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Refractory Myelodysplastic Syndrome

MedGen UID:
1656162
•Concept ID:
C4724986
•
Neoplastic Process

Definition

Myelodysplastic syndrome that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Myelodysplastic Syndrome

Professional guidelines

PubMed

MYC as a target for cancer treatment.
Duffy MJ, O'Grady S, Tang M, Crown J
Cancer Treat Rev 2021 Mar;94:102154. Epub 2021 Jan 19 doi: 10.1016/j.ctrv.2021.102154. PMID: 33524794
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

Clofarabine and Busulfan Myeloablative Conditioning in Allogeneic Hematopoietic Cell Transplantation for Patients With Active Myeloid Malignancies.
Connor MP, Loren AW, Hexner EO, Martin ME, Gill SI, Luger SM, Mangan JK, Perl AE, McCurdy SR, Pratz KW, Timlin C, Freyer CW, Carulli A, Catania C, Smith J, Hollander L, Zebrowski AM, Stadtmauer EA, Porter DL, Frey NV
Transplant Cell Ther 2023 Feb;29(2):113-118. Epub 2022 Nov 4 doi: 10.1016/j.jtct.2022.10.027. PMID: 36336258

Diagnosis

Subcutaneous histiocytoid Sweet's syndrome in a patient with myelodysplastic syndrome and acute myeloblastic leukemia.
Srisuttiyakorn C, Reeve J, Reddy S, Imaeda S, Lazova R
J Cutan Pathol 2014 May;41(5):475-9. doi: 10.1111/cup.12305. PMID: 24877196

Therapy

Clofarabine and Busulfan Myeloablative Conditioning in Allogeneic Hematopoietic Cell Transplantation for Patients With Active Myeloid Malignancies.
Connor MP, Loren AW, Hexner EO, Martin ME, Gill SI, Luger SM, Mangan JK, Perl AE, McCurdy SR, Pratz KW, Timlin C, Freyer CW, Carulli A, Catania C, Smith J, Hollander L, Zebrowski AM, Stadtmauer EA, Porter DL, Frey NV
Transplant Cell Ther 2023 Feb;29(2):113-118. Epub 2022 Nov 4 doi: 10.1016/j.jtct.2022.10.027. PMID: 36336258
A dose escalation study of RO6870810/TEN-10 in patients with acute myeloid leukemia and myelodysplastic syndrome.
Roboz GJ, Desai P, Lee S, Ritchie EK, Winer ES, DeMario M, Brennan B, Nüesch E, Chesne E, Brennan L, Lechner K, Kornacker M, DeAngelo DJ
Leuk Lymphoma 2021 Jul;62(7):1740-1748. Epub 2021 Feb 13 doi: 10.1080/10428194.2021.1881509. PMID: 33586590
A study of high-dose lenalidomide induction and low-dose lenalidomide maintenance therapy for patients with hypomethylating agent refractory myelodysplastic syndrome.
Cherian MA, Tibes R, Gao F, Fletcher T, Fiala M, Uy GL, Westervelt P, Jacoby MA, Cashen AF, Stockerl-Goldstein K, DiPersio JF, Vij R
Leuk Lymphoma 2016 Nov;57(11):2535-40. Epub 2016 Apr 27 doi: 10.3109/10428194.2016.1173213. PMID: 27122296
Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders.
Ladizinski B, Shannon EJ, Sanchez MR, Levis WR
J Drugs Dermatol 2010 Jul;9(7):814-26. PMID: 20677538
Acute lung injury induced by arsenic trioxide in a patient with refractory myelodysplastic syndrome.
Hassaballa HA, Lateef OB, Silver MR, Balk RA
J Crit Care 2005 Mar;20(1):111-3. doi: 10.1016/j.jcrc.2004.08.009. PMID: 16015525

Prognosis

Clofarabine and Busulfan Myeloablative Conditioning in Allogeneic Hematopoietic Cell Transplantation for Patients With Active Myeloid Malignancies.
Connor MP, Loren AW, Hexner EO, Martin ME, Gill SI, Luger SM, Mangan JK, Perl AE, McCurdy SR, Pratz KW, Timlin C, Freyer CW, Carulli A, Catania C, Smith J, Hollander L, Zebrowski AM, Stadtmauer EA, Porter DL, Frey NV
Transplant Cell Ther 2023 Feb;29(2):113-118. Epub 2022 Nov 4 doi: 10.1016/j.jtct.2022.10.027. PMID: 36336258
A study of high-dose lenalidomide induction and low-dose lenalidomide maintenance therapy for patients with hypomethylating agent refractory myelodysplastic syndrome.
Cherian MA, Tibes R, Gao F, Fletcher T, Fiala M, Uy GL, Westervelt P, Jacoby MA, Cashen AF, Stockerl-Goldstein K, DiPersio JF, Vij R
Leuk Lymphoma 2016 Nov;57(11):2535-40. Epub 2016 Apr 27 doi: 10.3109/10428194.2016.1173213. PMID: 27122296

Clinical prediction guides

A Phase I/II Open-Label Study of Molibresib for the Treatment of Relapsed/Refractory Hematologic Malignancies.
Dawson MA, Borthakur G, Huntly BJP, Karadimitris A, Alegre A, Chaidos A, Vogl DT, Pollyea DA, Davies FE, Morgan GJ, Glass JL, Kamdar M, Mateos MV, Tovar N, Yeh P, Delgado RG, Basheer F, Marando L, Gallipoli P, Wyce A, Krishnatry AS, Barbash O, Bakirtzi E, Ferron-Brady G, Karpinich NO, McCabe MT, Foley SW, Horner T, Dhar A, Kremer BE, Dickinson M
Clin Cancer Res 2023 Feb 16;29(4):711-722. doi: 10.1158/1078-0432.CCR-22-1284. PMID: 36350312Free PMC Article

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