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Burkitt Leukemia

MedGen UID:
1658558
•Concept ID:
C4721444
•
Neoplastic Process
Synonyms: Burkitt Cell Leukemia; Burkitt's Leukemia; Burkitts Leukemia; L3 Lymphocytic Leukemia; L3 Lymphocytic Leukemias; Leukemia, Burkitt; Leukemia, Burkitt Cell; Leukemia, Burkitt's; Leukemia, L3 Lymphocytic; Leukemia, Lymphoblastic, Burkitt-Type; Leukemia, Lymphocytic, L3; Lymphocytic Leukemia, L3
SNOMED CT: Acute lymphoblastic leukemia, mature B-cell type (22197008); Burkitt cell leukemia (22197008); Burkitt's cell leukemia (22197008); Acute lymphoblastic leukemia, Burkitt's type (22197008); Burkitt's leukemia (277571004)

Definition

The leukemic counterpart of Burkitt''s lymphoma. The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood. This is an aggressive leukemia. [from NCI]

Professional guidelines

PubMed

Liposomal cytarabine in prophylaxis or curative treatment of central nervous system involvement in Burkitt leukemia/lymphoma.
Segot A, Raffoux E, Lengline E, Thieblemont C, Dombret H, Boissel N, Cluzeau T
Ann Hematol 2015 Nov;94(11):1859-63. Epub 2015 Aug 18 doi: 10.1007/s00277-015-2475-z. PMID: 26280395

Recent clinical studies

Etiology

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.
Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse.
Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Progressive or relapsed Burkitt lymphoma or leukemia in children and adolescents after BFM-type first-line therapy.
Woessmann W, Zimmermann M, Meinhardt A, Müller S, Hauch H, Knörr F, Oschlies I, Klapper W, Niggli F, Kabickova E, Attarbaschi A, Reiter A, Burkhardt B
Blood 2020 Apr 2;135(14):1124-1132. doi: 10.1182/blood.2019003591. PMID: 31961927
High cure rates in Burkitt lymphoma and leukemia: a Northern Italy Leukemia Group study of the German short intensive rituximab-chemotherapy program.
Intermesoli T, Rambaldi A, Rossi G, Delaini F, Romani C, Pogliani EM, Pagani C, Angelucci E, Terruzzi E, Levis A, Cassibba V, Mattei D, Gianfaldoni G, Scattolin AM, Di Bona E, Oldani E, Parolini M, Gökbuget N, Bassan R
Haematologica 2013 Nov;98(11):1718-25. Epub 2013 Jun 10 doi: 10.3324/haematol.2013.086827. PMID: 23753030Free PMC Article
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Diagnosis

Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.
Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Burkitt Leukemia Presenting as Acute Appendicitis: A Case Report and Literature Review.
Mimery AH, Jabbour J, Sykes B, MacDermid E, Al-Askari M, De Clercq S
Am J Case Rep 2020 Feb 13;21:e921568. doi: 10.12659/AJCR.921568. PMID: 32094318Free PMC Article
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584
Adult Burkitt leukemia and lymphoma.
Blum KA, Lozanski G, Byrd JC
Blood 2004 Nov 15;104(10):3009-20. Epub 2004 Jul 20 doi: 10.1182/blood-2004-02-0405. PMID: 15265787
Oncogenes and leukemia.
Butturini A, Gale RP
Leukemia 1990 Feb;4(2):138-60. PMID: 2406517

Therapy

Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement.
Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Monoclonal antibodies in frontline acute lymphoblastic leukemia.
Chew S, Jammal N, Kantarjian H, Jabbour E
Best Pract Res Clin Haematol 2020 Dec;33(4):101226. Epub 2020 Nov 18 doi: 10.1016/j.beha.2020.101226. PMID: 33279178
Burkitt Leukemia Presenting as Acute Appendicitis: A Case Report and Literature Review.
Mimery AH, Jabbour J, Sykes B, MacDermid E, Al-Askari M, De Clercq S
Am J Case Rep 2020 Feb 13;21:e921568. doi: 10.12659/AJCR.921568. PMID: 32094318Free PMC Article
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Prognosis

Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse.
Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Efficacy of the GMALL-B-ALL/NHL2002 protocol in Burkitt leukemia/lymphoma and aggressive non-Hodgkin-lymphomas with or without CNS involvement.
Sakarou M, Eisele L, Dührsen U, Hüttmann A
Eur J Haematol 2019 Mar;102(3):241-250. Epub 2019 Jan 20 doi: 10.1111/ejh.13199. PMID: 30471148
Burkitt leukemia limited to the bone marrow has a better prognosis than Burkitt lymphoma with bone marrow involvement in adults.
Song JY, Venkataraman G, Fedoriw Y, Herrera AF, Siddiqi T, Alikhan MB, Kim YS, Murata-Collins J, Weisenburger DD, Liu X, Duffield AS
Leuk Lymphoma 2016;57(4):866-71. Epub 2015 Oct 8 doi: 10.3109/10428194.2015.1085529. PMID: 26450341
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584
Adult Burkitt leukemia and lymphoma.
Blum KA, Lozanski G, Byrd JC
Blood 2004 Nov 15;104(10):3009-20. Epub 2004 Jul 20 doi: 10.1182/blood-2004-02-0405. PMID: 15265787

Clinical prediction guides

Ibrutinib plus RICE or RVICI for relapsed/refractory mature B-cell non-Hodgkin lymphoma in children and young adults: SPARKLE trial.
Burke GAA, Vinti L, Kabickova E, Beishuizen A, Tacyildiz N, Uyttebroeck A, Kang HJ, Luisi F, Minard-Colin V, Burkhardt B, Tamegnon M, Sun S, Curtis M, Deshpande S, Nottage K, Howes A, Srinivasan S, Bhojwani D, Norris R, Cairo M
Blood Adv 2023 Feb 28;7(4):602-610. doi: 10.1182/bloodadvances.2022008802. PMID: 36541957Free PMC Article
Long-term outcome of hyper-CVAD-R for Burkitt leukemia/lymphoma and high-grade B-cell lymphoma: focus on CNS relapse.
Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
High cure rates in Burkitt lymphoma and leukemia: a Northern Italy Leukemia Group study of the German short intensive rituximab-chemotherapy program.
Intermesoli T, Rambaldi A, Rossi G, Delaini F, Romani C, Pogliani EM, Pagani C, Angelucci E, Terruzzi E, Levis A, Cassibba V, Mattei D, Gianfaldoni G, Scattolin AM, Di Bona E, Oldani E, Parolini M, Gökbuget N, Bassan R
Haematologica 2013 Nov;98(11):1718-25. Epub 2013 Jun 10 doi: 10.3324/haematol.2013.086827. PMID: 23753030Free PMC Article
Mature B-cell lymphoma and leukemia in children and adolescents-review of standard chemotherapy regimen and perspectives.
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584
Epoetin alpha decreases the number of erythrocyte transfusions in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, and Burkitt leukemia/lymphoma: results of a randomized clinical trial.
Cabanillas ME, Kantarjian H, Thomas DA, Mattiuzzi GN, Rytting ME, Bruera E, Xiao L, Bekele BN, Foudray MC, Cortes JE
Cancer 2012 Feb 1;118(3):848-55. Epub 2011 Jul 12 doi: 10.1002/cncr.26341. PMID: 21751205Free PMC Article

Recent systematic reviews

Pediatric precursor B-cell acute lymphoblastic leukemia with MYC 8q24 translocation - how to treat?
Zhang C, Amos Burke GA
Leuk Lymphoma 2018 Aug;59(8):1807-1813. Epub 2017 Oct 12 doi: 10.1080/10428194.2017.1387914. PMID: 29022749

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