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Refractory Chronic Myelomonocytic Leukemia

MedGen UID:
1660926
•Concept ID:
C4725603
•
Neoplastic Process

Definition

Chronic myelomonocytic leukemia that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Chronic Myelomonocytic Leukemia

Professional guidelines

PubMed

Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2013 Feb;88(2):141-50. doi: 10.1002/ajh.23384. PMID: 23349007
Primary myelofibrosis: 2012 update on diagnosis, risk stratification, and management.
Tefferi A
Am J Hematol 2011 Dec;86(12):1017-26. doi: 10.1002/ajh.22210. PMID: 22086865
Myelodysplastic syndromes clinical practice guidelines in oncology.
Greenberg PL, Baer MR, Bennett JM, Bloomfield CD, De Castro CM, Deeg HJ, Devetten MP, Emanuel PD, Erba HP, Estey E, Foran J, Gore SD, Millenson M, Navarro WH, Nimer SD, O'Donnell MR, Saba HI, Spiers K, Stone RM, Tallman MS
J Natl Compr Canc Netw 2006 Jan;4(1):58-77. PMID: 16403405

Recent clinical studies

Etiology

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Azacitidine plus venetoclax in patients with high-risk myelodysplastic syndromes or chronic myelomonocytic leukaemia: phase 1 results of a single-centre, dose-escalation, dose-expansion, phase 1-2 study.
Bazinet A, Darbaniyan F, Jabbour E, Montalban-Bravo G, Ohanian M, Chien K, Kadia T, Takahashi K, Masarova L, Short N, Alvarado Y, Yilmaz M, Ravandi F, Andreeff M, Kanagal-Shamanna R, Ganan-Gomez I, Colla S, Qiao W, Huang X, McCue D, Mirabella B, Kantarjian H, Garcia-Manero G
Lancet Haematol 2022 Oct;9(10):e756-e765. Epub 2022 Sep 2 doi: 10.1016/S2352-3026(22)00216-2. PMID: 36063832
Thalidomide in myelodysplastic syndromes.
Zorat F, Pozzato G
Biomed Pharmacother 2002 Feb;56(1):20-30. doi: 10.1016/s0753-3322(01)00145-7. PMID: 11905506
Magnetic resonance imaging in myelodysplastic syndromes.
Lewis S, Wainscoat JS, Moore NR, Golding SJ
Br J Radiol 1995 Feb;68(806):121-7. doi: 10.1259/0007-1285-68-806-121. PMID: 7735740
Globin chain synthesis in myelodysplastic syndromes.
Chalevelakis G, Karaoulis S, Yalouris AG, Economopoulos T, Tountas N, Raptis S
J Clin Pathol 1991 Feb;44(2):134-8. doi: 10.1136/jcp.44.2.134. PMID: 1864985Free PMC Article

Diagnosis

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Myelodysplastic/myeloproliferative neoplasms.
Hyjek E, Vardiman JW
Semin Diagn Pathol 2011 Nov;28(4):283-97. doi: 10.1053/j.semdp.2011.07.002. PMID: 22195406
Myelodysplastic/myeloproliferative neoplasms.
Cazzola M, Malcovati L, Invernizzi R
Hematology Am Soc Hematol Educ Program 2011;2011:264-72. doi: 10.1182/asheducation-2011.1.264. PMID: 22160044
Cytogenetic and molecular diagnosis of chromosome 5 deletions in myelodysplasia.
Westbrook CA, Hsu WT, Chyna B, Litvak D, Raza A, Horrigan SK
Br J Haematol 2000 Sep;110(4):847-55. doi: 10.1046/j.1365-2141.2000.02285.x. PMID: 11054067
Magnetic resonance imaging in myelodysplastic syndromes.
Lewis S, Wainscoat JS, Moore NR, Golding SJ
Br J Radiol 1995 Feb;68(806):121-7. doi: 10.1259/0007-1285-68-806-121. PMID: 7735740

Therapy

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Azacitidine plus venetoclax in patients with high-risk myelodysplastic syndromes or chronic myelomonocytic leukaemia: phase 1 results of a single-centre, dose-escalation, dose-expansion, phase 1-2 study.
Bazinet A, Darbaniyan F, Jabbour E, Montalban-Bravo G, Ohanian M, Chien K, Kadia T, Takahashi K, Masarova L, Short N, Alvarado Y, Yilmaz M, Ravandi F, Andreeff M, Kanagal-Shamanna R, Ganan-Gomez I, Colla S, Qiao W, Huang X, McCue D, Mirabella B, Kantarjian H, Garcia-Manero G
Lancet Haematol 2022 Oct;9(10):e756-e765. Epub 2022 Sep 2 doi: 10.1016/S2352-3026(22)00216-2. PMID: 36063832
Decitabine/Cedazuridine: First Approval.
Dhillon S
Drugs 2020 Sep;80(13):1373-1378. doi: 10.1007/s40265-020-01389-7. PMID: 32860582Free PMC Article
Thalidomide in myelodysplastic syndromes.
Zorat F, Pozzato G
Biomed Pharmacother 2002 Feb;56(1):20-30. doi: 10.1016/s0753-3322(01)00145-7. PMID: 11905506
Trisomy 14 in myeloid malignancies: report of two cases and review of the literature.
Horton YM, Johnson PR
Cancer Genet Cytogenet 2001 Jan 15;124(2):172-4. doi: 10.1016/s0165-4608(00)00345-9. PMID: 11172913

Prognosis

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Decitabine/Cedazuridine: First Approval.
Dhillon S
Drugs 2020 Sep;80(13):1373-1378. doi: 10.1007/s40265-020-01389-7. PMID: 32860582Free PMC Article
Myelodysplastic/myeloproliferative neoplasms.
Cazzola M, Malcovati L, Invernizzi R
Hematology Am Soc Hematol Educ Program 2011;2011:264-72. doi: 10.1182/asheducation-2011.1.264. PMID: 22160044
Trisomy 14 in myeloid malignancies: report of two cases and review of the literature.
Horton YM, Johnson PR
Cancer Genet Cytogenet 2001 Jan 15;124(2):172-4. doi: 10.1016/s0165-4608(00)00345-9. PMID: 11172913
Globin chain synthesis in myelodysplastic syndromes.
Chalevelakis G, Karaoulis S, Yalouris AG, Economopoulos T, Tountas N, Raptis S
J Clin Pathol 1991 Feb;44(2):134-8. doi: 10.1136/jcp.44.2.134. PMID: 1864985Free PMC Article

Clinical prediction guides

Natural history study of patients with familial platelet disorder with associated myeloid malignancy.
Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP
Blood 2023 Dec 21;142(25):2146-2158. doi: 10.1182/blood.2023019746. PMID: 37738626Free PMC Article
Decitabine/Cedazuridine: First Approval.
Dhillon S
Drugs 2020 Sep;80(13):1373-1378. doi: 10.1007/s40265-020-01389-7. PMID: 32860582Free PMC Article
Thalidomide for the treatment of patients with myelodysplastic syndromes.
Strupp C, Germing U, Aivado M, Misgeld E, Haas R, Gattermann N
Leukemia 2002 Jan;16(1):1-6. doi: 10.1038/sj.leu.2402330. PMID: 11840256
Cytogenetic and molecular diagnosis of chromosome 5 deletions in myelodysplasia.
Westbrook CA, Hsu WT, Chyna B, Litvak D, Raza A, Horrigan SK
Br J Haematol 2000 Sep;110(4):847-55. doi: 10.1046/j.1365-2141.2000.02285.x. PMID: 11054067
Sequential karyotypic evolutions and bone marrow aplasia preceding acute myelomonocytic transformation from myelodysplastic syndrome.
Tomonaga M, Tomonaga Y, Kusano M, Ichimaru M
Br J Haematol 1984 Sep;58(1):53-60. doi: 10.1111/j.1365-2141.1984.tb06058.x. PMID: 6590091

Recent systematic reviews

Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders.
Gu Y, Estcourt LJ, Doree C, Hopewell S, Vyas P
Cochrane Database Syst Rev 2015 Oct 5;2015(10):CD011577. doi: 10.1002/14651858.CD011577.pub2. PMID: 26436602Free PMC Article

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