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Intestinal T-Cell Lymphoma

MedGen UID:
1656655
•Concept ID:
C4721452
•
Neoplastic Process
Synonym: Intestinal T-cell lymphoma
SNOMED CT: Intestinal T-cell lymphoma (103686008)

Definition

A group of mature T-cell and NK-cell non-Hodgkin lymphomas that includes enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, and intestinal T-cell lymphoma, not otherwise specified. Most of these lymphomas arise from the small intestine and a minority from the large intestine or stomach. [from NCI]

Professional guidelines

PubMed

ACVIM consensus statement guidelines on diagnosing and distinguishing low-grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats.
Marsilio S, Freiche V, Johnson E, Leo C, Langerak AW, Peters I, Ackermann MR
J Vet Intern Med 2023 May-Jun;37(3):794-816. Epub 2023 May 2 doi: 10.1111/jvim.16690. PMID: 37130034Free PMC Article
Management of celiac disease in daily clinical practice.
Elli L, Ferretti F, Orlando S, Vecchi M, Monguzzi E, Roncoroni L, Schuppan D
Eur J Intern Med 2019 Mar;61:15-24. Epub 2018 Dec 5 doi: 10.1016/j.ejim.2018.11.012. PMID: 30528262
Treatment of T-cell non-Hodgkin's lymphoma.
Evens AM, Gartenhaus RB
Curr Treat Options Oncol 2004 Aug;5(4):289-303. doi: 10.1007/s11864-004-0020-8. PMID: 15233906

Recent clinical studies

Etiology

Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome.
Veloza L, Cavalieri D, Missiaglia E, Ledoux-Pilon A, Bisig B, Pereira B, Bonnet C, Poullot E, Quintanilla-Martinez L, Dubois R, Llamas-Gutierrez F, Bossard C, De Wind R, Drieux F, Fontaine J, Parrens M, Sandrini J, Fataccioli V, Delfau-Larue MH, Daniel A, Lhomme F, Clément-Filliatre L, Lemonnier F, Cairoli A, Morel P, Glaisner S, Joly B, El Yamani A, Laribi K, Bachy E, Siebert R, Vallois D, Gaulard P, Tournilhac O, De Leval L
Haematologica 2023 Jan 1;108(1):181-195. doi: 10.3324/haematol.2022.281226. PMID: 35708139Free PMC Article
New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Gastrointestinal T- and NK-cell lymphomas and indolent lymphoproliferative disorders.
Soderquist CR, Bhagat G
Semin Diagn Pathol 2020 Jan;37(1):11-23. Epub 2019 Aug 28 doi: 10.1053/j.semdp.2019.08.001. PMID: 31522873
Rare T-Cell Subtypes.
van der Weyden C, McCormack C, Lade S, Johnstone RW, Prince HM
Cancer Treat Res 2019;176:195-224. doi: 10.1007/978-3-319-99716-2_10. PMID: 30596220

Diagnosis

New developments in non-Hodgkin lymphoid malignancies.
Ganapathi KA, Brown LE, Prakash S, Bhargava P
Pathology 2021 Apr;53(3):349-366. Epub 2021 Mar 5 doi: 10.1016/j.pathol.2021.01.002. PMID: 33685720
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Gastrointestinal T- and NK-cell lymphomas and indolent lymphoproliferative disorders.
Soderquist CR, Bhagat G
Semin Diagn Pathol 2020 Jan;37(1):11-23. Epub 2019 Aug 28 doi: 10.1053/j.semdp.2019.08.001. PMID: 31522873
Rare T-Cell Subtypes.
van der Weyden C, McCormack C, Lade S, Johnstone RW, Prince HM
Cancer Treat Res 2019;176:195-224. doi: 10.1007/978-3-319-99716-2_10. PMID: 30596220
Refractory sprue.
Culliford AN, Green PH
Curr Gastroenterol Rep 2003 Oct;5(5):373-8. doi: 10.1007/s11894-003-0049-z. PMID: 12959717

Therapy

Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: A case report and review of literature.
Ozaka S, Inoue K, Okajima T, Tasaki T, Ariki S, Ono H, Ando T, Daa T, Murakami K
World J Gastroenterol 2021 Oct 14;27(38):6501-6510. doi: 10.3748/wjg.v27.i38.6501. PMID: 34720538Free PMC Article
Enteropathy-Associated T-Cell Lymphoma.
Ondrejka S, Jagadeesh D
Curr Hematol Malig Rep 2016 Dec;11(6):504-513. doi: 10.1007/s11899-016-0357-7. PMID: 27900603
Intestinal T-cell lymphomas: a retrospective analysis of 68 cases in China.
Sun ZH, Zhou HM, Song GX, Zhou ZX, Bai L
World J Gastroenterol 2014 Jan 7;20(1):296-302. doi: 10.3748/wjg.v20.i1.296. PMID: 24415885Free PMC Article
Refractory celiac disease.
Abdallah H, Leffler D, Dennis M, Kelly CP
Curr Gastroenterol Rep 2007 Oct;9(5):401-5. doi: 10.1007/s11894-007-0049-5. PMID: 17991341
Treatment of T-cell non-Hodgkin's lymphoma.
Evens AM, Gartenhaus RB
Curr Treat Options Oncol 2004 Aug;5(4):289-303. doi: 10.1007/s11864-004-0020-8. PMID: 15233906

Prognosis

Diagnostic approach to T- and NK-cell lymphoproliferative disorders in the gastrointestinal tract.
Susan SH, Ng SB, Wang S, Tan SY
Semin Diagn Pathol 2021 Jul;38(4):21-30. Epub 2021 Mar 31 doi: 10.1053/j.semdp.2021.03.004. PMID: 34016481
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Enteropathy-Associated T-Cell Lymphoma.
Ondrejka S, Jagadeesh D
Curr Hematol Malig Rep 2016 Dec;11(6):504-513. doi: 10.1007/s11899-016-0357-7. PMID: 27900603
Refractory celiac disease.
Abdallah H, Leffler D, Dennis M, Kelly CP
Curr Gastroenterol Rep 2007 Oct;9(5):401-5. doi: 10.1007/s11894-007-0049-5. PMID: 17991341
Refractory sprue.
Culliford AN, Green PH
Curr Gastroenterol Rep 2003 Oct;5(5):373-8. doi: 10.1007/s11894-003-0049-z. PMID: 12959717

Clinical prediction guides

Monomorphic Epitheliotropic Intestinal T-cell Lymphoma of the Stomach: Two Case Reports and a Literature Review.
Lu S, Zhou G, Chen M, Liu W, Zhao S
Int J Surg Pathol 2021 Jun;29(4):410-419. Epub 2020 Aug 28 doi: 10.1177/1066896920953906. PMID: 32856508
Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma.
Ishibashi H, Nimura S, Hirai F, Harada N, Iwasaki H, Kawauchi S, Oshiro Y, Matsuyama A, Nakamura S, Takamatsu Y, Yonemasu H, Shimokama T, Takeshita M
Diagn Pathol 2020 Oct 21;15(1):128. doi: 10.1186/s13000-020-01044-5. PMID: 33087157Free PMC Article
Peripheral T-cell lymphoma with gastrointestinal involvement and indolent T-lymphoproliferative disorders of the gastrointestinal tract.
Kohri M, Tsukasaki K, Akuzawa Y, Tanae K, Takahashi N, Saeki T, Okamura D, Ishikawa M, Maeda T, Kawai N, Matsuda A, Arai E, Arai S, Asou N
Leuk Res 2020 Apr;91:106336. Epub 2020 Feb 29 doi: 10.1016/j.leukres.2020.106336. PMID: 32151888
Intestinal T-cell lymphomas: a retrospective analysis of 68 cases in China.
Sun ZH, Zhou HM, Song GX, Zhou ZX, Bai L
World J Gastroenterol 2014 Jan 7;20(1):296-302. doi: 10.3748/wjg.v20.i1.296. PMID: 24415885Free PMC Article
Pathology of intestinal lymphomas.
Foss HD, Stein H
Recent Results Cancer Res 2000;156:33-41. doi: 10.1007/978-3-642-57054-4_5. PMID: 10802861

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