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Resectable Malignant Neoplasm

MedGen UID:: 1660568
•Concept ID:: C4725864
•: Neoplastic Process

Definition

Malignant neoplasm that is amenable to surgical resection. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVResectable Malignant Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Resectable Malignant Neoplasm
        Borderline Resectable Malignant Neoplasm
        Borderline Resectable Carcinoma
        Borderline Resectable Pancreatic Carcinoma
        Resectable Carcinoma
        Resectable Carcinoma of Unknown Primary
        Resectable Adenocarcinoma of Unknown Primary
        Resectable Digestive System Carcinoma
        Resectable Bile Duct Adenocarcinoma
        Resectable Colorectal Carcinoma
        Resectable Extrahepatic Bile Duct Carcinoma
        Resectable Liver and Intrahepatic Bile Duct Carcinoma
        Resectable Pancreatic Carcinoma
        Resectable Small Intestinal Carcinoma
        Resectable Head and Neck Squamous Cell Carcinoma
        Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck
        Resectable Oropharyngeal Squamous Cell Carcinoma
        Resectable Lung Non-Small Cell Carcinoma
        Resectable Renal Cell Carcinoma
        Resectable Skin Carcinoma
        Resectable Skin Squamous Cell Carcinoma
        Resectable Glioblastoma
        Resectable Malignant Female Reproductive System Neoplasm
        Resectable Malignant Liver Neoplasm
        Resectable Hepatoblastoma
        Resectable Malignant Mesothelioma
        Resectable Pleural Malignant Mesothelioma
        Resectable Neuroblastoma
        Localized Resectable Neuroblastoma
        Resectable Platinum-Resistant Malignant Germ Cell Tumor
        Resectable Sarcoma
        Resectable Leiomyosarcoma
        Resectable Liposarcoma
        Resectable Dedifferentiated Liposarcoma
        Resectable Osteosarcoma
        Resectable Soft Tissue Sarcoma
        Resectable Undifferentiated Pleomorphic Sarcoma

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 2: Treatment - Update 2022.

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Hoeller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:256-284. Epub 2022 May 24 doi: 10.1016/j.ejca.2022.04.018. PMID: 35623961

Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.

Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.

Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, Naruse M, Pacak K, Young WF Jr; Endocrine Society
J Clin Endocrinol Metab 2014 Jun;99(6):1915-42. doi: 10.1210/jc.2014-1498. PMID: 24893135

See all (14765)

Recent clinical studies

Etiology

Fifty Years of Surgery for Pancreatic Cancer.

Hackert T, Klaiber U, Pausch T, Mihaljevic AL, Büchler MW
Pancreas 2020 Sep;49(8):1005-1013. doi: 10.1097/MPA.0000000000001634. PMID: 32833940

Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?

Stewart CL, Warner S, Ito K, Raoof M, Wu GX, Kessler J, Kim JY, Fong Y
Curr Probl Surg 2018 Sep;55(9):330-379. Epub 2018 Oct 4 doi: 10.1067/j.cpsurg.2018.08.004. PMID: 30526930 Free PMC Article

HEPATOCELLULAR CARCINOMA: DIAGNOSIS AND OPERATIVE MANAGEMENT.

Chedid MF, Kruel CRP, Pinto MA, Grezzana-Filho TJM, Leipnitz I, Kruel CDP, Scaffaro LA, Chedid AD
Arq Bras Cir Dig 2017 Oct-Dec;30(4):272-278. doi: 10.1590/0102-6720201700040011. PMID: 29340553 Free PMC Article

Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages.

Gillen S, Schuster T, Meyer Zum Büschenfelde C, Friess H, Kleeff J
PLoS Med 2010 Apr 20;7(4):e1000267. doi: 10.1371/journal.pmed.1000267. PMID: 20422030 Free PMC Article

Extended parotidectomy.

De Vincentiis M, Magliulo G, Soldo P, Manciocco V, Pagliuca G, Del Gaizo R, Gallo A
Acta Otorhinolaryngol Ital 2005 Jun;25(3):169-73. PMID: 16450772 Free PMC Article

See all (113791)

Diagnosis

Chordoma.

Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396

Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure?

Stewart CL, Warner S, Ito K, Raoof M, Wu GX, Kessler J, Kim JY, Fong Y
Curr Probl Surg 2018 Sep;55(9):330-379. Epub 2018 Oct 4 doi: 10.1067/j.cpsurg.2018.08.004. PMID: 30526930 Free PMC Article

HEPATOCELLULAR CARCINOMA: DIAGNOSIS AND OPERATIVE MANAGEMENT.

Ameloblastoma.

Mendenhall WM, Werning JW, Fernandes R, Malyapa RS, Mendenhall NP
Am J Clin Oncol 2007 Dec;30(6):645-8. doi: 10.1097/COC.0b013e3181573e59. PMID: 18091060

Pancreatic cancer.

Murr MM, Sarr MG, Oishi AJ, van Heerden JA
CA Cancer J Clin 1994 Sep-Oct;44(5):304-18. doi: 10.3322/canjclin.44.5.304. PMID: 7521272

See all (85177)

Therapy

Immune-checkpoint inhibitors for glioblastoma: what have we learned?

Omuro A
Arq Neuropsiquiatr 2022 May;80(5 Suppl 1):266-269. doi: 10.1590/0004-282X-ANP-2022-S129. PMID: 35976319 Free PMC Article

MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer.

Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555

Neoadjuvant therapy or upfront surgery for resectable and borderline resectable pancreatic cancer: A meta-analysis of randomised controlled trials.

van Dam JL, Janssen QP, Besselink MG, Homs MYV, van Santvoort HC, van Tienhoven G, de Wilde RF, Wilmink JW, van Eijck CHJ, Groot Koerkamp B; Dutch Pancreatic Cancer Group
Eur J Cancer 2022 Jan;160:140-149. Epub 2021 Nov 24 doi: 10.1016/j.ejca.2021.10.023. PMID: 34838371

Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial.

Sohal DPS, Duong M, Ahmad SA, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL 3rd, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS
JAMA Oncol 2021 Mar 1;7(3):421-427. doi: 10.1001/jamaoncol.2020.7328. PMID: 33475684 Free PMC Article

Neoadjuvant Chemotherapy in Pancreatic Cancer: An Appraisal of the Current High-Level Evidence.

Müller PC, Frey MC, Ruzza CM, Nickel F, Jost C, Gwerder C, Hackert T, Z'graggen K, Kessler U
Pharmacology 2021;106(3-4):143-153. Epub 2020 Sep 23 doi: 10.1159/000510343. PMID: 32966993

See all (58173)

Prognosis

Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma.

Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, Weiss MJ, Zheng L, Wolfgang CL, He J
Ann Surg 2018 May;267(5):936-945. doi: 10.1097/SLA.0000000000002234. PMID: 28338509

Borderline resectable pancreatic cancer.

Hackert T, Ulrich A, Büchler MW
Cancer Lett 2016 Jun 1;375(2):231-237. Epub 2016 Mar 9 doi: 10.1016/j.canlet.2016.02.039. PMID: 26970276

Intrahepatic cholangiocarcinoma.

Poultsides GA, Zhu AX, Choti MA, Pawlik TM
Surg Clin North Am 2010 Aug;90(4):817-37. doi: 10.1016/j.suc.2010.04.011. PMID: 20637950

Lymphadenectomy in metastasectomy.

Dominguez-Ventura A, Nichols FC 3rd
Thorac Surg Clin 2006 May;16(2):139-43. doi: 10.1016/j.thorsurg.2005.12.001. PMID: 16805203

Reoperative pancreaticoduodenectomy.

Tyler DS, Evans DB
Ann Surg 1994 Feb;219(2):211-21. doi: 10.1097/00000658-199402000-00014. PMID: 7907464 Free PMC Article

See all (98712)

Clinical prediction guides

Indications for staging laparoscopy in pancreatic cancer.

De Rosa A, Cameron IC, Gomez D
HPB (Oxford) 2016 Jan;18(1):13-20. Epub 2015 Nov 18 doi: 10.1016/j.hpb.2015.10.004. PMID: 26776846 Free PMC Article

Early stage colon cancer.

Freeman HJ
World J Gastroenterol 2013 Dec 14;19(46):8468-73. doi: 10.3748/wjg.v19.i46.8468. PMID: 24379564 Free PMC Article

Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

Brunelli A, Kim AW, Berger KI, Addrizzo-Harris DJ
Chest 2013 May;143(5 Suppl):e166S-e190S. doi: 10.1378/chest.12-2395. PMID: 23649437

Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages.

Gillen S, Schuster T, Meyer Zum Büschenfelde C, Friess H, Kleeff J
PLoS Med 2010 Apr 20;7(4):e1000267. doi: 10.1371/journal.pmed.1000267. PMID: 20422030 Free PMC Article

Mediastinoscopic ultrasonography.

Hürtgen M, Wolf M, Witte B
J Thorac Oncol 2007 Apr;2(4):362-4. doi: 10.1097/01.JTO.0000263723.99814.d4. PMID: 17409812

See all (64092)

Recent systematic reviews

Evaluation of Clinical and Safety Outcomes of Neoadjuvant Immunotherapy Combined With Chemotherapy for Patients With Resectable Esophageal Cancer: A Systematic Review and Meta-analysis.

Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089 Free PMC Article

Malignant phyllodes tumor of the breast: a systematic review.

Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723 Free PMC Article

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.

Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310

Neoadjuvant immune checkpoint inhibitors in resectable non-small-cell lung cancer: a systematic review.

Ulas EB, Dickhoff C, Schneiders FL, Senan S, Bahce I
ESMO Open 2021 Oct;6(5):100244. Epub 2021 Aug 31 doi: 10.1016/j.esmoop.2021.100244. PMID: 34479033 Free PMC Article

Neoadjuvant Immunotherapy for NSCLC: Current Concepts and Future Approaches.

Uprety D, Mandrekar SJ, Wigle D, Roden AC, Adjei AA
J Thorac Oncol 2020 Aug;15(8):1281-1297. Epub 2020 Jun 6 doi: 10.1016/j.jtho.2020.05.020. PMID: 32522713

See all (3798)

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