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Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

MedGen UID:
1661682
•Concept ID:
C4744996
•
Neoplastic Process

Definition

The reemergence of T-cell/histiocyte-rich large B-cell lymphoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

Recent clinical studies

Etiology

Nodular lymphocyte predominant Hodgkin lymphoma: pathology, clinical course and relation to T-cell/histiocyte rich large B-cell lymphoma.
Hartmann S, Eichenauer DA
Pathology 2020 Jan;52(1):142-153. Epub 2019 Nov 28 doi: 10.1016/j.pathol.2019.10.003. PMID: 31785822
Bone Marrow Involvement in Patients With Nodular Lymphocyte Predominant Hodgkin Lymphoma.
Agbay RLMC, Loghavi S, Zuo Z, Fayad L, Dabaja B, Medeiros LJ, Khoury JD
Am J Surg Pathol 2018 Apr;42(4):492-499. doi: 10.1097/PAS.0000000000001005. PMID: 29309302

Diagnosis

Refractory T-cell/histiocyte-rich large B-cell lymphoma in a patient with ataxia-telangiectasia caused by novel compound heterozygous variants in ATM.
Sato D, Moriya K, Nakano T, Miyagawa C, Katayama S, Niizuma H, Sasahara Y, Kure S
Int J Hematol 2021 Dec;114(6):735-741. Epub 2021 Aug 23 doi: 10.1007/s12185-021-03203-w. PMID: 34424493
Nodular lymphocyte predominant Hodgkin lymphoma: pathology, clinical course and relation to T-cell/histiocyte rich large B-cell lymphoma.
Hartmann S, Eichenauer DA
Pathology 2020 Jan;52(1):142-153. Epub 2019 Nov 28 doi: 10.1016/j.pathol.2019.10.003. PMID: 31785822
JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.
Schuhmacher B, Bein J, Rausch T, Benes V, Tousseyn T, Vornanen M, Ponzoni M, Thurner L, Gascoyne R, Steidl C, Küppers R, Hansmann ML, Hartmann S
Haematologica 2019 Feb;104(2):330-337. Epub 2018 Sep 13 doi: 10.3324/haematol.2018.203224. PMID: 30213827Free PMC Article
Large B-cell lymphoma with T-cell-rich background and nodules lacking follicular dendritic cell meshworks: description of an insufficiently recognized variant.
Treetipsatit J, Metcalf RA, Warnke RA, Natkunam Y
Hum Pathol 2015 Jan;46(1):74-83. Epub 2014 Oct 8 doi: 10.1016/j.humpath.2014.09.009. PMID: 25456392
Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature.
Vezzoli P, Fiorani R, Girgenti V, Fanoni D, Tavecchio S, Balice Y, Mozzana R, Crosti C, Berti E
Dermatology 2011;222(3):225-30. Epub 2011 Apr 30 doi: 10.1159/000327376. PMID: 21540569

Therapy

Neurolymphomatosis diagnosed after a recurrence of facial palsy.
Shimizu Y, Kobayashi Y, Sato Y, Tozuka H, Oda K, Watanabe KI
Auris Nasus Larynx 2024 Aug;51(4):680-683. Epub 2024 May 4 doi: 10.1016/j.anl.2024.04.006. PMID: 38704896
Single-agent MOR208 salvage and maintenance therapy in a patient with refractory/relapsing diffuse large B-cell lymphoma: a case report.
Jurczak W, Bryk AH, Mensah P, Gałązka K, Trofimiuk-Müldner M, Wyrobek Ł, Sawiec A, Skotnicki AB
J Med Case Rep 2016 May 14;10(1):123. doi: 10.1186/s13256-016-0875-x. PMID: 27178351Free PMC Article

Prognosis

Nodular lymphocyte predominant Hodgkin lymphoma: pathology, clinical course and relation to T-cell/histiocyte rich large B-cell lymphoma.
Hartmann S, Eichenauer DA
Pathology 2020 Jan;52(1):142-153. Epub 2019 Nov 28 doi: 10.1016/j.pathol.2019.10.003. PMID: 31785822
Large B-cell lymphoma with T-cell-rich background and nodules lacking follicular dendritic cell meshworks: description of an insufficiently recognized variant.
Treetipsatit J, Metcalf RA, Warnke RA, Natkunam Y
Hum Pathol 2015 Jan;46(1):74-83. Epub 2014 Oct 8 doi: 10.1016/j.humpath.2014.09.009. PMID: 25456392
Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature.
Vezzoli P, Fiorani R, Girgenti V, Fanoni D, Tavecchio S, Balice Y, Mozzana R, Crosti C, Berti E
Dermatology 2011;222(3):225-30. Epub 2011 Apr 30 doi: 10.1159/000327376. PMID: 21540569

Clinical prediction guides

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.
Schuhmacher B, Bein J, Rausch T, Benes V, Tousseyn T, Vornanen M, Ponzoni M, Thurner L, Gascoyne R, Steidl C, Küppers R, Hansmann ML, Hartmann S
Haematologica 2019 Feb;104(2):330-337. Epub 2018 Sep 13 doi: 10.3324/haematol.2018.203224. PMID: 30213827Free PMC Article
Large B-cell lymphoma with T-cell-rich background and nodules lacking follicular dendritic cell meshworks: description of an insufficiently recognized variant.
Treetipsatit J, Metcalf RA, Warnke RA, Natkunam Y
Hum Pathol 2015 Jan;46(1):74-83. Epub 2014 Oct 8 doi: 10.1016/j.humpath.2014.09.009. PMID: 25456392
Cutaneous T-cell/histiocyte-rich B-cell lymphoma: a case report and review of the literature.
Vezzoli P, Fiorani R, Girgenti V, Fanoni D, Tavecchio S, Balice Y, Mozzana R, Crosti C, Berti E
Dermatology 2011;222(3):225-30. Epub 2011 Apr 30 doi: 10.1159/000327376. PMID: 21540569

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