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MGMT-Methylated Glioblastoma

MedGen UID:
1656515
Concept ID:
C4727587
Neoplastic Process
Synonym: Methylated MGMT Glioblastoma

Definition

A glioblastoma characterized by the presence of DNA methylation in the promoter region of the MGMT gene. It is associated with improved survival. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMGMT-Methylated Glioblastoma

Professional guidelines

PubMed

Ganesa S, Sule A, Sundaram RK, Bindra RS
Sci Rep 2022 Apr 6;12(1):5827. doi: 10.1038/s41598-022-09614-x. PMID: 35388070Free PMC Article
Castro M, Pampana A, Alam A, Parashar R, Rajagopalan S, Lala DA, Roy KGG, Basu S, Prakash A, Nair P, Joseph V, Agarwal A, G P, Behura L, Kulkarni S, Choudhary NR, Kapoor S
J Neurooncol 2021 Jul;153(3):393-402. Epub 2021 Jun 8 doi: 10.1007/s11060-021-03780-0. PMID: 34101093Free PMC Article
McDonald KL, Rapkins RW, Olivier J, Zhao L, Nozue K, Lu D, Tiwari S, Kuroiwa-Trzmielina J, Brewer J, Wheeler HR, Hitchins MP
Eur J Cancer 2013 Jan;49(2):360-8. Epub 2012 Sep 10 doi: 10.1016/j.ejca.2012.08.012. PMID: 22975219

Recent clinical studies

Etiology

Weller J, Schäfer N, Schaub C, Tzaridis T, Zeyen T, Schneider M, Potthoff AL, Giordano FA, Steinbach JP, Zeiner PS, Kowalski T, Sabel M, Hau P, Krex D, Grauer O, Goldbrunner R, Schnell O, Tabatabai G, Ringel F, Schmidt-Graf F, Brehmer S, Tonn JC, Bullinger L, Vajkoczy P, Glas M, Vatter H, Herrlinger U, Seidel C
J Neurooncol 2023 Jan;161(1):147-153. Epub 2023 Jan 7 doi: 10.1007/s11060-022-04203-4. PMID: 36609807Free PMC Article
Ganesa S, Sule A, Sundaram RK, Bindra RS
Sci Rep 2022 Apr 6;12(1):5827. doi: 10.1038/s41598-022-09614-x. PMID: 35388070Free PMC Article
Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N
Lancet Oncol 2019 Oct;20(10):1444-1453. Epub 2019 Sep 2 doi: 10.1016/S1470-2045(19)30502-9. PMID: 31488360
Rapkins RW, Wang F, Nguyen HN, Cloughesy TF, Lai A, Ha W, Nowak AK, Hitchins MP, McDonald KL
Neuro Oncol 2015 Dec;17(12):1589-98. Epub 2015 Apr 24 doi: 10.1093/neuonc/nov064. PMID: 25910840Free PMC Article
McDonald KL, Rapkins RW, Olivier J, Zhao L, Nozue K, Lu D, Tiwari S, Kuroiwa-Trzmielina J, Brewer J, Wheeler HR, Hitchins MP
Eur J Cancer 2013 Jan;49(2):360-8. Epub 2012 Sep 10 doi: 10.1016/j.ejca.2012.08.012. PMID: 22975219

Diagnosis

Weller J, Schäfer N, Schaub C, Tzaridis T, Zeyen T, Schneider M, Potthoff AL, Giordano FA, Steinbach JP, Zeiner PS, Kowalski T, Sabel M, Hau P, Krex D, Grauer O, Goldbrunner R, Schnell O, Tabatabai G, Ringel F, Schmidt-Graf F, Brehmer S, Tonn JC, Bullinger L, Vajkoczy P, Glas M, Vatter H, Herrlinger U, Seidel C
J Neurooncol 2023 Jan;161(1):147-153. Epub 2023 Jan 7 doi: 10.1007/s11060-022-04203-4. PMID: 36609807Free PMC Article
Weller J, Schäfer N, Schaub C, Potthoff AL, Steinbach JP, Schlegel U, Sabel M, Hau P, Seidel C, Krex D, Goldbrunner R, Pietsch T, Tzaridis T, Zeyen T, Borger V, Güresir E, Vatter H, Herrlinger U, Schneider M
J Neurooncol 2022 Aug;159(1):95-101. Epub 2022 Jun 15 doi: 10.1007/s11060-022-04046-z. PMID: 35704157Free PMC Article
Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N
Lancet Oncol 2019 Oct;20(10):1444-1453. Epub 2019 Sep 2 doi: 10.1016/S1470-2045(19)30502-9. PMID: 31488360
Hsu CY, Ho HL, Lin SC, Ho TD, Ho DM
PLoS One 2017;12(10):e0186430. Epub 2017 Oct 16 doi: 10.1371/journal.pone.0186430. PMID: 29036186Free PMC Article
McDonald KL, Rapkins RW, Olivier J, Zhao L, Nozue K, Lu D, Tiwari S, Kuroiwa-Trzmielina J, Brewer J, Wheeler HR, Hitchins MP
Eur J Cancer 2013 Jan;49(2):360-8. Epub 2012 Sep 10 doi: 10.1016/j.ejca.2012.08.012. PMID: 22975219

Therapy

Weller J, Schäfer N, Schaub C, Potthoff AL, Steinbach JP, Schlegel U, Sabel M, Hau P, Seidel C, Krex D, Goldbrunner R, Pietsch T, Tzaridis T, Zeyen T, Borger V, Güresir E, Vatter H, Herrlinger U, Schneider M
J Neurooncol 2022 Aug;159(1):95-101. Epub 2022 Jun 15 doi: 10.1007/s11060-022-04046-z. PMID: 35704157Free PMC Article
Ganesa S, Sule A, Sundaram RK, Bindra RS
Sci Rep 2022 Apr 6;12(1):5827. doi: 10.1038/s41598-022-09614-x. PMID: 35388070Free PMC Article
Zeyen T, Potthoff AL, Nemeth R, Heiland DH, Burger MC, Steinbach JP, Hau P, Tabatabai G, Glas M, Schlegel U, Grauer O, Krex D, Schnell O, Goldbrunner R, Sabel M, Thon N, Delev D, Clusmann H, Seidel C, Güresir E, Schmid M, Schuss P, Giordano FA, Radbruch A, Becker A, Weller J, Schaub C, Vatter H, Schilling J, Winkler F, Herrlinger U, Schneider M
Trials 2022 Jan 19;23(1):57. doi: 10.1186/s13063-021-05977-0. PMID: 35045869Free PMC Article
Wu Q, Berglund AE, Wang D, MacAulay RJ, Mulé JJ, Etame AB
Sci Rep 2019 Oct 1;9(1):14072. doi: 10.1038/s41598-019-50489-2. PMID: 31575897Free PMC Article
Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N
Lancet Oncol 2019 Oct;20(10):1444-1453. Epub 2019 Sep 2 doi: 10.1016/S1470-2045(19)30502-9. PMID: 31488360

Prognosis

Weller J, Schäfer N, Schaub C, Potthoff AL, Steinbach JP, Schlegel U, Sabel M, Hau P, Seidel C, Krex D, Goldbrunner R, Pietsch T, Tzaridis T, Zeyen T, Borger V, Güresir E, Vatter H, Herrlinger U, Schneider M
J Neurooncol 2022 Aug;159(1):95-101. Epub 2022 Jun 15 doi: 10.1007/s11060-022-04046-z. PMID: 35704157Free PMC Article
Ganesa S, Sule A, Sundaram RK, Bindra RS
Sci Rep 2022 Apr 6;12(1):5827. doi: 10.1038/s41598-022-09614-x. PMID: 35388070Free PMC Article
Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N
Lancet Oncol 2019 Oct;20(10):1444-1453. Epub 2019 Sep 2 doi: 10.1016/S1470-2045(19)30502-9. PMID: 31488360
Hsu CY, Ho HL, Lin SC, Ho TD, Ho DM
PLoS One 2017;12(10):e0186430. Epub 2017 Oct 16 doi: 10.1371/journal.pone.0186430. PMID: 29036186Free PMC Article
Sciuscio D, Diserens AC, van Dommelen K, Martinet D, Jones G, Janzer RC, Pollo C, Hamou MF, Kaina B, Stupp R, Levivier M, Hegi ME
Clin Cancer Res 2011 Jan 15;17(2):255-66. Epub 2010 Nov 19 doi: 10.1158/1078-0432.CCR-10-1931. PMID: 21097691

Clinical prediction guides

Weller J, Schäfer N, Schaub C, Tzaridis T, Zeyen T, Schneider M, Potthoff AL, Giordano FA, Steinbach JP, Zeiner PS, Kowalski T, Sabel M, Hau P, Krex D, Grauer O, Goldbrunner R, Schnell O, Tabatabai G, Ringel F, Schmidt-Graf F, Brehmer S, Tonn JC, Bullinger L, Vajkoczy P, Glas M, Vatter H, Herrlinger U, Seidel C
J Neurooncol 2023 Jan;161(1):147-153. Epub 2023 Jan 7 doi: 10.1007/s11060-022-04203-4. PMID: 36609807Free PMC Article
Weller J, Schäfer N, Schaub C, Potthoff AL, Steinbach JP, Schlegel U, Sabel M, Hau P, Seidel C, Krex D, Goldbrunner R, Pietsch T, Tzaridis T, Zeyen T, Borger V, Güresir E, Vatter H, Herrlinger U, Schneider M
J Neurooncol 2022 Aug;159(1):95-101. Epub 2022 Jun 15 doi: 10.1007/s11060-022-04046-z. PMID: 35704157Free PMC Article
Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N
Lancet Oncol 2019 Oct;20(10):1444-1453. Epub 2019 Sep 2 doi: 10.1016/S1470-2045(19)30502-9. PMID: 31488360
Rapkins RW, Wang F, Nguyen HN, Cloughesy TF, Lai A, Ha W, Nowak AK, Hitchins MP, McDonald KL
Neuro Oncol 2015 Dec;17(12):1589-98. Epub 2015 Apr 24 doi: 10.1093/neuonc/nov064. PMID: 25910840Free PMC Article
Sciuscio D, Diserens AC, van Dommelen K, Martinet D, Jones G, Janzer RC, Pollo C, Hamou MF, Kaina B, Stupp R, Levivier M, Hegi ME
Clin Cancer Res 2011 Jan 15;17(2):255-66. Epub 2010 Nov 19 doi: 10.1158/1078-0432.CCR-10-1931. PMID: 21097691

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