

Diagnosis

Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.
Schweppe RE, Kerege AA, Sharma V, Poczobutt JM, Gutierrez-Hartmann A, Grzywa RL, Haugen BR
Thyroid 2009 Aug;19(8):825-35. doi: 10.1089/thy.2008.0362. PMID: 19500021Free PMC Article

Therapy

High-throughput sequencing of the melanoma genome.
Kunz M, Dannemann M, Kelso J
Exp Dermatol 2013 Jan;22(1):10-7. Epub 2012 Nov 22 doi: 10.1111/exd.12054. PMID: 23174022

Prognosis

Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.
Schweppe RE, Kerege AA, Sharma V, Poczobutt JM, Gutierrez-Hartmann A, Grzywa RL, Haugen BR
Thyroid 2009 Aug;19(8):825-35. doi: 10.1089/thy.2008.0362. PMID: 19500021Free PMC Article

Clinical prediction guides

Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.
Schweppe RE, Kerege AA, Sharma V, Poczobutt JM, Gutierrez-Hartmann A, Grzywa RL, Haugen BR
Thyroid 2009 Aug;19(8):825-35. doi: 10.1089/thy.2008.0362. PMID: 19500021Free PMC Article

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