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Carcinoma, Pancreatic Ductal

MedGen UID:
165776
•Concept ID:
C0887833
•
Neoplastic Process
Synonyms: Carcinoma, Ductal, Pancreatic; Carcinoma, Pancreas Duct-Cell; Carcinomas, Pancreas Duct-Cell; Carcinomas, Pancreatic Ductal; Duct Cell Carcinoma of the Pancreas; Duct Cell Carcinoma, Pancreas; Duct-Cell Carcinoma of the Pancreas; Duct-Cell Carcinoma, Pancreas; Duct-Cell Carcinomas, Pancreas; Ductal Carcinoma of the Pancreas; Ductal Carcinoma, Pancreatic; Ductal Carcinomas, Pancreatic; Pancreas Duct-Cell Carcinoma; Pancreas Duct-Cell Carcinomas; Pancreatic Duct Cell Carcinoma; Pancreatic Ductal Carcinoma; Pancreatic Ductal Carcinomas

Definition

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma, Pancreatic Ductal

Professional guidelines

PubMed

Adjuvant treatment for pancreatic ductal carcinoma.
Macarulla T, Fernández T, Gallardo ME, Hernando O, López AM, Hidalgo M
Clin Transl Oncol 2017 Oct;19(10):1199-1204. Epub 2017 Jun 21 doi: 10.1007/s12094-017-1683-5. PMID: 28639051
Pancreatic carcinoma: Key-points from diagnosis to treatment.
Frampas E, David A, Regenet N, Touchefeu Y, Meyer J, Morla O
Diagn Interv Imaging 2016 Dec;97(12):1207-1223. Epub 2016 Aug 24 doi: 10.1016/j.diii.2016.07.008. PMID: 27567314
Ductal pancreatic adenocarcinoma.
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article

Recent clinical studies

Etiology

Pancreatic cancer: An update on diagnosis and management.
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
Molecular subtypes of pancreatic cancer.
Collisson EA, Bailey P, Chang DK, Biankin AV
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):207-220. doi: 10.1038/s41575-019-0109-y. PMID: 30718832
International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017.
Isaji S, Mizuno S, Windsor JA, Bassi C, Fernández-Del Castillo C, Hackert T, Hayasaki A, Katz MHG, Kim SW, Kishiwada M, Kitagawa H, Michalski CW, Wolfgang CL
Pancreatology 2018 Jan;18(1):2-11. Epub 2017 Nov 22 doi: 10.1016/j.pan.2017.11.011. PMID: 29191513
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Pancreatic cancer.
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Diagnosis

Pancreatic Ductal Adenocarcinoma.
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Pancreatic cancer: An update on diagnosis and management.
Loveday BPT, Lipton L, Thomson BN
Aust J Gen Pract 2019 Dec;48(12):826-831. doi: 10.31128/AJGP-06-19-4957. PMID: 31774983
Molecular subtypes of pancreatic cancer.
Collisson EA, Bailey P, Chang DK, Biankin AV
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):207-220. doi: 10.1038/s41575-019-0109-y. PMID: 30718832
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Pancreatic cancer.
Vincent A, Herman J, Schulick R, Hruban RH, Goggins M
Lancet 2011 Aug 13;378(9791):607-20. Epub 2011 May 26 doi: 10.1016/S0140-6736(10)62307-0. PMID: 21620466Free PMC Article

Therapy

Therapeutic developments in pancreatic cancer.
Hu ZI, O'Reilly EM
Nat Rev Gastroenterol Hepatol 2024 Jan;21(1):7-24. Epub 2023 Oct 5 doi: 10.1038/s41575-023-00840-w. PMID: 37798442
Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma.
Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C
J Hematol Oncol 2020 Oct 2;13(1):130. doi: 10.1186/s13045-020-00958-3. PMID: 33008426Free PMC Article
Challenges and Opportunities for Pancreatic Cancer Immunotherapy.
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Fibrosis and cancer: A strained relationship.
Piersma B, Hayward MK, Weaver VM
Biochim Biophys Acta Rev Cancer 2020 Apr;1873(2):188356. Epub 2020 Mar 5 doi: 10.1016/j.bbcan.2020.188356. PMID: 32147542Free PMC Article

Prognosis

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies.
Ayres Pereira M, Chio IIC
Genes (Basel) 2019 Dec 19;11(1) doi: 10.3390/genes11010006. PMID: 31861620Free PMC Article
Early Detection of Pancreatic Cancer: Opportunities and Challenges.
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Pancreatic Ductal Adenocarcinoma and Its Variants.
Luchini C, Capelli P, Scarpa A
Surg Pathol Clin 2016 Dec;9(4):547-560. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.003. PMID: 27926359

Clinical prediction guides

Immune profiling and prognostic model of pancreatic cancer using quantitative pathology and single-cell RNA sequencing.
Chen K, Wang Q, Liu X, Tian X, Dong A, Yang Y
J Transl Med 2023 Mar 21;21(1):210. doi: 10.1186/s12967-023-04051-4. PMID: 36944944Free PMC Article
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Early Detection of Pancreatic Cancer: Opportunities and Challenges.
Singhi AD, Koay EJ, Chari ST, Maitra A
Gastroenterology 2019 May;156(7):2024-2040. Epub 2019 Feb 2 doi: 10.1053/j.gastro.2019.01.259. PMID: 30721664Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806
Imaging diagnosis of pancreatic cancer: a state-of-the-art review.
Lee ES, Lee JM
World J Gastroenterol 2014 Jun 28;20(24):7864-77. doi: 10.3748/wjg.v20.i24.7864. PMID: 24976723Free PMC Article

Recent systematic reviews

Adjuvant Chemotherapy and Radiotherapy in Resected Pancreatic Ductal Adenocarcinoma: A Systematic Review and Clinical Practice Guideline.
Biagi JJ, Cosby R, Bahl M, Elfiki T, Goodwin R, Hallet J, Hirmiz K, Mahmud A
Curr Oncol 2023 Jul 8;30(7):6575-6586. doi: 10.3390/curroncol30070482. PMID: 37504342Free PMC Article
Predictive ability of pancreatic cyst fluid biomarkers: A systematic review and meta-analysis.
Pflüger MJ, Jamouss KT, Afghani E, Lim SJ, Rodriguez Franco S, Mayo H, Spann M, Wang H, Singhi A, Lennon AM, Wood LD
Pancreatology 2023 Nov;23(7):868-877. Epub 2023 May 15 doi: 10.1016/j.pan.2023.05.005. PMID: 37230894
Research advances and treatment perspectives of pancreatic adenosquamous carcinoma.
Zhang W, Zhang J, Liang X, Ding J
Cell Oncol (Dordr) 2023 Feb;46(1):1-15. Epub 2022 Nov 1 doi: 10.1007/s13402-022-00732-2. PMID: 36316580
Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma-a systematic review and meta-analysis.
Bunduc S, Gede N, Váncsa S, Lillik V, Kiss S, Juhász MF, Erőss B, Szakács Z, Gheorghe C, Mikó A, Hegyi P
Transl Res 2022 Jun;244:126-136. Epub 2022 Jan 20 doi: 10.1016/j.trsl.2022.01.001. PMID: 35066189
A systematic review of economic evaluation in pancreatic ductal adenocarcinoma.
Gérard C, Fagnoni P, Vienot A, Borg C, Limat S, Daval F, Calais F, Vardanega J, Jary M, Nerich V
Eur J Cancer 2017 Nov;86:207-216. Epub 2017 Oct 9 doi: 10.1016/j.ejca.2017.08.035. PMID: 29024890

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