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Malignant Ovarian Teratoma

MedGen UID:
1657209
•Concept ID:
C4724097
•
Neoplastic Process
Synonym: Grade 3 Ovarian Teratoma

Definition

A teratoma that arises from the ovary. It is composed exclusively of immature tissue elements. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Ovarian Teratoma

Professional guidelines

PubMed

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Ovarian teratomas: clinical features, imaging findings and management.
Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
Ovarian collision tumors: imaging findings, pathological characteristics, diagnosis, and differential diagnosis.
Peng Y, Lin J, Guan J, Chen L, Zhang X, Li S, Wang H, Liu M, Guo Y
Abdom Radiol (NY) 2018 Aug;43(8):2156-2168. doi: 10.1007/s00261-017-1419-6. PMID: 29198011

Recent clinical studies

Etiology

Risk of epilepsy in gonadal teratoma: a nationwide population-based study.
Kim S, Kim H, Lee J, Lee SB, Hong YJ, Oh YS, Park JW
Sci Rep 2023 Jul 11;13(1):11206. doi: 10.1038/s41598-023-38255-x. PMID: 37433861Free PMC Article
Calcified intraperitoneal and mediastinal implants in malignant ovarian teratoma.
Miller DL, Pirani M
J Can Assoc Radiol 1984 Jun;35(2):217-9. PMID: 6480679
Solid malignant ovarian teratoma: case of an 8 year survival.
Malkasian GD Jr, Symmonds RE
Am J Obstet Gynecol 1971 Aug 1;110(7):1020-1. doi: 10.1016/0002-9378(71)90562-x. PMID: 5558966

Diagnosis

Assessment of ovarian teratoma and lymphadenopathy by 18F-FDG PET/CT.
Balink H, Apperloo MJ, Collins J
Clin Nucl Med 2012 Aug;37(8):804-6. doi: 10.1097/RLU.0b013e3182485361. PMID: 22785518
Appearance of anti-NMDAR antibodies after plasma exchange and total removal of malignant ovarian teratoma in a patient with paraneoplastic limbic encephalopathy.
Wali SM, Cai A, Rossor AM, Clough C
BMJ Case Rep 2011 Mar 24;2011 doi: 10.1136/bcr.02.2011.3851. PMID: 22699468Free PMC Article
Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer.
Wolff EF, Hughes M, Merino MJ, Reynolds JC, Davis JL, Cochran CS, Celi FS
Thyroid 2010 Sep;20(9):981-7. doi: 10.1089/thy.2009.0458. PMID: 20718682Free PMC Article
Trisomy 12 and translocation (7;9) in an ovarian immature teratoma.
López Ginés C, Gil R, Pellin A, Martorell M, Vilar F, Llombart-Bosch A
Int J Gynecol Pathol 1989;8(3):277-85. doi: 10.1097/00004347-198909000-00012. PMID: 2767876
Malignant ovarian teratoma in childhood.
Kullendorff CM
Z Kinderchir 1983 Oct;38(5):350-2. doi: 10.1055/s-2008-1060004. PMID: 6649911

Therapy

Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer.
Wolff EF, Hughes M, Merino MJ, Reynolds JC, Davis JL, Cochran CS, Celi FS
Thyroid 2010 Sep;20(9):981-7. doi: 10.1089/thy.2009.0458. PMID: 20718682Free PMC Article
Solid malignant ovarian teratoma: case of an 8 year survival.
Malkasian GD Jr, Symmonds RE
Am J Obstet Gynecol 1971 Aug 1;110(7):1020-1. doi: 10.1016/0002-9378(71)90562-x. PMID: 5558966

Prognosis

Appearance of anti-NMDAR antibodies after plasma exchange and total removal of malignant ovarian teratoma in a patient with paraneoplastic limbic encephalopathy.
Wali SM, Cai A, Rossor AM, Clough C
BMJ Case Rep 2011 Mar 24;2011 doi: 10.1136/bcr.02.2011.3851. PMID: 22699468Free PMC Article
Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer.
Wolff EF, Hughes M, Merino MJ, Reynolds JC, Davis JL, Cochran CS, Celi FS
Thyroid 2010 Sep;20(9):981-7. doi: 10.1089/thy.2009.0458. PMID: 20718682Free PMC Article
Calcified intraperitoneal and mediastinal implants in malignant ovarian teratoma.
Miller DL, Pirani M
J Can Assoc Radiol 1984 Jun;35(2):217-9. PMID: 6480679
Malignant ovarian teratoma in childhood.
Kullendorff CM
Z Kinderchir 1983 Oct;38(5):350-2. doi: 10.1055/s-2008-1060004. PMID: 6649911
Solid malignant ovarian teratoma: case of an 8 year survival.
Malkasian GD Jr, Symmonds RE
Am J Obstet Gynecol 1971 Aug 1;110(7):1020-1. doi: 10.1016/0002-9378(71)90562-x. PMID: 5558966

Clinical prediction guides

Risk of epilepsy in gonadal teratoma: a nationwide population-based study.
Kim S, Kim H, Lee J, Lee SB, Hong YJ, Oh YS, Park JW
Sci Rep 2023 Jul 11;13(1):11206. doi: 10.1038/s41598-023-38255-x. PMID: 37433861Free PMC Article
Characterization of a human ovarian teratocarcinoma-derived cell line.
Zeuthen J, Nørgaard JO, Avner P, Fellous M, Wartiovaara J, Vaheri A, Rosén A, Giovanella BC
Int J Cancer 1980 Jan 15;25(1):19-32. doi: 10.1002/ijc.2910250104. PMID: 6931103

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