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Abdominal Undifferentiated Pleomorphic Sarcoma

MedGen UID:
1655678
•Concept ID:
C4726601
•
Neoplastic Process

Definition

Undifferentiated pleomorphic sarcoma involving the organs and structures in the abdomen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbdominal Undifferentiated Pleomorphic Sarcoma

Professional guidelines

PubMed

Diagnosis and treatment of primary adult renal sarcoma.
Huang ZM, Li HZ, Ji ZG, Shi BB
Chin Med Sci J 2011 Sep;26(3):172-4. doi: 10.1016/s1001-9294(11)60044-8. PMID: 22207927
The management of retroperitoneal soft tissue sarcoma: a single institution experience with a review of the literature.
Pirayesh A, Chee Y, Helliwell TR, Hershman MJ, Leinster SJ, Fordham MV, Poston GJ
Eur J Surg Oncol 2001 Aug;27(5):491-7. doi: 10.1053/ejso.2001.1146. PMID: 11504522
Intraoperative electron irradiation in the management of pediatric malignancies.
Schomberg PJ, Gunderson LL, Moir CR, Gilchrist GS, Smithson WA
Cancer 1997 Jun 1;79(11):2251-6. PMID: 9179074

Recent clinical studies

Etiology

Evaluation of PD-L1 Expression in Undifferentiated Pleomorphic Sarcomas, Liposarcomas and Chondrosarcomas.
Zhang Y, Chen Y, Papakonstantinou A, Tsagkozis P, Linder-Stragliotto C, Haglund F
Biomolecules 2022 Feb 11;12(2) doi: 10.3390/biom12020292. PMID: 35204793Free PMC Article
Sarcoma undifferentiated (unclassified) fusiform cell type of mesentery: a case report and literature review.
Ibtissem K, Asma K, Farouk E, Ahmed H, Manel N, Faiez B, Khadija Z, Raja F
Pan Afr Med J 2020;35:58. Epub 2020 Feb 26 doi: 10.11604/pamj.2020.35.58.17749. PMID: 32537062Free PMC Article
Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial.
Gronchi A, Ferrari S, Quagliuolo V, Broto JM, Pousa AL, Grignani G, Basso U, Blay JY, Tendero O, Beveridge RD, Ferraresi V, Lugowska I, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Palmerini E, De Sanctis R, Morosi C, Stacchiotti S, Bagué S, Coindre JM, Dei Tos AP, Picci P, Bruzzi P, Casali PG
Lancet Oncol 2017 Jun;18(6):812-822. Epub 2017 May 9 doi: 10.1016/S1470-2045(17)30334-0. PMID: 28499583
Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
Levy AD, Manning MA, Miettinen MM
Radiographics 2017 May-Jun;37(3):797-812. doi: 10.1148/rg.2017160201. PMID: 28493803Free PMC Article
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Diagnosis

Undifferentiated pleomorphic sarcoma of the pancreas: a rare case report and literature review.
Liang Z, Han J, Tuo H, Xue D, Yu H, Peng Y
World J Surg Oncol 2022 Feb 27;20(1):55. doi: 10.1186/s12957-022-02525-1. PMID: 35220968Free PMC Article
A Review of Effusion Cytomorphology of Small Round Cell Tumors.
Han LM, VandenBussche CJ, Abildtrup M, Chandra A, Vohra P
Acta Cytol 2022;66(4):336-346. Epub 2021 Jul 2 doi: 10.1159/000516497. PMID: 34218227
Soft-Tissue Sarcomas of the Abdomen and Pelvis: Radiologic-Pathologic Features, Part 2-Uncommon Sarcomas.
Levy AD, Manning MA, Miettinen MM
Radiographics 2017 May-Jun;37(3):797-812. doi: 10.1148/rg.2017160201. PMID: 28493803Free PMC Article
Abdominal and pelvic tumors with musculoskeletal histology.
Dyrstad SW, Fowler AM, Jokerst CE, Baker JC, Hillen TJ, Menias C
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):68-79. doi: 10.1067/j.cpradiol.2013.11.001. PMID: 24629660
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Therapy

The clinical outcomes of undifferentiated pleomorphic sarcoma (UPS): A single-centre experience of two decades with the assessment of PD-L1 expressions.
Lee K, Song JS, Kim JE, Kim W, Song SY, Lee MH, Chung HW, Cho KJ, Lee JS, Ahn JH
Eur J Surg Oncol 2020 Jul;46(7):1287-1293. Epub 2020 Feb 24 doi: 10.1016/j.ejso.2020.02.029. PMID: 32127249
Multidisciplinary approach to rare primary cardiac sarcoma: a case report and review.
Vaitiekiene A, Vaitiekus D, Urbonaite L, Jankauskas A, Portacenko J, Lapinskas T, Benetis R, Siudikas A, Veikutiene A, Poskiene L, Kavoliuniene A, Janciauskiene R, Jarusevicius L, Juozaityte E, Zaliunas R, Ereminiene E
BMC Cancer 2019 May 31;19(1):529. doi: 10.1186/s12885-019-5705-2. PMID: 31151427Free PMC Article
Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial.
Gronchi A, Ferrari S, Quagliuolo V, Broto JM, Pousa AL, Grignani G, Basso U, Blay JY, Tendero O, Beveridge RD, Ferraresi V, Lugowska I, Merlo DF, Fontana V, Marchesi E, Donati DM, Palassini E, Palmerini E, De Sanctis R, Morosi C, Stacchiotti S, Bagué S, Coindre JM, Dei Tos AP, Picci P, Bruzzi P, Casali PG
Lancet Oncol 2017 Jun;18(6):812-822. Epub 2017 May 9 doi: 10.1016/S1470-2045(17)30334-0. PMID: 28499583
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Prognosis

A Review of Effusion Cytomorphology of Small Round Cell Tumors.
Han LM, VandenBussche CJ, Abildtrup M, Chandra A, Vohra P
Acta Cytol 2022;66(4):336-346. Epub 2021 Jul 2 doi: 10.1159/000516497. PMID: 34218227
Synovial sarcoma of the abdominal wall: Imaging findings and review of the literature.
de Haas RJ, Bonenkamp JJ, Flucke UE, de Rooy JW
J Radiol Case Rep 2015 Feb;9(2):24-30. Epub 2015 Feb 28 doi: 10.3941/jrcr.v9i2.1992. PMID: 25926925Free PMC Article
Abdominal and pelvic tumors with musculoskeletal histology.
Dyrstad SW, Fowler AM, Jokerst CE, Baker JC, Hillen TJ, Menias C
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):68-79. doi: 10.1067/j.cpradiol.2013.11.001. PMID: 24629660
Dedifferentiated liposarcoma.
Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):263-6. PMID: 11757866
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171

Clinical prediction guides

Pulmonary Pleomorphic Carcinoma Mimicking Primary Sarcoma of the Neck: A Case Report and Literature Review.
Ogawa D, Arahata M, Kuriyama M, Shinagawa S, Tomizawa G, Shimizu Y
Clin Interv Aging 2021;16:325-333. Epub 2021 Feb 23 doi: 10.2147/CIA.S296875. PMID: 33654389Free PMC Article
The clinical outcomes of undifferentiated pleomorphic sarcoma (UPS): A single-centre experience of two decades with the assessment of PD-L1 expressions.
Lee K, Song JS, Kim JE, Kim W, Song SY, Lee MH, Chung HW, Cho KJ, Lee JS, Ahn JH
Eur J Surg Oncol 2020 Jul;46(7):1287-1293. Epub 2020 Feb 24 doi: 10.1016/j.ejso.2020.02.029. PMID: 32127249
Anaplastic large cell neuroblastoma.
Abramowsky CR, Katzenstein HM, Alvarado CS, Shehata BM
Pediatr Dev Pathol 2009 Jan-Feb;12(1):1-5. doi: 10.2350/07-04-0255.1. PMID: 18397155
Undifferentiated embryonal sarcoma of the liver: case report and literature survey.
Pachera S, Nishio H, Takahashi Y, Yokoyama Y, Oda K, Ebata T, Igami T, Nagino M
J Hepatobiliary Pancreat Surg 2008;15(5):536-44. Epub 2008 Oct 4 doi: 10.1007/s00534-007-1265-y. PMID: 18836810
Dedifferentiated liposarcoma.
Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):263-6. PMID: 11757866

Recent systematic reviews

Primary hepatic malignant fibrous histiocytoma: clinicopathologic characteristics and prognostic value of ezrin expression.
Li YR, Akbari E, Tretiakova MS, Hart J, Akbari M, Urbanski SJ, Gao ZH
Am J Surg Pathol 2008 Aug;32(8):1144-58. doi: 10.1097/PAS.0b013e3181659791. PMID: 18545143

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