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NF2 Gene Rearrangement

MedGen UID:
1661819
Concept ID:
C4725943
Cell or Molecular Dysfunction
Synonyms: ACN Gene Rearrangement; BANF Gene Rearrangement; Merlin Gene Rearrangement; Neurofibromin 2 Gene Rearrangement; NF-2 Gene Rearrangement; SCH Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the NF2 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNF2 Gene Rearrangement

Recent clinical studies

Etiology

Lin DI, Huang RSP, Mata DA, Decker B, Danziger N, Lechpammer M, Hiemenz M, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 Dec;34(12):2200-2210. Epub 2021 Jul 23 doi: 10.1038/s41379-021-00873-z. PMID: 34302054
Zhang Y, Chen F, Donehower LA, Scheurer ME, Creighton CJ
Nat Commun 2021 Feb 10;12(1):937. doi: 10.1038/s41467-021-21081-y. PMID: 33568653Free PMC Article
Mansouri S, Suppiah S, Mamatjan Y, Paganini I, Liu JC, Karimi S, Patil V, Nassiri F, Singh O, Sundaravadanam Y, Rath P, Sestini R, Gensini F, Agnihotri S, Blakeley J, Ostrow K, Largaespada D, Plotkin SR, Stemmer-Rachamimov A, Ferrer MM, Pugh TJ, Aldape KD, Papi L, Zadeh G
Acta Neuropathol 2021 Jan;141(1):101-116. Epub 2020 Oct 6 doi: 10.1007/s00401-020-02230-x. PMID: 33025139Free PMC Article
Pasmant E, Louvrier C, Luscan A, Cohen J, Laurendeau I, Vidaud M, Vidaud D, Goutagny S, Kalamarides M, Parfait B
Neurochirurgie 2018 Nov;64(5):335-341. Epub 2015 Jun 12 doi: 10.1016/j.neuchi.2015.01.004. PMID: 26073919
Malouf GG, Ali SM, Wang K, Balasubramanian S, Ross JS, Miller VA, Stephens PJ, Khayat D, Pal SK, Su X, Sircar K, Tamboli P, Jonasch E, Tannir NM, Wood CG, Karam JA
Eur Urol 2016 Aug;70(2):348-57. Epub 2016 Feb 16 doi: 10.1016/j.eururo.2016.01.051. PMID: 26895810

Diagnosis

Nobee A, Xu M, Seth A, Rong Y
Int J Mol Sci 2023 Aug 15;24(16) doi: 10.3390/ijms241612814. PMID: 37628996Free PMC Article
Malpica A
Adv Anat Pathol 2023 Jul 1;30(4):262-274. Epub 2022 Dec 12 doi: 10.1097/PAP.0000000000000387. PMID: 36729766
Collins K, Hwang M, Antic T, Paintal A, Argani P, Matoso A, Gopinath A, Baskovich B, Mehra R, Williamson SR, Idrees MT, Barletta JA, Anderson WJ, Hirsch MS, Hornick JL, Acosta AM
Histopathology 2022 Nov;81(5):577-586. Epub 2022 Aug 16 doi: 10.1111/his.14731. PMID: 35971742
Pasmant E, Louvrier C, Luscan A, Cohen J, Laurendeau I, Vidaud M, Vidaud D, Goutagny S, Kalamarides M, Parfait B
Neurochirurgie 2018 Nov;64(5):335-341. Epub 2015 Jun 12 doi: 10.1016/j.neuchi.2015.01.004. PMID: 26073919
Sestini R, Provenzano A, Bacci C, Orlando C, Genuardi M, Papi L
Genet Test 2008 Jun;12(2):311-8. doi: 10.1089/gte.2007.0096. PMID: 18554169

Therapy

Recondo G, Mezquita L, Facchinetti F, Planchard D, Gazzah A, Bigot L, Rizvi AZ, Frias RL, Thiery JP, Scoazec JY, Sourisseau T, Howarth K, Deas O, Samofalova D, Galissant J, Tesson P, Braye F, Naltet C, Lavaud P, Mahjoubi L, Abou Lovergne A, Vassal G, Bahleda R, Hollebecque A, Nicotra C, Ngo-Camus M, Michiels S, Lacroix L, Richon C, Auger N, De Baere T, Tselikas L, Solary E, Angevin E, Eggermont AM, Andre F, Massard C, Olaussen KA, Soria JC, Besse B, Friboulet L
Clin Cancer Res 2020 Jan 1;26(1):242-255. Epub 2019 Oct 4 doi: 10.1158/1078-0432.CCR-19-1104. PMID: 31585938Free PMC Article
Achkar T, Ali SM, Welsh A, Dhir R, Gollin SM, Parikh RA
Genes Chromosomes Cancer 2018 Aug;57(8):430-433. Epub 2018 Mar 30 doi: 10.1002/gcc.22537. PMID: 29532557
Agnihotri S, Suppiah S, Tonge PD, Jalali S, Danesh A, Bruce JP, Mamatjan Y, Klironomos G, Gonen L, Au K, Mansouri S, Karimi S, Sahm F, von Deimling A, Taylor MD, Laperriere NJ, Pugh TJ, Aldape KD, Zadeh G
Nat Commun 2017 Aug 4;8(1):186. doi: 10.1038/s41467-017-00174-7. PMID: 28775249Free PMC Article
Subbiah V, Wagner MJ, McGuire MF, Sarwari NM, Devarajan E, Lewis VO, Westin S, Kato S, Brown RE, Anderson P
Oncotarget 2015 Dec 1;6(38):40642-54. doi: 10.18632/oncotarget.5841. PMID: 26510912Free PMC Article

Prognosis

Hiltbrunner S, Fleischmann Z, Sokol ES, Zoche M, Felley-Bosco E, Curioni-Fontecedro A
Br J Cancer 2022 Nov;127(11):1997-2005. Epub 2022 Sep 22 doi: 10.1038/s41416-022-01979-0. PMID: 36138075Free PMC Article
Lin DI, Huang RSP, Mata DA, Decker B, Danziger N, Lechpammer M, Hiemenz M, Ramkissoon SH, Ross JS, Elvin JA
Mod Pathol 2021 Dec;34(12):2200-2210. Epub 2021 Jul 23 doi: 10.1038/s41379-021-00873-z. PMID: 34302054
Achkar T, Ali SM, Welsh A, Dhir R, Gollin SM, Parikh RA
Genes Chromosomes Cancer 2018 Aug;57(8):430-433. Epub 2018 Mar 30 doi: 10.1002/gcc.22537. PMID: 29532557
Pal SK, Ali SM, Yakirevich E, Geynisman DM, Karam JA, Elvin JA, Frampton GM, Huang X, Lin DI, Rosenzweig M, Lipson D, Stephens PJ, Ross JS, Miller VA, Agarwal N, Shuch B, Choueiri TK, Chung JH
Eur Urol 2018 Jan;73(1):71-78. Epub 2017 Jun 4 doi: 10.1016/j.eururo.2017.05.033. PMID: 28592388
Szijan I, Rochefort D, Bruder C, Surace E, Machiavelli G, Dalamon V, Cotignola J, Ferreiro V, Campero A, Basso A, Dumanski JP, Rouleau GA
Neuromolecular Med 2003;3(1):41-52. doi: 10.1385/NMM:3:1:41. PMID: 12665675

Clinical prediction guides

Collins K, Hwang M, Antic T, Paintal A, Argani P, Matoso A, Gopinath A, Baskovich B, Mehra R, Williamson SR, Idrees MT, Barletta JA, Anderson WJ, Hirsch MS, Hornick JL, Acosta AM
Histopathology 2022 Nov;81(5):577-586. Epub 2022 Aug 16 doi: 10.1111/his.14731. PMID: 35971742
Agnihotri S, Suppiah S, Tonge PD, Jalali S, Danesh A, Bruce JP, Mamatjan Y, Klironomos G, Gonen L, Au K, Mansouri S, Karimi S, Sahm F, von Deimling A, Taylor MD, Laperriere NJ, Pugh TJ, Aldape KD, Zadeh G
Nat Commun 2017 Aug 4;8(1):186. doi: 10.1038/s41467-017-00174-7. PMID: 28775249Free PMC Article
Szijan I, Rochefort D, Bruder C, Surace E, Machiavelli G, Dalamon V, Cotignola J, Ferreiro V, Campero A, Basso A, Dumanski JP, Rouleau GA
Neuromolecular Med 2003;3(1):41-52. doi: 10.1385/NMM:3:1:41. PMID: 12665675
Legoix P, Sarkissian HD, Cazes L, Giraud S, Sor F, Rouleau GA, Lenoir G, Thomas G, Zucman-Rossi J
Genomics 2000 Apr 1;65(1):62-6. doi: 10.1006/geno.2000.6139. PMID: 10777666
Zucman-Rossi J, Legoix P, Der Sarkissian H, Cheret G, Sor F, Bernardi A, Cazes L, Giraud S, Ollagnon E, Lenoir G, Thomas G
Hum Mol Genet 1998 Dec;7(13):2095-101. doi: 10.1093/hmg/7.13.2095. PMID: 9817927

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