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Metastatic Neuroblastoma

MedGen UID:
1660128
•Concept ID:
C4722306
•
Neoplastic Process

Definition

A neuroblastoma that has metastasized from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Neuroblastoma

Professional guidelines

PubMed

Mechanisms, Characteristics, and Treatment of Neuropathic Pain and Peripheral Neuropathy Associated with Dinutuximab in Neuroblastoma Patients.
Mastrangelo S, Rivetti S, Triarico S, Romano A, Attinà G, Maurizi P, Ruggiero A
Int J Mol Sci 2021 Nov 23;22(23) doi: 10.3390/ijms222312648. PMID: 34884452Free PMC Article
Clinical characteristics, treatment and prognosis of paediatric patients with metastatic neuroblastoma to the brain.
Hu H, Zhang W, Huang D, Wang Y, Zhang Y, Yi Y, Liu A, Li J
Clin Neurol Neurosurg 2019 Sep;184:105372. Epub 2019 May 23 doi: 10.1016/j.clineuro.2019.105372. PMID: 31155296
Incidence, Survival, and Treatment of Localized and Metastatic Neuroblastoma in Germany 1979-2015.
Berthold F, Spix C, Kaatsch P, Lampert F
Paediatr Drugs 2017 Dec;19(6):577-593. doi: 10.1007/s40272-017-0251-3. PMID: 28786082Free PMC Article

Recent clinical studies

Etiology

Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
Role and toxicity of radiation therapy in neuroblastoma patients: A literature review.
Zhao Q, Liu Y, Zhang Y, Meng L, Wei J, Wang B, Wang H, Xin Y, Dong L, Jiang X
Crit Rev Oncol Hematol 2020 May;149:102924. Epub 2020 Mar 3 doi: 10.1016/j.critrevonc.2020.102924. PMID: 32172225
Incidence, Survival, and Treatment of Localized and Metastatic Neuroblastoma in Germany 1979-2015.
Berthold F, Spix C, Kaatsch P, Lampert F
Paediatr Drugs 2017 Dec;19(6):577-593. doi: 10.1007/s40272-017-0251-3. PMID: 28786082Free PMC Article
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov K, Cheung NK
Semin Oncol 2014 Oct;41(5):589-612. Epub 2014 Jul 21 doi: 10.1053/j.seminoncol.2014.07.003. PMID: 25440605Free PMC Article

Diagnosis

Phase 1 study of intraventricular (131)I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kramer K, Pandit-Taskar N, Kushner BH, Zanzonico P, Humm JL, Tomlinson U, Donzelli M, Wolden SL, Haque S, Dunkel I, Souweidane MM, Greenfield JP, Tickoo S, Lewis JS, Lyashchenko SK, Carrasquillo JA, Chu B, Horan C, Larson SM, Cheung NV, Modak S
J Hematol Oncol 2022 Nov 12;15(1):165. doi: 10.1186/s13045-022-01383-4. PMID: 36371226Free PMC Article
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Incidence, Survival, and Treatment of Localized and Metastatic Neuroblastoma in Germany 1979-2015.
Berthold F, Spix C, Kaatsch P, Lampert F
Paediatr Drugs 2017 Dec;19(6):577-593. doi: 10.1007/s40272-017-0251-3. PMID: 28786082Free PMC Article
Pediatric primary and metastatic neuroblastoma: MRI findings: pictorial review.
Nour-Eldin NE, Abdelmonem O, Tawfik AM, Naguib NN, Klingebiel T, Rolle U, Schwabe D, Harth M, Eltoukhy MM, Vogl TJ
Magn Reson Imaging 2012 Sep;30(7):893-906. Epub 2012 Apr 12 doi: 10.1016/j.mri.2012.02.028. PMID: 22503092
Intrathoracic neural tumours.
Davidson KG, Walbaum PR, McCormack RJ
Thorax 1978 Jun;33(3):359-67. doi: 10.1136/thx.33.3.359. PMID: 210531Free PMC Article

Therapy

Phase 1 study of intraventricular (131)I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kramer K, Pandit-Taskar N, Kushner BH, Zanzonico P, Humm JL, Tomlinson U, Donzelli M, Wolden SL, Haque S, Dunkel I, Souweidane MM, Greenfield JP, Tickoo S, Lewis JS, Lyashchenko SK, Carrasquillo JA, Chu B, Horan C, Larson SM, Cheung NV, Modak S
J Hematol Oncol 2022 Nov 12;15(1):165. doi: 10.1186/s13045-022-01383-4. PMID: 36371226Free PMC Article
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
Mechanisms, Characteristics, and Treatment of Neuropathic Pain and Peripheral Neuropathy Associated with Dinutuximab in Neuroblastoma Patients.
Mastrangelo S, Rivetti S, Triarico S, Romano A, Attinà G, Maurizi P, Ruggiero A
Int J Mol Sci 2021 Nov 23;22(23) doi: 10.3390/ijms222312648. PMID: 34884452Free PMC Article
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov K, Cheung NK
Semin Oncol 2014 Oct;41(5):589-612. Epub 2014 Jul 21 doi: 10.1053/j.seminoncol.2014.07.003. PMID: 25440605Free PMC Article

Prognosis

Phase 1 study of intraventricular (131)I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies.
Kramer K, Pandit-Taskar N, Kushner BH, Zanzonico P, Humm JL, Tomlinson U, Donzelli M, Wolden SL, Haque S, Dunkel I, Souweidane MM, Greenfield JP, Tickoo S, Lewis JS, Lyashchenko SK, Carrasquillo JA, Chu B, Horan C, Larson SM, Cheung NV, Modak S
J Hematol Oncol 2022 Nov 12;15(1):165. doi: 10.1186/s13045-022-01383-4. PMID: 36371226Free PMC Article
Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program.
Jiménez C, Antonelli R, Nadal-Ribelles M, Devis-Jauregui L, Latorre P, Solé C, Masanas M, Molero-Valenzuela A, Soriano A, Sánchez de Toledo J, Llobet-Navas D, Roma J, Posas F, de Nadal E, Gallego S, Moreno L, Segura MF
Mol Cancer 2022 Sep 3;21(1):175. doi: 10.1186/s12943-022-01643-4. PMID: 36057593Free PMC Article
Neuroblastoma: Essential genetic pathways and current therapeutic options.
Salemi F, Alam W, Hassani MS, Hashemi SZ, Jafari AA, Mirmoeeni SMS, Arbab M, Mortazavizadeh SMR, Khan H
Eur J Pharmacol 2022 Jul 5;926:175030. Epub 2022 May 20 doi: 10.1016/j.ejphar.2022.175030. PMID: 35605657
Mechanisms, Characteristics, and Treatment of Neuropathic Pain and Peripheral Neuropathy Associated with Dinutuximab in Neuroblastoma Patients.
Mastrangelo S, Rivetti S, Triarico S, Romano A, Attinà G, Maurizi P, Ruggiero A
Int J Mol Sci 2021 Nov 23;22(23) doi: 10.3390/ijms222312648. PMID: 34884452Free PMC Article
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S
Nat Commun 2021 Jan 21;12(1):511. doi: 10.1038/s41467-020-20785-x. PMID: 33479234Free PMC Article

Clinical prediction guides

Vitamin D Receptor Activation Attenuates Hippo Pathway Effectors and Cell Survival in Metastatic Neuroblastoma.
Ladumor Y, Seong BKA, Hallett R, Valencia-Sama I, Adderley T, Wang Y, Kee L, Gont A, Kaplan DR, Irwin MS
Mol Cancer Res 2022 Jun 3;20(6):895-908. doi: 10.1158/1541-7786.MCR-21-0425. PMID: 35190818Free PMC Article
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S
Nat Commun 2021 Jan 21;12(1):511. doi: 10.1038/s41467-020-20785-x. PMID: 33479234Free PMC Article
Establishment and characterization of new orthotopic and metastatic neuroblastoma models.
Daudigeos-Dubus E, LE Dret L, Rouffiac V, Bawa O, Leguerney I, Opolon P, Vassal G, Geoerger B
In Vivo 2014 Jul-Aug;28(4):425-34. PMID: 24982206
Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma.
Asgharzadeh S, Salo JA, Ji L, Oberthuer A, Fischer M, Berthold F, Hadjidaniel M, Liu CW, Metelitsa LS, Pique-Regi R, Wakamatsu P, Villablanca JG, Kreissman SG, Matthay KK, Shimada H, London WB, Sposto R, Seeger RC
J Clin Oncol 2012 Oct 1;30(28):3525-32. Epub 2012 Aug 27 doi: 10.1200/JCO.2011.40.9169. PMID: 22927533Free PMC Article
Chronic metastatic neuroblastoma.
Kazanowska B, Reich A, Jelen M, Chybicka A
Pediatr Blood Cancer 2008 Apr;50(4):898-900. doi: 10.1002/pbc.21366. PMID: 17914736

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