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Transcription Factor Binding Site Amplification

MedGen UID:
1661130
Concept ID:
C4727641
Cell or Molecular Dysfunction
Synonym: TFBS Amplification

Definition

An increase in the copy number of a region containing a transcription factor binding site for a gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTranscription Factor Binding Site Amplification

Professional guidelines

PubMed

Jiang J, Yu Y
Trends Pharmacol Sci 2024 Jun;45(6):577-578. Epub 2024 May 14 doi: 10.1016/j.tips.2024.04.005. PMID: 38749882Free PMC Article
Rengel BD, Kowalski TW, Bremm JM, do Amaral Gomes J, Schüler-Faccini L, Vianna FSL, Fraga LR
Birth Defects Res 2022 Dec 1;114(20):1354-1363. Epub 2022 Sep 30 doi: 10.1002/bdr2.2092. PMID: 36177858
Maznyczka A, Braund P, Mangino M, Samani NJ
Atherosclerosis 2008 Aug;199(2):328-32. Epub 2008 Jan 7 doi: 10.1016/j.atherosclerosis.2007.11.027. PMID: 18179798

Recent clinical studies

Etiology

Fuchs S, Danßmann C, Klironomos F, Winkler A, Fallmann J, Kruetzfeldt LM, Szymansky A, Naderi J, Bernhart SH, Grunewald L, Helmsauer K, Rodriguez-Fos E, Kirchner M, Mertins P, Astrahantseff K, Suenkel C, Toedling J, Meggetto F, Remke M, Stadler PF, Hundsdoerfer P, Deubzer HE, Künkele A, Lang P, Fuchs J, Henssen AG, Eggert A, Rajewsky N, Hertwig F, Schulte JH
Nat Commun 2023 Jul 4;14(1):3936. doi: 10.1038/s41467-023-38747-4. PMID: 37402719Free PMC Article
Hagemann S, Misiak D, Bell JL, Fuchs T, Lederer MI, Bley N, Hämmerle M, Ghazy E, Sippl W, Schulte JH, Hüttelmaier S
Mol Cancer 2023 May 29;22(1):88. doi: 10.1186/s12943-023-01792-0. PMID: 37246217Free PMC Article
Karadkhelkar NM, Lin M, Eubanks LM, Janda KD
J Am Chem Soc 2023 Feb 15;145(6):3259-3269. Epub 2023 Feb 3 doi: 10.1021/jacs.2c12732. PMID: 36734615Free PMC Article
Gialesaki S, Bräuer-Hartmann D, Issa H, Bhayadia R, Alejo-Valle O, Verboon L, Schmell AL, Laszig S, Regényi E, Schuschel K, Labuhn M, Ng M, Winkler R, Ihling C, Sinz A, Glaß M, Hüttelmaier S, Matzk S, Schmid L, Strüwe FJ, Kadel SK, Reinhardt D, Yaspo ML, Heckl D, Klusmann JH
Blood 2023 Mar 9;141(10):1105-1118. doi: 10.1182/blood.2022017619. PMID: 36493345Free PMC Article
Fennell K, Keller MA, Villa MA, Paccapelo C, Kucerakova M, Rosochova J, Clemente DosSantos C, Brackney L, Lee CJ, Metcalf R, Crovetti G, Barbieri M, Travali S, Barrotta G, Giuca G, Guerra LE, Ochoa-Garay G
Immunohematology 2021;37(4):178-184. doi: 10.21307/immunohematology-2021-029. PMID: 34964317

Diagnosis

Koka H, Zhou W, McMaster ML, Bai J, Luo W, Klein A, Zhang T, Hua X, Li X, Wang D, Xiong Y, Jones K, Vogt A, Hicks B, Parry D, Goldstein AM, Yang XR
Acta Neuropathol Commun 2024 Aug 12;12(1):129. doi: 10.1186/s40478-024-01833-9. PMID: 39135136Free PMC Article
Wakabayashi Y, Shimono A, Terauchi Y, Zeng C, Hamada M, Semba K, Watanabe S, Ishikawa K
Gene 2024 Jul 30;917:148464. Epub 2024 Apr 12 doi: 10.1016/j.gene.2024.148464. PMID: 38615981
Keck MK, Sill M, Wittmann A, Joshi P, Stichel D, Beck P, Okonechnikow K, Sievers P, Wefers AK, Roncaroli F, Avula S, McCabe MG, Hayden JT, Wesseling P, Øra I, Nistér M, Kranendonk MEG, Tops BBJ, Zapotocky M, Zamecnik J, Vasiljevic A, Fenouil T, Meyronet D, von Hoff K, Schüller U, Loiseau H, Figarella-Branger D, Kramm CM, Sturm D, Scheie D, Rauramaa T, Pesola J, Gojo J, Haberler C, Brandner S, Jacques T, Sexton Oates A, Saffery R, Koscielniak E, Baker SJ, Yip S, Snuderl M, Ud Din N, Samuel D, Schramm K, Blattner-Johnson M, Selt F, Ecker J, Milde T, von Deimling A, Korshunov A, Perry A, Pfister SM, Sahm F, Solomon DA, Jones DTW
Acta Neuropathol 2023 Jan;145(1):49-69. Epub 2022 Nov 27 doi: 10.1007/s00401-022-02516-2. PMID: 36437415Free PMC Article
Choi N, Kim HY, Lim BC, Chae JH, Kim SY, Ko JM
Mol Genet Genomic Med 2021 Oct;9(10):e1791. Epub 2021 Aug 24 doi: 10.1002/mgg3.1791. PMID: 34427995Free PMC Article
Zhang Y, Xiang D, Tang B, Zhang CY
Anal Chem 2017 Oct 3;89(19):10439-10445. Epub 2017 Sep 21 doi: 10.1021/acs.analchem.7b02451. PMID: 28845979

Therapy

Shiroma Y, Takahashi RU, Yamamoto Y, Tahara H
Cancer Sci 2020 Apr;111(4):1058-1064. Epub 2020 Mar 24 doi: 10.1111/cas.14355. PMID: 32073717Free PMC Article
Bushweller JH
Nat Rev Cancer 2019 Nov;19(11):611-624. Epub 2019 Sep 11 doi: 10.1038/s41568-019-0196-7. PMID: 31511663Free PMC Article
Karthigeyan D, Prasad SB, Shandilya J, Agrawal S, Kundu TK
Med Res Rev 2011 Sep;31(5):757-93. Epub 2010 Mar 1 doi: 10.1002/med.20203. PMID: 20196102
Kuwano M, Uchiumi T, Hayakawa H, Ono M, Wada M, Izumi H, Kohno K
Cancer Sci 2003 Jan;94(1):9-14. doi: 10.1111/j.1349-7006.2003.tb01344.x. PMID: 12708467Free PMC Article
Banerjee D, Ercikan-Abali E, Waltham M, Schnieders B, Hochhauser D, Li WW, Fan J, Gorlick R, Goker E, Bertino JR
Acta Biochim Pol 1995;42(4):457-64. PMID: 8852336

Prognosis

Liao R, Chen X, Cao Q, Bai L, Ma C, Dai Z, Dong C
Breast Cancer Res 2024 Apr 23;26(1):70. doi: 10.1186/s13058-024-01825-6. PMID: 38654332Free PMC Article
Choi N, Kim HY, Lim BC, Chae JH, Kim SY, Ko JM
Mol Genet Genomic Med 2021 Oct;9(10):e1791. Epub 2021 Aug 24 doi: 10.1002/mgg3.1791. PMID: 34427995Free PMC Article
Donati B, Ciarrocchi A
Int J Mol Sci 2019 Jun 13;20(12) doi: 10.3390/ijms20122887. PMID: 31200515Free PMC Article
Orzol P, Holcakova J, Nekulova M, Nenutil R, Vojtesek B, Coates PJ
Histol Histopathol 2015 May;30(5):503-21. Epub 2014 Dec 16 doi: 10.14670/HH-30.503. PMID: 25510918
Katoh M, Igarashi M, Fukuda H, Nakagama H, Katoh M
Cancer Lett 2013 Jan 28;328(2):198-206. Epub 2012 Sep 27 doi: 10.1016/j.canlet.2012.09.017. PMID: 23022474

Clinical prediction guides

Zhu X, Chen C, Wei D, Xu Y, Liang S, Jia W, Li J, Qu Y, Zhai J, Zhang Y, Wu P, Hao Q, Zhang L, Zhang W, Yang X, Pan L, Qi R, Li Y, Wang F, Yi R, Yang Z, Wang J, Zhao Y
Elife 2023 Sep 5;12 doi: 10.7554/eLife.81258. PMID: 37668356Free PMC Article
Rengel BD, Kowalski TW, Bremm JM, do Amaral Gomes J, Schüler-Faccini L, Vianna FSL, Fraga LR
Birth Defects Res 2022 Dec 1;114(20):1354-1363. Epub 2022 Sep 30 doi: 10.1002/bdr2.2092. PMID: 36177858
Fletcher CE, Deng L, Orafidiya F, Yuan W, Lorentzen MPGS, Cyran OW, Varela-Carver A, Constantin TA, Leach DA, Dobbs FM, Figueiredo I, Gurel B, Parkes E, Bogdan D, Pereira RR, Zhao SG, Neeb A, Issa F, Hester J, Kudo H, Liu Y, Philippou Y, Bristow R, Knudsen K, Bryant RJ, Feng FY, Reed SH, Mills IG, de Bono J, Bevan CL
Mol Cancer 2022 Mar 22;21(1):82. doi: 10.1186/s12943-022-01540-w. PMID: 35317841Free PMC Article
Choi N, Kim HY, Lim BC, Chae JH, Kim SY, Ko JM
Mol Genet Genomic Med 2021 Oct;9(10):e1791. Epub 2021 Aug 24 doi: 10.1002/mgg3.1791. PMID: 34427995Free PMC Article
Wu Z, Zhou J, Zhang X, Zhang Z, Xie Y, Liu JB, Ho ZV, Panda A, Qiu X, Cejas P, Cañadas I, Akarca FG, McFarland JM, Nagaraja AK, Goss LB, Kesten N, Si L, Lim K, Liu Y, Zhang Y, Baek JY, Liu Y, Patil DT, Katz JP, Hai J, Bao C, Stachler M, Qi J, Ishizuka JJ, Nakagawa H, Rustgi AK, Wong KK, Meyerson M, Barbie DA, Brown M, Long H, Bass AJ
Nat Genet 2021 Jun;53(6):881-894. Epub 2021 May 10 doi: 10.1038/s41588-021-00859-2. PMID: 33972779Free PMC Article

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