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Burkitt Leukemia

MedGen UID:
1658558
Concept ID:
C4721444
Neoplastic Process
Synonyms: Burkitt Cell Leukemia; Burkitt's Leukemia; Burkitts Leukemia; L3 Lymphocytic Leukemia; L3 Lymphocytic Leukemias; Leukemia, Burkitt; Leukemia, Burkitt Cell; Leukemia, Burkitt's; Leukemia, L3 Lymphocytic; Leukemia, Lymphoblastic, Burkitt-Type; Leukemia, Lymphocytic, L3; Lymphocytic Leukemia, L3
SNOMED CT: Acute lymphoblastic leukemia, mature B-cell type (22197008); Burkitt cell leukemia (22197008); Burkitt's cell leukemia (22197008); Acute lymphoblastic leukemia, Burkitt's type (22197008); Burkitt's leukemia (277571004)

Definition

The leukemic counterpart of Burkitt''s lymphoma. The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood. This is an aggressive leukemia. [from NCI]

Professional guidelines

PubMed

Segot A, Raffoux E, Lengline E, Thieblemont C, Dombret H, Boissel N, Cluzeau T
Ann Hematol 2015 Nov;94(11):1859-63. Epub 2015 Aug 18 doi: 10.1007/s00277-015-2475-z. PMID: 26280395

Recent clinical studies

Etiology

Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Woessmann W, Zimmermann M, Meinhardt A, Müller S, Hauch H, Knörr F, Oschlies I, Klapper W, Niggli F, Kabickova E, Attarbaschi A, Reiter A, Burkhardt B
Blood 2020 Apr 2;135(14):1124-1132. doi: 10.1182/blood.2019003591. PMID: 31961927
Intermesoli T, Rambaldi A, Rossi G, Delaini F, Romani C, Pogliani EM, Pagani C, Angelucci E, Terruzzi E, Levis A, Cassibba V, Mattei D, Gianfaldoni G, Scattolin AM, Di Bona E, Oldani E, Parolini M, Gökbuget N, Bassan R
Haematologica 2013 Nov;98(11):1718-25. Epub 2013 Jun 10 doi: 10.3324/haematol.2013.086827. PMID: 23753030Free PMC Article
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Diagnosis

Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Mimery AH, Jabbour J, Sykes B, MacDermid E, Al-Askari M, De Clercq S
Am J Case Rep 2020 Feb 13;21:e921568. doi: 10.12659/AJCR.921568. PMID: 32094318Free PMC Article
Huang Q
Arch Pathol Lab Med 2004 Dec;128(12):1459-60. doi: 10.5858/2004-128-1459-BL. PMID: 15578900
Blum KA, Lozanski G, Byrd JC
Blood 2004 Nov 15;104(10):3009-20. Epub 2004 Jul 20 doi: 10.1182/blood-2004-02-0405. PMID: 15265787
Butturini A, Gale RP
Leukemia 1990 Feb;4(2):138-60. PMID: 2406517

Therapy

Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung KTM, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GAA, Cazzaniga G, Gohring G, De Groot-Kruseman HA, Haferlach C, Nigro LL, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, Van der Velden VHJ, Rand V, Hunger SP, Harrison CJ, Bacon CM, Van Delft FW, Loh ML, Moppett J, Vormoor J, Walker BA, Moorman AV, Russell LJ
Haematologica 2023 Mar 1;108(3):717-731. doi: 10.3324/haematol.2021.280557. PMID: 35484682Free PMC Article
Chew S, Jammal N, Kantarjian H, Jabbour E
Best Pract Res Clin Haematol 2020 Dec;33(4):101226. Epub 2020 Nov 18 doi: 10.1016/j.beha.2020.101226. PMID: 33279178
Mimery AH, Jabbour J, Sykes B, MacDermid E, Al-Askari M, De Clercq S
Am J Case Rep 2020 Feb 13;21:e921568. doi: 10.12659/AJCR.921568. PMID: 32094318Free PMC Article
Woessmann W, Zimmermann M, Meinhardt A, Müller S, Hauch H, Knörr F, Oschlies I, Klapper W, Niggli F, Kabickova E, Attarbaschi A, Reiter A, Burkhardt B
Blood 2020 Apr 2;135(14):1124-1132. doi: 10.1182/blood.2019003591. PMID: 31961927
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584

Prognosis

Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Song JY, Venkataraman G, Fedoriw Y, Herrera AF, Siddiqi T, Alikhan MB, Kim YS, Murata-Collins J, Weisenburger DD, Liu X, Duffield AS
Leuk Lymphoma 2016;57(4):866-71. Epub 2015 Oct 8 doi: 10.3109/10428194.2015.1085529. PMID: 26450341
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584
Zhukova N, Naqvi A
J Pediatr Hematol Oncol 2013 Jan;35(1):e30-2. doi: 10.1097/MPH.0b013e318270672f. PMID: 23018576
Blum KA, Lozanski G, Byrd JC
Blood 2004 Nov 15;104(10):3009-20. Epub 2004 Jul 20 doi: 10.1182/blood-2004-02-0405. PMID: 15265787

Clinical prediction guides

Samra B, Khoury JD, Morita K, Ravandi F, Richard-Carpentier G, Short NJ, El Hussein S, Thompson P, Jain N, Kantarjian H, Jabbour E
Blood Adv 2021 Oct 26;5(20):3913-3918. doi: 10.1182/bloodadvances.2021004427. PMID: 34464974Free PMC Article
Odaman Al I, Bayram C, Koç B, Ersoy G, Pasli Uysalol E, Aki H, Özdemir GN
J Pediatr Hematol Oncol 2020 Jan;42(1):e61-e63. doi: 10.1097/MPH.0000000000001354. PMID: 30499905
Intermesoli T, Rambaldi A, Rossi G, Delaini F, Romani C, Pogliani EM, Pagani C, Angelucci E, Terruzzi E, Levis A, Cassibba V, Mattei D, Gianfaldoni G, Scattolin AM, Di Bona E, Oldani E, Parolini M, Gökbuget N, Bassan R
Haematologica 2013 Nov;98(11):1718-25. Epub 2013 Jun 10 doi: 10.3324/haematol.2013.086827. PMID: 23753030Free PMC Article
Worch J, Rohde M, Burkhardt B
Pediatr Hematol Oncol 2013 Sep;30(6):465-83. Epub 2013 Apr 9 doi: 10.3109/08880018.2013.783891. PMID: 23570584
Cabanillas ME, Kantarjian H, Thomas DA, Mattiuzzi GN, Rytting ME, Bruera E, Xiao L, Bekele BN, Foudray MC, Cortes JE
Cancer 2012 Feb 1;118(3):848-55. Epub 2011 Jul 12 doi: 10.1002/cncr.26341. PMID: 21751205Free PMC Article

Recent systematic reviews

Zhang C, Amos Burke GA
Leuk Lymphoma 2018 Aug;59(8):1807-1813. Epub 2017 Oct 12 doi: 10.1080/10428194.2017.1387914. PMID: 29022749

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